HRAS
HGNC:5173 · 27 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HRAS | “The RAS family of oncoproteins (KRAS, HRAS, and NRAS) drive aggressive cancers like pancreatic ductal adenocarcinoma (PDAC) and non-small cell lung cancer (NSCLC), yet targeting mutant RAS has historically been challenging due to its "undruggable" structure.” | 0.98 | hgnc_dict_v1 |
| gene | HRAS | “NRAS, HRAS and TP53 mutations showed no significant difference.” | 0.98 | hgnc_dict_v1 |
| gene | HRAS | “In contrast, downregulation was discovered for 39 genes associated with immunity, regulation of cell cycle, and DNA damage response (HRAS, CCND1, ATM, CXCR1, and MIF).” | 0.98 | hgnc_dict_v1 |
| gene | HRAS | “The three isoforms of the RAS gene are HRAS, NRAS, and KRAS.” | 0.98 | hgnc_dict_v1 |
| gene | HRAS | “Targeted next-generation sequencing (NGS) was used to detect BRAF, NRAS, KRAS, HRAS, RET/PTC fusions, and TERT promoter mutations.” | 0.98 | hgnc_dict_v1 |
| gene | HRAS | “The mass excised in the case was positive for somatic missense mutations in RET (R813W) and HRAS (G12S) genes, identified at low variant allele frequencies.” | 0.98 | hgnc_dict_v1 |
| gene | HRAS | “Nine variants were missense, which included an insertion in EGFR c.1819_1820insCA, causing frameshifting, and a single nucleotide deletion in HRAS and HNF1A genes, causing frameshifting in these genes.” | 0.98 | hgnc_dict_v1 |
| gene | HRAS | “NRAS mutations predominated at 67 % compared to HRAS (24 %) and KRAS (12 %).” | 0.98 | hgnc_dict_v1 |
| gene | HRAS | “After comprehensively analyzing these 233 ferroptosis driver genes by various TCGA databases, RNA-sequencing (RNA-seq), and Reverse Transcription Quantitative Real-Time Polymerase Chain Reaction (RT-qPCR) techniques, TP53 (tumor protein 53), PTEN (Phosphatase and TENsin homolog deleted on chromosome 10), KRAS (Ki-ras2 Kirsten rat sarcoma viral oncogene homolog), and HRAS (Harvey Rat sarcoma virus) were identified as differentially expressed hub genes.” | 0.98 | hgnc_dict_v1 |
| gene | HRAS | “Pathway, gene expression, and survival studies were performed on the top 10 highly mutated genes (BRAF, NRAS, TG, TTN, HRAS, MUC16, ZFHX3, CSMD2, EIFIAX, SPTA1).” | 0.98 | hgnc_dict_v1 |
| gene | HRAS | “Predicting the effects of rare genetic variants on oncogenic signaling pathways: A computational analysis of HRAS protein function.” | 0.98 | hgnc_dict_v1 |
| gene | HRAS | “RESULTS: Three tumors were tested only by Sanger sequencing and were negative for BRAFV600E, HRAS, KRAS, NRAS, TERT promoter, PTEN, and PIK3CA mutations.” | 0.98 | hgnc_dict_v1 |
| gene | HRAS | “Human malignancies typically show mutations in the Ras gene including HRAS, KRAS, and NRAS.” | 0.98 | hgnc_dict_v1 |
| gene | HRAS | “Seven patients had single-gene TERT promoter mutations, and 17 had concurrent mutations, including BRAF V600E, HRAS, NRAS, PIK3CA, and EIF1AX.” | 0.98 | hgnc_dict_v1 |
| gene | HRAS | “TP53 and HRAS exhibited mutually exclusive mutation patterns.” | 0.98 | hgnc_dict_v1 |
| gene | HRAS | “The antioxidant activity of GR15 was accessed by the cell-free antioxidant assays such as ABTS, SARS, HRAS and NO; the results showed dose-dependent antioxidant activity.” | 0.98 | hgnc_dict_v1 |
| gene | HRAS | “Two genetic variants in the HRAS gene, which were present initially in the primary tumor, have been completely lost in the liver tumor.” | 0.98 | hgnc_dict_v1 |
| gene | HRAS | “Mutations in known driver genes including BRAF, NRAS, and HRAS were shared and preferentially clonal in both sites.” | 0.98 | hgnc_dict_v1 |
| gene | HRAS | “Eight synonymous mutations were found in FGFR3, PDGFRA, EGFR, RET, HRAS, FLT3, APC and SMAD4 genes.” | 0.98 | hgnc_dict_v1 |
| gene | HRAS | “We evaluated variants in the following genes: BRAF, CBL, HRAS, KRAS, MAP2K1, MAP2K2, NF1, NRAS, PTPN11, RAF1, SHOC2, and SOS1.” | 0.98 | hgnc_dict_v1 |
| gene | HRAS | “This study comprehensively investigated a large series of pediatric DTC for single point mutations in BRAF, HRAS, KRAS, NRAS, PIK3CA, PTEN, and TERT.” | 0.98 | hgnc_dict_v1 |
| gene | HRAS | “In addition to confirming known genes of OSCC (TP53, CDKNA2, CASP8, PIK3CA, HRAS, FAT1, TP63, CCND1 and FADD) the analysis identified several candidate novel driver events including mutations of NOTCH3, CSMD3, CRB1, CLTCL1, OSMR and TRPM2, amplification of the proto-oncogenes FOSL1, RELA, TRAF6, MDM2, FRS2 and BAG1, and deletion of the recently described tumor suppressor SMARCC1.” | 0.98 | hgnc_dict_v1 |
| gene | HRAS | “Orthologs of these viral oncogenes were then found in transforming DNA fragments in human cancers in the form of mutated versions of the HRAS and KRAS proto-oncogenes.” | 0.98 | hgnc_dict_v1 |
| gene | HRAS | “Mutation in BRAF exon 15, KRAS, NRAS, and HRAS were studied by polymerase chain reaction (PCR)-sequencing of tumor DNA; RET/PTC rearrangement was determined by reverse transcription (RT)-PCR-sequencing of tumor cDNA.” | 0.98 | hgnc_dict_v1 |
| gene | HRAS | “Costello syndrome is a rare syndrome associated with de novo mutations in the HRAS gene.” | 0.98 | hgnc_dict_v1 |
| gene | HRAS | “Comprehensive survey of HRAS, KRAS, and NRAS mutations in proliferative thyroid lesions from an ethnically diverse population.” | 0.98 | hgnc_dict_v1 |
| gene | HRAS | “Mutational screening of RET, HRAS, KRAS, NRAS, BRAF, AKT1, and CTNNB1 in medullary thyroid carcinoma.” | 0.98 | hgnc_dict_v1 |