CYP1A1
HGNC:2595 · 28 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CYP1A1 | “Meta-Analysis of CYP1A1 MspI and Ile462Val Polymorphisms in Cancer Susceptibility Among Different Ethnic Populations.” | 0.98 | hgnc_dict_v1 |
| gene | CYP1A1 | “The Influence of Genetic Polymorphisms in Cytochrome P450 (CYP1A1 and 2D6) Gene on the Susceptibility to Philadelphia Negative Chronic Myeloid Leukemia in Sudanese Patients.” | 0.98 | hgnc_dict_v1 |
| gene | CYP1A1 | “Moreover, 3FPP augmented the promoter-driven luciferase activities and expression of AhR-regulated genes encoding cytochrome P450 1A1 (CYP1A1) and microRNA (miR)-212/132 cluster.” | 0.98 | hgnc_dict_v1 |
| gene | CYP1A1 | “Association of genetic predisposition studies in CYP1A1 polymorphism studies in acute myeloid leukemia.” | 0.98 | hgnc_dict_v1 |
| gene | CYP1A1 | “Furthermore, BM-MSCs from both mice and rats produced a significant decrease in the elevated mRNA expression of liver CYP1A1, MMP-9, procollagen α1, TGF-β1, and increase in expression of lowered IL-4, IL-10, cluster CD-105, and Oct3/4.” | 0.98 | hgnc_dict_v1 |
| gene | CYP1A1 | “This induced a 15.4-fold upregulation of CYP1A1 in EV-HaCaTs, which was significantly reduced in AHR-silenced cells.” | 0.98 | hgnc_dict_v1 |
| gene | CYP1A1 | “The basal and inducible levels of BCL-2, AhR, and CYP1A1 in vitro breast cancer and epithelial cell lines and in vivo mice animal models were determined by RT-PCR, Western blot analysis, immunofluorescence, flow cytometry, silencing of the target, and immunohistochemistry.” | 0.98 | hgnc_dict_v1 |
| gene | CYP1A1 | “On the other hand, specific mutations in ABCC1, ADIPOQ, CYP1A1, KIR, IL-17A, MMP2, NOTCH3, PRNCR1, RETN, TDG, TLR2, BRAF, PARP-1, TLR4, TLR-9, TNF-α, TSLP and XRCC1 genes demonstrated a substantial augmented CRC risk development in Saudi patients.” | 0.98 | hgnc_dict_v1 |
| gene | CYP1A1 | “Even the presence of one copy of a variant allele in the CYP1A1 gene can predispose CRC risk.” | 0.98 | hgnc_dict_v1 |
| gene | CYP1A1 | “Moreover, there was a dowin-regulated trend in Bax, Caspases-3, Caspases-7, Caspases-9, CYP1A1, CYP2H1, and P53 gene expression with in ovo injection of AFB1+Met compared to AFB1 alone.” | 0.98 | hgnc_dict_v1 |
| gene | CYP1A1 | “CYP1A1 and CYP2D6 Polymorphisms and Susceptibility to Chronic Myelocytic Leukaemia.” | 0.98 | hgnc_dict_v1 |
| gene | CYP1A1 | “CYP1A1 gene (6235T<C) polymorphism as a risk factor for polycystic ovarian syndrome among Egyptian women.” | 0.98 | hgnc_dict_v1 |
| gene | CYP1A1 | “We initially characterized resveratrol-aspirin derivatives as products that can inhibit cytochrome P450 Family 1 Subfamily A Member 1 (CYP1A1) activity, DNA methyltransferase (DNMT) activity, and cyclooxygenase (COX) activity.” | 0.98 | hgnc_dict_v1 |
| gene | CYP1A1 | “Dasatinib induces gene expression of CYP1A1, CYP1B1, and cardiac hypertrophy markers (BNP, β-MHC) in rat cardiomyocyte H9c2 cells.” | 0.98 | hgnc_dict_v1 |
| gene | CYP1A1 | “RESULTS: We identified 42 smoking-methylation and 42 smoking-expression signals, where five genes (AHRR, CYP1A1, CYP1B1, CYTL1, F2RL3) were both hypo-methylated and upregulated in current smokers.” | 0.98 | hgnc_dict_v1 |
| gene | CYP1A1 | “This model depicted hypertension and alcohol intake as the key predictors of CAD risk followed by cSHMT C1420T, GCPII C1561T, diabetes, GSTT1, CYP1A1 m2, TYMs 5'-UTR 28 bp tandem repeat and MTRR A66G.” | 0.98 | hgnc_dict_v1 |
| gene | CYP1A1 | “In single-variant analyses, we identified single nucleotide polymorphisms at seven new loci associated with eGFRcrea (PPM1J, EDEM3, ACP1, SPEG, EYA4, CYP1A1, and ATXN2L; PStage1<3.7×10-7), of which most were common and annotated as nonsynonymous variants.” | 0.98 | hgnc_dict_v1 |
| gene | CYP1A1 | “In comparison with the human enzymes, camel CYPs showed lower evolution rate, especially CYP1A1.” | 0.98 | hgnc_dict_v1 |
| gene | CYP1A1 | “Multifactor dimensionality reduction analysis showed the following interactions in responders to folate: RFC1 G80A × MTHFR C677T (primary), COMT H108L × CYP1A1 m2 (secondary), MTR A2756G (tertiary).” | 0.98 | hgnc_dict_v1 |
| gene | CYP1A1 | “Ultrastructural changes in kidney were examined by transmission electron microscope (TEM) and the gene expression of xenobiotic metabolizing enzymes including cytochrome P-450-1A1 (CYP1A1) and CYP1A2 were studied by real time PCR.” | 0.98 | hgnc_dict_v1 |
| gene | CYP1A1 | “Real-time PCR analysis showed that SUN significantly induced the hepatic and renal CYP1A1, 1A2, 1B1, 2E1 and 4F4, whereas it inhibited CYP2C11 and 4A2.” | 0.98 | hgnc_dict_v1 |
| gene | CYP1A1 | “Therefore, the overall objectives of the present study are to elucidate the potential chemopreventive effect of MET in non-cancerous human breast MCF10A cells and explore the underlying mechanism involved, specifically the role of cytochrome P4501A1 (CYP1A1)/aryl hydrocarbon receptor (AhR) pathway.” | 0.98 | hgnc_dict_v1 |
| gene | CYP1A1 | “The aim of the present study was to investigate contributions of CYP1A1, CYP2E1, and GSTM1 gene polymorphisms.” | 0.98 | hgnc_dict_v1 |
| gene | CYP1A1 | “The current study was designed to investigate the potential effect of Pb(2+) to induce cardiotoxicity in vivo and in vitro rat model and to explore the molecular mechanisms and the role of aryl hydrocarbon receptor (AhR) and regulated gene, cytochrome P4501A1 (CYP1A1), in Pb(2+)-mediated cardiotoxicity.” | 0.98 | hgnc_dict_v1 |
| gene | CYP1A1 | “METHODS: 223 incident papillary thyroid cancer cases and 513 controls recruited from Saudi Arabian population were analyzed for the association between polymorphisms in genes encoding folic acid metabolizing enzymes MTHFR and six xenobiotics-metabolizing enzymes including CYP1A1 T3801C, C4887A, GSTP1 A1578G, C2293T, GSTM1, GSTT1, NAT2 G590A, NQO*1 C609T, using PCR-RELP.” | 0.98 | hgnc_dict_v1 |
| gene | CYP1A1 | “Polymorphisms of drug-metabolizing enzymes CYP1A1, GSTT and GSTP contribute to the development of diffuse large B-cell lymphoma risk in the Saudi Arabian population.” | 0.98 | hgnc_dict_v1 |
| gene | CYP1A1 | “We used PCR analysis to catalog the frequencies of alleles and genotypes for CYP1A1, NAT2, GSTs, MTHFR, MTR (MS) and NQO*1 in Arabs.” | 0.98 | hgnc_dict_v1 |
| gene | CYP1A1 | “The PAH-exposure biomarker levels were not significantly influenced by polymorphic variations of CYP1A1 (MspI) and glutathione S-transferases M1 and T1.” | 0.98 | hgnc_dict_v1 |