STAT1
HGNC:11362 · 42 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | STAT1 | “We examined how ursolic acid affects the expression of Th1 (IFN-γ, TNF-α, STAT1, STAT4, and T-bet), Th17 (IL-17, RORγt, and STAT3), and T regulatory (Treg; IL-10, TGF-β1, and Foxp3) markers in CD4+ T cells within the spleens of BTBR and C57BL/6 mice.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “Patient cells showed markedly reduced OSM-induced phosphorylation of STAT1, STAT3, and STAT5, while signaling through other IL-6 family receptor complexes remained intact.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “METHODS: Using a combination of protein-protein interaction prediction tools and transcriptional regulatory interaction databases, we identified JUN, FOS, ATF2, ATF4, RELA, NF-κB, SMAD3, STAT1, STAT3, and SP1 as potential candidate TFs that might be involved in Aβ1-42 related pathways.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “Gene expression analysis revealed decreased pro-inflammatory activity and changes in stress response indicators such as PTGS2, PARP1, STAT1, TNF-⍺, IL-1β, and NF-κB.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “Alpha‑lipoic acid-loaded chitosan nanoparticles ameliorate streptozotocin‑induced diabetic liver injury via Nrf2/HO‑1 activation and TLR4/NF‑κB and JAK2/STAT1 inhibition.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “STAT1 is a potential prognostic biomarker in lung adenocarcinoma regulated by hsa-miR-145-3p and hsa-let-7b-5p.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “Of these, 23 (50%) were diagnosed with Mendelian susceptibility to mycobacterial disease (MSMD), involving mutations in the IL12RB1, STAT1, IFNGR1, SPPL2A, TYK2, and TBX21 (T-bet) genes.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “Case Report: Dual molecular diagnosis of gain-of-function STAT1 mutation and regulatory STAT3 variant in a patient with a hyper-IgE-like phenotype.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “Notably, 38 patients were classified as rare monogenic SAIDs, linked to mutations in genes, including NLRC4, LPIN2, RIPK1, PLCG2, PIK3CD, ISG15, ZNFX1, STAT1, SOCS1, OTULIN, PTEN, GJB2, SLC29A3, and IL-17RA.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “MSC-EVs impaired the activation of the STAT3/STAT1 signaling pathway and reduced the cytokine storm and coagulopathy associated with COVID-19.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “Survival analysis identified CXCL11 and STAT1 as potential prognostic biomarkers, with lower expression correlating with poorer survival in both cancers.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “Elevated TNFα and IFN-γ levels, with low STAT1 and STAT6, were observed.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “Interleukin 1B (IL1B), CAPS1, and signal transducer and activator of transcription 1 (STAT1) were identified by intersection out of 22 DE-ATGs discovered by differential expression analysis.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “Integrating Artificial Intelligence and Bioinformatics Methods to Identify Disruptive STAT1 Variants Impacting Protein Stability and Function.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “In Silico Prioritization of STAT1 3' UTR SNPs Identifies rs190542524 as a miRNA-Linked Variant with Potential Oncogenic Impact.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “Signal transducer and activator of transcription 1 (STAT1) gene mutation is a genetic trigger that causes CMC, which increases the risk of infections, multisystem disorders, and cancer susceptibility.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “In the network pharmacology, STAT1, MX1, DDX58, EIF2AK2, ISG15, IFIT1, IFIH1, OAS1, IRF9, and OASL were identified as the top 10 hub genes.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “This report suggests that activation of type I IFN through Signal Transducers and Activators of Transcription1 (STAT1) could bypass the early IFN-γ signaling defects and activate IFN-γ production.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “Moreover, 8 patients presented with rare interferonopathy conditions, including three with ISG15, 3 with ZNFX1, 1 with the SOCS1 variant, and 1 the STAT1 variant.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “A term infant with severe hypereosinophilia secondary to CMV infection and the STAT1 gene mutation: a case report : List of authors.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “IRF9 interacts with STAT1 and STAT2 to form IFN-I-stimulated gene factor 3 (ISGF3) in response to type I IFN stimulation, which promotes ISG transcription.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “In addition, we investigated the potential molecular mechanisms that underlie the impact of AFB1 on the production of Th1 (IFN-γ, STAT1, and T-bet), Th9 (IL-9 and IRF4), Th17 (IL-17A, IL-21, RORγT, and STAT3), Th22 (IL-22, AhR, and TNF-α), and T regulatory (Treg) (IL-10, TGF-β1, and FoxP3) cells in the spleen.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “One of its accessory proteins, ORF6, has been found to play a critical role in immune evasion by interacting with KPNA2 to antagonize IFN signaling and production pathways, resulting in the inhibition of IRF3 and STAT1 nuclear translocation.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “We used flow cytometry to investigate the molecular mechanism behind the effect of Pb exposure on subsets of CD4+ T cells in the spleen expressing IFN-γ, T-bet, STAT1, STAT4, IL-9, IRF4, IL-22, AhR, IL-10, and Foxp3.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “Flow cytometry was used to detect the surface expressions of IFN-γR1 and IFN-γR2 as well as IL-12Rβ1and IL-12Rβ2 on monocytes and T lymphocytes, respectively.The phosphorylation of signal transducer and activator of transcription 1(STAT1) on monocytes and STAT4 on T lymphocytes were also detected by flow cytometry.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “OBJECTIVES: Using different online available databases and Bioinformatics tools, we extensively studied the role STAT1 across different cancers.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “A child with bronchiectasis, chronic mucocutaneous candidiasis, and hypothyroidism secondary to STAT1 gain-of-function mutation: A case report and review of the literature.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “Genetic, Immunological, and Clinical Features of 32 Patients with Autosomal Recessive STAT1 Deficiency.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “The other seven patients had different PIDs genetic defects that include SCID caused by PNP deficiency, CGD, CVID (PIK3CD), IL-2RB mutation, DNase II deficiency, STAT1 mutation, ISG15 mutation and Griscelli syndrome type 3.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “However, STAT1, important for tissue wasting, did show further increased phosphorylation at 32°C.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “Kyoto Encyclopedia of Gene and Genome pathway analysis found that L-PRF mediates NF-k B signaling, Toll-like receptor signaling (TLR), and MAPK signaling via T-cell receptor signaling pathway. i-PRF is significantly involved in JAK-STAT signaling pathway through upregulation of STAT1.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “TMPRSS2, including IFNβ, STAT1, and STAT2, has the PARP1 binding site near to TSS either up or downstream promoter region.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “Combined immunodeficiency (CID) patients secondary to AK2, PTPRC, CD247, DCLREC1 and STAT1 had normal TREC and KREC counts.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “Upregulated genes preferentially associated with other gene ontologies (GO) were, e.g., STAT1, MMP9, TOP2A, and BRCA2.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “In the current study, we investigated the cytokines and transcription factors produced by CXCR1+ cells (IL-31, IL-9, IL-21R, IL-21, NF-κB p65, RORγT, STAT1, and FoxP3) in peripheral blood mononuclear cells (PBMCs), from children with ASD and typically developing (TD) control children, using flow cytometric analysis.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “Furthermore, 5-AIQ treatment decreased CXCR4, IFN-γ, IL-22, STAT1, and RORγT mRNA expression levels in brain tissue.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “Mutations in the coiled-coil and DNA-binding domains of STAT1 lead to delayed STAT1 dephosphorylation and subsequently gain-of-function.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “Hub genes such as YWHAZ, STAT1, ICAM1, SH3BP5, CD83, FN1, TK1, HIST1H1C, CABLES1, and MCM3 were associated with poor overall survival, while hub genes such as STAT1, ICAM1, CD83, FN1, TK1, HIST1H1C, and MCM3 were highly expressed in stage 4.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “Gene expression of CCND2, STAT1, ITGB8, ALDH2, and ADAMTS5 was measured using real-time PCR.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “IFN-α-induced signaling was impaired in the patient fibroblasts, as evidenced by decreased STAT1/STAT2 phosphorylation, nuclear translocation of STAT1, and expression of IFN-α-stimulated genes critical for CMV immunity.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “They include immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome, which is caused by mutations in forkhead box P3 (FOXP3), and IPEX-like disorders caused by mutations in IL-2 receptor α (IL2RA), signal transducer and activator of transcription 5b (STAT5b), and signal transducer and activator of transcription 1 (STAT1).” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “There are 6 MSMD-causing genes, including 1 X-linked gene (nuclear factor-kappaB-essential modulator [NEMO]) and 5 autosomal genes (IFN-gamma receptor 1 [IFNGR1], IFN-gamma receptor 2 [IFNGR2], signal transducer and activator of transcription 1 [STAT1], IL-12 p40 subunit [IL12P40], and IL-12 receptor beta-subunit [IL12RB1]).” | 0.98 | hgnc_dict_v1 |