Alzheimer disease
SaudiVarKB evidence summary derived from retained literature mentions.
338Phenotype mentions
100Publications
50Associated gene records
39Associated variant records
Associated gene records
Co-mentioned in the same publications| Gene | Identifier / context | Articles | Mentions |
|---|---|---|---|
| APOE | HGNC:613 | 15 | 15 |
| APP | HGNC:620 | 12 | 12 |
| BACE1 | HGNC:933 | 11 | 11 |
| PSEN1 | HGNC:9508 | 8 | 8 |
| BDNF | HGNC:1033 | 7 | 7 |
| NLRP3 | HGNC:16400 | 6 | 6 |
| PSEN2 | HGNC:9509 | 6 | 6 |
| TREM2 | HGNC:17761 | 6 | 6 |
| TLR4 | HGNC:11850 | 5 | 5 |
| MAPT | HGNC:6893 | 4 | 4 |
| STAT3 | HGNC:11364 | 4 | 4 |
| PTEN | HGNC:9588 | 4 | 4 |
| SORL1 | HGNC:11185 | 4 | 4 |
| CASP3 | HGNC:1504 | 4 | 4 |
| TNF | HGNC:11892 | 3 | 3 |
| BCL2 | HGNC:990 | 3 | 3 |
| AKT1 | HGNC:391 | 3 | 3 |
| BIN1 | HGNC:1052 | 3 | 3 |
| HSP90AA1 | HGNC:5253 | 3 | 3 |
| LRP1 | HGNC:6692 | 3 | 3 |
| PARP1 | HGNC:270 | 2 | 2 |
| SIRT1 | HGNC:14929 | 2 | 2 |
| SHH | HGNC:10848 | 2 | 2 |
| SOD1 | HGNC:11179 | 2 | 2 |
| GSK3B | HGNC:4617 | 2 | 2 |
| MARK4 | HGNC:13538 | 2 | 2 |
| CLU | HGNC:2095 | 2 | 2 |
| ABCA1 | HGNC:29 | 2 | 2 |
| HTRA1 | HGNC:9476 | 2 | 2 |
| DYRK1A | HGNC:3091 | 2 | 2 |
| CDK2 | HGNC:1771 | 2 | 2 |
| SRC | HGNC:11283 | 2 | 2 |
| GAPDH | HGNC:4141 | 2 | 2 |
| CDK5 | HGNC:1774 | 2 | 2 |
| LINGO2 | HGNC:21207 | 2 | 2 |
| ABCA7 | HGNC:37 | 2 | 2 |
| CXCL9 | HGNC:7098 | 1 | 1 |
| CDKN1A | HGNC:1784 | 1 | 1 |
| GFAP | HGNC:4235 | 1 | 1 |
| ALDH3A2 | HGNC:403 | 1 | 1 |
| LRRC7 | HGNC:18531 | 1 | 1 |
| HDAC2 | HGNC:4853 | 1 | 1 |
| MSR1 | HGNC:7376 | 1 | 1 |
| ALDH4A1 | HGNC:406 | 1 | 1 |
| CYP2D6 | HGNC:2625 | 1 | 1 |
| ASTN2 | HGNC:17021 | 1 | 1 |
| STAT1 | HGNC:11362 | 1 | 1 |
| NR4A2 | HGNC:7981 | 1 | 1 |
| MTHFR | HGNC:7436 | 1 | 1 |
| HMOX1 | HGNC:5013 | 1 | 1 |
Associated variant records
Co-mentioned in the same publications| Variant | Identifier / context | Articles | Mentions |
|---|---|---|---|
| rs6265 | rs6265 | 1 | 1 |
| rs744373 | rs744373 | 1 | 1 |
| rs7561528 | rs7561528 | 1 | 1 |
| rs11136000 | rs11136000 | 1 | 1 |
| rs9331888 | rs9331888 | 1 | 1 |
| rs1887922 | rs1887922 | 1 | 1 |
| p.Val297Met | p.Val297Met | 1 | 1 |
| p.Arg1084Cys | p.Arg1084Cys | 1 | 1 |
| p.Asp1100Asn | p.Asp1100Asn | 1 | 1 |
| p.Pro1213Ser | p.Pro1213Ser | 1 | 1 |
| p.Glu380Lys | p.Glu380Lys | 1 | 1 |
| c.105delG | c.105delG | 1 | 1 |
| c.103del | c.103del | 1 | 1 |
| rs180177442 | rs180177442 | 1 | 1 |
| R262L | R262L | 1 | 1 |
| R262P | R262P | 1 | 1 |
| rs201875324 | rs201875324 | 1 | 1 |
| T659I | T659I | 1 | 1 |
| rs139814109 | rs139814109 | 1 | 1 |
| T897M | T897M | 1 | 1 |
| rs182024939 | rs182024939 | 1 | 1 |
| P301S | P301S | 1 | 1 |
| rs429358 | rs429358 | 1 | 1 |
| rs7412 | rs7412 | 1 | 1 |
| rs11136000 | rs11136000 | 1 | 1 |
| rs1532278 | rs1532278 | 1 | 1 |
| rs1800629 | rs1800629 | 1 | 1 |
| rs1799724 | rs1799724 | 1 | 1 |
| rs1800796 | rs1800796 | 1 | 1 |
| rs1800795 | rs1800795 | 1 | 1 |
| L84P | L84P | 1 | 1 |
| L99A | L99A | 1 | 1 |
| rs199716082 | rs199716082 | 1 | 1 |
| rs267603119 | rs267603119 | 1 | 1 |
| G1135T | G1135T | 1 | 1 |
| p.G379W | p.G379W | 1 | 1 |
| c.3706C>T | c.3706C>T | 1 | 1 |
| rs75932628 | rs75932628 | 1 | 1 |
| G196A | G196A | 1 | 1 |
Associated population records
Co-mentioned in the same publications| Population | Identifier / context | Articles | Mentions |
|---|---|---|---|
| Saudi Arabia | — | 4 | 4 |
| Population record | Cohort 50 | 3 | 3 |
| Population record | Cohort 2 | 2 | 2 |
| Population record | Cohort 10 | 1 | 1 |
| Saudi Arabia | Cohort 64 | 1 | 1 |
| Population record | Cohort 21 | 1 | 1 |
| Saudi Arabia | Cohort 42 | 1 | 1 |
| Saudi Arabia | Cohort 117 | 1 | 1 |
| Population record | Cohort 250 | 1 | 1 |
| Saudi Arabia | Cohort 40 | 1 | 1 |
| Saudi Arabia | Cohort 52 | 1 | 1 |
| Saudi Arabia · Eastern Province | — | 1 | 1 |
| Population record | Cohort 273 | 1 | 1 |
| Population record | Cohort 263 | 1 | 1 |
| Saudi Arabia · Riyadh | Cohort 385 | 1 | 1 |
| Population record | Cohort 502 | 1 | 1 |
| Population record | Cohort 834 | 1 | 1 |
| Saudi Arabia · Jeddah | Cohort 9 | 1 | 1 |
| Population record | Cohort 536 | 1 | 1 |
| Saudi Arabia · Riyadh | Cohort 143 | 1 | 1 |
| Population record | Cohort 370 | 1 | 1 |
| Population record | Cohort 466 | 1 | 1 |
| Population record | Cohort 1,136 | 1 | 1 |
Supporting publications
100 records- 2026Synthesis of 2,4-bis(trifluoromethyl)benzaldehyde Hybrid Thiosemicarbazones as Prolyl Oligopeptidase Inhibitors for Neurodegenerative Disorders and their In silico Analysis.Current medicinal chemistry1 mentions
- 2026Synthesis, DFT, ADMET and molecular docking studies of thiazole derived thiazolidinone-based chalcone derivatives: alzheimer's disease current therapies.Future medicinal chemistry1 mentions
- 2026Neuronal plasticity and its role in Alzheimer's disease and Parkinson's disease.Neural regeneration research1 mentions
- 2026Ginkgolide as a Promising Multi-Target Therapeutic for Alzheimer's Disease: Targeting ApoE4 and Beyond.Current pharmaceutical design1 mentions
- 2026Essential Oils from Olea europaea and Cyperus esculentus Exhibit Promising Therapeutic Effect against Alzheimer's Disease in a Rat Model.Current pharmaceutical biotechnology1 mentions
- 2026Targeting cathepsin B activity by natural inhibitors: a structural dynamics and network pharmacology approach for amyloid-beta dysregulation in Alzheimer's disease.Molecular diversity1 mentions
- 2026The gut-brain axis: role of gut microbiota in neurological disease pathogenesis and pharmacotherapeutics.Naunyn-Schmiedeberg's archives of pharmacology1 mentions
- 2026Characterizing Alzheimer's Disease and Related Dementia in a Hypertension Population Within the State of Florida Using Electronic Health Record-Based Data.Clinical pharmacology and therapeutics1 mentions
- 2026Unraveling the metabolic potential of Moringa oleifera derived metabolites in combating Parkinson's and Alzheimer's disease.Bioorganic chemistry1 mentions
- 2026Precision therapeutic strategies for Alzheimer's disease: Amyloid β-targeted foundations and multimodal next-generation approaches.Molecular and cellular neurosciences1 mentions
- 2026Targeting of PCSK9 in the Management of Alzheimer's Disease: Expanding the New Potential Key Player.Drug development research1 mentions
- 2026Betanin-encapsulated nanoparticles mitigate neurotoxicity against AlCl3-induced Alzheimer's disease via modulation of AChE/TNF-α/IL-1β expression.Biochemical and biophysical research communications1 mentions
- 2026Adenosine A₂A receptor as a dual-acting molecular switch: Glial morphological changes and neurovascular tissue remodeling in neuroinflammation and neurodegeneration.Tissue & cell1 mentions
- 2026Unraveling the molecular mechanisms in severe Alzheimer's disease based on transcriptomic data using next generation knowledge discovery methods.Pakistan journal of medical sciences1 mentions
- 2026Cheminformatics-driven discovery of natural isoquinoline alkaloid inhibitors of Beta-secretase I for Alzheimer's management.PloS one1 mentions
- 2026Biological implications and therapeutic potential of phosphodiesterase inhibitors: A review.Medicine1 mentions
- 2026TREM2 in neurodegeneration and diseases.Molecular psychiatry1 mentions
- 2026Ligustilide Attenuates Neuroinflammation and Fibrosis in an Aluminum Chloride-induced Rat Model of Alzheimer's Disease via mTOR/STAT3 Signaling Inhibition.The Keio journal of medicine1 mentions
- 2026Exploring the Epigenetic Mechanisms Underlying Chronic Diseases: A Comprehensive Review.Current gene therapy1 mentions
- 2026Reconnoitering the Potential of the Pharmacogenomics Approach in the Management of Alzheimer's Disease: A Review.CNS & neurological disorders drug targets1 mentions
- 2026Association of genetic variants in cyclin-dependent kinase 5 with Alzheimer's disease in a Saudi cohort.Journal of Alzheimer's disease : JAD1 mentions
- 2026Personalized Hearing Loss Care Using SNOMED CT-Aligned Ontology and Random Forest Machine Learning: A Hybrid Decision-Support Framework.Audiology research1 mentions
- 2026Extracellular Vesicles as Key SASP Carriers Driving Cellular Senescence, Inflammaging, and Therapeutic Opportunities in Aging and Age-Related Diseases.Aging and disease1 mentions
- 2026CRISPR-Cas9 and next-generation gene editing strategies for therapeutic intervention of neurodegenerative pathways in Alzheimer's disease: a state-of-the-art review.Acta neurologica Belgica1 mentions
- 2026The mRNA Expression Levels of General Transcription Factors Altered in Alzheimer Cases Possibly Due to Amyloid Beta 1-42 Exposure.Noro psikiyatri arsivi1 mentions
- 2026Targeting the FOXO4-p53 axis by retro-inverso peptide senolytic agents: a pharmacological strategy to mitigate brain aging and cognitive decline.Naunyn-Schmiedeberg's archives of pharmacology1 mentions
- 2026LASSO-HHO two-stage hybrid gene selection framework for accurate Alzheimer's disease diagnosis.Scientific reports1 mentions
- 2026Small-Molecule Targeting of the Iron-Responsive Element in the APP mRNA 5'-UTR to Control Amyloid Translation in Alzheimer's Disease.International journal of molecular sciences1 mentions
- 2026Neuroprotective Properties of Litchi chinensis and Its Phytochemicals in Preclinical Models of Alzheimer's Disease.Brain and behavior1 mentions
- 2026Development of coumarin-sulfonate scaffolds for cholinesterase inhibition: experimental and computational studies toward Alzheimer's disease therapy.RSC advances1 mentions
- 2026Exosomal miRNA in cerebrospinal fluid as biomarkers for neurodegenerative disease.Clinica chimica acta; international journal of clinical chemistry1 mentions
- 2026predALZ: An Ensemble Learning Framework for Identifying Genetic Biomarkers in Familial Alzheimer's Disease.Current drug targets1 mentions
- 2026Rare and novel genetic variants in sporadic and familial Alzheimer's disease: insights from the first Saudi cohort.Frontiers in aging1 mentions
- 2026Exosome-mediated gut-brain axis signaling in neurodegenerative diseases: Mechanisms, experimental evidence, and therapeutic perspectives-A narrative review.Animal models and experimental medicine1 mentions
- 2026Immunotherapeutic Advances in Alzheimer's Disease: The Convergence of Vaccinology and Nanoscience.Current Alzheimer research1 mentions
- 2026Omics-driven strategies for identifying biomarkers in Alzheimer's disease.Metabolic brain disease1 mentions
- 2026Beyond categorical boundaries: Common molecular and cellular pathways in autism spectrum disorder and schizophrenia.Progress in neuro-psychopharmacology & biological psychiatry1 mentions
- 2026Retraction notice to "Exploring the molecular mechanisms of MSC-derived exosomes in Alzheimer's disease: Autophagy, insulin and the PI3K/Akt/mTOR signaling pathway" [Biomedicine & Pharmacotherapy 176 (2024) 116836].Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie1 mentions
- 2026Neuroinflammation mediated repurposing of clemastine for Alzheimer's disease through network pharmacology, molecular dynamics, and experimental validation studies.Inflammopharmacology1 mentions
- 2026Apolipoprotein E in Alzheimer's disease: A review of APOE receptors, signalling pathways and therapeutic opportunities.Molecular and cellular neurosciences1 mentions
- 2026Targeting PARP1-dependent parthanatos in Alzheimer's disease: Mechanisms and therapeutic opportunities.Life sciences1 mentions
- 2025Comprehensive mapping of mutations in TDP-43 and α-Synuclein that affect stability and binding.Journal of biomolecular structure & dynamics1 mentions
- 2025Network pharmacology and molecular dynamic simulation integrated strategy for the screening of active components and mechanisms of phytochemicals from Datura innoxia on Alzheimer and cognitive decline.Journal of biomolecular structure & dynamics1 mentions
- 2025Computational Identification and Functional Analysis of Potentially Pathogenic nsSNPs in the NLRP3 Gene Linked to Alzheimer's Disease.Cell biochemistry and biophysics1 mentions
- 2025Crotalaria quinquefolia L. Revealed as a Potential Source of Neuropharmacophore in Both Experimental and Computational Studies.Chemistry & biodiversity1 mentions
- 2025Decoding the Therapeutic Potential of Cannabis and Cannabinoids in Neurological Disorders.Current pharmaceutical design1 mentions
- 2025Inflammatory signaling pathways in Alzheimer's disease: Mechanistic insights and possible therapeutic interventions.Ageing research reviews1 mentions
- 2025Biochemical Investigation of the Association of Apolipoprotein E Gene Allele Variations with Insulin Resistance and Amyloid-β Aggregation in Cardiovascular Disease.Clinical and experimental pharmacology & physiology1 mentions
- 2025CNV-Finder: Streamlining Copy Number Variation Discovery.bioRxiv : the preprint server for biology1 mentions
- 2025Dietary supplementation and the role of phytochemicals against the Alzheimer's disease: Focus on polyphenolic compounds.The journal of prevention of Alzheimer's disease1 mentions
- 2025Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies.Food science & nutrition1 mentions
- 2025Untangling the complex mechanisms associated with Alzheimer's disease in elderly patients using high-throughput RNA sequencing data and next-generation knowledge discovery methods: Focus on potential gene signatures and drugs for dementia.Heliyon1 mentions
- 2025Repurposing of dipeptidyl peptidase FDA-approved drugs in Alzheimer's disease using network pharmacology and in-silico approaches.Computational biology and chemistry1 mentions
- 2025Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review.Frontiers in pharmacology1 mentions
- 2025Alzheimer's disease in the Kingdom of Saudi Arabia: Current perspectives and genetic insights.Journal of Alzheimer's disease : JAD1 mentions
- 2025Portulaca oleracea L. Methanolic Extract Protects the Brain of Male Rats Against Alzheimer's Disease.Scientifica1 mentions
- 2025Caffeine and sclareol take the edge off the sedative effects of linalool, possibly through the GABAA interaction pathway: molecular insights through in vivo and in silico studies.Naunyn-Schmiedeberg's archives of pharmacology1 mentions
- 2025Nano-healing: Exploring the Therapeutic Potentials of Nanomedicine for CNS Disorders.Current pharmaceutical design1 mentions
- 2025The role of VEGF in vascular dementia: impact of aging and cellular senescence.Biogerontology1 mentions
- 2025GSK-3β dysregulation in aging: Implications for tau pathology and Alzheimer's disease progression.Molecular and cellular neurosciences1 mentions
- 2025Molecular mechanisms and biomarkers in neurodegenerative disorders: a comprehensive review.Molecular biology reports1 mentions
- 2025Flavonoids and their role in oxidative stress, inflammation, and human diseases.Chemico-biological interactions1 mentions
- 2025Serotonergic Modulators in Alzheimer's Disease: A Hope in the Hopeless Condition.Chemistry & biodiversity1 mentions
- 2025Experimental and theoretical studies on structural changes in the microtubule affinity-regulating kinase 4 (MARK4) protein induced by N-hetarenes: a new class of therapeutic candidates for Alzheimer's disease.Frontiers in medicine1 mentions
- 2025NMR Metabolomic Profiling of Differentiated SH-SY5Y Neuronal Cells: Amyloid-β Toxicity and Protective Effects of Galantamine and Lycorine.Cells1 mentions
- 2025Regulation of Apoptotic Pathways by MicroRNAs: A Therapeutic Strategy for Alzheimer's Disease.Molecular neurobiology1 mentions
- 2025Targeting of PP2 A/GSK3β/PTEN Axis in Alzheimer Disease: The Mooting Evidence, Divine, and Devil.Cellular and molecular neurobiology1 mentions
- 2025Key biomarkers in Alzheimer's disease: Insights for diagnosis and treatment strategies.Journal of Alzheimer's disease : JAD1 mentions
- 2025Structural Dynamics and Network Pharmacology for the Discovery of Inhibitors Targeting DYRK1 A in Neurological Disorders.Molecular neurobiology1 mentions
- 2025Mechanistic Insights into the Neuroprotective Potential of Aegle marmelos (L.) Correa Fruits against Aβ-Induced Cell Toxicity in Human Neuroblastoma SH-SY5Y Cells.Pharmaceuticals (Basel, Switzerland)1 mentions
- 2025Role of artificial intelligence in early identification and risk evaluation of non-communicable diseases: a bibliometric analysis of global research trends.BMJ open1 mentions
- 2025SG06, a Chalcone Derivative Targets PI3K/AKT1 Pathway for Neuroprotection and Cognitive Enhancement in an Alzheimer's Disease-Like Zebrafish Model.Molecular neurobiology1 mentions
- 2025In silico screening of naturally derived dietary compounds as potential butyrylcholinesterase inhibitors for Alzheimer's disease treatment.Scientific reports1 mentions
- 2025LRP1 at the crossroads of Parkinson's and Alzheimer's: Divergent roles in α-synuclein and amyloid pathology.European journal of pharmacology1 mentions
- 2025Generative artificial intelligence, integrative bioinformatics, and single-cell analysis reveal Alzheimer's genetic and immune landscape.Molecular therapy. Nucleic acids1 mentions
- 2025Ferroptosis and its contribution to cognitive impairment in Alzheimer's disease: mechanisms and therapeutic potential.Brain research1 mentions
- 2025Iron-Mediated Overexpression of Amyloid Precursor Protein via Iron Responsive mRNA in Alzheimer's Disease.International journal of molecular sciences1 mentions
- 2025Zebrafish-Based Parkinson's Disease Models: Unveiling Genetic Mechanisms and Therapeutic Pathways.CNS & neurological disorders drug targets1 mentions
- 2025Advances in alginate-based nanoformulations: Innovative and effective strategies for targeting and treating brain disorders.International journal of pharmaceutics1 mentions
- 2025Neuraminidase as a novel therapeutic management strategy for Alzheimer's disease: evidenced through molecular docking, molecular dynamic simulation and gene expression analysis.Frontiers in chemistry1 mentions
- 2025Unlocking the potential: advancements and applications of gene therapy in severe disorders.Annals of medicine1 mentions
- 2025In vitro antioxidant, anticholinesterase, and antiproliferative activities of methanol extracts of Crateva religiosa bark.Journal of Cancer1 mentions
- 2025The potential role of aryl hydrocarbon receptor in Alzheimer's disease: Protective or detrimental.Ageing research reviews1 mentions
- 2025Taurine and Neuroprotection: A Potential Shield Against Methylglyoxal-Induced Toxicity in SH-SY5Y Cells.Journal of biochemical and molecular toxicology1 mentions
- 2025Deep ensemble learning with transformer models for enhanced Alzheimer's disease detection.Scientific reports1 mentions
- 2025Unveiling the Therapeutic Potential of Piper chaba Hunter: Computational Approaches Shed Light on Targeting Proteins in Alzheimer's Disease.BioMed research international1 mentions
- 2025Decoding the Dialogue: Immunity and central nervous system interactions in neurodegenerative diseases.The Egyptian journal of immunology1 mentions
- 2025Iron activates Alzheimer's amyloid precursor protein synthesis through an iron responsive element (IRE) mRNA binding to translation initiation factor.International journal of biological macromolecules1 mentions
- 2025From Molecules to Medicines: The Role of AI-Driven Drug Discovery Against Alzheimer's Disease and Other Neurological Disorders.Pharmaceuticals (Basel, Switzerland)1 mentions
- 2025Advancing Alzheimer's Diagnosis with AI-Enhanced MRI: A Review of Challenges and Implications.Current neuropharmacology1 mentions
- 2025High inter-rater reliability in consensus diagnoses and overall assessment in the Asian Cohort for Alzheimer's Disease Study.NPJ dementia1 mentions
- 2025SCRIPT: Predicting Single-Cell Long-Range Cis-Regulation Based on Pretrained Graph Attention Networks.Advanced science (Weinheim, Baden-Wurttemberg, Germany)1 mentions
- 2025Multifaceted neuroprotective potential of phytocompounds and extracts from Eichhornia crassipes (Mart.) Solms flowers against alzheimer's disease: An in vitro and in silico approach.Computers in biology and medicine1 mentions
- 2025Pharmacological Activity of Scopoletin: Deciphering the Potential of Coumarins in Cognitive Dysfunction.Current drug research reviews1 mentions
- 2025The Microbiota-Gut-Brain Connection: A New Horizon in Neurological and Neuropsychiatric Disorders.CNS neuroscience & therapeutics1 mentions
- 2025The Prevalence of Epilepsy Among Patients With Alzheimer's Disease at the King Abdulaziz Medical City, Riyadh, Saudi Arabia.Cureus1 mentions
- 2025Pharmacological landscape of linarin: From benchside mechanisms to potential bedside applications.Fitoterapia1 mentions
- 2025Taming hyper-active Cdk5: Disrupting the Cdk5-p25 axis as a therapeutic avenue for neurodegeneration and beyond.Pathology, research and practice1 mentions
- 2025Non-coding RNA-mediated gene regulation in Alzheimer's disease pathogenesis: molecular insights and emerging innovations.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society1 mentions
- 2025Therapeutic Potential of products derived from Pluchea lanceolata for Alzheimer's Disease Treatment.Journal of molecular neuroscience : MN1 mentions