HLA-DRB1
HGNC:4948 · 44 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HLA-DRB1 | “We found the top differentially upregulated pruritus-associated genes were CLEC7A, IL7R and TNFRSF1B in acne; HLA-DRA, IL2RG and POU2AF1 in alopecia areata; IL2RG, PLEC and CTLA4 in atopic dermatitis; CLEC7A, IL7R and LIPA in cutaneous lupus erythematosus; HLA-DRA, ABCA12 and IL7R in lichen planus; CLEC7A, TGM1 and SDR9C7 in psoriasis and IL7R, HLA-DRB1/HLA-DRB3/HLA-DRB4/HLA-DRB5/LOC105369230 and POU2AF1 in rosacea.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “The available evidence suggests, but does not prove, that MS susceptibility in GCC populations may be heterogeneous and not fully explained by Western-derived HLA-DRB1×15:01-centered models.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “Frequency of HLA-DRB1*15:03-DRB5 Haplotypes in Saudi Population: A Predominance of DRB5*01:01 and Rare Absence of DRB5.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “The paper discusses the crucial roles of genetic predisposition, highlighting the HLA-DRB1*15:01 allele and other non-HLA loci, and environmental triggers, such as Epstein-Barr virus infection, vitamin D deficiency, and smoking.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “This study identifies several significant genetic variants associated with autoimmune diseases, including PTPN22, HLA-DRB1, HLA-DQA1, IRF5, IL10, and other immune-regulatory genes.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “The gene with the highest number of variants was HLA-DRB1, followed by HLA-B, ABO, HPS4, and SP110 displaying both common polymorphisms and rare variants.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “A rare likely pathogenic HLA-DRB1 variant with compromised immunity in severe COVID-19 patient and in-hospital mortality.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “Polymorphism Analysis as Biomarker in Genes AIRE, CD40, HLA-DRB1 and TRAF1/C5 SNPs in Rheumatoid Arthritis Patients.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “The Distribution of HLA-DRB4 Alleles Among HLA-DRB1*07:01-Positive Haplotypes in Saudi Arabia.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “HLA-B* 51:01:01 G was protective from severe disease while HLA-B* 50:01:01 G, HLA-C* 06:02:01 G and HLA-DRB1 * 07:01:01 G were associated with risk to severe disease as well as the total COVID-19 cohort.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “It specifically highlights genes associated with antigen processing and presentation, such as HLA-B, HLA-A and HLA-DRB1 and their possible effects on tumour progression and immune evasion.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “Detection of Nonsynonymous Single Variants in Human HLA-DRB1 Exon 2 Associated with Renal Transplant Rejection.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “We identified 17 HLA-A, 28 HLA-B, 14 HLA-C, 13 HLA-DRB1, and 5 HLA-DQB1 alleles, of which HLA-A*02 (22.2%), -B*51 (19.5%), -C*07 (20.0%), -DRB1*03 (22.2%), and -DQB1*02 (32.8%) were the most frequent allele lineages.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “The frequency of HLA-DRB1 and -DQB1 alleles and DRB1-DQB1 haplotypes were determined in 122 RA patients and 100 controls.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “Novel Heterozygous Variants in the HLA-DRB1 Gene in a Saudi Family With Early-Onset Familial Multiple Sclerosis: Therapeutic Failure and Success.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “Among these genes, HNF4A, PPARA, VEGFA, TCF7L2, HLA-DRB1, PPARG, NOS3, KCNJ11, PRKAA2, and HNF1A were mentioned in more than 200 articles.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “HLA-DRB1 and -DQB1 Alleles, Haplotypes and Genotypes in Emirati Patients with Type 1 Diabetes Underscores the Benefits of Evaluating Understudied Populations.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “METHODS: Accordingly, we compared frequencies of five different single nucleotide polymorphisms (SNPs) in T1DM patients and healthy controls who had been typed for HLA-DRB1, HLA-DQA1, and HLA-DQB1 genes.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “We were able to identify 15 HLA-A, 20 HLA-B, 11 HLA-C, 13 HLA-DRB1, and five HLA-DQB1 homozygous alleles demonstrating a very low genetic diversity in the Saudi population.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “We analysed frequencies for 24 HLA-A alleles (3 alleles for HLA-A∗26 at four digits), 50 HLA-B alleles (11 alleles for HLA-B∗51 at four digits), 15 HLA-C alleles, 16 HLA-DRB1 alleles, 6 HLA-DQB1 alleles, and 15 HLA-DPB1 alleles.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “In this study, we compared frequencies of HLA-DRB1 alleles and single-nucleotide polymorphisms (SNPs) associated the genes coding for: toll-like receptors (TLRs), tumour necrosis factor (TNF), interleukin-1 (IL-1), interleukin-1 receptor type 1 (IL-1R1), interleukin-1 receptor antagonist (IL-1RN), interleukin-2 (IL-2) and interleukin-12B (IL-12B), between T1D patients and healthy controls.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “In terms of HLA class II, HLA-DRB1*04 was significantly higher in the control group compared to infected patients (27.4% vs.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “METHODS: A total of 222 children with T1D and 342 controls were genotyped for HLA-DRB1, -DQA1, and -DQB1 using reverse sequence-specific oligonucleotide (rSSO) Lab Type high definition (HD) kits.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “The novel HLA-DRB1*13:290 allele, identified by next-generation sequencing in a Saudi individual.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “Large libraries of potentially alloreactive recipient peptides binding both sets of molecules were identified, with HLA-DRB1 generally presenting a greater number of peptides.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “HLA-DQA1*0201, HLA-DQB1*0201, and HLA-DRB1*0701 were the classic HLA alleles with the most significant associations with SSNS risk.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “We found that several HLA-DRB1 and DQB1 alleles were associated with MS.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “PCR-based amplification of HLA and sequencing with Illumina MiSeq technology were used for extended sequencing of the HLA class II haplotypes HLA-DRB1, DRB3, DRB4, DRB5, DQA1 and DQB1, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “SUBJECTS/METHODS: HLA-B (n=395), HLA-DRB1 (n=501) and HLA-DQB1 (n=475) alleles were genotyped in pregnant women (mothers of children who later developed type 1 diabetes and mothers of non-diabetic children).” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “Seven HLA-DRB1 alleles accounted for more than 70% of the total HLA DRB1 alleles, of which HLA- DRB1*16 contributed the highest frequency (29.56%).” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “OBJECTIVE: This study investigated the association between HLA-DRB1 and -DQB1 alleles and DRB1-DQB1 haplotypes, and polycystic ovary syndrome (PCOS) in Bahraini women.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “After controlling for the associated haplotypes in HLA-B, we observe independent associations with variants in the HLA-A, HLA-DPB1 and HLA-DRB1 loci.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “AIMS: This study was carried out to investigate, the association of HLA-DRB1, DRB3, DRB4, DRB5, and DQB1 alleles in SLE patients and clinical presentations at Qassim, Saudi Arabia.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “Multivariate logistic regression analyses showed that only HLA-DRB1 mismatch significantly influenced graft loss (p=0.0135).” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “Thus, we examined the frequency of some HLA-DRB1 alleles in 100 autistic children and 100 healthy matched-children by differential hybridization with sequence-specific oligonucleotide probes.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “The most frequently observed allele for HLA-A was HLA-A*02:01:01:01 (13.6%); for HLA-B, HLA-B*50:01:01 (15.8%); for HLA-C, HLA-C*06:02:01:01 (18.7%); for HLA-DRB1, HLA-DRB1*07:01:01:01 (26.6%); and for HLA-DQB1, HLA-DQB1*02:01:01 (20.3%).” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “So this study aimed to identifying the possible association between the class-II HLA-DRB1 alleles with the occurrence of hydatidosis and the clinical course in Saudi patients using Micro SSP HLA-DRB1 kits.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “No significant differences were observed between the two groups in respect of HLA-A2, HLA-B50(21), HLA-B51(5) and HLA-Cw7 (HLA Class I), and HLA-DRB1*04, HLA-DRB1*07 and HLA-DQB1*02 (HLA Class II).” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “This study is the first and largest of its kind to describe the distribution of HLA-DQB1 and HLA-DRB1 alleles in Lebanon and the region.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “HLA-DRB1 association with schizophrenia in Saudi Arabian patients.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “HLA-DRB1 among patients with Vogt-Koyanagi-Harada disease in Saudi Arabia.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “We have generated T-cell lines and clones that specifically recognized a WT1-84 (RYFKLSHLQMHSRKH) peptide in an HLA-DRB1*0402-restricted manner.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “In this study, we searched for a factor at the DPB1 locus by analysing DPB1 polymorphism using sequence-based typing in 86 Saudi IDDM patients and control subjects, all carrying the HLA-DRB1*04/DQB1*02 haplotype or the known susceptibility allele DQB1*0201/0202.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “Thirteen Saudi Arabian patients with Behçet's disease (BD) were typed for HLA-A and -B alleles by the conventional serologic typing and for HLA-DRB1, -DQB1 and -DPB1 alleles by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.” | 0.98 | hgnc_dict_v1 |