amyotrophic lateral sclerosis
SaudiVarKB evidence summary derived from retained literature mentions.
86Phenotype mentions
86Publications
29Associated gene records
16Associated variant records
Associated gene records
Co-mentioned in the same publications| Gene | Identifier / context | Articles | Mentions |
|---|---|---|---|
| SOD1 | HGNC:11179 | 16 | 16 |
| C9orf72 | HGNC:28337 | 8 | 8 |
| FUS | HGNC:4010 | 6 | 6 |
| TARDBP | HGNC:11571 | 4 | 4 |
| OPTN | HGNC:17142 | 3 | 3 |
| APOE | HGNC:613 | 2 | 2 |
| TBK1 | HGNC:11584 | 2 | 2 |
| SIRT1 | HGNC:14929 | 1 | 1 |
| BDNF | HGNC:1033 | 1 | 1 |
| TTR | HGNC:12405 | 1 | 1 |
| CYP2D6 | HGNC:2625 | 1 | 1 |
| IGF1 | HGNC:5464 | 1 | 1 |
| PINK1 | HGNC:14581 | 1 | 1 |
| CTNNB1 | HGNC:2514 | 1 | 1 |
| AKT1 | HGNC:391 | 1 | 1 |
| HTT | HGNC:4851 | 1 | 1 |
| SMCR8 | HGNC:17921 | 1 | 1 |
| RIOK2 | HGNC:18999 | 1 | 1 |
| MBP | HGNC:6925 | 1 | 1 |
| SIGMAR1 | HGNC:8157 | 1 | 1 |
| ALS2 | HGNC:443 | 1 | 1 |
| CCL2 | HGNC:10618 | 1 | 1 |
| CHRNA1 | HGNC:1955 | 1 | 1 |
| DLG5 | HGNC:2904 | 1 | 1 |
| SPTLC1 | HGNC:11277 | 1 | 1 |
| RCC1 | HGNC:1913 | 1 | 1 |
| PLA2G4C | HGNC:9037 | 1 | 1 |
| ZNF512B | HGNC:29212 | 1 | 1 |
| GLE1 | HGNC:4315 | 1 | 1 |
Associated variant records
Co-mentioned in the same publicationsAssociated population records
Co-mentioned in the same publications| Population | Identifier / context | Articles | Mentions |
|---|---|---|---|
| Population record | — | 2 | 2 |
| Saudi Arabia | — | 1 | 1 |
| Saudi Arabia | — | 1 | 1 |
| Saudi Arabia | Cohort 24 | 1 | 1 |
| Saudi Arabia | Cohort 32 | 1 | 1 |
| Population record | Cohort 155 | 1 | 1 |
| Saudi Arabia | Cohort 270 | 1 | 1 |
| Population record | Cohort 66 | 1 | 1 |
Supporting publications
86 records- 2026Unraveling the molecular mechanisms of ALS: a network biology and structural modeling approach of investigating the impact of C9orf72 mutations.Journal of biomolecular structure & dynamics1 mentions
- 2026Investigating the impact of SOD1 mutations on amyotrophic lateral sclerosis progression and potential drug repurposing through in silico analysis.Journal of biomolecular structure & dynamics1 mentions
- 2026The gut-brain axis: role of gut microbiota in neurological disease pathogenesis and pharmacotherapeutics.Naunyn-Schmiedeberg's archives of pharmacology1 mentions
- 2026Amyotrophic lateral sclerosis in Saudi Arabia: a multicenter descriptive study.Amyotrophic lateral sclerosis & frontotemporal degeneration1 mentions
- 2026Adenosine A₂A receptor as a dual-acting molecular switch: Glial morphological changes and neurovascular tissue remodeling in neuroinflammation and neurodegeneration.Tissue & cell1 mentions
- 2026Amyotrophic Lateral Sclerosis (ALS) Genetics and Microbiota: A Comprehensive Review.International journal of molecular sciences1 mentions
- 2026Advancement in therapeutic application of quantum dots in amyotrophic lateral sclerosis: current opportunities and challenges.Drug delivery and translational research1 mentions
- 2026Hereditary transthyretin amyloidosis mimicking ALS: First genetically proven case report from Saudi Arabia.eNeurologicalSci1 mentions
- 2026A framework for the exploration of subcellular compartmentalization of RNA-binding proteins.Nature communications1 mentions
- 2026miRNAs in Amyotrophic Lateral Sclerosis: Tiny Molecules, Tremendous Impact.Molecular neurobiology1 mentions
- 2026Exosomal miRNA in cerebrospinal fluid as biomarkers for neurodegenerative disease.Clinica chimica acta; international journal of clinical chemistry1 mentions
- 2026Exosome-mediated gut-brain axis signaling in neurodegenerative diseases: Mechanisms, experimental evidence, and therapeutic perspectives-A narrative review.Animal models and experimental medicine1 mentions
- 2026ZNF512B safeguards genome integrity at regulatory regions to repress the SASP and inflammation.Cell stem cell1 mentions
- 2025Comprehensive mapping of mutations in TDP-43 and α-Synuclein that affect stability and binding.Journal of biomolecular structure & dynamics1 mentions
- 2025Molecular mechanisms and biomarkers in neurodegenerative disorders: a comprehensive review.Molecular biology reports1 mentions
- 2025Discovering Novel Biomarkers and Potential Therapeutic Targets of Amyotrophic Lateral Sclerosis Through Integrated Machine Learning and Gene Expression Profiling.Journal of molecular neuroscience : MN1 mentions
- 2025NanoBiT-based Analysis of Canine SOD1 Protein Dynamics: Understanding the Role of CCS and Ebselen Derivatives as Potential Therapeutics for Canine Degenerative Myelopathy.Cell biochemistry and biophysics1 mentions
- 2025Advances in alginate-based nanoformulations: Innovative and effective strategies for targeting and treating brain disorders.International journal of pharmaceutics1 mentions
- 2025Extreme exercise in males is linked to mTOR signalling and onset of amyotrophic lateral sclerosis.Brain : a journal of neurology1 mentions
- 2025Emerging biomarkers in amyotrophic lateral sclerosis: from pathogenesis to clinical applications.Frontiers in molecular biosciences1 mentions
- 2025Decoding the Dialogue: Immunity and central nervous system interactions in neurodegenerative diseases.The Egyptian journal of immunology1 mentions
- 2025Acute-onset axonal neuropathy following infection in children with biallelic RCC1 variants: a case series.The Lancet. Neurology1 mentions
- 2025The CCL2-CCR2 axis drives neuromuscular denervation in amyotrophic lateral sclerosis.Nature communications1 mentions
- 2025Aggregation-Prone Pathogenic SOD1 Variants in Amyotrophic Lateral Sclerosis: Insights from Computational Genomics and Evolutionary Conservation.Journal of molecular neuroscience : MN1 mentions
- 2025CRISPR/Cas9 a genomic engineering technology for treatment in ALS mouse models.Regenerative therapy1 mentions
- 2025FUS-related amyotrophic lateral sclerosis-frontotemporal dementia and links to the DNA damage response: a systematic review.Frontiers in molecular neuroscience1 mentions
- 2025Exploring TANK-Binding Kinase 1 in Amyotrophic Lateral Sclerosis: From Structural Mechanisms to Machine Learning-Guided Therapeutics.Life (Basel, Switzerland)1 mentions
- 2024Multifunctional Nanocarriers for Alzheimer's Disease: Befriending the Barriers.Molecular neurobiology1 mentions
- 2024Oxidative stress and ion channels in neurodegenerative diseases.Frontiers in physiology1 mentions
- 2024Cannabidiol and neurodegeneration: From molecular mechanisms to clinical benefits.Ageing research reviews1 mentions
- 2024Intellectual assessment of amyotrophic lateral sclerosis using deep resemble forward neural network.Neural networks : the official journal of the International Neural Network Society1 mentions
- 2024Molecular mechanisms and antisense oligonucleotide therapies of familial amyotrophic lateral sclerosis.Molecular therapy. Nucleic acids1 mentions
- 2024Multiple sclerosis and amyotrophic lateral sclerosis: is there an association or a red flag? A case report and literature review.BMC neurology1 mentions
- 2024The role of sirtuin 1 in ageing and neurodegenerative disease: A molecular perspective.Ageing research reviews1 mentions
- 2024A Review of Biomarkers of Amyotrophic Lateral Sclerosis: A Pathophysiologic Approach.International journal of molecular sciences1 mentions
- 2024Recent advances in stem cell therapy: efficacy, ethics, safety concerns, and future directions focusing on neurodegenerative disorders - a review.International journal of surgery (London, England)1 mentions
- 2024Pharmacogenomics for neurodegenerative disorders - a focused review.Frontiers in pharmacology1 mentions
- 2024Mechanisms and Potential Benefits of Neuroprotective Agents in Neurological Health.Nutrients1 mentions
- 2023Boosting Mitochondrial Potential: An Imperative Therapeutic Intervention in Amyotrophic Lateral Sclerosis.Current neuropharmacology1 mentions
- 2023Mitochondrial Dysfunction as a Signaling Target for Therapeutic Intervention in Major Neurodegenerative Disease.Neurotoxicity research1 mentions
- 2023Integrated Omic Analysis Delineates Pathways Modulating Toxic TDP-43 Protein Aggregates in Amyotrophic Lateral Sclerosis.Cells1 mentions
- 2023Mitochondrial dysfunction and oxidative stress in Alzheimer's disease, and Parkinson's disease, Huntington's disease and Amyotrophic Lateral Sclerosis -An updated review.Mitochondrion1 mentions
- 2023Neuromuscular junction denervation and terminal Schwann cell loss in the hTDP-43 overexpression mouse model of amyotrophic lateral sclerosis.Neuropathology and applied neurobiology1 mentions
- 2023Caenorhabditis elegans: A transgenic model for studying age-associated neurodegenerative diseases.Ageing research reviews1 mentions
- 2023Mesenchymal Stem Cell-Derived Extracellular Vesicles: An Emerging Diagnostic and Therapeutic Biomolecules for Neurodegenerative Disabilities.Biomolecules1 mentions
- 2023The microRNAs (miRs) overexpressing mesenchymal stem cells (MSCs) therapy in neurological disorders; hope or hype.Biotechnology progress1 mentions
- 2023Unveiling promising inhibitors of superoxide dismutase 1 (SOD1) for therapeutic interventions.International journal of biological macromolecules1 mentions
- 2023CRISPR-Cas9 guided rna based model for the treatment of Amyotrophic Lateral Sclerosis: A progressive neurodegenerative disorder.Acta biochimica Polonica1 mentions
- 2023A computational biology approach to identify potential protein biomarkers and drug targets for sporadic amyotrophic lateral sclerosis.Cellular signalling1 mentions
- 2022Small junction, big problems: Neuromuscular junction pathology in mouse models of amyotrophic lateral sclerosis (ALS).Journal of anatomy1 mentions
- 2022The Role of Mitochondrial Genes in Neurodegenerative Disorders.Current neuropharmacology1 mentions
- 2022Gene Therapy Approach with an Emphasis on Growth Factors: Theoretical and Clinical Outcomes in Neurodegenerative Diseases.Molecular neurobiology1 mentions
- 2022DNA Methylation: A Promising Approach in Management of Alzheimer's Disease and Other Neurodegenerative Disorders.Biology1 mentions
- 2022Involvement of molecular chaperone in protein-misfolding brain diseases.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie1 mentions
- 2022Atypical Familial Amyotrophic Lateral Sclerosis Secondary to Superoxide Dismutase 1 Gene Mutation With Coexistent Axonal Polyneuropathy: A Challenging Diagnosis.Cureus1 mentions
- 2022Protective effects of apigenin on methylmercury-induced behavioral/neurochemical abnormalities and neurotoxicity in rats.Human & experimental toxicology1 mentions
- 2022Activation of IGF-1/GLP-1 Signalling via 4-Hydroxyisoleucine Prevents Motor Neuron Impairments in Experimental ALS-Rats Exposed to Methylmercury-Induced Neurotoxicity.Molecules (Basel, Switzerland)1 mentions
- 2022Frustration analysis of TBK1 missense mutations reported in ALS/FTD and cancer patients.3 Biotech1 mentions
- 2022Ceftriaxone as a Novel Therapeutic Agent for Hyperglutamatergic States: Bridging the Gap Between Preclinical Results and Clinical Translation.Frontiers in neuroscience1 mentions
- 2022Focusing the pivotal role of nanotechnology in Huntington's disease: an insight into the recent advancements.Environmental science and pollution research international1 mentions
- 2022Stem-Cell-Based Therapy: The Celestial Weapon against Neurological Disorders.Cells1 mentions
- 2021Deciphering the Role of Aberrant Protein Post-Translational Modification in the Pathology of Neurodegeneration.CNS & neurological disorders drug targets1 mentions
- 2021Targeting Adenosine Receptors in Neurological Diseases.Cellular reprogramming1 mentions
- 2021A recessive S174X mutation in Optineurin causes amyotrophic lateral sclerosis through a loss of function via allele-specific nonsense-mediated decay.Neurobiology of aging1 mentions
- 2021Association of Variants in the SPTLC1 Gene With Juvenile Amyotrophic Lateral Sclerosis.JAMA neurology1 mentions
- 2021Recurrence eigenvalues of movements from brain signals.Brain informatics1 mentions
- 2021Delineating the Aggregation-Prone Hotspot Regions (Peptides) in the Human Cu/Zn Superoxide Dismutase 1.ACS omega1 mentions
- 2020Revisiting the blood-brain barrier: A hard nut to crack in the transportation of drug molecules.Brain research bulletin1 mentions
- 2020Oligodendrocyte pathology exceeds axonal pathology in white matter in human amyotrophic lateral sclerosis.The Journal of pathology1 mentions
- 2020Frequency and methylation status of selected retrotransposition competent L1 loci in amyotrophic lateral sclerosis.Molecular brain1 mentions
- 2018Biomechanistic insights into the roles of oxidative stress in generating complex neurological disorders.Biological chemistry1 mentions
- 2018Potential Application of Venom Proteins in Designing of Medicines for Treating Human Neurodegenerative Disorders.Protein and peptide letters1 mentions
- 2018Recent Status of Nanomaterial Fabrication and Their Potential Applications in Neurological Disease Management.Nanoscale research letters1 mentions
- 2018From Mouse Models to Human Disease: An Approach for Amyotrophic Lateral Sclerosis.In vivo (Athens, Greece)1 mentions
- 2018Chronic Traumatic Encephalopathy Within an Amyotrophic Lateral Sclerosis Brain Bank Cohort.Journal of neuropathology and experimental neurology1 mentions
- 2017Organophosphate neurotoxicity to the voluntary motor system on the trail of environment-caused amyotrophic lateral sclerosis: the known, the misknown, and the unknown.Archives of toxicology1 mentions
- 2016Deficiency in the mRNA export mediator Gle1 impairs Schwann cell development in the zebrafish embryo.Neuroscience1 mentions
- 2016Monomelic amyotrophy with proximal upper limb involvement: a case report.Journal of medical case reports1 mentions
- 2016Seeking environmental causes of neurodegenerative disease and envisioning primary prevention.Neurotoxicology1 mentions
- 2015Current Update on Synopsis of miRNA Dysregulation in Neurological Disorders.CNS & neurological disorders drug targets1 mentions
- 2015Implication of Caspase-3 as a Common Therapeutic Target for Multineurodegenerative Disorders and Its Inhibition Using Nonpeptidyl Natural Compounds.BioMed research international1 mentions
- 2014Infantile-onset ascending hereditary spastic paraplegia with bulbar involvement due to the novel ALS2 mutation c.2761C>T.Gene1 mentions
- 2014The role of viruses in neurodegenerative and neurobehavioral diseases.CNS & neurological disorders drug targets1 mentions
- 2011A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis.Annals of neurology1 mentions
- 2006The X-linked adrenoleukodystrophy (X-ALD) and oxidative stress.Journal of herbal pharmacotherapy1 mentions
- 2004Psychiatric Consequences of WTC Collapse and The Gulf War.Mens sana monographs1 mentions