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Phenotype profile

osteogenesis imperfecta

SaudiVarKB evidence summary derived from retained literature mentions.

27Phenotype mentions
27Publications
12Associated gene records
10Associated variant records

Associated gene records

Co-mentioned in the same publications
GeneIdentifier / contextArticlesMentions
COL1A1HGNC:219733
COL1A2HGNC:219833
WNT1HGNC:1277433
SP7HGNC:1732122
FKBP10HGNC:1816922
TMEM38BHGNC:2553522
ARHGNC:64411
PLS3HGNC:909111
LRP5HGNC:669711
SERPINF1HGNC:882411
SPARCHGNC:1121911
TAPT1HGNC:2688711

Associated variant records

Co-mentioned in the same publications
VariantIdentifier / contextArticlesMentions
p.Cys275Tyrp.Cys275Tyr11
p.Gln133*p.Gln133*11
p.Arg166Hisp.Arg166His11
p.Ser226Leup.Ser226Leu11
c.1490G>Ac.1490G>A11
p.Trp497*p.Trp497*11
c.344G>Ac.344G>A11
p.Arg115Glnp.Arg115Gln11
c.831dupCc.831dupC11
p.Trp351Argp.Trp351Arg11

Associated population records

Co-mentioned in the same publications
PopulationIdentifier / contextArticlesMentions
Population record22
Saudi Arabia11
Saudi Arabia11
Population recordCohort 8711
Saudi ArabiaCohort 2311
Population recordCohort 3411
Saudi Arabia · JeddahCohort 111
Saudi Arabia · RiyadhCohort 1911
Population recordCohort 1111
Population recordCohort 11011
Population recordCohort 68711

Supporting publications

27 records
  1. 2026Impact of preoperative halo-gravity traction on radiographic and surgical outcomes following posterior spinal fusion in osteogenesis imperfecta: a comparative study.Spine deformity1 mentions
  2. 2026Corrective osteotomy for 111.4-degree tibial procurvatum in osteogenesis imperfecta type III patient: a rare case report with multistage interventions.Journal of surgical case reports1 mentions
  3. 2025Comprehensive Bibliometric Assessment of the Top 50 Cited Articles on Osteogenesis Imperfecta.Orthopedic reviews1 mentions
  4. 2023A progeroid syndrome caused by a deep intronic variant in TAPT1 is revealed by RNA/SI-NET sequencing.EMBO molecular medicine1 mentions
  5. 2023Morphological and Ultrastructural Collagen Defects: Impact and Implications in Dentinogenesis Imperfecta.Dentistry journal1 mentions
  6. 2022A single-centre study of genetic mutations, audiology, echocardiogram and pulmonary function in Saudi children with osteogenesis imperfecta.Journal of pediatric endocrinology & metabolism : JPEM1 mentions
  7. 2022Spinal Cord Ischemia After Lower Extremity Surgery in Pediatric Osteogenesis Imperfecta With Thoracic Kyphoscoliosis: Tertiary Care Center Experience in Jeddah, Saudi Arabia.Cureus1 mentions
  8. 2021Detection of a Recurrent TMEM38B Gene Deletion Associated with Recessive Osteogenesis Imperfecta.Discoveries (Craiova, Romania)1 mentions
  9. 2021Diagnostic utility of next-generation sequence genetic panel testing in children presenting with a clinically significant fracture history.Archives of osteoporosis1 mentions
  10. 2021Outcome of COVID19 in Patients With Osteogenesis Imperfecta: A Retrospective Multicenter Study in Saudi Arabia.Frontiers in endocrinology1 mentions
  11. 2020Biallelic variants in four genes underlying recessive osteogenesis imperfecta.European journal of medical genetics1 mentions
  12. 2018Interventions for Improving Bone Mineral Density and Reducing Fracture Risk in Osteogenesis Imperfecta: A Mixed Treatment Comparison Network Meta-analysis of Randomized Controlled Clinical Trials.Current clinical pharmacology1 mentions
  13. 2018Heterozygous WNT1 variant causing a variable bone phenotype.American journal of medical genetics. Part A1 mentions
  14. 2017Hip Dysplasia in Children With Osteogenesis Imperfecta: Association With Collagen Type I C-Propeptide Mutations.Journal of pediatric orthopedics1 mentions
  15. 2016Homozygous sequence variants in the FKBP10 gene underlie osteogenesis imperfecta in consanguineous families.Journal of human genetics1 mentions
  16. 2016Variable brain phenotype primarily affects the brainstem and cerebellum in patients with osteogenesis imperfecta caused by recessive WNT1 mutations.Journal of medical genetics1 mentions
  17. 2015Are Fassier-Duval rods at risk of migration in patients undergoing spine magnetic resonance imaging?Journal of pediatric orthopedics1 mentions
  18. 2015Osteotomy Healing in Children With Osteogenesis Imperfecta Receiving Bisphosphonate Treatment.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research1 mentions
  19. 2013Clinical manifestations and dental management of dentinogenesis imperfecta associated with osteogenesis imperfecta: Case report.The Saudi dental journal1 mentions
  20. 2012Study of autosomal recessive osteogenesis imperfecta in Arabia reveals a novel locus defined by TMEM38B mutation.Journal of medical genetics1 mentions
  21. 2011Mutations in FKBP10 cause both Bruck syndrome and isolated osteogenesis imperfecta in humans.American journal of medical genetics. Part A1 mentions
  22. 2011Osteogenesis imperfecta.Saudi medical journal1 mentions
  23. 2007Second-trimester diagnosis of osteogenesis imperfecta associated with schizencephaly by sonography.Saudi medical journal1 mentions
  24. 2007Severe cerebellar hypoplasia associated with osteogenesis imperfecta type III.The Journal of pediatrics1 mentions
  25. 2004Radiological features of bisphosphonate therapy in children with osteogenesis imperfecta.Saudi medical journal1 mentions
  26. 2001Effect of lower limb Sofield procedure on ambulation in osteogenesis imperfecta.Journal of pediatric orthopedics1 mentions
  27. 2001Functional outcome of Sofield procedure in the upper limb in osteogenesis imperfecta.Journal of pediatric orthopedics1 mentions