ABCB1
HGNC:40 · 34 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | ABCB1 | “Genetic polymorphisms in membrane transporters like ABCB1 and ABCG2 could modulate the distribution and absorption of rivaroxaban, leading to inter-individual variation in response.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “Kaplan-Meier survival analysis, univariate Cox regression, and Lasso regression led to the identification of 17 key genes (ADRB2, ALDH2, CAT, CCNE1, MAP3K8, DSG2, EIF6, ABCB1, PIK3R1, RAD51, SFTPD, SOD3, CLEC3B, ADAM12, EXO1, FBLN5, and IGF2BP3) associated with patient survival.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “In humans, it may induce neurological disorders, particularly in individuals with mutations in the ABCB1 gene.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “Integrative bioinformatics of cisplatin-treated ovarian cancer datasets from the Gene Expression Omnibus (n=255) identified six molecular drivers of resistance: Kaiso (ZBTB33), pregnane X receptor (PXR), NF-κB, HER2 (ERBB2), P-glycoprotein (P-gp/ABCB1), and HIF1A.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “In populations across Saudi Arabia, Jordan, Egypt, Tunisia, and Iraq, genetic testing for variants in genes like MTHFR, MDR1, ABCB1, miR-146a, GABARG2, IL-1β, EPHX1, and CYP3A422 can predict drug resistance, and response, improve drug dosing, and minimize ADRs.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “Impact of ABCB1 gene polymorphism on clopidogrel plasma concentration and cardiovascular events in post-PCI patients.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “Before receiving AC therapy, venous blood was collected from female patients with BC for DNA extraction and the genotyping of four SNPs: rs2228100 in ALDH3A1 gene, rs12248560 in CYP2C19 gene, rs1045642 in ABCB1 gene, and rs6907567 in SLC22A16 gene.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “Investigating the role of genetic variations of ABCB1 (rs1045642) and CYP7A1 (rs3808607) genes on serum lipid level among Malaysian male patients treated with atorvastatin.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “It highlights the impact of polymorphisms in drug metabolism and transport genes, such as UDP-glucuronosyltransferase 1A1 (UGT1A1), carbonyl reductase 1 (CBR1), and ATP-binding cassette multidrug transporter (ABCB1) on the risk of adverse effects, including cardiotoxicity and hematological toxicities.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “The key host genes involved in immune responses (e.g., BoLA-DRB3 and TLR4), oxidative stress defense (SOD2 and GPX1), drug metabolism (ABCB1 and CYP3A4), and ectoparasite resistance (MC1R and MHC) have been identified as contributors to resistance phenotypes.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “Pharmacogenetic insights into ABCB1, ABCC2, CYP1A2, and CYP2B6 variants with epilepsy susceptibility among Egyptian Children: A retrospective case-control study.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “Molecular docking studies were conducted to analyze interactions of PD& SOF with protein kinases as well as apoptotic and multidrug resistance proteins, including AKT1, PI3K, mTOR, Apaf-1, and ABCB1 in MCF-7 cells.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “This study investigated the correlation between single nucleotide polymorphisms (SNPs) in selected genes (CACNA1C, CACNA1D, ABCB1, ACE, ADBR2, and NOS1AP) and the blood pressure (BP) control by amlodipine.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “This review discusses new molecular mechanisms of taxane resistance, such as overexpression of genes like the multidrug resistance genes and EDIL3, ABCB1, MRP1, and TRAG-3/CSAG2 genes.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “Rivaroxaban is a substrate for P-glycoprotein, which is encoded by the ABCB1 gene.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “Polymorphisms in the Drug Transporter Gene ABCB1 Are Associated with Drug Response in Saudi Epileptic Pediatric Patients.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “On the other hand, anti-TNF medicine helped the levels of ABCB1 and E-cadherin return to normal in IBD patients who were not receiving treatment.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “Definite genetic variants in ABCB1, ADIPOQ, CTNNB1, SFRP3, LRP6, CYP19A1, PARP-1, TDG genes exhibited significant protection against CRC development in Saudi population.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “DNA was obtained by a buccal swab (FTA®technology) for genotyping of different genes (ABCB1, COMT, DRD2, OPRM1, CLOCK, CRY2, and PER2) using the Lightcycler®(Roche).” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “Using network topology parameters, phenotype associations, and functional similarity analysis with ACE2 and TMPRSS2-two key receptors for this virus-we identified 17 genes with high connectivity (CXCL10, IDO1, LEPR, MME, PTAFR, PTGS2, MAOB, PDE4B, PLA2G2A, COL5A1, ICAM1, SERPINE1, ABCB1, IL1R1, ITGAL, NCAM1 and PRKD1) potentially contributing to the clinical severity of COVID-19 infection in patients with comorbidities.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “Using this approach, we replicate 11 known drug-gene interactions including, for example, CYP2C9/CYP2C8 variants and sulfonylurea/thiazolidinedione prescribing and ABCB1/ABCG2 variants and statin prescribing.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “Impact of ABCB1 Gene (C3435T/A2677G) Polymorphic Sequence Variations on the Outcome of Patients with Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia in Kashmiri Population: A Case-Control Study.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “Genotyping for CYP2B6, CYP2A6, CYP3A5, ABCB1, NR1I2, and NR1I3 single nucleotide polymorphism (SNPs) was performed by TaqMan® allelic discrimination method.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “Combinations of common SNPs of the transporter gene ABCB1 influence apparent bioavailability, but not renal elimination of oral digoxin.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “Association between ABCB1, ABCG2 carrier protein and COX-2 enzyme gene polymorphisms and breast cancer risk in a Turkish population.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “Several ABC (ABCG2, ABCC1,2,4) and SLC (SLC21A9, SLC22A1,3,11) transporters were significantly downregulated in placentas isolated from HIV(+) women as compared with HIV(-) controls (p < 0.05-0.001), while ABCB1 and SLC21A12 were significantly upregulated (p < 0.001).” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “ABCB1 variants C3435T and T129C are not associated with colorectal cancer risk.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “In the present study, single nucleotide polymorphisms (SNPs) from the ABCC1, ABCC2, ABCB1, and ABCG2 genes were screened in breast cancer patients and healthy volunteers from the Jordanian-Arab population.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “The influence of polymorphisms in the drug transporter, ABCB1 on the toxicity of glucocorticoids in Saudi children with acute lymphoblastic leukaemia.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “Predicted activity of UGT2B7, ABCB1, OPRM1, and COMT using full-gene haplotypes and their association with the CYP2D6-inferred metabolizer phenotype.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “Awan P34 Comparative genomics and network-based analyses of early hepatocellular carcinoma Ibrahim Hamza Kaya, Olfat Al-Harazi, Dilek Colak P35 A TALEN-based oncolytic viral vector approach to knock out ABCB1 gene mediated chemoresistance in cancer stem cells Nabila A Alkousi, Takis Athanasopoulos P36 Cartilage differentiation and gene expression of synovial fluid mesenchymal stem cells derived from osteoarthritis patients Afnan O Bahmaid, Etimad A Alhwait, Mamdooh A Gari, Haneen S Alsehli, Mohammed M Abbas, Mohammed H Alkaf, Roaa Kadam, Ashraf Dallol, Gauthaman Kalamegam P37 E-GRASP: Adding an evolutionary component to the genome-wide repository of associations (GRASP) resource Hend F Nour Eldin, Sajjad Karim, Heba Abusamra, Elham Alhathli, Nada Salem, Mohammed H Al-Qahtani, Sudhir Kumar P38 Screening of AGL gene mutation in Saudi family with glycogen storage disease Type III Salma N Alsayed, Fawziah H Aljohani, Samaher M Habeeb, Rawan A Almashali, Sulman Basit, Samia M Ahmed P39 High throughput proteomic data suggest modulation of cAMP dependent protein kinase A and mitochondrial function in infertile patients with varicocele Rakesh Sharma, Ashok Agarwal, Damayanthi Durairajanayagam, Luna Samanta, Muhammad Abu-Elmagd, Adel M.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “MCF-7 cell acquired several copy number gains on chromosome 7, including ABC transporter genes, including ABCB1 and ABCB4, as well as DMTF1, CLDN12, CROT, and SRI.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “The aim of this study was to evaluate whether genetic polymorphisms in CYP3A5 and ABCB1 are responsible for the interindividual variability observed in quetiapine pharmacokinetics.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “Influence of CYP3A5 6986A > G and ABCB1 3435C > T Polymorphisms on Adverse Events Associated With Tacrolimus in Jordanian Pediatric Renal Transplant Patients.” | 0.98 | hgnc_dict_v1 |