CYP3A4
HGNC:2637 · 37 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CYP3A4 | “CYP3A4 and CYP3A5 polymorphisms greatly impacted the pharmacokinetics of rivaroxaban; CYP2J2 polymorphisms were not greatly associated with the clinical outcome.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “For metabolism, most drugs rely on CYP3A-mediated metabolism, primarily through CYP3A4, CYP2D6, and CYP2C8.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “This review examines current evidence on how selected herbal extracts influence key enzymes such as cytochrome P450 family 3 subfamily A member 4 (CYP3A4), cytochrome P450 family 2 subfamily D member 6 (CYP2D6), cytochrome P450 family 2 subfamily C member 9 (CYP2C9), and UDP-glucuronosyltransferases (UGTs), and highlights the implications for drug safety and efficacy.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “The drug metabolism analysis revealed that 25% of approved drugs undergo Phase 1 metabolism via CYP3A4, followed by the combined involvement of CYP3A4 and CYP2C9 for 10% of approved drugs.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “A chromosomal localization analysis showed that diabetes-associated genes were randomly positioned on human chromosomes, with four genes (ELMO1, GCK, GNAI, and CYP3A4) on Chr7, while seven individual genes included PPM1K, TDO2, GALNT7, PIK3R1, VEGFA, PTGS1, TCF7L2, GNG3, SIRT4, and SSTR2 on chromosome numbers 5, 6, 9, 10, 11, 12, and 17, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “Its metabolism by CYP3A4 and transported by efflux pump P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) render it susceptible to drug, food, and herbal interactions.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “Impact of CYP3A4 and CYP3A5 polymorphisms on tacrolimus dose requirements in Saudi kidney transplant patients.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “CYP3A4 and CYP3A5 Genes in Cyclophosphamide-treated Chronic Lymphocytic Leukemia Patients: A Pharmacogenetics Study.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “Three alleles were identified in CYP3A4, including a common (CYP3A4 rs2242480) and two rare alleles (*3 and *22).” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “Significant downregulation (P < 0.05) was observed for CYP3A4, AOX1, NAT1 and several SULTs in inflamed ileum as well as UGT1A10, NAT1, BCRP and several SULTs in inflamed and non-inflamed colon.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “The key host genes involved in immune responses (e.g., BoLA-DRB3 and TLR4), oxidative stress defense (SOD2 and GPX1), drug metabolism (ABCB1 and CYP3A4), and ectoparasite resistance (MC1R and MHC) have been identified as contributors to resistance phenotypes.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “The Axiom PharmacoFocus Array technique was employed to generate accurate star allele-predicted phenotypes of 3 PK genes (CYP3A4, CYP3A5, and CYP2D6).” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “Survival and network analysis revealed that five genes named heat shot protein 90 AA1 (HSP90AA1), estrogen receptor 1 (ESR1), cytochrome P450 3A4 (CYP3A4), cyclin-dependent kinase 1 (CDK1), and matrix metalloproteinase-9 (MMP9) are linked with the survival of LC patients.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “Expression of CYP3A7 - in contrast to the related adult hepatic CYP3A4 and CYP3A5 forms - was confirmed in u-HepaRG cells.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “The Frequency of CYP2D6 and CYP3A4/5 Genotypes and The Impact of Their Allele Translation and Phenoconversion-Predicted Enzyme Activity on Risperidone Pharmacokinetics in Saudi Children with Autism.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “Ensitrelvir is clinically especially relevant due to its single-substance formulation, avoiding drug-drug interactions by the co-formulated CYP3A4 inhibitor ritonavir in Paxlovid.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “CYP3A4 Mutation Causes Vitamin D-Dependent Rickets Type 3: A Case Report in Saudi Arabia.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “In in silico ADME prediction, ALC was shown to have poor water solubility and high gastrointestinal absorption along with inhibition of some cytochrome P450s (CYP2C19 and CYP2C9) without inhibition of others (CYP1A2, CYP3A4, and CYP2D6) and P-glycoprotein substrate.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “The impact of CYP3A4 and CYP3A5 genetic variations on tacrolimus treatment of living-donor Egyptian kidney transplanted patients.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “RT-PCR confirmed that LG and citral targeted metabolic molecules in resistant cells and significantly downregulated PXR, CYP3A4, GST, MDR1, MRP1, and PCRP genes.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “Tacrolimus, the most common immunosuppressant for organ transplant, has a narrow therapeutic range and is metabolized by CYP3A4/5.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “We also find that ADCY8, MYC, PTK2, CTNNB1, TP53, RB1, PRKCA, TCF7L2, PAK1, ITPR2, CYP3A4, UGT1A6, GCK, and FGFR2/3 appear to be among the prominent genes based on the networks of genes and pathways based on the copy number alterations, mutations, and structural variants study.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “Probing PXR activation and modulation of CYP3A4 by Tinospora crispa and Tinospora sinensis.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “Only one report was available on liver DMETs in CD, and indicated reduced CYP3A4 activity.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “In inflamed Crohn's ileum, CYP3A4, CYP20A1, CYP51A1, ADH1B, ALPI, FOM1, SULT1A2, SULT1B1 and ABCB7 showed ≥10-fold reduction in abundance compared with healthy baseline.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “This study aimed to investigate the association of CYP3A4*22 (rs35599367), CYP3A5*3 (rs776746) single nucleotide polymorphism (SNP) with response to simvastatin in hypercholesterolemia patients conducted at King Abdulaziz University hospital (KAUH) in Jeddah, Saudi Arabia.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “Missense variants were filtered as potential nonsynonymous single nucleotide polymorphisms among the available data for the target genes (REN, CYP2D6, CYP3A4).” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “It is commonly used to reduce the risk of blood coagulation in patients diagnosed with acute coronary syndrome, or ischemic stroke.Area covered: We reviewed published articles in PubMed and Google Scholar that focused on the mutations of CYP2C19, CYP3A4, CYP2C9, CYP2B6, and CYP1A2 genes related to clopidogrel clinical efficacy and safety.Expert opinion: Based on current pharmacogenetic studies, patients carrying CYP2C19*2, CYP2C19*3, CYP2C9*3, and CYP2B6*5 alleles may not respond to clopidogrel due to poor platelet inhibition efficacy revealed among them.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “Ticagrelor's primary active metabolite, ARC124910XX (ARC), is formed via the most abundant hepatic cytochrome P450 (CYP) enzyme, CYP3A4, and CYP3A5.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “Oncoglabrinol C, a new flavan from Oncocalyx glabratus protects endothelial cells against oxidative stress and apoptosis, and modulates hepatic CYP3A4 activity.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “Therefore, this study aims to determine if there is any single nucleotide polymorphism (SNP) within CYP19A1, CYP2C19, CYP2C9, CYP1B1, CYP3A4, and CYP1A2 genes associated with BC in the Jordanian population.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “Degradation of pristine and oxidized single wall carbon nanotubes by CYP3A4.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “A molecular dynamics analysis of the Arg376 > Lys mutation based on the CYP3A4 (a human CYP450) protein structure found that it was responsible for the increase in axis length toward the heme (active site), which is critically important for biological activity and ligand binding.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “Investigating the Effect of Demographics, Clinical Characteristics, and Polymorphism of MDR-1, CYP1A2, CYP3A4, and CYP3A5 on Clopidogrel Resistance.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “High frequency and founder effect of the CYP3A4*20 loss-of-function allele in the Spanish population classifies CYP3A4 as a polymorphic enzyme.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “BACKGROUND AND AIMS: Tacrolimus is a macrolide immunosuppressant used for prevention of allograft rejection in organ transplantation and metabolized in the liver and intestine by cytochrome P450 3A4 (CYP3A4) enzyme.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A4 | “CYP3A4 promoter variant in Saudi, Ghanaian and Scottish Caucasian populations.” | 0.98 | hgnc_dict_v1 |