RET
HGNC:9967 · 26 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | RET | “Modeling the Effects of Single Nucleotide Polymorphisms (SNPs) on the Structure and Function of the Human RET Gene: An In Silico Study.” | 0.98 | hgnc_dict_v1 |
| gene | RET | “These tumours vary significantly in histological architecture, immunohistochemical profiles, and genetic alterations, ranging from TRIM33::RET fusions and BRAF V600E mutations in OIDC to NR4A3 rearrangements in ACC and ETV6::NTRK3 fusions in SC.” | 0.98 | hgnc_dict_v1 |
| gene | RET | “De novo mutation of the RET proto-oncogene revealing multiple endocrine neoplasia type 2A: a sporadic case from Western Algeria.” | 0.98 | hgnc_dict_v1 |
| gene | RET | “In addition, 1 case was reclassified as an intraductal carcinoma after the identification of an NCOA4::RET gene fusion.” | 0.98 | hgnc_dict_v1 |
| gene | RET | “Recent advancements in next-generation sequencing methodologies have elucidated significant genetic mutations, which include RET, BRAF, TPO, and more, which are associated with thyroid cancers and autoimmune disorders.” | 0.98 | hgnc_dict_v1 |
| gene | RET | “Advances in molecular diagnostics have identified key genetic alterations - particularly BRAFV600E, RAS mutations, RET/PTC fusions, and TERT promoter mutations - that are strongly linked to tumor aggressiveness and prognosis.” | 0.98 | hgnc_dict_v1 |
| gene | RET | “The mass excised in the case was positive for somatic missense mutations in RET (R813W) and HRAS (G12S) genes, identified at low variant allele frequencies.” | 0.98 | hgnc_dict_v1 |
| gene | RET | “BACKGROUND: Medullary Thyroid Carcinoma (MTC) is closely associated with mutations in the RET proto-oncogene, placing the activated RET protein at the center of MTC pathogenesis.” | 0.98 | hgnc_dict_v1 |
| gene | RET | “Various genetic modifications including BRAF mutations, RAS mutations, RET mutations, paired-box gene 8/peroxisome proliferator-activated receptor-gamma fusion oncogene, RET/PTC rearrangements, telomerase reverse transcriptase mutations, neurotrophic tyrosine receptor kinase fusion genes, TP53 mutations, and eukaryotic translation initiation factor 1A X-linked mutations can effectively serve as potential biomarkers in both diagnosis and prognosis of TC.” | 0.98 | hgnc_dict_v1 |
| gene | RET | “BRAF and RET polymorphism association with thyroid cancer risk, a preliminary study from Khyber Pakhtunkhwa population.” | 0.98 | hgnc_dict_v1 |
| gene | RET | “The RET splice variant (c.1880-2A>C) found in both meningioma tumours is reported (rs193922699) as likely pathogenic in the Single Nucleotide Polymorphism Database (dbSNP).” | 0.98 | hgnc_dict_v1 |
| gene | RET | “Further search in miRNAwalk and miRDB databases showed that certainly most of these dysregulated miRNAs identified target HSCR associated genes, such as RET, GDNF, BDNF, EDN3, EDNRB, ERBB, NRG1, SOX10; and other genes implied in neuronal migration and neurogenesis.” | 0.98 | hgnc_dict_v1 |
| gene | RET | “The other 19 tumors tested by NGS showed definitely pathogenic alterations in 10 patients (52.6%): 2/19 (10.5%) BRAFV600E, 5/19 (26.3%) CCDC6-RET (RET/PTC1), 1/19 (5.3%) NCOA4-RET (RET/PTC3), 1/19 (5.3%) STRN-ALK fusion, and 2/19 (10.6%) TP53 mutations.” | 0.98 | hgnc_dict_v1 |
| gene | RET | “Controversy on the management of patients carrying RET p.V804M mutation.” | 0.98 | hgnc_dict_v1 |
| gene | RET | “A total of 13 genetic variants were found to be significantly associated with ESRD in PLCE1, CLCN5, ATP6V1B1, LAMB2, INVS, FRAS1, C5orf42, SLC12A3, COL4A6, SLC3A1, RET, WNK1, and BICC1, including four novel variants that were not previously reported in any other population.” | 0.98 | hgnc_dict_v1 |
| gene | RET | “Multiple robust and well-tolerated TKIs targeting single or multiple targets, including EGFR, ALK, ROS1, HER2, NTRK, VEGFR, RET, MET, MEK, FGFR, PDGFR, and KIT, have been developed over the last two decades, contributing to our understanding of precision cancer medicine based on a patient's genetic alteration profile.” | 0.98 | hgnc_dict_v1 |
| gene | RET | “The known synonymous mutations were found in this tumor were, in exon 14 of FGFR3 in c.1953G>A; in exon 12 of PDGFRA in c.1701A>G; in exon 18 of PDGFRA c.2472C>T; in exon 20 of EGFR in c.2361G>A; in exon 13 of RET in c.2307G>T; in exon 16 of APC in c.4479G>A; and in exon 2 of MET in c.534C>T.” | 0.98 | hgnc_dict_v1 |
| gene | RET | “APC, RET, and EGFR genes were most frequently mutated.” | 0.98 | hgnc_dict_v1 |
| gene | RET | “Seven synonymous mutations were detected in this tumor, viz., in IDH1 (rs11554137), in FGFR3 (rs7688609), in PDGFRA (rs1873778), in APC (COSM3760869), in EGFR (rs1050171), in MET (rs35775721), and in RET (rs1800861), respectively.” | 0.98 | hgnc_dict_v1 |
| gene | RET | “RET S409Y Germline Mutation and Associated Medullary Thyroid Carcinoma.” | 0.98 | hgnc_dict_v1 |
| gene | RET | “Eight synonymous mutations were found in FGFR3, PDGFRA, EGFR, RET, HRAS, FLT3, APC and SMAD4 genes.” | 0.98 | hgnc_dict_v1 |
| gene | RET | “The following genes were mutated in 1 patient each (1%), RET, SDHA, SDHAF2, TMEM127 and NF1.” | 0.98 | hgnc_dict_v1 |
| gene | RET | “Multiple endocrine neoplasia 2A (MEN 2A), or Sipple's syndrome is a rare inherited dominant syndrome, characterised by medullary thyroid carcinoma, adrenal pheochromocytoma and hyperparathyroidism, due to specific RET proto-oncogene mutations.” | 0.98 | hgnc_dict_v1 |
| gene | RET | “Concomitant RAS, RET/PTC, or BRAF mutations in advanced stage of papillary thyroid carcinoma.” | 0.98 | hgnc_dict_v1 |
| gene | RET | “RET codon 618 mutations in Saudi families with multiple endocrine neoplasia Type 2A and familial medullary thyroid carcinoma.” | 0.98 | hgnc_dict_v1 |
| gene | RET | “Several early events, including ras mutations in follicular thyroid carcinoma and RET gene rearrangement in papillary tumors, have been implicated in the neoplastic transformation of thyrocytes.” | 0.98 | hgnc_dict_v1 |