AKT1
HGNC:391 · 53 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | AKT1 | “Multitargeted comparative evaluation suggests 2-Aoeobenoxmide shows favourable in silico binding compared to Tucatinib against ERα, HER2, AKT1, EGFR, and PIK3CA in breast cancer.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “Protein-protein interaction analysis identified ten hub genes, including AKT1, STAT3, EGFR, and MMP9, representing highly connected nodes within the predicted interaction network.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “Network pharmacology and molecular docking identified AP9 as a lead chemical with high affinity for hub proteins: as AKT1, EGFR, ESR1, HIF1A, MTOR, and PARP1, implying an involvement in neurodegenerative disease pathways.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “Host immune hub genes and Salmonella virulence regulators were identified, followed by docking of curcumin to key host (AKT1, STAT3, TNF) and pathogen proteins (invA, phoP, ssrB).” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “At the molecular level, MPs downregulated CREB1 (-82.2%) and BDNF (-80.2%) while markedly upregulating AKT1 (~ fivefold) and pro-inflammatory cytokines (TNF-α, IL-6, CXCL-10, and IL-1β; 5.2-7.2-fold).” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “By focusing on hub genes (SRC, AKT1, MAPK1/3, STAT3, EGFR) implicated in key signaling pathways such as PI3K-Akt, MAPK, JAK-STAT, and GABAergic synapse signaling, network analysis showed that these drugs had 15-25 targets in common with epilepsy.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “BACKGROUND: Protein kinase B (AKT1) plays a critical role in neuronal development, synaptic plasticity, and cognitive function.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “The constructed network identified AKT1 as a central hub, hsa-miR-140-3p assumes a critical role by interacting with both AKT1 and CTSD, while circRNAs such as hsa_circ_0020776, hsa_circ_0033552, and hsa_circ_0020773 significantly modulate these interactions.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “OBJECTIVE: AKT1 and AKT2 are central but functionally distinct kinases within the PI3K-AKT-mTOR pathway, and isoform-specific genomic alterations in these proteins have important implications for cancer prognosis and therapeutic responsiveness.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “Subsequently, protein-protein interaction (PPI) network analysis identified top hub genes including AKT1, CASP3, TNF, and BCL2 as central to disease modulation.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “Molecular docking revealed strong binding affinities between these compounds and cancer-related targets (AKT1, CDK2, ERK1, TNFα), with simplicildone D and mollicellin G demonstrating particularly high interactions.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “SG06, a Chalcone Derivative Targets PI3K/AKT1 Pathway for Neuroprotection and Cognitive Enhancement in an Alzheimer's Disease-Like Zebrafish Model.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “Markers of renal tissue damage (TGF-β/iNOS/NGLA/KIM-1) and renoprotective molecules (Nrf2/AMKα/AKT1) genes and proteins were measured by quantitative RT-PCR and Immunohistochemistry, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “PAC increased oxidative stress, CYP2E1/CYP3A2 expression, apoptosis markers, and suppressed Nrf2/AMPK/AKT1.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “The protein-protein interaction network, constructed via the STRING database, underwent topological analysis in Cytoscape, identifying AKT1, SRC, TNF, PPARG and IL1B as top targets.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “Protein-protein interaction analysis establishes a complex network, identifying central targets like SRC and AKT1.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “Bio-molecular Fe(III) and Zn(II) complexes stimulate the interplay between PI3K/AKT1/EGFR inhibition and induce autophagy and apoptosis in epidermal skin cell cancer.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “Our findings indicate that, based on alteration patterns, survivability, differential gene and protein level expressions, the genes ERBB3, ERBB4, HLA-B, AKT1, GNAS, FGFR4, PIK3R3 and AXIN2 emerge as primary risk factors in TNBC.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “Dysregulation of this pathway, often due to mutations in genes such as PIK3CA, PTPN11, EGFR, and AKT1, contributes to tumorigenesis and therapy resistance.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “Unique or novel PSVs, particularly in BRCA2 and AKT1, were also reported, suggesting potential founder effects or region-specific genetic risks.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “Theoretical investigation of AKT1 mutations in breast cancer: a computational approach to structural and functional insights.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “Network pharmacology identified 24 hub targets, and molecular docking revealed strong binding affinities (-6.5 to -9.1 kcal/mol) between BRLE compounds and inflammatory proteins including EGFR, SRC, STAT3, and AKT1.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “In silico results identified 112 inflammation-associated gene targets, whereas tumor necrosis factor (TNF), IL6, and AKT1 were identified as top hub genes.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “NP study identified key genes related to HCC, particularly the enzymes AKT1 and GSK3β.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “In silico analysis, particularly of the binding affinities of Z. rosea bulb phytoconstituents for IL6, AKT1, and Src, supported in vivo results.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “Key targets like MMP9, EGFR, and AKT1 were highlighted, and the PPAR and PI3K-AKT signaling pathways were identified as the primary mechanisms through which CT may treat DN.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “Molecular docking studies were conducted to analyze interactions of PD& SOF with protein kinases as well as apoptotic and multidrug resistance proteins, including AKT1, PI3K, mTOR, Apaf-1, and ABCB1 in MCF-7 cells.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “Our analysis revealed that hsa-miR-320a-3p and its key targets, including PTEN, AKT1, BCL2, FOXO1 and MYC, are dysregulated in T1D, along with their interacting partners namely BLIMP3, GSK3B, CAV1, CXCL3, TGFB, and IL10.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “Pathway enrichment was performed with Gene Ontology and KEGG databases; (3) Results: We identified 28 active phytoconstituents, targeting proteins such as EGFR, SRC, STAT3, AKT1, and HSP90AA1.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “Using a protein-protein interaction network, AKT1, GAPDH, TNF-α, IL-6, caspase 3, signal transducer and activator of transcription 3, Catenin Beta 1, epidermal growth factor receptor, B-cell lymphoma -2, and HSP90AA1 were identified as the top 10 most significant genes.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “Furthermore, network pharmacology analysis identified the top 10 hub genes, namely AKT1 (protein kinase B), CTNNB1 (catenin beta-1), SRC (proto-oncogene c-Src), TNF (tumor necrosis factor), EGFR (epidermal growth factor receptor), HSP90AA1 (heat shock protein 90α), MAPK3 (mitogen-activated protein kinase 3), STAT3 (signal transducer and activator of transcription 3), CASP3 (caspase protein), and ESR1 (estrogen receptor 1), which are responsible for hepatoprotective activity.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “Top hub genes identified were TLR4, MMP9, MAPK14, AKT1, VEGFA and HSP90AA1 with their respective associates.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “Following that, a compound-target protein-pathway network was constructed, which uncovered that, namely, hispidulin, stigmasterol, ascorbic acid, octopamine, cyperene, kaempferol, pungenin, citric acid, d-tartaric acid, beta-sitosterol, (-)-epicatechin gallate, and (+)-catechin demonstrably influence cell proliferation and growth by impacting the AKT1 and VEGFA proteins.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “The observed effects of Rapamycin on tumor suppression are likely to involve the autophagy process, evidenced by the inhibition of autophagy modulators (TGFβ1, RGS19 and AKT1), autophagosome biogenesis components (AMBRA1, ATG9B and TMEM74) and autophagy byproducts (APP).” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “The in-depth analysis based on the degree revealed that AKT1 and EGFR formed the foundation of the PPI network.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “RESULTS: The findings revealed that Cucurbita pepo contains 18 active components and has 192 potential gene targets, including AR, EGFR, ESR1, AKT1, MAPK3, SRC, and MTOR.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “We systematically compiled compound data from public databases and reviewed literature, revealing active compounds like apigenin, kaempferol, moupinamide, cyclocurcumin, chrysoeriol, isorhamnetin, rheinanthrone, cyclocurcumin, and riboflavin.Constructing a compound-target genes-obesity network unveiled their significant impact on metabolic regulation and fat accumulation, interacting notably with key proteins AKT1 and PTGS2.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “These results from a study on S. androgynus used molecular docking and network pharmacology to gain insight into the prime target genes and potential mechanisms identified for AKT1, mTOR, AR, PPID, FKBP5, and NR3C1.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “From enrichment analysis, we found NF-ΚB1, AKT1, EGFR, JUN, and RELA as the main regulators in the DCKD development through mitogen activated protein kinase (MAPK) pathway signalling.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “The PPIN analysis resulted in identifying four CPBs (namely RIOK2, AKT1, CTNNB1, and TNF) that commonly overlapped with one another in network parameters (degree, bottleneck and maximum neighbourhood component).” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “In the framework of this study, we explored the active ingredient-target-pathway network and figured out that oleanolic acid, arjunolic acid, luteolin, kaempferol, cholesterol, ellagic acid 4-O-xylopyranoside 3,3'-dimethyl ether, and cyclohexyl (2,4-dimethyl phenyl) methanone contributed significantly to the development of CCF by affecting AKT1, MAPK14, TNF, IL6, ESR1, and HSP90AA1 genes.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “In contrast, among mTOR signaling genes, the abundance of IRS1 was greatest (P < 0.01) in muscle and lowest in the intestine, whereas, abundance of AKT1 and mTOR was greater (P < 0.01) in intestine and muscle than liver.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “In summary, we proposed that quercetin, luteolin, apigenin, catechin, epicatechin, stigmasterol, beta-sitosterol, celastrol, and betulic acid inhibit tumor growth by affecting tumor protein 53 (TP53), interleukin 6 (IL6), RAC-alpha serine/threonine protein kinases 1 (AKT1), caspase-3 (CASP3), tumor necrosis factor (TNF), jun proto-oncogene (JUN), heat shot protein 90 AA1 (HSP90AA1), vascular endothelial growth factor A (VEGFA), epidermal growth factor receptor (EGFR), and SRC proto-oncogene (SRC).” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “METHODS: We carried out targeted next-generation sequencing of six PI3K pathway genes (PIK3CA, PIK3R1, PTEN, AKT1, TSC2, and mTOR) in a total of 93 South Indian cervical cancer samples and confirmed them by sanger sequencing.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “Among these 14 genes, GAPDH and AKT1 were the most significant.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “In the framework of this study, we explored the active ingredient-target-pathway network and figured out that abrectorin, abrusin, abrisapogenol J, sophoradiol, cholanoic acid, precatorine, and cycloartenol decisively contributed to the development of T2DM by affecting AKT1, MAPK3, TNFalpha, and MAPK1 genes.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “Sevoflurane reverses cisplatin resistance in neuroblastoma cells through the linc00473/miR-490-5p/AKT1 axis.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “Proteus syndrome caused by novel somatic AKT1 duplication.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “A computational approach for investigating the mutational landscape of RAC-alpha serine/threonine-protein kinase (AKT1) and screening inhibitors against the oncogenic E17K mutation causing breast cancer.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “Focused study of primary cultures of a low-grade mucoepidermoid carcinoma demonstrated amphiregulin-mechanistic target of rapamycin-protein kinase B (AKT; AKT1) pathway activation, identified through bioinformatics and subsequently confirmed as present in primary tissue and preserved through different secondary 2D and 3D culture media and xenografts.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “Whole genome array CGH technique can be used to identify potential genes, biofunctions and chromosomal abnormalities associated with RSA which is supported by our findings of a number of novel CNVs/genes (22q11.23/GSTT1, 3p22.2/CTDSPL, 6p21.32/HLA, 8p22/MSR1, and 14q32.33/AKT1) and pathways in patients affected with RSA.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “Oncogenic PI3K mutations are as common as AKT1 and SMO mutations in meningioma.” | 0.98 | hgnc_dict_v1 |
| gene | AKT1 | “Mutational screening of RET, HRAS, KRAS, NRAS, BRAF, AKT1, and CTNNB1 in medullary thyroid carcinoma.” | 0.98 | hgnc_dict_v1 |