Crohn disease
SaudiVarKB evidence summary derived from retained literature mentions.
437Phenotype mentions
100Publications
50Associated gene records
17Associated variant records
Associated gene records
Co-mentioned in the same publications| Gene | Identifier / context | Articles | Mentions |
|---|---|---|---|
| NOD2 | HGNC:5331 | 5 | 5 |
| CYP3A4 | HGNC:2637 | 3 | 3 |
| IL10 | HGNC:5962 | 2 | 2 |
| CPT1A | HGNC:2328 | 1 | 1 |
| ULK1 | HGNC:12558 | 1 | 1 |
| NLRP3 | HGNC:16400 | 1 | 1 |
| APOE | HGNC:613 | 1 | 1 |
| STAT3 | HGNC:11364 | 1 | 1 |
| CFTR | HGNC:1884 | 1 | 1 |
| TYK2 | HGNC:12440 | 1 | 1 |
| RIPK1 | HGNC:10019 | 1 | 1 |
| CXCL8 | HGNC:6025 | 1 | 1 |
| MALAT1 | HGNC:29665 | 1 | 1 |
| IMPACT | HGNC:20387 | 1 | 1 |
| PCK1 | HGNC:8724 | 1 | 1 |
| NPC1 | HGNC:7897 | 1 | 1 |
| ITGA4 | HGNC:6140 | 1 | 1 |
| TLR4 | HGNC:11850 | 1 | 1 |
| CARD9 | HGNC:16391 | 1 | 1 |
| LACC1 | HGNC:26789 | 1 | 1 |
| MEFV | HGNC:6998 | 1 | 1 |
| NCF2 | HGNC:7661 | 1 | 1 |
| RAC2 | HGNC:9802 | 1 | 1 |
| JAK1 | HGNC:6190 | 1 | 1 |
| ATG16L1 | HGNC:21498 | 1 | 1 |
| CD200R1 | HGNC:24235 | 1 | 1 |
| MAOA | HGNC:6833 | 1 | 1 |
| XIAP | HGNC:592 | 1 | 1 |
| NOD1 | HGNC:16390 | 1 | 1 |
| CXCL1 | HGNC:4602 | 1 | 1 |
| IL4 | HGNC:6014 | 1 | 1 |
| UGT1A1 | HGNC:12530 | 1 | 1 |
| SLC22A5 | HGNC:10969 | 1 | 1 |
| CYBB | HGNC:2578 | 1 | 1 |
| BIRC3 | HGNC:591 | 1 | 1 |
| CD14 | HGNC:1628 | 1 | 1 |
| NQO1 | HGNC:2874 | 1 | 1 |
| HLA-G | HGNC:4964 | 1 | 1 |
| ITLN1 | HGNC:18259 | 1 | 1 |
| SLC22A4 | HGNC:10968 | 1 | 1 |
| DLG5 | HGNC:2904 | 1 | 1 |
| ABCB7 | HGNC:48 | 1 | 1 |
| TRAF1 | HGNC:12031 | 1 | 1 |
| NCF4 | HGNC:7662 | 1 | 1 |
| TNFSF15 | HGNC:11931 | 1 | 1 |
| AOX1 | HGNC:553 | 1 | 1 |
| NAT1 | HGNC:7645 | 1 | 1 |
| UGT1A10 | HGNC:12531 | 1 | 1 |
| IL27 | HGNC:19157 | 1 | 1 |
| NLRP1 | HGNC:14374 | 1 | 1 |
Associated variant records
Co-mentioned in the same publications| Variant | Identifier / context | Articles | Mentions |
|---|---|---|---|
| rs9533338 | rs9533338 | 1 | 1 |
| rs9595049 | rs9595049 | 1 | 1 |
| p.H312Y | p.H312Y | 1 | 1 |
| C1672T | C1672T | 1 | 1 |
| G113A | G113A | 1 | 1 |
| C4136A | C4136A | 1 | 1 |
| rs1799964 | rs1799964 | 1 | 1 |
| rs1050152 | rs1050152 | 1 | 1 |
| V109D | V109D | 1 | 1 |
| rs3810936 | rs3810936 | 1 | 1 |
| rs7848647 | rs7848647 | 1 | 1 |
| rs6478108 | rs6478108 | 1 | 1 |
| P268S | P268S | 1 | 1 |
| IVS8+158 | IVS8+158 | 1 | 1 |
| G908R | G908R | 1 | 1 |
| R702W | R702W | 1 | 1 |
| T300A | T300A | 1 | 1 |
Associated population records
Co-mentioned in the same publicationsSupporting publications
100 records- 2026Diagnosis and Management of Upper Gastrointestinal Involvement in Adult Patients With Crohn's Disease: A Systematic Review.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association1 mentions
- 2026AQP9 and IFITM1 as drivers of immune infiltration and tumor progression in IBD-associated colorectal cancer: from computational insights to experimental validation.Naunyn-Schmiedeberg's archives of pharmacology1 mentions
- 2026Ultraprocessed Grains and Risk of Inflammatory Bowel Disease: Results From the Prospective Urban Rural Epidemiology Study.The American journal of gastroenterology1 mentions
- 2026Cost calculation model of introducing Upadacitinib and Risankizumab for adult ulcerative colitis and Crohn's disease in the Kingdom of Saudi Arabia.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association1 mentions
- 2026Initial Management of Intra-Abdominal Abscess in Crohn's Disease: A Systematic Review and Meta-Analysis.Inflammatory bowel diseases1 mentions
- 2026Systematic Review of Bile Acids Metabolism in Crohn's Disease: Implications for Pathogenesis and Therapeutic Interventions.Digestive diseases and sciences1 mentions
- 2026The Impact of Disease Activity and Medications on Pregnancy and Fetal Outcomes in Women With Inflammatory Bowel Disease: A Cohort Study From the IBD-ME Group.Journal of gastroenterology and hepatology1 mentions
- 2026Inflammatory Bowel Disease in Children and Young People Living With Overweight or Obesity: A Critical Narrative Review.Obesity reviews : an official journal of the International Association for the Study of Obesity1 mentions
- 2026Precision medicine in Crohn's disease: Navigating the path from biomarker discovery to clinical implementation.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association1 mentions
- 2026The efficacy of adipose-derived stem cell therapy for complex perianal fistulas in Crohn's disease patients: A systematic review.Surgery open science1 mentions
- 2026Definitions, diagnosis, management, and outcomes of upper gastrointestinal Crohn's disease: an international, expert RAND/UCLA appropriateness study.The lancet. Gastroenterology & hepatology1 mentions
- 2026Co-Occurrence of Inflammatory Bowel Disease in Patients with Vitiligo: A Systematic Review and Meta-Analysis.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology1 mentions
- 2026Anastomotic configurations and early endoscopic recurrence following ileocolonic resection in Crohn's disease: systematic review and meta-analysis.International journal of colorectal disease1 mentions
- 2026Association between spicy food consumption and inflammatory bowel disease: A case-control study from Saudi Arabia.Nutrition (Burbank, Los Angeles County, Calif.)1 mentions
- 2026Redrawing the gut map: evolving probiotic approaches to microbiota modulation in inflammatory bowel disease.Antonie van Leeuwenhoek1 mentions
- 2026Simultaneous duodenal and ileocolic obstruction in Crohn's disease: a case report.Journal of surgical case reports1 mentions
- 2026Anesthetic management of a cesarean section in a pregnant patient with congenital complete atrioventricular block without pacemaker - A case report.Saudi journal of anaesthesia1 mentions
- 2026In Vitro Effects of Twelve Food Additives on Gut Microbiome and Its Fibre Fermentation Capacity in Adults with Crohn's Disease in Remission and Healthy Controls.Nutrients1 mentions
- 2026Ulcerative colitis, pathophysiological mechanisms and drug repurposing: a new therapeutic dawn-narrative review.Inflammopharmacology1 mentions
- 2026Characteristics, Complications, Comorbidities, and Other Manifestations of Inflammatory Bowel Disease: A 7-Year Tertiary Center Experience.Clinics and practice1 mentions
- 2026Harnessing Nanocarriers to Modulate Gut Inflammation: A New Era in IBD Management.Recent advances in inflammation & allergy drug discovery1 mentions
- 2026Mode of birth and risk of inflammatory bowel disease in offspring: an updated systematic review and meta-analysis.Frontiers in reproductive health1 mentions
- 2026Cutaneous Leukocytoclastic Vasculitis as a rare adverse event of infliximab in Crohn's disease: a case report.Oxford medical case reports1 mentions
- 2026An Integrated Review of Conventional and Emerging Diagnostic and Therapeutic Modalities to Reduce the Risk of Surgical Resections in Intestinal Tuberculosis.Diagnostics (Basel, Switzerland)1 mentions
- 2026Prevalence, patient characteristics, and outcomes of high-dose upadacitinib in inflammatory bowel disease.Therapeutic advances in gastroenterology1 mentions
- 2026Medication Use and Guideline Adherence in Inflammatory Bowel Disease Management: A Retrospective Study from a Tertiary Care Hospital in Pakistan (2019-2024).International journal of general medicine1 mentions
- 2026STRIDE-II treatment target achievement in inflammatory bowel disease: a cross-sectional study from a tertiary IBD centre in the United Arab Emirates.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association1 mentions
- 2026Orbital manifestations of inflammatory bowel disease - a systematic review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie1 mentions
- 2026Disease burden of inflammatory bowel disease and subtypes in older adults in 172 high- and middle-income countries: Trends from 2000 to 2023 and projections to 2040.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association1 mentions
- 2026BIRC3 (Encoding Cellular Inhibitor of Apoptosis Protein 2) Variants Result in Dysregulated Receptor-Interacting Protein Kinase 1 Signaling Leading to Increased Epithelial Cell Death and Are Associated With Monogenic Crohn's Disease.Gastroenterology1 mentions
- 2026Adherent-Invasive Escherichia coli (AIEC) in Crohn's Disease: A Bibliometric Analysis of 25 Years of Research (1999-2025).Microorganisms1 mentions
- 2026Patient Preferences for Virtual Versus In-Person Care in Inflammatory Bowel Disease: A Cross-Sectional Study.Telemedicine journal and e-health : the official journal of the American Telemedicine Association1 mentions
- 2026Patients with Crohn's disease achieving transmural healing experience superior long-term outcomes compared with those with endoscopic or radiologic healing alone.Inflammatory bowel diseases1 mentions
- 2026Patient preferences toward the attributes of treatment used for inflammatory bowel disease in Saudi Arabia: Subgroup analysis from an international multicenter discrete choice experiment.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association1 mentions
- 2025Ustekinumab Drug Levels and Outcomes in Inflammatory Bowel Disease.Journal of clinical gastroenterology1 mentions
- 2025Brucellosis in a patient with Crohn's disease treated with infliximab: A case report.Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology1 mentions
- 2025Rates, Predictors, and Outcomes of Ustekinumab Dose Escalation in Inflammatory Bowel Disease.Journal of clinical gastroenterology1 mentions
- 2025Clinical effectiveness and safety of ustekinumab in youth with refractory inflammatory bowel disease: A retrospective cohort study.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association1 mentions
- 2025Periodontitis increases the risk of gastrointestinal dysfunction: an update on the plausible pathogenic molecular mechanisms.Critical reviews in microbiology1 mentions
- 2025Endoscopic Skipping, Stricturing, and Penetrating Complications in Crohn's Disease on Tandem Ileo-colonoscopy and Cross-sectional Imaging: A Retrospective Cohort Study.Inflammatory bowel diseases1 mentions
- 2025Acute tubulointerstitial nephritis associated with infliximab therapy in a patient with Crohn's disease: a case report.CEN case reports1 mentions
- 2025Coexisting autoimmune disorders among patients with inflammatory bowel disease at a tertiary center in Saudi Arabia: A cross-sectional study.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association1 mentions
- 2025Hepatobiliary manifestations of inflammatory bowel disease in Saudi Arabia: A retrospective analysis.Saudi medical journal1 mentions
- 2025Prevalence and clinical implications of anti-drug antibody formation and serum drug levels among patients with IBD receiving anti-TNF therapy: A cross-sectional study.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association1 mentions
- 2025Protective Role of Nano-encapsulated Bifidobacterium breve, Bacilllus coagulans, and Lactobacillus plantarum in Colitis Model: Insights Toward Propagation of Short-Chain Fatty Acids and Reduction of Exaggerated Inflammatory and Oxidative Response.Probiotics and antimicrobial proteins1 mentions
- 2025Colorectal Neoplasia in Inflammatory Bowel Disease.Cancers1 mentions
- 2025High-Throughput Whole-Exome Sequencing and Large-Scale Computational Analysis to Identify the Genetic Biomarkers to Predict the Vedolizumab Response Status in Inflammatory Bowel Disease Patients from Saudi Arabia.Biomedicines1 mentions
- 2025Chloride channels and mast cell function: pioneering new frontiers in IBD therapy.Molecular and cellular biochemistry1 mentions
- 2025Variability in intestinal drug metabolizing enzymes and transporters in Crohn's disease and potential impact on oral drug absorption.British journal of clinical pharmacology1 mentions
- 2025Bowel Obstruction Due to the Mesenteric Mass Being an Enteritis Cystica Profunda: A Case Report.Cureus1 mentions
- 2025The outcomes of robotic ileocolic resection in Crohn's disease compared with laparoscopic and open surgery: a meta-analysis and systematic review.Techniques in coloproctology1 mentions
- 2025Impact of Microbiota Diversity on Inflammatory Bowel Disease.Microorganisms1 mentions
- 2025Challenges of concurrent HIV infection in the course and management of Crohn's disease.Journal of medicine and life1 mentions
- 2025Hyperimmunoglobulinemia D Syndrome Masquerading as Familial Mediterranean Fever, Hidradenitis Suppurativa, and Crohn's Disease: A Case Report.Saudi journal of medicine & medical sciences1 mentions
- 2025Clinical Progress in Mesenchymal Stem Cell Therapy: A Focus on Rheumatic Diseases.Immunity, inflammation and disease1 mentions
- 2025Incidental low-grade appendiceal mucinous neoplasm in Crohn's disease patient post ileocecal resection: a case report.Journal of surgical case reports1 mentions
- 2025Expression Profile of Serum CircFUNDC1 and CircUHRF1 Can Differentiate Between Colorectal Cancer and Inflammatory Bowel Diseases (Ulcerative Colitis and Crohn's Disease).Journal of clinical laboratory analysis1 mentions
- 2025Exploring the dual role of Mangifera indica L. in regulating immune response and pain persistence in inflammatory bowel disease.Pharmacological research1 mentions
- 2025The role of gut leakage and immune cell miss-homing on gut dysbiosis-induced lung inflammation in a DSS mice model.PloS one1 mentions
- 2025Indicators for early surgery in patients with intra-abdominal fistulizing Crohn's disease.Annals of Saudi medicine1 mentions
- 2025Development and validation of a novel Endoscopic ulcer Activity Score for Evaluation of Crohn's Disease (EASE-CD) using data from two randomised controlled trials.The lancet. Gastroenterology & hepatology1 mentions
- 2025The Association Between Fast Food Consumption and Inflammatory Bowel Disease: A Case-Control Study and Meta-Analysis.Nutrients1 mentions
- 2025Patient Preferences for Treatment Attributes in Inflammatory Bowel Disease: A Discrete Choice Experiment Among Patients in Five Non-Western Countries.Advances in therapy1 mentions
- 2025Real-World Clinical Effectiveness and Safety of Vedolizumab and Ustekinumab in Biologic-Naive Patients With Crohn's Disease By Disease Location: Results from the EVOLVE Expansion Study.Journal of clinical gastroenterology1 mentions
- 2025Diagnostic yield of video capsule endoscopy vs simple balloon enteroscopy in small intestinal disorders: A systematic review.World journal of gastrointestinal endoscopy1 mentions
- 2025Efficacy and Safety of 1 L PEG-ASC Preparation for Colonoscopy in Patients with Inflammatory Bowel Diseases: A Multicenter Observational Study.Journal of clinical medicine1 mentions
- 2025Association between the early diagnosis of Crohn's disease (CD) and the development of its clinical complications among adults at King Abdulaziz University Hospital.Annals of medicine and surgery (2012)1 mentions
- 2025Age and sex but not disease activity or duration are associated with muscle mass in paediatric Crohn's disease.Clinical nutrition ESPEN1 mentions
- 2025Exploring Anti-TNF Therapy in Relapsing Polychondritis with Co-Existing Ulcerative Colitis: A Case Report and Literature Review.The American journal of case reports1 mentions
- 2025Association of SLC22A4 and TNF-α gene polymorphism with susceptibility to inflammatory bowel disease among patients in the Eastern Province of Saudi Arabia.Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology1 mentions
- 2025Prevalence and Impact of Zinc Deficiency on Clinical Outcomes in Inflammatory Bowel Disease.Nutrients1 mentions
- 2025C-Reactive Protein Levels in Patients with Isolated Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis) and Coexisting H. pylori Infection and IBD: A Comparative Study.Inflammatory intestinal diseases1 mentions
- 2025Utilisation and real-world effectiveness of advanced therapies for inflammatory bowel disease in Middle Eastern populations: a systematic review.BMJ open gastroenterology1 mentions
- 2025TNF antagonists withdrawal is not advised in patients with inflammatory bowel disease in remission: a systematic review and meta-analysis of randomized controlled trials.International journal of colorectal disease1 mentions
- 2025Immunogenetics of Behçet's disease: Is there a link to recent phenotypic changes?Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society1 mentions
- 2025The Evolving Role of Cine MRI in Crohn's Disease: From Functional Motility Analysis to Precision Management: A Review of the Last 10 Years.Diagnostics (Basel, Switzerland)1 mentions
- 2025Bibliometric analysis of inflammatory bowel disease and emotional factors: trends, impact, and emerging research areas.Annals of medicine and surgery (2012)1 mentions
- 2025Compartment Syndrome Secondary to Phlegmasia Cerulea Dolens in a Patient With Crohn's Disease.The American journal of case reports1 mentions
- 2025Filgotinib in Moderate-to-Severe Crohn's Disease: A Network Meta-Analysis of Efficacy and Adverse Events.Healthcare (Basel, Switzerland)1 mentions
- 2025Therapeutic Agents Targeting the Nrf2 Signaling Pathway to Combat Oxidative Stress and Intestinal Inflammation in Veterinary and Translational Medicine.Veterinary sciences1 mentions
- 2024Safety & feasibility of targeted mesenteric approaches with Kono-S anastomosis and extended mesenteric excision in ileocolic resection and anastomosis in Crohn's disease.American journal of surgery1 mentions
- 2024Analysis of the risk of future gastrointestinal surgery in Crohn's disease with stricture.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association1 mentions
- 2024Biologic Therapy for Inflammatory Bowel Disease: Real-World Comparative Effectiveness and Impact of Drug Sequencing in 13 222 Patients within the UK IBD BioResource.Journal of Crohn's & colitis1 mentions
- 2024Bridging autoimmunity and epigenetics: The influence of lncRNA MALAT1.Pathology, research and practice1 mentions
- 2024The role of molecular imaging in detecting fibrosis in Crohn's disease.Annals of medicine1 mentions
- 2024Epstein-Barr virus seroprevalence among inflammatory bowel disease patients in Saudi Arabia.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association1 mentions
- 2024Analysis of the Accuracy of Magnetic Resonance Enterography for the Detection of Active Inflammation and Disease Activity in Patients With Crohn's Disease: A Single-Center Experience in Najran, Saudi Arabia.Cureus1 mentions
- 2024In vitro mucin degradation and paracellular permeability by fecal water from Crohn's disease patients.Future microbiology1 mentions
- 2024Association between body mass index and age of disease onset with clinical outcomes in paediatric-onset Crohn's Disease (CD): a UK nation-wide analyses using the NIHR-IBD BioResource.European journal of clinical nutrition1 mentions
- 2024Inflammatory bowel disease evolution in the past two decades: a chronological multinational study.EClinicalMedicine1 mentions
- 2024A Retrospective Observational Study of Patterns of Biologic Drug Change in Inflammatory Bowel Disease.Inflammatory intestinal diseases1 mentions
- 2024Helminth-derived proteins as immune system regulators: a systematic review of their promise in alleviating colitis.BMC immunology1 mentions
- 2024Gut microbiota composition in patients with Crohn's disease in Saudi Arabia.PloS one1 mentions
- 2024Unveiling Therapeutic Avenues for Crohn's Disease Management: Exploring Inhibitors for Adherent-Invasive Escherichia coli Propanediol Dehydratase.Medicinal chemistry (Shariqah (United Arab Emirates))1 mentions
- 2024Creation of an institutional preoperative checklist to support clinical risk assessment in patients with ulcerative colitis (UC) considering ileoanal pouch surgery.Frontline gastroenterology1 mentions
- 2024Clinical Decision Making in Inflammatory Bowel Disease Mimics: Practice Management from Inflammatory Bowel Disease LIVE.Crohn's & colitis 3601 mentions
- 2024Prevalence of Classical Extraintestinal Manifestations among Inflammatory Bowel Disease Patients in Saudi Arabia: A Single Tertiary Center Experience.Saudi journal of medicine & medical sciences1 mentions
- 2024A Rare Abdominal Pain Associated With Chronic Intestinal Schistosomiasis Diagnosed Endoscopically: A Case Study From Saudi Arabia.Cureus1 mentions
- 2024Awareness of inflammatory bowel disease among the general population of Al-Baha region, Saudi Arabia.Journal of medicine and life1 mentions
- 2024Prevalence of Autoimmune Diseases Among Patients With Psoriasis: A Single Tertiary Center Experience.Cureus1 mentions