metabolic syndrome
SaudiVarKB evidence summary derived from retained literature mentions.
125Phenotype mentions
100Publications
50Associated gene records
33Associated variant records
Associated gene records
Co-mentioned in the same publications| Gene | Identifier / context | Articles | Mentions |
|---|---|---|---|
| STAT3 | HGNC:11364 | 3 | 3 |
| TG | HGNC:11764 | 2 | 2 |
| TCF7L2 | HGNC:11641 | 2 | 2 |
| VDR | HGNC:12679 | 2 | 2 |
| CCL2 | HGNC:10618 | 2 | 2 |
| SCAP | HGNC:30634 | 2 | 2 |
| SIRT1 | HGNC:14929 | 1 | 1 |
| CCR7 | HGNC:1608 | 1 | 1 |
| MCM4 | HGNC:6947 | 1 | 1 |
| BDNF | HGNC:1033 | 1 | 1 |
| SLC52A3 | HGNC:16187 | 1 | 1 |
| ALDH4A1 | HGNC:406 | 1 | 1 |
| KLF14 | HGNC:23025 | 1 | 1 |
| MTHFR | HGNC:7436 | 1 | 1 |
| CCL17 | HGNC:10615 | 1 | 1 |
| LDLR | HGNC:6547 | 1 | 1 |
| FADS1 | HGNC:3574 | 1 | 1 |
| FADS2 | HGNC:3575 | 1 | 1 |
| ELOVL2 | HGNC:14416 | 1 | 1 |
| ABCA1 | HGNC:29 | 1 | 1 |
| FAS | HGNC:11920 | 1 | 1 |
| CXCL10 | HGNC:10637 | 1 | 1 |
| SIRT2 | HGNC:10886 | 1 | 1 |
| GSTM1 | HGNC:4632 | 1 | 1 |
| GSTT1 | HGNC:4641 | 1 | 1 |
| ADIPOQ | HGNC:13633 | 1 | 1 |
| CXCL1 | HGNC:4602 | 1 | 1 |
| CD36 | HGNC:1663 | 1 | 1 |
| TLR2 | HGNC:11848 | 1 | 1 |
| GCA | HGNC:15990 | 1 | 1 |
| MCM2 | HGNC:6944 | 1 | 1 |
| PCNA | HGNC:8729 | 1 | 1 |
| S100B | HGNC:10500 | 1 | 1 |
| CXCR4 | HGNC:2561 | 1 | 1 |
| TOP2A | HGNC:11989 | 1 | 1 |
| ROCK1 | HGNC:10251 | 1 | 1 |
| MCM6 | HGNC:6949 | 1 | 1 |
| GCLM | HGNC:4312 | 1 | 1 |
| SGK1 | HGNC:10810 | 1 | 1 |
| SLC52A2 | HGNC:30224 | 1 | 1 |
| CXCL2 | HGNC:4603 | 1 | 1 |
| ANGPTL8 | HGNC:24933 | 1 | 1 |
| IRS1 | HGNC:6125 | 1 | 1 |
| ABCG1 | HGNC:73 | 1 | 1 |
| CIDEA | HGNC:1976 | 1 | 1 |
| SCG5 | HGNC:10816 | 1 | 1 |
| BCO2 | HGNC:18503 | 1 | 1 |
| CXCL16 | HGNC:16642 | 1 | 1 |
| PCSK2 | HGNC:8744 | 1 | 1 |
| PCSK1N | HGNC:17301 | 1 | 1 |
Associated variant records
Co-mentioned in the same publications| Variant | Identifier / context | Articles | Mentions |
|---|---|---|---|
| rs7903146 | rs7903146 | 1 | 1 |
| rs5743708 | rs5743708 | 1 | 1 |
| rs699947 | rs699947 | 1 | 1 |
| rs4025935 | rs4025935 | 1 | 1 |
| rs71748309 | rs71748309 | 1 | 1 |
| rs4646994 | rs4646994 | 1 | 1 |
| rs7903146 | rs7903146 | 1 | 1 |
| p.D172N | p.D172N | 1 | 1 |
| p.D178N | p.D178N | 1 | 1 |
| p.E140* | p.E140* | 1 | 1 |
| p.L135* | p.L135* | 1 | 1 |
| rs2278426 | rs2278426 | 1 | 1 |
| rs972283 | rs972283 | 1 | 1 |
| rs895819 | rs895819 | 1 | 1 |
| rs1799983 | rs1799983 | 1 | 1 |
| rs12255372 | rs12255372 | 1 | 1 |
| 894G>T | 894G>T | 1 | 1 |
| -786T>C | -786T>C | 1 | 1 |
| rs693 | rs693 | 1 | 1 |
| rs737337 | rs737337 | 1 | 1 |
| rs7799039 | rs7799039 | 1 | 1 |
| rs2236242 | rs2236242 | 1 | 1 |
| 2386A>G | 2386A>G | 1 | 1 |
| rs846910 | rs846910 | 1 | 1 |
| rs375319 | rs375319 | 1 | 1 |
| rs4844488 | rs4844488 | 1 | 1 |
| rs846906 | rs846906 | 1 | 1 |
| rs2241766 | rs2241766 | 1 | 1 |
| rs6444174 | rs6444174 | 1 | 1 |
| rs1063537 | rs1063537 | 1 | 1 |
| rs2082940 | rs2082940 | 1 | 1 |
| rs1063539 | rs1063539 | 1 | 1 |
| rs1761667 | rs1761667 | 1 | 1 |
Associated population records
Co-mentioned in the same publicationsSupporting publications
100 records- 2026Unlocking potentials of a prenylated flavonoid: Xanthohumol's role in combating inflammatory conditions and Rhematic diseases.Cytokine1 mentions
- 2026Comparative study of obeticholic acid and rosuvastatin in high-fat/fructose diet-induced metabolic dysfunction: role of AMPK, PPAR-γ, SREBP-1c, and STAT3 pathways.Journal of molecular histology1 mentions
- 2026Built-environment correlates of physical activity in youth with multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England)1 mentions
- 2026Clinical biomarkers and biosensors for early detection of metabolic dysfunction-associated steatohepatitis (MASH): a translational perspective.Frontiers in bioengineering and biotechnology1 mentions
- 2026Atypical antipsychotics and metabolic dysfunction-associated steatotic liver disease in children and adolescents: A systematic review.International journal of psychiatry in medicine1 mentions
- 2026Effect of methanolic extract of Salix babylonica on biochemical parameters and gene expression in streptozotocin induced diabetic rat model.Fitoterapia1 mentions
- 2026Impacts of Dietary Patterns and Screen Time on the Risk of Developing Type 2 Diabetes Mellitus Among Children in Saudi Arabia: A Cross-Sectional Study.Cureus1 mentions
- 2026Chromium as a Modulator of Insulin Receptor Activity: A Systematic Review of Its Role in Metabolic Syndrome and Type 2 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy1 mentions
- 2026Oxidative Stress-Gut Microbiome Crosstalk: Intestinal Redox Imbalance and Probiotics Therapeutic Potential.Antioxidants (Basel, Switzerland)1 mentions
- 2026Diallyl trisulfide attenuates metabolic syndrome via integrated modulation of PCSK-9/LDL-R axis, redox homeostasis, and inflammatory cytokine networks in high-carbohydrate high-fat (HCHF) diet-fed rats.Frontiers in pharmacology1 mentions
- 2026Association Between Metabolic Syndrome and Prostate Cancer: A Systematic Review.Cancers1 mentions
- 2026Silymarin-loaded phytosomal nanoparticles mitigate dyslipidemia, oxidative damage, and hepatic injury in high-fat diet-induced metabolic dysfunction-associated steatotic liver disease in rats.BMC gastroenterology1 mentions
- 2025Network-base approaches to identify therapeutic biomarkers in hepatocellular carcinoma and search for drug hunting utilizing molecular dynamics simulations.Journal of biomolecular structure & dynamics1 mentions
- 2025Yogurt Supplementation Can Ameliorate Fatty Liver Diseases and Metabolic Syndrome in High Fat-Induced Conditions in Mice.Food science & nutrition1 mentions
- 2025Serum levels of Wnt5a in Egyptian women with obesity and their association with toll like receptor 2 Arg753Gln gene polymorphism in a pilot case control study of obesity as a state of metaflammation.Scientific reports1 mentions
- 2025Identification of Interactive Genetic Loci Linked to Insulin Resistance in Metabolic Syndrome-An Update.Medicina (Kaunas, Lithuania)1 mentions
- 20253D facial imaging: a novel approach for metabolic abnormalities risk profiling.Science China. Life sciences1 mentions
- 2025Triglyceride-glucose index: a potent predictor of metabolic risk factors and eating behavior patterns among obese individuals.BMC endocrine disorders1 mentions
- 2025Identification of variants in exon 4 of the LDLR gene and assessment of their effects on the produced proteins in saudi women with metabolic syndrome.Diabetology & metabolic syndrome1 mentions
- 2025Clinical characterization of blood pressure phenotypes: the BP phenotype score.Blood pressure1 mentions
- 2025Interaction between the TCF7L2 gene and dietary intake on metabolic syndrome risk factors among Saudi Arabian adults.Frontiers in nutrition1 mentions
- 2025The prevalence of metabolic syndrome in patients with non-alcoholic fatty liver disease in primary care clinics at King Saud University Medical City, Riyadh, Saudi Arabia.Frontiers in endocrinology1 mentions
- 2025Evaluating the Impact of rs4025935, rs71748309, rs699947, and rs4646994 Genetic Determinants on Polycystic Ovary Syndrome Predisposition-A Case-Control Study.Life (Basel, Switzerland)1 mentions
- 2025Gut Microbiome Engineering for Diabetic Kidney Disease Prevention: A Lactobacillus rhamnosus GG Intervention Study.Biology1 mentions
- 2025An Integrative Polygenic and Epigenetic Risk Score for Overweight-related Hypertension in Chinese Population.Genomics, proteomics & bioinformatics1 mentions
- 2025Acquired Generalized Lipodystrophy with Extensive Autoimmune Involvement: A Case Report and Review of the Literature.Hormone research in paediatrics1 mentions
- 2025Cranberry improves metabolic syndrome-related organ dysfunction in rats by modulating AMPK/SREBP1, ROCK1 and TGF-β1.Scientific reports1 mentions
- 2025The Intricacies of Polypharmacy and Drug Interactions in Schizophrenia Treatment.Current drug metabolism1 mentions
- 2025Modulation of endoplasmic reticulum stress-induced insulin resistance by the low-carbohydrate high-fat ketogenic diet.Frontiers in nutrition1 mentions
- 2024A Mechanistic Review on Therapeutic Potential of Medicinal Plants and their Pharmacologically Active Molecules for Targeting Metabolic Syndrome.Current pharmaceutical design1 mentions
- 2024Molecular effects of Vitamin-D and PUFAs metabolism in skeletal muscle combating Type-II diabetes mellitus.Gene1 mentions
- 2024Impacts of chitosan and its nanoformulations on the metabolic syndromes: a review.Brazilian journal of biology = Revista brasleira de biologia1 mentions
- 2024The Association Between Components of Metabolic Syndrome and Abnormal Electrocardiograms in the Saudi Population: A Retrospective Study.Cureus1 mentions
- 2024An international multidisciplinary consensus on pediatric metabolic dysfunction-associated fatty liver disease.Med (New York, N.Y.)1 mentions
- 2024Naringin: Cardioprotective properties and safety profile in diabetes treatment.Fitoterapia1 mentions
- 2024Case Report: A rare treatable metabolic syndrome (Brown-Vialetto-Van Laere syndrome) masquerading as chronic inflammatory demyelinating polyneuropathy from Saudi Arabia.Frontiers in pediatrics1 mentions
- 2024Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021.Lancet (London, England)1 mentions
- 2024Abdominal Obesity-Metabolic Syndrome 3 Misclassified as Type 1 Diabetes Mellitus.JCEM case reports1 mentions
- 2024Synthesis, in vitro and in silico study of novel 1,3-diphenylurea derived Schiff bases as competitive α-glucosidase inhibitors.RSC advances1 mentions
- 2024Genotype Performance Estimation in Targeted Production Environments by Using Sparse Genomic Prediction.Plants (Basel, Switzerland)1 mentions
- 2024Extended Review and Updates of Nonalcoholic Fatty Pancreas Disease.Saudi journal of medicine & medical sciences1 mentions
- 2024Awareness of Obesity and Weight Loss Management Among Adults in the Asir Region, Saudi Arabia.Cureus1 mentions
- 2023Is metabolic syndrome a modifiable risk factor for gout?Neurosciences (Riyadh, Saudi Arabia)1 mentions
- 2023Fatty Acid Profile and Genetic Variants of Proteins Involved in Fatty Acid Metabolism Could Be Considered as Disease Predictor.Diagnostics (Basel, Switzerland)1 mentions
- 2023Obesity and metabolic syndrome in patients with epilepsy, their relation with epilepsy control.Annals of African medicine1 mentions
- 2023Corrigendum: The association between FokI vitamin D receptor polymorphisms with metabolic syndrome among pregnant Arab women.Frontiers in endocrinology1 mentions
- 2023Is metabolic syndrome a modifiable risk factor for gout?Saudi medical journal1 mentions
- 2023The Ethnopharmacological Properties of Green-Engineered Metallic Nanoparticles against Metabolic Disorders.Medicina (Kaunas, Lithuania)1 mentions
- 2023Is metabolic syndrome a modifiable risk factor for gout?Neurosciences (Riyadh, Saudi Arabia)1 mentions
- 2023Autophagy characteristics of phytoestrogens in management and prevention of diseases: A narrative review of in-vivo and in-vitro studies.Journal of advanced veterinary and animal research1 mentions
- 2023Molecular Study of the Protective Effect of a Low-Carbohydrate, High-Fat Diet against Brain Insulin Resistance in an Animal Model of Metabolic Syndrome.Brain sciences1 mentions
- 2022Metabolic Syndrome and Its Components in Psoriatic Arthritis.Open access rheumatology : research and reviews1 mentions
- 2022The Association Between FokI Vitamin D Receptor Polymorphisms With Metabolic Syndrome Among Pregnant Arab Women.Frontiers in endocrinology1 mentions
- 2022Modulation of Dyslipidemia Markers Apo B/Apo A and Triglycerides/HDL-Cholesterol Ratios by Low-Carbohydrate High-Fat Diet in a Rat Model of Metabolic Syndrome.Nutrients1 mentions
- 2022The role of progranulin in ischemic heart disease and its related risk factors.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences1 mentions
- 2022Arsenic Exposure through Dietary Intake and Associated Health Hazards in the Middle East.Nutrients1 mentions
- 2022Metabolic syndrome and underlying genetic determinants-A systematic review.Journal of diabetes and metabolic disorders1 mentions
- 2022Non-HDL Cholesterol, Obesity, and Metabolic Syndrome in Epileptic Patients.The primary care companion for CNS disorders1 mentions
- 2022Modulation of Pulmonary Toxicity in Metabolic Syndrome Due to Variations in Iron Oxide Nanoparticle-Biocorona Composition.Nanomaterials (Basel, Switzerland)1 mentions
- 2022Hongqu Rice Wines Ameliorate High-Fat/High-Fructose Diet-Induced Metabolic Syndrome in Rats.Alcohol and alcoholism (Oxford, Oxfordshire)1 mentions
- 2022Effects of Resveratrol Against Induced Metabolic Syndrome in Rats: Role of Oxidative Stress, Inflammation, and Insulin Resistance.Evidence-based complementary and alternative medicine : eCAM1 mentions
- 2022Yield of soybean genotypes identified through GGE biplot and path analysis.PloS one1 mentions
- 2022Metabolic Syndrome and Cardiometabolic Risk Factors in the Mixed Hypercholesterolemic Populations with Respect to Gender, Age, and Obesity in Asir, Saudi Arabia.International journal of environmental research and public health1 mentions
- 2022Genetic Determinants of Cardiovascular Disease: The Endothelial Nitric Oxide Synthase 3 (eNOS3), Krüppel-Like Factor-14 (KLF-14), Methylenetetrahydrofolate Reductase (MTHFR), MiRNAs27a and Their Association with the Predisposition and Susceptibility to Coronary Artery Disease.Life (Basel, Switzerland)1 mentions
- 2022Is metabolic syndrome a modifiable risk factor for gout?Saudi medical journal1 mentions
- 2022Gene Expression Profiling of Peripheral Blood Mononuclear Cells in Type 2 Diabetes: An Exploratory Study.Medicina (Kaunas, Lithuania)1 mentions
- 2021Dietary Recommendations for Familial Hypercholesterolaemia: an Evidence-Free Zone.BMJ evidence-based medicine1 mentions
- 2021Generation of an iPSC cohort of isogenic iPSC lines (46-XY and 47-XXY) from a non-mosaic Klinefelter Syndrome patient (47-XXY) (KAUSTi008-A, KAUSTi008-B, KAUSTi008-C, KAUSTi008-D, KAUSTi008-E, KAUSTi008-F, KAUSTi008-G).Stem cell research1 mentions
- 2021Pregnant women who develop preeclampsia have lower abundance of the butyrate-producer Coprococcus in their gut microbiota.Pregnancy hypertension1 mentions
- 2021Strain-based and sex-biased differences in adrenal and pancreatic gene expression between KK/HlJ and C57BL/6 J mice.BMC genomics1 mentions
- 2021Diet-induced differential effects on plasma lipids secretion by the inositol-requiring transmembrane kinase/endoribonuclease 1α.Frontiers in bioscience (Landmark edition)1 mentions
- 2021Prevalence of ApoB100 rs693 gene polymorphism in metabolic syndrome among female students at King Abdulaziz University.Saudi journal of biological sciences1 mentions
- 2021Impact of combined therapy of mesenchymal stem cells and sitagliptin on a metabolic syndrome rat model.Journal of diabetes and metabolic disorders1 mentions
- 2021Lycopene corrects metabolic syndrome and liver injury induced by high fat diet in obese rats through antioxidant, anti-inflammatory, antifibrotic pathways.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie1 mentions
- 2021A metabolomics approach to investigate the proceedings of mitochondrial dysfunction in rats from prediabetes to diabetes.Saudi journal of biological sciences1 mentions
- 2021Associations of transcription factor 7-Like 2 (TCF7L2) gene polymorphism in patients of type 2 diabetes mellitus from Khyber Pakhtunkhwa population of Pakistan.African health sciences1 mentions
- 2021Disruption of pulmonary resolution mediators contribute to exacerbated silver nanoparticle-induced acute inflammation in a metabolic syndrome mouse model.Toxicology and applied pharmacology1 mentions
- 2021Cardiovascular Health and The Intestinal Microbial Ecosystem: The Impact of Cardiovascular Therapies on The Gut Microbiota.Microorganisms1 mentions
- 2021Systematic Review of Polyherbal Combinations Used in Metabolic Syndrome.Frontiers in pharmacology1 mentions
- 2021Mechanistic insights into the role of serum-glucocorticoid kinase 1 in diabetic nephropathy: A systematic review.International journal of biological macromolecules1 mentions
- 2021Identification of drought tolerant Chickpea genotypes through multi trait stability index.Saudi journal of biological sciences1 mentions
- 2021Study Protocol for a Randomized Controlled Trial Evaluating the Effectof Chromium Picolinate Supplementation on Gene Expression of TumorNecrosis Factor-α and DNA Damage in Metabolic Syndrome Patients.Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia1 mentions
- 2020Natural Peroxisome Proliferator-Activated Receptor γ (PPARγ) Activators for Diabetes.Alternative therapies in health and medicine1 mentions
- 2020Inhibition of the mitochondrial citrate carrier, Slc25a1, reverts steatosis, glucose intolerance, and inflammation in preclinical models of NAFLD/NASH.Cell death and differentiation1 mentions
- 2020Metabolic syndrome, malnutrition, and its associations with cardiovascular and all-cause mortality in hemodialysis patients: Follow-up for three years.Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia1 mentions
- 2020Comparison of silver nanoparticle-induced inflammatory responses between healthy and metabolic syndrome mouse models.Journal of toxicology and environmental health. Part A1 mentions
- 2020Association of ANGPTL8 (Betatrophin) Gene Variants with Components of Metabolic Syndrome in Arab Adults.Scientific reports1 mentions
- 2020Exacerbation of Nanoparticle-Induced Acute Pulmonary Inflammation in a Mouse Model of Metabolic Syndrome.Frontiers in immunology1 mentions
- 2020Targeting metabolic syndrome with phytochemicals: Focus on the role of molecular chaperones and hormesis in drug discovery.Pharmacological research1 mentions
- 2020Molecular & biochemical analysis of Pro12Ala variant of PPAR-γ2 gene in type 2 diabetes mellitus.Saudi journal of biological sciences1 mentions
- 2020The association between plasma homocysteine level and metabolic syndrome. A record-based study of Saudi patients attending King Abdulaziz Medical City in Riyadh, Saudi Arabia.Saudi medical journal1 mentions
- 2019The differential effects of high-fat and high- -fructose diets on the liver of male albino rat and the proposed underlying mechanisms.Folia morphologica1 mentions
- 2019Salts and energy balance: A special role for dietary salts in metabolic syndrome.Clinical nutrition (Edinburgh, Scotland)1 mentions
- 2019Relative reduction of biological and phylogenetic diversity of the oral microbiota of diabetes and pre-diabetes patients.Microbial pathogenesis1 mentions
- 2019Molecular targets of fenofibrate in the cardiovascular-renal axis: A unifying perspective of its pleiotropic benefits.Pharmacological research1 mentions
- 2018Metabolic Syndrome, Dyslipidemia and Regulation of Lipoprotein Metabolism.Current diabetes reviews1 mentions
- 2018Prevalence of metabolic syndrome in Middle-East countries: Meta-analysis of cross-sectional studies.Diabetes & metabolic syndrome1 mentions
- 2018Effect of genetic polymorphisms in SREBF-SCAP pathway on therapeutic response to rosuvastatin in Saudi metabolic syndrome patients.Pharmacogenomics1 mentions
- 2018PPARα receptor expression in patients with metabolic syndrome.Diabetes & metabolic syndrome1 mentions
- 2017Cardiorespiratory fitness and incident heart failure: The Henry Ford ExercIse Testing (FIT) Project.American heart journal1 mentions