TP53
HGNC:11998 · 202 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TP53 | “DMH also inhibited apoptosis, as demonstrated by reduced expression of BAX, caspase-3, and TP53, along with increased BCL-2 expression.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “O-glycosylation was associated with genomic stability, including lower TP53 mutation frequency (p = 0.0056), reduced aneuploidy (p = 0.0116), and decreased fraction of genome altered (p = 0.0309).” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “RESULTS: Treated cells exhibited increased SA-β-gal staining and increased expression of CDKN2A and CDKN2B (and modestly TP53).” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Genomic alteration analysis using cBioPortal across 21 pancreatic cancer studies (n = 5189 samples) identified seven recurrently altered genes (TP53, HSF1, PARP10, ZFP36, SIRT2, ECH1, and ENPP2) with alteration frequencies ≥ 3%.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “One case exhibited progression to a pleomorphic xanthoastrocytoma-like profile, while another acquired glioblastoma-like infiltrative pattern and TP53 mutations, associated with a more aggressive course.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Although the diagnosis and subclassification of VSCC is often straightforward, using immunohistochemical markers such as p16 and p53 as surrogate markers for high-risk HPV infection and TP53 mutation respectively, rare and unusual scenarios exist that can complicate VSCC classification.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “However, TP53 mutations were more common (50.0% vs.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “The disease is driven by complex molecular mechanisms, including hormone receptor signaling, genetic mutations (e.g., TP53, BRCA), and HER2 pathways.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Low-fucosylation tumours demonstrated mesenchymal phenotypes, TP53 mutations, chromosomal instability, comprehensive multi-family RTK signalling, immune-excluded microenvironments, and poor outcomes.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Matched transcriptomic analysis in GLASS pairs supported recurrent-specific reductions in LMNB1, MKI67, and SOX2, with no consistent changes in TP53, HLA-DRA, B2M, or NCAM1.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “High-risk MM is driven by three major biological determinants: (1) molecular and genomic abnormalities, including high-risk IgH translocations, del(17p), TP53 mutation, gain(1q), and high-risk gene expression signatures; (2) increased proliferative capacity, with an elevated plasma-cell S-phase fraction identifying a subgroup with markedly inferior survival independent of conventional staging; and (3) extramedullary dissemination biology, reflected by circulating tumor cells and soft-tissue extramedullary disease, both associated with marrow independence, clonal evolution, and poor outcomes.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Despite the use of antiviral therapies and targeted monoclonal antibodies, therapeutic failure is common due to genomic instability-specifically TP53 mutations compromising Zidovudine/Interferon efficacy and CCR4 antigenic variations leading to mogamulizumab resistance.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Eleven patients (4.5%) harbored germline PVs/LPVs in cancer susceptibility genes including STK11, TP53, BRCA1, BRCA2, FANCA, SLX4, RAD50, MSH6, POLD1 and NF1.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Clinicopathological characteristics, biomarker profiles (ER, PR, Ki-67), molecular alterations (PIK3CA, TP53, BRCA) and survival outcomes (overall survival (OS), cancer-specific survival (CSS), disease-free survival (DFS), and distant disease-free survival (DDFS)) were compared.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “0.14% of controls; OR = 51.3; p < 1.0 × 10-10) and RPDVs in TP53 (4.9% vs.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “A cross-comparison of targets related to compounds and diseases revealed nine common genes, among which three central genes TP53, CASP8, and EGFR were identified using protein-protein interaction (PPI) network analysis.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “TP53 aberrations were found in 9.0% of CLL-treated and 9.8% of TN cohorts.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “TP53 apoptosis biomarkers in breast cancer.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Gene expression analysis using qRT-PCR examined key apoptosis-related markers (TP53, BAX, BCL2, CASP3).” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Molecular profiling when available revealed 83.3% of EC (n = 10/12) had TP53 overexpression and 33.3% (n = 4/12) had mismatch repair deficiency whereas 20% of OC patients (n = 2/10) had a germline BRCA mutation.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “This review provides a comprehensive overview of the pathogenesis, key biomarkers, and diagnostic innovations in AML-MRC, highlighting the role of genetic mutations (e.g., TP53, RUNX1, and splicing factors), cytogenetic abnormalities, and immune microenvironment alterations.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Clinical and genetic insights into novel TP53 mutations in De Novo AML patients.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Among hub genes, TP53 was found to be particularly promising through computational analysis.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “NRAS, HRAS and TP53 mutations showed no significant difference.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “ML identified three BC-CML clusters: (1) Cluster 1 [breast cancer susceptibility gene 2 (BRCA2), TP53]; (2) Cluster 2 [isocitrate dehydrogenase (IDH) 1/2, ten-eleven translocation 2]; and (3) Cluster 3 [Janus kinase (JAK) 2, colony-stimulating factor 3 receptor], with distinct COSMIC signatures.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “SFN-NLPs modulated key molecular pathways by suppressing inflammatory gene expression (NF-κB, COX-2) and shifting the balance toward apoptosis via upregulation of TP53 and Bax and concomitant downregulation of Bcl-2.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “GSONE enhanced gene expression of pro-apoptotic markers (Bax, TP53, caspase-3, caspase-9), suppressed anti-apoptotic Bcl-2, and significantly increased the proportion of p53- and cleaved caspase-3-positive tumor cells.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “The chosen phytochemicals are found to be non-toxic, anti-carcinogenic, anti-mutagenic, anti-neoplastic, TP53 expression enhancer, hepatoprotectant, cardioprotectant and possess drug-like properties based on the pharmacological and biological activity studies.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Protein-protein interaction (PPI) analysis highlighted ten key genes-EGFR, ESR1, HIF1A, HSP90AA1, MAPK1, BCL2, STAT3, TP53, CASP3, and SRC-implicated in the progression of various cancers, including breast, colorectal, liver, and lung tumors.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Both alkaloids induced late apoptosis in HCT116-WT cells, increased the cleavage of PARP and caspase-3, and upregulated Bax and TP53 while decreasing BCL-2.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “High-risk genes, including BRCA1, BRCA2, PALB2, TP53 and PTEN, with germline pathogenic or likely pathogenic variants (PVs/LPVs), substantially increase the risk of breast cancer and other malignancies.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Results: Gene expression profiling (TP53, Bax, and Bcl-2) and flow cytometry (p53 and Ki-67) elucidated the modulation of apoptosis.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Mutational Disruption of TP53: A Structural Approach to Understanding Chemoresistance.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “TP53 mutations drive oncogenesis and therapeutic resistance in myelodysplastic syndromes (MDSs) and acute myeloid leukemia (AML), impairing p53-regulated functions such as apoptosis, immune surveillance, and genomic stability, leading to immune evasion and metabolic reprogramming.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “We performed next-generation sequencing and found mutations in the TP53, NRAS, EGFR PDGFR, MET, KIT, ERBB2, and GUSP genes.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “The downregulation of ESR1 led to G0/G1 cell cycle arrest and apoptosis through the activation of downstream pathways, resulting in increased expression of TP53 and BAX, while reducing Bcl2 levels, ultimately leading to apoptosis.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Additional benefits included downregulating stress-related mRNA markers (HSP1A1 and TNC) and apoptotic markers (BAX and TP53).” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Moreover, it can inhibit inflammatory markers (IL-6, TNF-α, and IL-1β), downregulate oncogenes (Ras, HER2, MYC, and BCR/ABL1), and upregulate tumor suppressor genes (TSGs) such as TP53, PTEN, and BRCA1 and BRCA2 expression.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Ten hub genes were obtained based on maximum clique centrality (MCC), maximum neighborhood component (MNC), degree, closeness and betweenness using cytoHubba which included ACTB, ATM, ESR1, GAPDH, HNRNPK, KRAS, MDM2, SIRT1, TP53, and H3F3C (H3-5).” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “The TP53 gene was mutated in 82.5% of the analyzed cohort, followed by PIK3 CA (45%), FGFR3 (43.75%) and APC (35%).” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “PL is associated with high DNA aneuploidy, alterations in tumor suppressor genes (TP53, CDKN2A), and exhibits immune evasion markers, such as PD-L1.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Finally, prevalence of somatic mutations in TP53, PIK3CA, and ESR1 were higher in ADI ≥ 60.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Genetic abnormalities, including TP53 mutation and chromosomal anomalies, suggest clonal evolution.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “It has prominent levels of mutated genes such as TP53, KRAS, MET, and EGFR.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Notably, KRAS, CUL3, TP53, ESR1, and PARP1 were influenced by both upregulated and downregulated miRNAs.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Coevolutionary dynamics of 53BP1 and its impact on TP53 interaction for DNA damage repair.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Proficiency Testing of p53 Immunohistochemistry Pattern Read-out in Vulvar Biopsies Demonstrates Frequent Basal Overexpression Interpretation in TP53 Wild-type Cases.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “RESULTS: The combination index showed that HT-29 cells were the most responsive to the combined treatment, even with PIK3CA, B-RAF (V600E), and TP53 mutations.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “This review highlights key molecular pathways involved in oncogenesis, focusing on genetic alterations (mutations, amplifications, and translocations) in oncogenes (RAS and MYC) and tumor suppressor genes (TP53 and PTEN).” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “These alterations include mutations in driver genes like TP53 and RB1, epigenetic modifications such as DNA methylation and histone changes, and pathway alterations, notably involving RANK-RANKL signaling and the PI3K/AKT/mTOR cascade.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Moreover, anthocyanins downregulate oncogenes (Bcl-2, MYC, and HER2) and improve the activity of tumor suppressor genes (TP53, BRCA1, and RB1).” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Genetic tools like CRISPR-Cas9 and RNA interference also precisely modulate TP53 and CDKN1A expression to optimize MSC functionality.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Besides, younger BC women are statistically more likely than older ones to have pathogenic germline variants in BC susceptibility genes (BRCA1/2, TP53, PALB2).” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “One patient with a TP53 mutation had the shortest latency (28 months), suggesting a possible genetic predisposition.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “To address this issue, advances have been made in therapies targeting molecular pathways related to the murine double minute 2 proto-oncogene (MDM2)-tumor proteinp53 (TP53) interaction.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Wild-Type TP53 Predicts Poor Prognosis in Lower-Grade Glioma via TP53-CXCL14-GATA3 Axis.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Herein, we reported mutations in five DNA Damage Repair (DDR) i.e., TP53, ATR, ATM, CHEK1 and CHEK2 involved in OSCC using NG-WES and their analysis using bioinformatics tools.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “METHODS: We utilized a set of patient-derived premalignant and malignant tissue samples to investigate the protein (Ki67 and Lamin B1) and gene (TP53, IL1A, CCL2, and MMP9) expression of several OIS-associated biomarkers using immunohistochemistry (IHC) and qRT-PCR, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Genetic variants and breast carcinoma susceptibility: Unveiling the role of MTHFR (rs1801131, rs1801133) and TP53 (rs1042522).” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “RESULTS: In the pan-cancer group, TP53 (58.5%), EGFR (20.4%), and KRAS (18.9%) were the most frequently mutated genes.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Mutations of TP53 and BRCA1 genes have been associated with HGSC, which has been suggested as a subtype that arises from the fallopian tube lesion called serous tubal intraepithelial carcinoma (STIC).” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Variations in DNA repair (PARP-1, XRCC1, TP53) and cellular protection/drug metabolism genes (ABCC1, MDR1, GSTM1) also modulated susceptibility.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Breast, colorectal, and lung cancers were the most studied, with BRCA1/2 and TP53 among the most frequently mutated genes.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Methods: Gene set enrichment analyses (GSEAs) and drug ontology enrichment analyses (DOEAs) of PARPi response gene sets were applied as the surrogates of PARPi response to two CRC cohorts in order to compare the predictive capacities of TP53 mutation status, MSI status, as well as PARP1 and PARP2 expression for PARP inhibition to those of a homologous repair deficiency surrogate, and large-scale state transition (LST).” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “METHODS: This prospective research analyzed 150 OSCC patients, investigating the prognostic value of three genetic markers: TP53 mutations, miR-31 expression, and "mismatch repair (MMR)" protein loss.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Prostate cancer commonly involves TMPRSS2-ERG fusions and BRCA2 mutations, affecting treatment strategies, and penile squamous cell carcinoma follows distinct HPV-dependent and HPV-independent pathways, with mutations in TP53 and CDKN2A genes.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “NGS already has the capacity to ameliorate genetic screening in families with previous histories of the high occurrence of various cancer-associated genes, including TP53, APC, BRCA2, and BRCA1.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Knockout (KO) of the TP53/p53 gene decreased the ability of FL496 to inhibit MPM cell growth (i.e., increase FL496 IC50 values) and colony formation.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “To validate the pipeline, a case study on the TP53 gene, a critical tumour suppressor often mutated in cancers, was conducted.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Molecular insights into TP53 mutation (p.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “INTRODUCTION: Li-Fraumeni syndrome (LFS) is a rare autosomal dominant disorder brought on by pathogenic mutations in the TP53 tumor suppressor gene.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Furthermore, the Real-Time Quantitative Polymerase Chain Reaction (RT-qPCR) results indicated a significant elevation in the TP53 gene expression in groups subjected to RFM.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Various genetic modifications including BRAF mutations, RAS mutations, RET mutations, paired-box gene 8/peroxisome proliferator-activated receptor-gamma fusion oncogene, RET/PTC rearrangements, telomerase reverse transcriptase mutations, neurotrophic tyrosine receptor kinase fusion genes, TP53 mutations, and eukaryotic translation initiation factor 1A X-linked mutations can effectively serve as potential biomarkers in both diagnosis and prognosis of TC.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “RESULTS: Our study identified genetic mutations in BRCA1, BRCA2, TP53, and PMS2.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Molecular docking (MD) was used to assess the binding affinity of the most enriched constituents in AgRE toward the active sites of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and p53 tumor suppressor protein (TP53).” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Genetic polymorphisms in FABP2, CYP2E1, and TP53 genes are potentially associated with colorectal cancer susceptibility.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “A pharmacological network analysis was subsequently conducted using STITCH and Cytoscape, pinpointing six highly upregulated genes within the rutin network, including TP53, PCNA, CDK4, CCNEB1, CDKN1A, and LDHA.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “TP53, a guardian of the genome, suppresses or enhances tumors through various regulatory pathways.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Murine Double Minute 2 (MDM2) is an oncogene located at chromosome 12 (12q13-15) that inhibits the tumor suppressor gene TP53.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Methods: This study investigated the ACR-induced renal damage mechanisms, particularly focusing on the regulating role of miR-21a-5p/fibrotic and miR-122-5p/inflammatory signaling pathways via targeting Timp-3 and TP53 proteins in an In silico preliminary study.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Sanger sequencing was used to analyze peripheral blood DNA from these individuals to detect disease-causing mutations in the BRCA1, BRCA2, PTEN, TP53, and ATM genes.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “TAA exposure showed the tissue-specific expression of TP53, with decreased expression in the liver and increased expression in the kidney.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “We did not find any mutations in genes such as BRAF, IDH1, CDKN2A, PTEN, and TP53, which are also listed as cancer-driver genes in gliomas.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “PPI networks constructed in String DB and network topological analyzing parameters performed in Cytoscape v3.10 revealed three therapeutic targets: TP53 from MS-, NR-, and NS-induced genes; HSPCB and Nf-kB1 from MR-induced genes.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “This panel was designed to sequence the complete genome of CALR, IDH1, IDH2, JAK2, FLT3, NPM1, MPL, TET2, SF3B1, TP53, and MLL.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “The neoepitopes were identified from somatic mutations in the MUC16, TP53, RYR2, F5, DNAH17, ASPM, and ABCA13 self-antigenic proteins.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “This latter group of HPVi VSCC arises in most cases secondary to mutations in TP53, but recently, attention has focused on the uncommon TP53 wild-type HPVi VSCC.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Mutational Landscape and In-Silico Analysis of TP53, PIK3CA, and PTEN in Patients with Breast Cancer from Khyber Pakhtunkhwa.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “The analysis revealed pathogenic mutations in TP53 and RB genes, as well as copy number gains in NTRK1, MDM4, and BRAF.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “A bioinformatic analysis of the role of TP53 status on the infiltration of CD8+ T cells into the tumor microenvironment.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “According to the PPI network and core targets study, the main targets against PSO were EGFR, SRC, STAT3, ERBB2, PTK2, SYK, EP300, CBL, TP53, and AR.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “The association between IDH mutation, TP53 mutation, and MHC-I expression with recurrence-free interval were investigated.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Following that, a compound-target protein-pathway network was constructed which uncovered that namely abrectorin, genistin, (+)-catechin, precatorine, (+)-ascorbic acid, licoflavanone, skrofulein, stigmasterone, 5,7-Dihydroxy-4'-methoxy-8,3'-di-C-prenylflavanone could potentially be used as antagonists for the therapeutic management of epilepsy by targeting TNF and TP53 proteins.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Out of a total of 25 PI3K pathway-related genes, we developed and validated a diagnostic and prognostic model based on the up-regulation of TP53 (tumor protein 53) and CCND1 (Cyclin D1) and the down-regulation of PTEN (Phosphatase and TENsin homolog deleted on chromosome 10), and GSK3B (Glycogen synthase kinase-3 beta) hub genes.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “After comprehensively analyzing these 233 ferroptosis driver genes by various TCGA databases, RNA-sequencing (RNA-seq), and Reverse Transcription Quantitative Real-Time Polymerase Chain Reaction (RT-qPCR) techniques, TP53 (tumor protein 53), PTEN (Phosphatase and TENsin homolog deleted on chromosome 10), KRAS (Ki-ras2 Kirsten rat sarcoma viral oncogene homolog), and HRAS (Harvey Rat sarcoma virus) were identified as differentially expressed hub genes.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “The study also revealed the presence of specific somatic aberrations, including TP53, PIK3CA, APOB, CTNNB1, DPYD, LRP1B, MYC, and NFE2L2, which were identified in two patients.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “The TP53 signaling pathway is utilized by these agents to effectively trigger cell death and apoptosis, and p53 functions as a master regulator in a variety of cellular stress responses, including genotoxic stress.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Of the 310 subjects, 119 (38.4%) were carriers of pathogenic or likely pathogenic variants (PVs) affecting one or more of the following genes: TP53, ATM, CHEK2, CDH1, CDKN2A, BRCA1, BRCA2, PALB2, BRIP1, RAD51D, APC, MLH1, MSH2, MSH6, PMS2, PTEN, NBN/NBS1 and MUTYH.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “In summary, we proposed that quercetin, luteolin, apigenin, catechin, epicatechin, stigmasterol, beta-sitosterol, celastrol, and betulic acid inhibit tumor growth by affecting tumor protein 53 (TP53), interleukin 6 (IL6), RAC-alpha serine/threonine protein kinases 1 (AKT1), caspase-3 (CASP3), tumor necrosis factor (TNF), jun proto-oncogene (JUN), heat shot protein 90 AA1 (HSP90AA1), vascular endothelial growth factor A (VEGFA), epidermal growth factor receptor (EGFR), and SRC proto-oncogene (SRC).” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Other important genetic alterations in the more advanced types of TC include TERT promoter, TP53, EIF1AX, and epigenetic alterations.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Genetic alterations and the overexpression of several genes, such as FOXA1, AR, PTEN, RB1, TP53, etc., suppress the immune response, resulting in drug resistance to conventional drugs in prostate cancer.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “The other 19 tumors tested by NGS showed definitely pathogenic alterations in 10 patients (52.6%): 2/19 (10.5%) BRAFV600E, 5/19 (26.3%) CCDC6-RET (RET/PTC1), 1/19 (5.3%) NCOA4-RET (RET/PTC3), 1/19 (5.3%) STRN-ALK fusion, and 2/19 (10.6%) TP53 mutations.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Noncomplementary p16 and p53 patterns were resolved by repeating p53 IHC and HPV RNA in situ hybridization (ISH) on whole sections, and sequencing for TP53.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “By using databases like UALCAN, TIMER, GEPIA, and PredictProtein, we investigated TP53's expression pattern and prognostic relevance in various cancer settings.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Transcriptional Analysis of TP53 Gene in Chronic Hepatitis C Patients Treated with Sofosbuvir, Daclatasvir, Pegylated Interferon, and Ribavirin.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “The p53abn in situ lesions at a margin were confirmed to have TP53 mutations by sequencing. p53 IHC staining identified morphologically occult p53abn in situ lesions surrounding human papillomavirus-independent VSCC. p53abn IHC staining at a margin was associated with a 3-fold increased risk of local recurrence.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “The TP53 mutations inactivating the tumor suppressor can probably be explored as a possible target in treating urachal carcinoma.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “The most repeated mutations were identified in 3 of 9 examined genes, namely TP53, PIK3CA and PTEN, with highest rates of increase in Group 3.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “WEE1 kinase inhibitor MK-1775 sensitizes oral tongue squamous cell carcinoma cells to radiation irrespective of TP53 status.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “No unique factor was correlated with aggressiveness; however, CNA-positive thyroid nodules that were associated with high-risk mutations such as BRAF V600E, TP53, NTRK1/3 fusion, or PTEN mutation with high allele frequency (AF) ended up being aggressive cancers.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “We also find that ADCY8, MYC, PTK2, CTNNB1, TP53, RB1, PRKCA, TCF7L2, PAK1, ITPR2, CYP3A4, UGT1A6, GCK, and FGFR2/3 appear to be among the prominent genes based on the networks of genes and pathways based on the copy number alterations, mutations, and structural variants study.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “RNF43 mutations were found in 5.9% (13/220) of CRC cases and was inversely correlated to APC and TP53 mutations.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “RESULTS: Significantly, higher positivity was noted with p53 immuno-expression, TP53 gene amplification, and combined p53 and TP53 expression in the study group compared to the control group (C0.05).” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Development and tumorigenic potential of TP53: A therapeutic target for head and neck squamous cell carcinoma.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Moreover, gene alterations in APC, EGFR, FBXW7, TP53, PTEN, K-ras genes were concomitant in CRC.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Various studies on genomic analyses of glioma found a variety of deregulated genes with somatic mutations including TERT, TP53, IDH1, ATRX, TTN, etc.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “RESULTS: Of 132 women with breast cancer, 40 women were found to be genetically positive (31.4%), 31 women of 40 (77.5%) had a BRCA mutation, 3 (7.5%) had ATM, 2 (5%) had CHK2, and one (2.5%) for each of the following genes: PALP2, NF, MUTYH.c.536A, and TP53.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “TP53 Expression and Mutational Analysis in Hematological Malignancy in Jeddah, Saudi Arabia.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Mutations were predominantly focused on two genes, PIK3CA and TP53, in the BC genomes of the sample set.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Mutations in TP53 and PIK3CA genes in hepatocellular carcinoma patients are associated with chronic Schistosomiasis.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “For a panel of 12 genes, 25% had the tumor protein 53 (TP53) gene mutation and 39% had the gene Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Other studies showed that these compounds downregulate ITGAV, CARPIN1, CCL5 and COG5 and TNFRSF10B gene that reduces chondrogenesis and inflammation, Artocarpetin and 5-galloylquinic acid are TP53 expression enhancer and inhibit MM9 expression that promote immunomodulation and apoptosis in these cancers.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “In some cases, gene mutations including P16, TP53, and EGFR, have been observed in GBM.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “The key genes, including EGFR, MYC, VEGFA, and PTEN, are targeted by TF such as AR, Sp1, TP53, NF-KB1, STAT3, RELA.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “The gene network analysis has identified the inverse expression correlation between 8 target genes (TP53, DYSF, GAB2, GFRA2, NACC2, FAM53C, JNK and GAB2) and 3 key miRNAs (hsa-mir-940, hsa-mir-765, hsa-mir-612), which are further regulated by 24 key transcription factors.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Host genetics impact on SARS-CoV-2 vaccine-induced immunoglobulin levels and dynamics: The role of TP53, ABO, APOE, ACE2, HLA-A, and CRP genes.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Our analysis showed RELA, TP53 and SP1 TFs that may regulate the upregulated DEGs.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “TP73 belongs to the TP53 family of transcription factors and has therefore been well studied in cancer research.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Missense mutation in c.395G>A; in exon 4 of the IDH1 gene, and a missense mutation in c.215C>G; in exon 4 of the TP53 gene were found in this tumor were previously reported.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Prevalence of germline TP53 mutation among early onset middle eastern breast cancer patients.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “The histopathological research was conducted with H&E staining along with the TP53 protein expression by implementing immunohistochemical analyses.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Canine tumor mutational burden is correlated with TP53 mutation across tumor types and breeds.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Moreover, various potential genetic biomarkers of venetoclax resistance have been proposed, including chromosome 17p deletion, trisomy 12, and TP53 loss or mutation.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “We identified several frequently mutated genes, including TP53, NOTCH1, CASP8, RYR2, LRP2, CDKN2A, and ATM.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “TP53 and its inhibitor the murine double minute 2 (MDM2) genes encode proteins that have crucial functions in the DNA damage response.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Risk of Colorectal Carcinoma May Predispose to the Genetic Variants of the GST, CYP450, and TP53 Genes Among Nonsmokers in the Saudi Community.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Among the genes analyzed, the highest mutation rates were found in PIK3CA (12.9%), BRCA2 (11.7%), BRCA1 (10.2%), TP53 (6.0%), MSH2 (3.8%), PMS2 (3.8%), BARD1 (3.8%), MLH1 (3.4%), CDH1 (3.0%), RAD50 (3.0%), MSH6 (3.0%), NF1 (2.6%), in addition to others.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Clinical Features of Breast Cancer in South Korean Patients with Germline TP53 Gene Mutations.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Prognostic value of TP53 expression and MGMT methylation in glioblastoma patients treated with temozolomide combined with other chemotherapies.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “The tumor suppressor gene TP53 and its downstream genes P21 and MDM2 play crucial roles in combating DNA damage at the G1/S cell cycle checkpoint.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Integrated somatic mutational and chromosomal copy number analyses showed frequent inactivation of TP53, RB1 and activation of RTK/PI3K/AKT pathways.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Out of these, most mutations were observed in TP53.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “The most commonly mutated genes were ASXL1(20%), TP53 (19%), DNMT3A (15%), and TET2 (12%).” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “We found that the OB-fold network comprised of 227 nodes forming 5523 interactions, and has a scale-free topology having UBA52, ATR, and TP53 as leading hub proteins that control efficient communication within the network.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “In addition, case 1 had a missense TP53 variant.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “In CTNNB1 gene a known missense mutation in c.101G>T; in TP53 a known missense mutation in c.215C>G; and two known missense variants in PIK3CA, viz., in c.1173A>G; in exon 7, and in c.3128T>C; in exon 21, were found, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Three patients with B-ALL had heterozygous pathogenic mutations in TP53, BRCA1, and BRCA2; one patient with B-ALL had homozygous pathogenic mutation in PMS2; and one patient with T-ALL had LP homozygous mutation in AK2 that was associated with reticular dysgenesis.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “RESULTS: Sequencing analysis identified missense, nonsense and frameshift mutations in TP53 (66%), PIK3CA (27%), CDKN2A (25%), EGFR (18%), and PTEN (14%).” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Genetic polymorphisms of TP53 (rs1042522) and MDM2 (rs2279744) and colorectal cancer risk: An updated meta-analysis based on 59 case-control studies.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “The genetic association study of TP53 polymorphisms in Saudi obese patients.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “METHODS: We have utilized a cost-effective targeted sequencing approach of high priority actionable BC genes (BRCA1, BRCA2, ERBB2 and TP53) in a homogeneous patient cohort from Bangladesh (n = 52) by using tumor and blood samples.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Results: NGS analysis identified 19 variants, of which four were previously reported missense variants; c.395G>A in IDH1, c.1173A>G in PIK3CA, c.1416A>T in KDR and c.215C>G in TP53.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “This study aim to investigate the association of breast cancer risk and prognostic factors with single nucleotide variants of the BRCA1, BRCA2, DAPK1, MMP9, TOX3, and TP53 genes in Jordanian women.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “BACKGROUND: Colorectal cancer (CRC) is categorized by alteration of vital pathways such as β-catenin (CTNNB1) mutations, WNT signaling activation, tumor protein 53 (TP53) inactivation, BRAF, Adenomatous polyposis coli (APC) inactivation, KRAS, dysregulation of epithelial to mesenchymal transition (EMT) genes, MYC amplification, etc.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Mutations in the tumor protein (TP53) and the mammalian target of rapamycin (mTOR) pathway have been elucidated as driver mutations in ovarian carcinomas that transform into an invasive phenotype under hypoxic conditions.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “We investigated the cytotoxicity of lapatinib by MTT assay, mode of cell death using apoptosis-necrosis assay, DNA damage using micronucleus test, EGFR protein expression by immunocytochemistry, and assessed its effect on EGFR (7p11.2 locus) and TP53 (17p13 locus) genes using interphase-FISH technique.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Germline TP53 mutation spectrum in Sudanese premenopausal breast cancer patients: correlations with reproductive factors.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “PIK3CA and ARID1A mutation frequencies were higher in White and Asian patients compared with other ethnicities; TP53 and FAT1 mutation frequencies were higher in Black/African Americans; and CTNNB1 and RYR2 mutation frequencies were higher Native Hawaiians or Asian Natives.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “CDH1 copy number was associated with copy number loss of TP53, ATM, BRCA1, and BRCA2 (p < 0.001).” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “RESULTS: Mutations in BRAF V600E and TP53 were detected in our case.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Apoptosis signal-regulating kinase (ASK1) and transcription factor tumor suppressor protein TP53 suppress rabbit ovarian granulosa cell functions.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Rare TP53 variant associated with Li-Fraumeni syndrome exhibits variable penetrance in a Saudi family.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “In this study, we studied epidermal growth factor receptor (EGFR), tumor protein p53 (TP53), Kirsten rat sarcoma 2 viral oncogene homolog (KRAS), and Serine/Threonine Kinase 11 (STK11) to construct the ERSDM profile.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Researchers observed that a protective genetic variant TP53 codon 72 proline allele was more commonly found in this population and appear to be over-transmitted compared to others known for their high rate of cervical cancer.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “In addition to genes previously implicated in Wilms tumors (WT1, CTNNB1, AMER1, DROSHA, DGCR8, XPO5, DICER1, SIX1, SIX2, MLLT1, MYCN, and TP53), we identified mutations in genes not previously recognized as recurrently involved in Wilms tumors, the most frequent being BCOR, BCORL1, NONO, MAX, COL6A3, ASXL1, MAP3K4, and ARID1A.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Important cancer genes affected by CNVs included TP53, BRCA1, BRCA2, ERBB2, IDH1, and IDH2.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Recurrent somatic mutations in APC, TP53, and KRAS were frequently detected in highly heterogeneous colorectal cancer.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “TP53 mutations play a significant role in glioma tumorigenesis.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Reduced rate of human papillomavirus infection and genetic overtransmission of TP53 72C polymorphic variant lower cervical cancer incidence.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Genomic DNA was taken from buccal cells of 52 patients with UBC and 104 controls for genotyping of GSTT1, GSTM1, rs4646903, rs1048943, TP53 rs1042522, rs1801133, and rs1801394 using PCR and TaqMan® assays.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Quantitative real-time PCR for miR-34a and its targets; MET oncogene; gene-regulating apoptosis (TP53INP2 and DFFA); cell proliferation (E2F3); and cell differentiation (SOX2 and TGFB3) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Li-Fraumeni syndrome (LFS) patients harbor germ line mutations in the TP53 gene and are at increased risk of hormone receptor-positive breast cancers.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Following these changes, loss of Casein kinase Iα and induction of chronic DNA damage and TP53 mutations are increased compared with X-ray irradiation.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “In addition to confirming known genes of OSCC (TP53, CDKNA2, CASP8, PIK3CA, HRAS, FAT1, TP63, CCND1 and FADD) the analysis identified several candidate novel driver events including mutations of NOTCH3, CSMD3, CRB1, CLTCL1, OSMR and TRPM2, amplification of the proto-oncogenes FOSL1, RELA, TRAF6, MDM2, FRS2 and BAG1, and deletion of the recently described tumor suppressor SMARCC1.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “These tumours also acquire KRAS mutations during the development from precursor to primary disease, and primary testicular GCTs (TGCTs) are uniformly wild type for TP53.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Mutations commonly observed in astrocytic tumors (IDH1/2, TP53, ATRX, and PTEN) or ependymoma were not identified.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “TP53 mutations emerge with HDM2 inhibitor SAR405838 treatment in de-differentiated liposarcoma.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “RESULTS: Targeted sequencing lead to the identification of frequent mutations in TP53 (65 %), APC (36 %), KRAS (35 %), PIK3CA (19 %), PTEN (13 %), EGFR (11 %), SMAD4 (11 %), and FBXW7 (7 %).” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Moreover, we conducted a comparative study between isogenic derivatives cell lines of the normal HCECs in order to mimic the mutation of three major genes found in CRC genetic models: APC, KRAS, and TP53.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “RESULTS: The wide variation in SF2 (0.12-0.50; mean=0.33) was significantly associated with 3 SNPs: TP53 G72C (P=0.007), XRCC1 G399A (P=0.002) and ATM G1853A (P=0.01).” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Clinical significance of TP53 (R72P) and MDM2 (T309G) polymorphisms in breast cancer patients.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Potential impact of (rs 4645878) BAX promoter -248G>A and (rs 1042522) TP53 72Arg>pro polymorphisms on epithelial ovarian cancer patients.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Exome sequencing showed that OVC samples lacked mutations in genes commonly associated with OSCC (TP53, NOTCH1, NOTCH2, CDKN2A and FAT1).” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “The most frequently mutated gene in both populations was the BRCA2 gene, followed by BRCA1 and TP53.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “We analyzed 4 carcinosarcomas with basal cell carcinoma and osteosarcomatous components for CNVs/CN-LOH by comparative genomic hybridization/single-nucleotide polymorphism array, TP53 hot spot mutations by polymerase chain reaction and Sanger sequencing, and TP53 genomic rearrangements by fluorescence in situ hybridization.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “These include WTX, (on chromosome X), CTNNB1 (chromosome 3), and TP53 (chromosome 17) among others.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Apoptosis is a mechanism that results in graft injury, and TP53 is an important involved gene.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “The major tumor clone harbored APC and TP53 mutations as early oncogenic events, whereas the minor clone contained preponderant CDC27 and PABPC1 mutations.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Proliferative activity and expressed tumor protein 53 (TP53) gene mutations were demonstrated in both tumors.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Frequently mutated genes were: TP53 (39.6%), KRAS exons 3/4 (8.8%), NRAS exons 2/3 (7.1%), PIK3CA exons 9/20 (13.2%), BRAF (8.2%).” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Eleven candidate genes (ATM, XRCC1, XRCC3, XRCC4, XRCC5, PRKDC, LIG4, TP53, HDM2, CDKN1A, TGFB1) were selected for their presumed influence on radiosensitivity.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Therefore, have investigated whether or not the expression levels, of selected genes [tumor necrosis factor-α (TNFα), interleukin 6 (IL-6), adiponectin, leptin, C-reactive protein (CRP), parathyroid hormone (PTH), tumor protein 53 (TP53) and erythroblastic leukemia viral oncogene 2 (ErbB2)] were altered in blood samples of lean, overweight/obese and breast cancer subjects.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “A total of 45 SNPs in 11 candidate genes (ATM, XRCC1, XRCC3, XRCC4, XRCC5, PRKDC, LIG4, TP53, HDM2, CDKN1A, TGFB1) were genotyped by direct genomic DNA sequencing.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Therefore, we investigated HPV prevalence and genotype distribution in cervical cancer as well as the association with 9 genetic single nucleotide polymorphisms (SNPs): CDKN1A (p21) C31A, TP53 C72G, ATM G1853A, HDM2 promoter T309G, HDM2 A110G, LIG4 A591G, XRCC1 G399A, XRCC3 C241T and TGFβ1 T10C, presumed to predispose to cancer.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Owing to the importance of the TP53 gene in breast carcinogenesis, we analyzed the possible link between TP53 single nucleotide polymorphisms (SNPs) and the risk of breast cancer in Saudi women by direct sequencing of the TP53 gene exon 4 from 100 breast cancer tissues.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “A single-nucleotide polymorphism in the TP53 and MDM-2 gene modifies breast cancer risk in an ethnic Arab population.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “TP53 genetic alterations in Arab breast cancer patients: Novel mutations, pattern and distribution.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Amplification of the two oncogenes ERBB2 and MYC and deletion of the tumor suppressor gene TP53 are frequently encountered in cancerous tissues.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “KRAS and TP53 mutations in colorectal carcinoma.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “OBJECTIVE: To evaluate the overall incidence of microsatellite instability (MSI), hereditary non polyposis colorectal cancer, and tumor supressor gene (TP53) mutations in Saudi colorectal carcinomas.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “Association between TP53 codon 72 single-nucleotide polymorphism and radiation sensitivity of human fibroblasts.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “PURPOSE: To test the hypothesis that breast cancer patients could have a predisposing defect in the induction of TP53 tumor suppressor protein (known as p53) that could be a marker of genetic instability and increased cancer susceptibility.” | 0.98 | hgnc_dict_v1 |