infertility
SaudiVarKB evidence summary derived from retained literature mentions.
157Phenotype mentions
100Publications
50Associated gene records
50Associated variant records
Associated gene records
Co-mentioned in the same publications| Gene | Identifier / context | Articles | Mentions |
|---|---|---|---|
| CFTR | HGNC:1884 | 4 | 4 |
| DCAF17 | HGNC:25784 | 3 | 3 |
| WT1 | HGNC:12796 | 2 | 2 |
| AR | HGNC:644 | 2 | 2 |
| MTHFR | HGNC:7436 | 2 | 2 |
| PGD | HGNC:8891 | 2 | 2 |
| FSHR | HGNC:3969 | 2 | 2 |
| FTO | HGNC:24678 | 2 | 2 |
| LARS2 | HGNC:17095 | 2 | 2 |
| HOXA10 | HGNC:5100 | 2 | 2 |
| TLE6 | HGNC:30788 | 2 | 2 |
| ZP1 | HGNC:13187 | 2 | 2 |
| SYCP3 | HGNC:18130 | 2 | 2 |
| PAH | HGNC:8582 | 1 | 1 |
| CYP11A1 | HGNC:2590 | 1 | 1 |
| NLRP3 | HGNC:16400 | 1 | 1 |
| CD40 | HGNC:11919 | 1 | 1 |
| TG | HGNC:11764 | 1 | 1 |
| TFRC | HGNC:11763 | 1 | 1 |
| G6PD | HGNC:4057 | 1 | 1 |
| PTEN | HGNC:9588 | 1 | 1 |
| MTM1 | HGNC:7448 | 1 | 1 |
| SQSTM1 | HGNC:11280 | 1 | 1 |
| AGL | HGNC:321 | 1 | 1 |
| ABCB1 | HGNC:40 | 1 | 1 |
| LDLR | HGNC:6547 | 1 | 1 |
| CTNNB1 | HGNC:2514 | 1 | 1 |
| VEGFA | HGNC:12680 | 1 | 1 |
| BRAF | HGNC:1097 | 1 | 1 |
| BRCA1 | HGNC:1100 | 1 | 1 |
| H19 | HGNC:4713 | 1 | 1 |
| CXCR2 | HGNC:6027 | 1 | 1 |
| STS | HGNC:11425 | 1 | 1 |
| CCNO | HGNC:18576 | 1 | 1 |
| CCR5 | HGNC:1606 | 1 | 1 |
| CLPP | HGNC:2084 | 1 | 1 |
| BRCA2 | HGNC:1101 | 1 | 1 |
| ASPM | HGNC:19048 | 1 | 1 |
| ATG5 | HGNC:589 | 1 | 1 |
| NEB | HGNC:7720 | 1 | 1 |
| ATP8B1 | HGNC:3706 | 1 | 1 |
| EGFR | HGNC:3236 | 1 | 1 |
| ESR1 | HGNC:3467 | 1 | 1 |
| NFE2 | HGNC:7780 | 1 | 1 |
| SLC2A1 | HGNC:11005 | 1 | 1 |
| DNAH11 | HGNC:2942 | 1 | 1 |
| IGF2 | HGNC:5466 | 1 | 1 |
| IPO8 | HGNC:9853 | 1 | 1 |
| CD44 | HGNC:1681 | 1 | 1 |
| BAX | HGNC:959 | 1 | 1 |
Associated variant records
Co-mentioned in the same publications| Variant | Identifier / context | Articles | Mentions |
|---|---|---|---|
| C677T | C677T | 1 | 1 |
| rs1800629 | rs1800629 | 1 | 1 |
| rs2230054 | rs2230054 | 1 | 1 |
| rs333 | rs333 | 1 | 1 |
| rs12970134 | rs12970134 | 1 | 1 |
| rs17782313 | rs17782313 | 1 | 1 |
| p.W577C | p.W577C | 1 | 1 |
| G894T | G894T | 1 | 1 |
| p.Lys1154Gln | p.Lys1154Gln | 1 | 1 |
| c.1154G>A | c.1154G>A | 1 | 1 |
| p.Arg385Gln | p.Arg385Gln | 1 | 1 |
| R385Q | R385Q | 1 | 1 |
| p.Tyr364His | p.Tyr364His | 1 | 1 |
| rs10434 | rs10434 | 1 | 1 |
| rs3025053 | rs3025053 | 1 | 1 |
| rs699947 | rs699947 | 1 | 1 |
| rs2010963 | rs2010963 | 1 | 1 |
| rs833061 | rs833061 | 1 | 1 |
| rs25648 | rs25648 | 1 | 1 |
| rs1583384537 | rs1583384537 | 1 | 1 |
| rs1450198518 | rs1450198518 | 1 | 1 |
| rs78255744 | rs78255744 | 1 | 1 |
| rs1463893698 | rs1463893698 | 1 | 1 |
| rs766843910 | rs766843910 | 1 | 1 |
| rs104893956 | rs104893956 | 1 | 1 |
| rs140630557 | rs140630557 | 1 | 1 |
| rs1596423459 | rs1596423459 | 1 | 1 |
| rs1596405923 | rs1596405923 | 1 | 1 |
| rs762454979 | rs762454979 | 1 | 1 |
| rs1384121511 | rs1384121511 | 1 | 1 |
| rs1554259481 | rs1554259481 | 1 | 1 |
| rs188957694 | rs188957694 | 1 | 1 |
| rs755667747 | rs755667747 | 1 | 1 |
| rs1467954450 | rs1467954450 | 1 | 1 |
| rs6166 | rs6166 | 1 | 1 |
| rs2296545 | rs2296545 | 1 | 1 |
| p.Phe191Leu | p.Phe191Leu | 1 | 1 |
| 1799T>A | 1799T>A | 1 | 1 |
| rs1801272 | rs1801272 | 1 | 1 |
| 1799A>T | 1799A>T | 1 | 1 |
| rs17817449 | rs17817449 | 1 | 1 |
| rs1421085 | rs1421085 | 1 | 1 |
| rs8050136 | rs8050136 | 1 | 1 |
| p.Glu50Ala | p.Glu50Ala | 1 | 1 |
| c.1408G>A | c.1408G>A | 1 | 1 |
| c.4389G>A | c.4389G>A | 1 | 1 |
| c.2562T>G | c.2562T>G | 1 | 1 |
| c.869+11C>T | c.869+11C>T | 1 | 1 |
| c.2909-92G>A | c.2909-92G>A | 1 | 1 |
| c.3469-65C>A | c.3469-65C>A | 1 | 1 |
Associated population records
Co-mentioned in the same publicationsSupporting publications
100 records- 2026The Global State of Contemporary Andrology Practice: A Comprehensive Analysis of Clinical Practice, Training Pathways, and Emerging Challenges.The world journal of men's health1 mentions
- 2026Exosomal ncRNAs in seminal fluid: Unraveling their regulatory roles in male infertility.Reproductive biology1 mentions
- 2026Impact of physical activity on the hypothalamic-pituitary-gonadal axis in older males: a comparative and AI-based predictive modeling study of demographic factors and stress markers.Journal of computer-aided molecular design1 mentions
- 2026Endometrial molecular genetic phenotypes and histological endometrial phase in women with reproductive failure.Journal of reproductive immunology1 mentions
- 2026Epigenetic Landscape of Female Infertility: An Integrated Bioinformatics Perspective on DNA Methylation, MicroRNAs, and Gene Regulatory Networks Across PCOS, Endometriosis, and Diminished Ovarian Reserve.International journal of molecular sciences1 mentions
- 2026Pathogenic homozygous PLCZ1 mutation reduces sperm protein levels with a simulated reduction of PIP2 binding: a case report.Reproduction & fertility1 mentions
- 2026Human stem cell-based embryo models: innovation, ethics, and policy.Human reproduction (Oxford, England)1 mentions
- 2026Condyloma acuminata prevalence, clinical characteristics, and associated malignancies in Saudi patients at a tertiary care center.Dermatology reports1 mentions
- 2026Exosomes in oncofertility: emerging roles in chemotherapy-induced reproductive damage and fertility preservation.Reproduction & fertility1 mentions
- 2026The fortunate amelioration of Costus speciosus on phenotypes of letrozole-induced polycystic ovary syndrome in female rats.Brazilian journal of biology = Revista brasleira de biologia1 mentions
- 2026Secondary antibody therapy outperforms corticosteroids in an ameliorating lipopolysaccharide-induced rat model of premature ovarian failure.Veterinarni medicina1 mentions
- 2026A novel MOS variant causes large polar body formation and parthenogenetic activation; case report of an unusual phenomenon leading to female infertility.Zygote (Cambridge, England)1 mentions
- 2026Modern Polycystic Ovary Syndrome (PCOS) Management: Intelligent Drug Delivery and Metabolic Reprogramming for Ovarian Restoration and Fertility Optimization.Biomolecules1 mentions
- 2026Diagnostic and prognostic biomarkers in PCOS: Navigating insulin resistance, systemic inflammation, and endometrial receptivity.Clinica chimica acta; international journal of clinical chemistry1 mentions
- 2025Unraveling the impact of semaglutide in a diabetic rat model of testicular dysfunction: Insights into spermatogenesis pathways and miRNA-148a-5p.Steroids1 mentions
- 2025Evaluation of circANKLE2 & circL3MBTL4 -RNAs Expression in Fertile and Infertile Men.Biochemical genetics1 mentions
- 2025The Preventive Effect of Zinc Sulfate against Olanzapine-Induced Testicular Toxicity in Male Rats.Biological trace element research1 mentions
- 2025A non-hormonal reversible contraceptive targeting GSK3α, a protein kinase, essential for epididymal sperm maturation.Andrology1 mentions
- 2025Women's issues in epilepsy: Knowledge, awareness, and attitudes among a sample of the Bahraini population.Epilepsy & behavior : E&B1 mentions
- 2025Prevalence and clinical considerations of Y chromosome microdeletions in azoospermic and oligozoopsermic infertile men from Al Madinah Al Munawarah, Saudi Arabia.Saudi medical journal1 mentions
- 2025Dyslipidemia and female reproductive failures: perspectives on lipid metabolism and endometrial immune dysregulation.Seminars in immunopathology1 mentions
- 2025Ameliorative effect of Fagonia indica-coated chitosan nanoparticles on the ovulatory pattern in PCOS rat model.Journal of ovarian research1 mentions
- 2025L-Citrulline Alleviates Testicular Ischemia/Reperfusion Injury in Rats by Modulating eNOS/iNOS Induced Nitric Oxide Production, Inflammation, and Apoptosis.Journal of experimental zoology. Part A, Ecological and integrative physiology1 mentions
- 2025The Role of Exosomal miRNAs in Female Infertility: Therapeutic Potential and Mechanisms of Action.Stem cell reviews and reports1 mentions
- 2025The Role of Hypoxia-Inducible Factor-1α (HIF-1α) in the Progression of Ovarian Cancer: Perspectives on Female Infertility.Cells1 mentions
- 2025BIOCHEMICAL INSIGHTS AND HORMONAL MARKERS OF POLYCYSTIC OVARY SYNDROME IN SUDANESE WOMEN: EXPLORING INFERTILITY AND RISK FACTORS IN RED SEA STATE.Georgian medical news1 mentions
- 2025Genetic Polymorphisms of Vascular Endothelial Growth Factor and Their Impact on Recurrent Spontaneous Miscarriage in Saudi Women.International journal of molecular sciences1 mentions
- 2025No Genomic Signatures Were Found in Escherichia coli Isolates from Camels With or Without Clinical Endometritis.Veterinary sciences1 mentions
- 2025Investigation of testis proteome alterations associated with male infertility in Dcaf17-deficient mice.Systems biology in reproductive medicine1 mentions
- 2025PCM1 orchestrates centrosomal and flagellar protein transport to promote sperm maturation.Communications biology1 mentions
- 2025Morin hydrate protects against cisplatin-induced testicular toxicity by modulating ferroptosis and steroidogenesis genes' expression and upregulating Nrf2/Heme oxygenase-1.Scientific reports1 mentions
- 2025Assessing the knowledge, attitudes, and perceptions of ovarian cryopreservation technology among women with ovarian diseases.Frontiers in public health1 mentions
- 2025Impact of CYP2A6 genetic polymorphism on letrozole efficacy in Iraqi women with polycystic ovary syndrome.Journal of Taibah University Medical Sciences1 mentions
- 2025Derivative Complex Small Supernumerary Marker Chromosomes (sSMC) Involving Chromosomes 2 and 15-A Novel Report.Clinical case reports1 mentions
- 2025Pharmacological Evaluation of the Combination Therapy of Novel Herbal Mixture in Polycystic Ovary Syndrome.Current protein & peptide science1 mentions
- 2025Astragalus polysaccharides protect against Di-n-butyl phthalate-induced testicular damage by modulating oxidative stress, apoptosis, and the PI3K/Akt/mTOR pathway in rats.Frontiers in veterinary science1 mentions
- 2025Steroid hormone-treated endometrial organoids enhance implantation of in vitro-produced porcine embryos.Journal of veterinary science1 mentions
- 2025Polycystic ovarian syndrome a risk factor for non-communicable diseases: insights into recent research and prevention approaches.Journal of ovarian research1 mentions
- 2025Breathing new life into male fertility: the potential of mitochondrial transplantation.Molecular biology reports1 mentions
- 2025Familial novel androgen receptor gene variant associated with bilateral cryptorchidism and severe male infertility: A case report.Urology case reports1 mentions
- 2025Computational Identification of Genetic Background of Infertility and Calculating Inbreeding Coefficient in Dromedary Camel Herds.Genes1 mentions
- 2025Prevalence of polycystic ovary syndrome (PCOS) and its associated hormonal and comorbid risk factors in Northeast India: a cross-sectional comparative study.Therapeutic advances in reproductive health1 mentions
- 2025Integrated Bioinformatics and Experimental Analysis Revealed Crosstalk Between IL-6, Autophagy, Ubiquitination, and Key miRNAs in Female Infertility: Insights from Ovarian Endometriosis and Polycystic Ovary Syndrome.Cells1 mentions
- 2025The Evolution of In Vitro Fertilization Practices in Saudi Arabia: Historical Perspectives and Future Directions.Cureus1 mentions
- 2025Efficacy & safety of sodium-glucose cotransporter-2 inhibitors in polycystic ovary syndrome: A meta-analysis with trial sequential analysis.The Indian journal of medical research1 mentions
- 2025Inevitable Posterior Lower Segment Cesarean Section Due to Irreducible Uterine Torsion in a Woman Carrying X-Linked Myotubular Myopathy: A Case Report.Cureus1 mentions
- 2025First serological evidence and risk factor analysis of Neospora caninum and Besnoitia besnoiti infections in cattle and sheep from three regions of Saudi Arabia.Veterinary world1 mentions
- 2025Thymoquinone Attenuates Aluminum Chloride-Induced Testicular Injury by Inhibiting NLRP3/Caspase 1/IL-1β Inflammasome Signaling and Polarizing the Macrophages Toward Anti-Inflammatory M2 Phenotype.Cells1 mentions
- 2025Protective Effects of Olea europaea L. Leaves and Equisetum arvense L. Extracts Against Testicular Toxicity Induced by Metronidazole Through Reducing Oxidative Stress and Regulating NBN, INSL-3, STAR, HSD-3β, and CYP11A1 Signaling Pathways.Toxics1 mentions
- 2024Technical Aspects and Clinical Limitations of Sperm DNA Fragmentation Testing in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations.The world journal of men's health1 mentions
- 2024Pharmacological update of mirtazapine: a narrative literature review.Naunyn-Schmiedeberg's archives of pharmacology1 mentions
- 2024Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity.Human reproduction (Oxford, England)1 mentions
- 2024The Role of Chlorella vulgaris in Attenuating Infertility Induced by Cadmium Chloride via Suppressing Oxidative Stress and Modulating Spermatogenesis and Steroidogenesis in Male Rats.Biological trace element research1 mentions
- 2024Exploring the association of ESR1 and ESR2 gene SNPs with polycystic ovary syndrome in human females: a comprehensive association study.Journal of ovarian research1 mentions
- 2024miRNA expression in PCOS: unveiling a paradigm shift toward biomarker discovery.Archives of gynecology and obstetrics1 mentions
- 2024Evaluation of telomere length, reactive oxygen species, and apoptosis in spermatozoa of patients with oligospermia.Cell biochemistry and function1 mentions
- 2024The mammalian sperm factor phospholipase C zeta is critical for early embryo division and pregnancy in humans and mice.Human reproduction (Oxford, England)1 mentions
- 2024Exome Sequencing to Identify Novel Variants Associated with Secondary Amenorrhea and Premature Ovarian Insufficiency (POI) in Saudi Women.Biomedicines1 mentions
- 2024The Aftermath of COVID-19: Exploring the Long-Term Effects on Organ Systems.Biomedicines1 mentions
- 2024Autophagy and Female Fertility: Mechanisms, Clinical Implications, and Emerging Therapies.Cells1 mentions
- 2024Exploring the Association of Biochemical Characterization and Genetic Determinants of TNF-α, CXCR2, and CCR5 Delta 32 Mutation with Predisposition to Polycystic Ovary Syndrome.Life (Basel, Switzerland)1 mentions
- 2024Ameliorative Effect of Chitosan/Spirulina platensis Ethanolic Extract Nanoformulation against Cyclophosphamide-Induced Ovarian Toxicity: Role of PPAR-γ/Nrf-2/HO-1 and NF-kB/TNF-α Signaling Pathways.Marine drugs1 mentions
- 2024Nanostructured biloalbuminosomes loaded with berberine and berberrubine for Alleviating heavy Metal-Induced male infertility in rats.International journal of pharmaceutics1 mentions
- 2024Perrault syndrome: a forgotten presentation for infertile women.Clinical case reports1 mentions
- 2024Polycystic ovary syndrome: Recent research and therapeutic advancements.Life sciences1 mentions
- 2024Decoding the Genes Orchestrating Egg and Sperm Fusion Reactions and Their Roles in Fertility.Biomedicines1 mentions
- 2024Comprehensive epidemiological evaluation of ruminant brucellosis and associated risk factors in some Egyptian Governorates.Veterinary world1 mentions
- 2023The effect of toxic air pollutants on fertility men and women, fetus and birth rate.Reviews on environmental health1 mentions
- 2023Impact of Varicocele Repair on Semen Parameters in Infertile Men: A Systematic Review and Meta-Analysis.The world journal of men's health1 mentions
- 2023The role of CFTR channel in female infertility.Human fertility (Cambridge, England)1 mentions
- 2023The Renaissance of Male Infertility Management in the Golden Age of Andrology.The world journal of men's health1 mentions
- 2023The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review.Metabolites1 mentions
- 2023An Analysis of the Structural Relationship between Thyroid Hormone-Signaling Disruption and Polybrominated Diphenyl Ethers: Potential Implications for Male Infertility.International journal of molecular sciences1 mentions
- 2023The Therapeutic and Diagnostic Potential of Phospholipase C Zeta, Oocyte Activation, and Calcium in Treating Human Infertility.Pharmaceuticals (Basel, Switzerland)1 mentions
- 2023Oral phosphodiesterase type 5 inhibitors and male reproductive potential: an overview.Sexual medicine reviews1 mentions
- 2023The interplay between androgens and the immune response in polycystic ovary syndrome.Journal of translational medicine1 mentions
- 2023Controversy and Consensus on Indications for Sperm DNA Fragmentation Testing in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations.The world journal of men's health1 mentions
- 2023Controversy and Consensus on the Management of Elevated Sperm DNA Fragmentation in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations.The world journal of men's health1 mentions
- 2023Using autophagy, apoptosis, cytoskeleton, and epigenetics markers to investigate the origin of infertility in ex-fissiparous freshwater planarian individuals (nomen nudum species) with hyperplasic ovaries.Journal of invertebrate pathology1 mentions
- 2023Molecular Role of Asn680Ser and Asp37Glu Missense Variants in Saudi Women with Female Infertility and Polycystic Ovarian Syndrome.Current issues in molecular biology1 mentions
- 2023The mutational analysis of mitochondrial DNA in maternal inheritance of polycystic ovarian syndrome.Frontiers in endocrinology1 mentions
- 2023Reduced expression of miR-221 is associated with the pro-apoptotic pathways in spermatozoa of oligospermia men.Journal of reproductive immunology1 mentions
- 2023A DNA Methylation Perspective on Infertility.Genes1 mentions
- 2022ASTL is mutated in female infertility.Human genetics1 mentions
- 2022Effect of obesity on fertility parameters in WIO mice model.Advances in clinical and experimental medicine : official organ Wroclaw Medical University1 mentions
- 2022Recurrent spontaneous oocyte activation causes female infertility.Journal of assisted reproduction and genetics1 mentions
- 2022Protamines and DNA integrity as a biomarkers of sperm quality and assisted conception outcome.Andrologia1 mentions
- 2022Fertilization, Oocyte Activation, Calcium Release and Epigenetic Remodelling: Lessons From Cancer Models.Frontiers in cell and developmental biology1 mentions
- 2022Consanguineous Marriages and Dental Anomalies: A Cross-Sectional Analytical Study.International journal of dentistry1 mentions
- 2022Polycystic Ovary Syndrome: A Disorder of Reproductive Age, Its Pathogenesis, and a Discussion on the Emerging Role of Herbal Remedies.Frontiers in pharmacology1 mentions
- 2022Disruption of male fertility-critical Dcaf17 dysregulates mouse testis transcriptome.Scientific reports1 mentions
- 2021Generation of an iPSC cohort of isogenic iPSC lines (46-XY and 47-XXY) from a non-mosaic Klinefelter Syndrome patient (47-XXY) (KAUSTi008-A, KAUSTi008-B, KAUSTi008-C, KAUSTi008-D, KAUSTi008-E, KAUSTi008-F, KAUSTi008-G).Stem cell research1 mentions
- 2021First evidence of involvement of TBC1D25 in causing human male infertility.European journal of medical genetics1 mentions
- 2021Estrogen induces shift in abundances of specific groups of the coral microbiome.Scientific reports1 mentions
- 2021A review on inositol's potential in cyclic disturbances of adipose-endocrinology-associated polycystic ovary syndrome.Molecular and cellular biochemistry1 mentions
- 2021Next-Generation Sequencing-Based Pre-Implantation Genetic Testing for Aneuploidy (PGT-A): First Report from Saudi Arabia.Genes1 mentions
- 2021A Critical Review of the Therapeutic Potential of Vitamin D-Mediated Suppression of miRNA222-Associated Metabolic Defects in Polycystic Ovarian Syndrome.Critical reviews in eukaryotic gene expression1 mentions
- 2021A 46-Year-Old Woman with Primary Infertility and a Diagnosis of Microcystic Stromal Tumor of the Ovary Confirmed by Histology and Gene Sequencing: A Case Report and Review of the Literature.The American journal of case reports1 mentions
- 2021Polycystic ovary syndrome is linked with the fat mass obesity (FTO) gene variants rs17817449 and rs1421085 in western Saudi Arabia.Bioinformation1 mentions
- 2020Ameliorative effect of combined low dose of Pioglitazone and omega-3 on spermatogenesis and steroidogenesis in diabetic rats.Journal of cellular biochemistry1 mentions