CDKN1A
HGNC:1784 · 27 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CDKN1A | “Gene expression profiling revealed a pro-proliferative, anti-apoptotic signature, marked by the upregulation of PTTG1 and the downregulation of TNFRSF10D, CDK4, and CDKN1A.” | 0.98 | hgnc_dict_v1 |
| gene | CDKN1A | “Validated targets concentrated on key leukemia-related genes like PTEN, BCL2L11, CDKN1A, CCND1, RB1, E2F1, and TGFBR2.” | 0.98 | hgnc_dict_v1 |
| gene | CDKN1A | “Pairwise analysis of senescence-related gene expression (LMNB1, MKI67, CDKN1A, ATM, IGFBP7, MMP2, CXCL14, and CCL5) was performed in an independent geneset of 68 paired pre- and post-NAC BC patient samples.” | 0.98 | hgnc_dict_v1 |
| gene | CDKN1A | “METHODS: Senescence was cytochemically confirmed via Senescence-associated β-galactosidase upregulation (and quantified by flow cytometry), CDKN1A induction, and the senescence-associated secretory phenotype (SASP) expression (using qRT-PCR).” | 0.98 | hgnc_dict_v1 |
| gene | CDKN1A | “Genetic tools like CRISPR-Cas9 and RNA interference also precisely modulate TP53 and CDKN1A expression to optimize MSC functionality.” | 0.98 | hgnc_dict_v1 |
| gene | CDKN1A | “TIS Markers, like senescence-associated beta-galactosidase (SA-β-gal), CDKN1A, and senescence-associated secretory phenotype (SASP) marker IL-6, were altered following talazoparib and radiation in both 4T1 and MDA-MB-231 TNBC cell lines.” | 0.98 | hgnc_dict_v1 |
| gene | CDKN1A | “We used a set of patient-derived precancerous (n = 32) and noncancerous (chronic cervicitis; n = 10) tissue samples to investigate the gene expression of several OIS (LMNB1, CDKN2A, CDKN2B, and CDKN1A), and SASP (IL1A, CCL2, TGFB1, CXCL8, and MMP9) biomarkers using qRT-PCR.” | 0.98 | hgnc_dict_v1 |
| gene | CDKN1A | “Several tumor suppressor genes emerged as validated direct targets of the 13 OncomiRs, including TFDP2, YWHAG, SMAD2, SMAD4, CDKN1A, CDKN1B, BCL2L11, and TGIF2.” | 0.98 | hgnc_dict_v1 |
| gene | CDKN1A | “A pharmacological network analysis was subsequently conducted using STITCH and Cytoscape, pinpointing six highly upregulated genes within the rutin network, including TP53, PCNA, CDK4, CCNEB1, CDKN1A, and LDHA.” | 0.98 | hgnc_dict_v1 |
| gene | CDKN1A | “The nanostructures lead to an increase in the expression of genes encoding proteins related to oxidative stress (SIRT1, FOXO3, NFE2L2, and MAP3K5) and cyclin-dependent kinase inhibitors (CDKN1A and CDKN1B) in response to ROS.” | 0.98 | hgnc_dict_v1 |
| gene | CDKN1A | “The study identified a total of five genes (CDKN1A, DKK1, CYP1B1, NTS, and GDF15) that were differentially expressed in OC.” | 0.98 | hgnc_dict_v1 |
| gene | CDKN1A | “The protein-protein interaction (PPI) network of DEGs was then constructed and six genes named RAD51, ALDH1A1, UBA52, CUL3, GADD45B, and CDKN1A were identified as the commonly dysregulated hub genes among HFRS and COVID-19.” | 0.98 | hgnc_dict_v1 |
| gene | CDKN1A | “RESULTS: We screened the most important shared genes (CDKN1A, COL22A1, EIF4A, GFAP, SLC1A1, and VIM) and essential human molecular pathways that motivate these diseases.” | 0.98 | hgnc_dict_v1 |
| gene | CDKN1A | “By combining the PARP inhibitor (PARPi), talazoparib, with radiation, senescence was enhanced in 4T1 and MDA-MB-231 triple-negative breast cancer cell lines (based on SA-β-gal upregulation, increased expression of CDKN1A and the senescence-associated secretory phenotype (SASP) marker, IL6).” | 0.98 | hgnc_dict_v1 |
| gene | CDKN1A | “BACKGROUND: The polymorphisms of the cyclin-dependent kinase inhibitor (CDKN1A) gene and matrix metalloproteinase-9 (MMP9) gene may increase one's susceptibility to malignancies.” | 0.98 | hgnc_dict_v1 |
| gene | CDKN1A | “Inactivation of either p53 or p21/CDKN1A conferred the p53 mutant phenotype.” | 0.98 | hgnc_dict_v1 |
| gene | CDKN1A | “Moreover, pathway analysis showed that the H3F3A, CDKN1A, and MAPK13 genes were the most common regulators among the most differentially methylated promoters.” | 0.98 | hgnc_dict_v1 |
| gene | CDKN1A | “Combining CDKN1A gene expression and genome-wide SNPs in a twin cohort to gain insight into the heritability of individual radiosensitivity.” | 0.98 | hgnc_dict_v1 |
| gene | CDKN1A | “Finally, we identified CARD11 and CDKN1A (encoding p21) as transcriptional targets of SPI-B involved in regulation of proliferation and apoptosis.” | 0.98 | hgnc_dict_v1 |
| gene | CDKN1A | “By transactivation assays, all EBF3 mutants showed significantly reduced or no ability to activate transcription of the reporter gene CDKN1A, and in situ subcellular fractionation experiments demonstrated that EBF3 mutant proteins were less tightly associated with chromatin.” | 0.98 | hgnc_dict_v1 |
| gene | CDKN1A | “Six SNPs (CDKN1A C31A, ATM G1853A, HDM2 T309G, TGFB1 T10C, XRCC1 G399A, and XRCC3 C241T) were genotyped by direct sequencing.” | 0.98 | hgnc_dict_v1 |
| gene | CDKN1A | “We have also shown that p16INK4A enhances the binding efficiency of p53 to its cognate sequence presents in the CDKN1A promoter in vitro, and both proteins are present at the promoters of CDKN1A and BAX in vivo.” | 0.98 | hgnc_dict_v1 |
| gene | CDKN1A | “Eleven candidate genes (ATM, XRCC1, XRCC3, XRCC4, XRCC5, PRKDC, LIG4, TP53, HDM2, CDKN1A, TGFB1) were selected for their presumed influence on radiosensitivity.” | 0.98 | hgnc_dict_v1 |
| gene | CDKN1A | “A total of 45 SNPs in 11 candidate genes (ATM, XRCC1, XRCC3, XRCC4, XRCC5, PRKDC, LIG4, TP53, HDM2, CDKN1A, TGFB1) were genotyped by direct genomic DNA sequencing.” | 0.98 | hgnc_dict_v1 |
| gene | CDKN1A | “Therefore, we investigated HPV prevalence and genotype distribution in cervical cancer as well as the association with 9 genetic single nucleotide polymorphisms (SNPs): CDKN1A (p21) C31A, TP53 C72G, ATM G1853A, HDM2 promoter T309G, HDM2 A110G, LIG4 A591G, XRCC1 G399A, XRCC3 C241T and TGFβ1 T10C, presumed to predispose to cancer.” | 0.98 | hgnc_dict_v1 |
| gene | CDKN1A | “We hypothesized that amino acid substitution variants in two highly radiation-responsive proteins, TP53 (p53) and CDKN1A (p21, Waf1, Cip1), are associated with and could explain individual variations in radiosensitivity.” | 0.98 | hgnc_dict_v1 |
| gene | CDKN1A | “The accumulation of p53 was triggered by ionizing radiation, and its transcriptional activity was estimated from the induction of CDKN1A (known as p21).” | 0.98 | hgnc_dict_v1 |