systemic lupus erythematosus
SaudiVarKB evidence summary derived from retained literature mentions.
162Phenotype mentions
100Publications
50Associated gene records
38Associated variant records
Associated gene records
Co-mentioned in the same publications| Gene | Identifier / context | Articles | Mentions |
|---|---|---|---|
| HLA-DRB1 | HGNC:4948 | 3 | 3 |
| CTLA4 | HGNC:2505 | 3 | 3 |
| DNASE1L3 | HGNC:2959 | 3 | 3 |
| CD4 | HGNC:1678 | 2 | 2 |
| STAT1 | HGNC:11362 | 2 | 2 |
| ISG15 | HGNC:4053 | 2 | 2 |
| MALAT1 | HGNC:29665 | 2 | 2 |
| ADAMTS13 | HGNC:1366 | 2 | 2 |
| PNP | HGNC:7892 | 2 | 2 |
| PRKCD | HGNC:9399 | 2 | 2 |
| APOE | HGNC:613 | 1 | 1 |
| F12 | HGNC:3530 | 1 | 1 |
| TG | HGNC:11764 | 1 | 1 |
| IL2RA | HGNC:6008 | 1 | 1 |
| CYP2D6 | HGNC:2625 | 1 | 1 |
| STAT3 | HGNC:11364 | 1 | 1 |
| LIPA | HGNC:6617 | 1 | 1 |
| PTEN | HGNC:9588 | 1 | 1 |
| STAT4 | HGNC:11365 | 1 | 1 |
| CRP | HGNC:2367 | 1 | 1 |
| IFIH1 | HGNC:18873 | 1 | 1 |
| CLEC7A | HGNC:14558 | 1 | 1 |
| IL7R | HGNC:6024 | 1 | 1 |
| TNFRSF1B | HGNC:11917 | 1 | 1 |
| HLA-DRA | HGNC:4947 | 1 | 1 |
| IL2RG | HGNC:6010 | 1 | 1 |
| POU2AF1 | HGNC:9211 | 1 | 1 |
| PLEC | HGNC:9069 | 1 | 1 |
| ABCA12 | HGNC:14637 | 1 | 1 |
| TGM1 | HGNC:11777 | 1 | 1 |
| SDR9C7 | HGNC:29958 | 1 | 1 |
| HLA-DRB3 | HGNC:4951 | 1 | 1 |
| HLA-DRB4 | HGNC:4952 | 1 | 1 |
| HLA-DRB5 | HGNC:4953 | 1 | 1 |
| IL10 | HGNC:5962 | 1 | 1 |
| CSF1R | HGNC:2433 | 1 | 1 |
| PIK3CD | HGNC:8977 | 1 | 1 |
| MECP2 | HGNC:6990 | 1 | 1 |
| H19 | HGNC:4713 | 1 | 1 |
| PTPN22 | HGNC:9652 | 1 | 1 |
| EGR1 | HGNC:3238 | 1 | 1 |
| ACE | HGNC:2707 | 1 | 1 |
| ACR | HGNC:126 | 1 | 1 |
| PIP | HGNC:8993 | 1 | 1 |
| GATA6 | HGNC:4174 | 1 | 1 |
| HLA-A | HGNC:4931 | 1 | 1 |
| MMP9 | HGNC:7176 | 1 | 1 |
| CD44 | HGNC:1681 | 1 | 1 |
| SOD2 | HGNC:11180 | 1 | 1 |
| GSTP1 | HGNC:4638 | 1 | 1 |
Associated variant records
Co-mentioned in the same publications| Variant | Identifier / context | Articles | Mentions |
|---|---|---|---|
| p.Gly506Asp | p.Gly506Asp | 1 | 1 |
| rs2758332 | rs2758332 | 1 | 1 |
| rs1695 | rs1695 | 1 | 1 |
| c.265G>A | c.265G>A | 1 | 1 |
| E89K | E89K | 1 | 1 |
| R173P | R173P | 1 | 1 |
| G20210A | G20210A | 1 | 1 |
| rs231775 | rs231775 | 1 | 1 |
| rs2476601 | rs2476601 | 1 | 1 |
| rs3135388 | rs3135388 | 1 | 1 |
| rs2075876 | rs2075876 | 1 | 1 |
| c.289_290delAC | c.289_290delAC | 1 | 1 |
| rs1234315 | rs1234315 | 1 | 1 |
| rs11980379 | rs11980379 | 1 | 1 |
| rs11671784 | rs11671784 | 1 | 1 |
| rs1080985 | rs1080985 | 1 | 1 |
| rs28624811 | rs28624811 | 1 | 1 |
| rs1065852 | rs1065852 | 1 | 1 |
| rs28371725 | rs28371725 | 1 | 1 |
| rs1135840 | rs1135840 | 1 | 1 |
| rs10783618 | rs10783618 | 1 | 1 |
| rs1942347 | rs1942347 | 1 | 1 |
| rs3200401 | rs3200401 | 1 | 1 |
| rs2666433 | rs2666433 | 1 | 1 |
| rs8177374 | rs8177374 | 1 | 1 |
| rs2734647 | rs2734647 | 1 | 1 |
| rs231775 | rs231775 | 1 | 1 |
| rs4284505 | rs4284505 | 1 | 1 |
| c.212C>T | c.212C>T | 1 | 1 |
| p.T71M | p.T71M | 1 | 1 |
| rs114580964 | rs114580964 | 1 | 1 |
| rs5749201 | rs5749201 | 1 | 1 |
| rs886471 | rs886471 | 1 | 1 |
| rs13277113 | rs13277113 | 1 | 1 |
| rs10516487 | rs10516487 | 1 | 1 |
| rs3747517 | rs3747517 | 1 | 1 |
| rs610604 | rs610604 | 1 | 1 |
| rs7574865 | rs7574865 | 1 | 1 |
Associated population records
Co-mentioned in the same publicationsSupporting publications
100 records- 2026The expression of pruritus-associated genes in seven skin diseases: Evidence from microarray.Journal of the European Academy of Dermatology and Venereology : JEADV1 mentions
- 2026Association of CTLA-4 exon 1(+49 A/G) polymorphism and susceptibility to SLE in Egyptian children and adolescents.Lupus1 mentions
- 2026Platelet-derived non-coding RNAs as emerging contributors to autoimmune inflammation.Naunyn-Schmiedeberg's archives of pharmacology1 mentions
- 2026Functional Hemispherectomy for Rasmussen Encephalitis in a Patient with Systemic Lupus Erythematosus and Type 1 Diabetes Mellitus: A Case Report.International medical case reports journal1 mentions
- 2026Apolipoprotein L1 High-Risk Genotypes are Associated With Lupus Nephritis Incidence.Kidney international reports1 mentions
- 2026Biomarker-stratified efficacy and safety of biologics in systemic lupus erythematosus: a systematic review and meta-analysis.Lupus science & medicine1 mentions
- 2026Genetic and phenotypic landscape of monogenic lupus: insights from an international cohort.Lupus science & medicine1 mentions
- 2026TNFSF4/OX40L and IKZF1/IKAROS Genetic Variant Associations with Egyptian Juvenile Systemic Lupus Erythematosus (JSLE).Biology1 mentions
- 2026Epigenetic Alterations in Microbiome-Host Interactions in Inflammatory and Autoimmune Diseases.International journal of molecular sciences1 mentions
- 2026Clinical Response to Baricitinib in Monogenic Lupus: Real-World Evidence from a Case Series of Seven Patients.Mediterranean journal of rheumatology1 mentions
- 2026Systemic lupus erythematosus in pregnancy: Maternal and fetal outcomes and management strategies (Review).Medicine international1 mentions
- 2026Long-Term Treatment With Emapalumab in an Adult Patient With Refractory Hemophagocytic Lymphohistiocytosis and Systemic Lupus Erythematosus: A Case Report.Case reports in hematology1 mentions
- 2025A proposed clinical tool to identify high-risk patients for monogenic lupus: a pilot study.Clinical and experimental rheumatology1 mentions
- 2025The PPAR-α selective agonist WY14643 improves lupus nephritis via the downregulation of the RORγT/STAT3 signaling pathway in MRL/lpr mice.International immunopharmacology1 mentions
- 2025Glucose metabolism is controlled by non-coding RNAs in autoimmune diseases; a glimpse into immune system dysregulation.Human immunology1 mentions
- 2025Glucose transporter-1 (GLUT-1) upregulation in vitiligo: A possible link to skin depigmentation.Gene1 mentions
- 2025Systematic review of the reporting of extrarenal manifestations in observational studies of Saudi patients with systemic lupus erythematosus.Lupus science & medicine1 mentions
- 2025The multifaceted role of CS1 (SLAMF7) in immunoregulation: Implications for cancer therapy and autoimmune disorders.Experimental cell research1 mentions
- 2025Co-Occurrence of Systemic Sclerosis, Lupus, and Celiac Disease in Multiple Autoimmune Syndrome: A Case Report.The American journal of case reports1 mentions
- 2025Clinical Progress in Mesenchymal Stem Cell Therapy: A Focus on Rheumatic Diseases.Immunity, inflammation and disease1 mentions
- 2025Role of Molecular Diagnosis in Imported Cutaneous Leishmaniasis and Its Public Health Significance in India.Pathogens (Basel, Switzerland)1 mentions
- 2025Prevalence and determinants of hearing loss in systemic lupus erythematosus: A cross-sectional study in a tertiary care center in Saudi Arabia.Saudi medical journal1 mentions
- 2025Association between sickle cell disease and autoimmune diseases in Saudi population: a single center study.Expert review of hematology1 mentions
- 2025The PPAR-β/δ agonist GW0742 alleviates DNA damage and lupus nephritis in an animal model of systemic lupus erythematosus via restoring DNA repair gene expression.Mutation research. Genetic toxicology and environmental mutagenesis1 mentions
- 2025A Novel Radiographic and Genetic Variant of Adult-Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia: Case Report.The Neurohospitalist1 mentions
- 2025Protein Kinase Cδ deficiency in Arab children: A link to fatal monogenic lupus and BCGitis susceptibility.Lupus1 mentions
- 2025Neuropsychiatric Systemic Lupus Erythematosus With Early-Onset Brain Atrophy: A Case Report and Literature Review.Cureus1 mentions
- 2025Exploring genetic linkage between rheumatoid arthritis and systemic lupus erythematosus through biological networks and prioritizing omega-3 fatty acids as a potent therapeutic.Allergologia et immunopathologia1 mentions
- 2025Exploring the role of genetic variants in susceptibility to autoimmune Diseases: A molecular genetics approach.Human immunology1 mentions
- 2025Bioinformatics analysis of Rickettsia typhi autoimmune associations and screening of Streptomyces-derived inhibitors.BioData mining1 mentions
- 2025The correlation of lupus anticoagulant and anticardiolipin antibodies with hematological parameters and clinical findings in sickle cell disease at steady state phase.Thrombosis journal1 mentions
- 2025Thrombotic thrombocytopenic purpura in a patient with systemic lupus erythematosus after anifrolumab: a possible association.Archive of clinical cases1 mentions
- 2024Bridging autoimmunity and epigenetics: The influence of lncRNA MALAT1.Pathology, research and practice1 mentions
- 2024Lupus Nephritis Biomarkers: A Critical Review.International journal of molecular sciences1 mentions
- 2024Knowledge and Awareness of Systemic Lupus Erythematosus Among the Population of Jeddah, Saudi Arabia: A Cross-Sectional Study.Cureus1 mentions
- 2024Potential clinical implications of molecular mimicry-induced autoimmunity.Immunity, inflammation and disease1 mentions
- 2024Revolutionizing Treatment Strategies for Autoimmune and Inflammatory Disorders: The Impact of Dipeptidyl-Peptidase 4 Inhibitors.Journal of inflammation research1 mentions
- 2024Mycophenolate-induced colitis in a patient with lupus nephritis: a case report and review of the literature.Journal of medical case reports1 mentions
- 2024Awareness of Side Effects of Corticosteroids among Users and Nonusers in Saudi Arabia.Journal of pharmacy & bioallied sciences1 mentions
- 2024Prevalence of Autoimmune Diseases Among Patients With Psoriasis: A Single Tertiary Center Experience.Cureus1 mentions
- 2024Clinical characteristics and prognostic value of autoantibody profile in children with monogenic lupus.Journal of rheumatic diseases1 mentions
- 2024Role of Podocyte in Kidney Disease.Frontiers in bioscience (Landmark edition)1 mentions
- 2024Association of BLK and BANK1 gene polymorphisms with systemic lupus erythematous in Egyptian patients.The Egyptian journal of immunology1 mentions
- 2024Headaches in SLE patients: a cross-sectional analysis of clinical, immunological, and Radiological Correlations.BMC rheumatology1 mentions
- 2023Cytotoxic T-lymphocyte associated protein 4 (CTLA4) polymorphisms are linked to systemic lupus erythematosus: an updated meta-analysis.Biotechnology & genetic engineering reviews1 mentions
- 2023Significance of Interleukin 23 in Systemic Lupus Patients: Relation to Disease Activity and Damage Indices.Biologics : targets & therapy1 mentions
- 2023CYP2D6 genetic polymorphisms in Saudi systemic lupus erythematosus patients: A cross-sectional study.Saudi medical journal1 mentions
- 2023Analysis of MIR27A (rs11671784) Variant Association with Systemic Lupus Erythematous.Life (Basel, Switzerland)1 mentions
- 2023Immunoprofiling of cytokines, chemokines, and growth factors in female patients with systemic lupus erythematosus- a pilot study.BMC immunology1 mentions
- 2023SLE initially presenting with neuropsychiatric manifestations and seizure, case report.Immunity, inflammation and disease1 mentions
- 2023The developing role of extracellular vesicles in autoimmune diseases: special attention to mesenchymal stem cell-derived extracellular vesicles.International immunopharmacology1 mentions
- 2023The use of extracorporeal shock wave therapy (ESWT) in treating osteonecrosis of the femoral head (AVNFH): a retrospective study.International orthopaedics1 mentions
- 2023Knowledge and Awareness of Systemic Lupus Erythematosus Among the Population of Makkah, Saudi Arabia: A Cross-Sectional Study.Cureus1 mentions
- 2023Advanced glycation end product signaling and metabolic complications: Dietary approach.World journal of diabetes1 mentions
- 2023Exploring the impact of chronic medical conditions on maternal mental health: A National Inpatient Sample analysis.European journal of obstetrics, gynecology, and reproductive biology1 mentions
- 2023Long Non-Coding RNA TUG1 Gene Polymorphism and TUG1 Expression Level as Molecular Biomarkers of Systemic Lupus Erythematosus and Lupus Nephritis.Non-coding RNA1 mentions
- 2023Metabolite Alterations in Autoimmune Diseases: A Systematic Review of Metabolomics Studies.Metabolites1 mentions
- 2023Phenotype and disease course differences in monogenic and sporadic childhood lupus.Lupus1 mentions
- 2023Trends of Coagulation Parameters in Human Immunodeficiency Virus Patients.Medicina (Kaunas, Lithuania)1 mentions
- 2023Increased development of T-bet+CD11c+ B cells predisposes to lupus in females: Analysis in BXD2 mouse and genetic crosses.Clinical immunology (Orlando, Fla.)1 mentions
- 2023Prevalence and Characteristics of Knee Osteoarthritis Among the General Public in Saudi Arabia.Cureus1 mentions
- 2023Pregnancy and Inflammatory Rheumatological Diseases: A Single-Center Retrospective Cohort Study.Cureus1 mentions
- 2023Homozygous missense variant F12 (Gly506Asp) associated with severe factor XII deficiency: a case report.Journal of medical case reports1 mentions
- 2023The Relationship between Serum TWEAK Levels and Carotid Intima-media Thickness in Patients with Fabry Disease.Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia1 mentions
- 2022Progressive Multifocal Leukoencephalopathy Misdiagnosed as Neuropsychiatric Systemic Lupus Erythematosus With a Catastrophic Outcome.The neurologist1 mentions
- 2022Rheumatologic diseases in patients with inborn errors of immunity in the USIDNET registry.Clinical rheumatology1 mentions
- 2022Application of extracellular vesicles derived from mesenchymal stem cells as potential therapeutic tools in autoimmune and rheumatic diseases.International immunopharmacology1 mentions
- 2022Identification and Validation of Pathogenic Genes in Sepsis and Associated Diseases by Integrated Bioinformatics Approach.Genes1 mentions
- 2022Shining the light on clinical application of mesenchymal stem cell therapy in autoimmune diseases.Stem cell research & therapy1 mentions
- 2022Diabetic mastopathy: A rare clinicopathologic entity with considerable autoimmune potential.International journal of surgery case reports1 mentions
- 2022Performance of the EULAR/ACR 2019 classification criteria for systemic lupus erythematous in monogenic lupus.Clinical rheumatology1 mentions
- 2022Genotype Triad for HOTAIR rs10783618, LINC-ROR rs1942347, and MALAT1 rs3200401 as Molecular Markers in Systemic Lupus Erythematous.Diagnostics (Basel, Switzerland)1 mentions
- 2022Extragenital lichen sclerosus: A comprehensive review.The Australasian journal of dermatology1 mentions
- 2022A case report of pediatric systemic lupus erythematosus with diffuse alveolar hemorrhage following COVID-19 infection: Causation, association, or chance?Medicine1 mentions
- 2022Anti-Inflammatory microRNAs for Treating Inflammatory Skin Diseases.Biomolecules1 mentions
- 2022Lupus Anticoagulant-Hypoprothrombinemia Syndrome and Pseudotumor Cerebri as an Initial Presentation of Systemic Lupus Erythematosus in a 16-Year-Old Male Patient: A Case Report and Literature Review.The American journal of case reports1 mentions
- 2022In silico analysis of missense variants of the C1qA gene related to infection and autoimmune diseases.Journal of Taibah University Medical Sciences1 mentions
- 2022Gastrointestinal Manifestations in Patients with Systemic Lupus Erythematosus.Open access rheumatology : research and reviews1 mentions
- 2022Neonatal Lupus presenting with neonatal hemochromatosis-like liver disease that responded to steroids: a case report.BMC pediatrics1 mentions
- 2022Circulating Levels of Hypoxia-regulating MicroRNAs in Systemic Lupus Erythematosus Patients with Hemolytic Anemia.Current medical science1 mentions
- 2022Nephrogenic Diabetes Insipidus and Distal Renal Tubular Acidosis in a Patient with Systemic Lupus Erythematosus and Secondary Antiphospholipid Syndrome.Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia1 mentions
- 2021Association of AIRE (rs2075876), but not CTLA4 (rs231775) polymorphisms with systemic lupus erythematosus.Gene1 mentions
- 2021Single-nucleotide polymorphisms (SNPs) of antioxidant enzymes SOD2 and GSTP1 genes and SLE risk and severity in an Egyptian pediatric population.Clinical biochemistry1 mentions
- 2021A case of dyschromatosis symmetrica hereditaria with an associated eyelid hemangioma.International journal of surgery case reports1 mentions
- 2021Major histocompatibility complex (MHC) associations with diseases in ethnic groups of the Arabian Peninsula.Immunogenetics1 mentions
- 2021Lupus manifestations in children with primary immunodeficiency diseases: Comprehensive phenotypic and genetic features and outcome.Modern rheumatology1 mentions
- 2021Autosomal Recessive ISG15 Deficiency Underlies Type I Interferonopathy with Systemic Lupus Erythematosus and Inflammatory Myositis.Journal of clinical immunology1 mentions
- 2021Immunoglobulin levels in systemic lupus erythematosus: A narrative review.Lupus1 mentions
- 2021Long-COVID and Post-COVID Health Complications: An Up-to-Date Review on Clinical Conditions and Their Possible Molecular Mechanisms.Viruses1 mentions
- 2021Systemic Lupus Erythematosus with Crohn's Disease: A Rare Combination and Unusual Presentation.European journal of case reports in internal medicine1 mentions
- 2021Genetic Polymorphisms in Genes Involved in the Type I Interferon System (IFIH1/MDA-5, TNFAIP3/A20, and STAT4): Association with SLE Risk in Egyptian Children and Adolescents.Journal of inflammation research1 mentions
- 2021National systemic lupus erythematosus prospective cohort in Saudi Arabia: A study protocol.Medicine1 mentions
- 2021Association between alopecia areata and thyroid dysfunction.Postgraduate medicine1 mentions
- 2021Prognostic Impact of Genetic Variants of MECP2 and TIRAP on Clinical Outcomes of Systemic Lupus Erythematosus with and without Nephritis.Biomolecules1 mentions
- 2021Association of microRNA-34a rs2666433 (A/G) Variant with Systemic Lupus Erythematosus in Female Patients: A Case-Control Study.Journal of clinical medicine1 mentions
- 2021Metoclopramide-induced Acute Dystonia Misdiagnosed as an Epileptic Seizure in a Lupus Patient.Journal of epilepsy research1 mentions
- 2020Systemic lupus erythematosus in a girl with PTEN variant and transaldolase deficiency: a novel phenotype.Clinical rheumatology1 mentions
- 2020A Case with Purine Nucleoside Phosphorylase Deficiency Suffering from Late-Onset Systemic Lupus Erythematosus and Lymphoma.Journal of clinical immunology1 mentions
- 2020Association of microRNA 17 host gene variant (rs4284505) with susceptibility and severity of systemic lupus erythematosus.Immunity, inflammation and disease1 mentions
- 2020Evaluation of etiology and pregnancy outcome in recurrent miscarriage patients.Saudi journal of biological sciences1 mentions