ACE
HGNC:2707 · 58 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | ACE | “Assessing the Association Between Genetic Variants in ACE, SOD1, and PER3 and their Role in Breast Cancer Risk among Jordanian Women.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “The angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) gene polymorphism has been studied for its possible role in INS in different ethnic groups with conflicting results reported.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “Pharmacogenetics of RAS-affecting AGT and ACE variants and the efficacy of Valsartan/HCTZ therapy.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “Also, several common gene variants were reported in MTHFR, KLF14, eNOS3, and ACE by whole-exome sequencing.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “This study investigates the influence of genetic polymorphisms on renal outcomes in HFrEF patients treated with dapagliflozin, focusing on variations in genes such as SLC5A2, UMOD, KCNJ11, and ACE.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “Genetic variability influences responses to common CVD drugs, including antiplatelet drugs (clopidogrel and aspirin), anticoagulants (warfarin), statins, and antihypertensives (ACE inhibitors and β-blockers).” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “This study investigated the correlation between single nucleotide polymorphisms (SNPs) in selected genes (CACNA1C, CACNA1D, ABCB1, ACE, ADBR2, and NOS1AP) and the blood pressure (BP) control by amlodipine.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “The I/D polymorphism (rs1799752) in the ACE1 gene was genotyped by polymerase chain reaction (PCR), meanwhile the ACE serum concentrations were assessed by ELISA.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “Association of ACE*(Insertion/Deletion) Variant with the Elevated Risk of Preeclampsia Among Gestational Women.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “The Impact of ACE Gene Variants on Acute-Phase Reactants in Children with Rheumatic Heart Disease.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “Thirteen genetic variants, including FV G1691A, FV A4070G, F2 G20210A, F13A1 G103T, FGB - 455G > A, PAI-1 - 675 4G/5G, ITGB3 T1565C, MTHFR C677T, MTHFR A1298C, ACE I/D, APOB G10708A, APOE T388C, and APOE C526T were genotyped using ViennaLab StripAssay.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “Impact of ACE and Endoplasmic Reticulum Aminopeptidases Polymorphisms on COVID-19 Outcome.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “Meta-analysis studies have shown that the Angiotensin converting enzyme (ACE) gene insertion and deletion polymorphism is closely associated with vitiligo in many ethnicities.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “Based on the variant zygosity, a marked phenotypic heterogeneity in terms of LDL-C levels, clinical presentations and resistance to anti-lipid treatment regimen (ACE inhibitors, β-blockers, ezetimibe, statins) of the FH patients was observed.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “In the present study, we hypothesize that a functional insertion/deletion polymorphism-rs4646994 I/D and rs4240157 T > C in the ACE gene could be associated with SARS-CoV-2 infection and mortality.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “Angiotensin-Converting Enzyme (ACE) 1 Gene Polymorphism and Phenotypic Expression of COVID-19 Symptoms.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “BACKGROUND: Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism may play a role in the pathogenesis of coronavirus-19 disease (COVID-19).” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “OBJECTIVES: The association of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and the development of type 2 diabetes mellitus (T2DM) has been debated vigorously but still remains controversial.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “BACKGROUND: Polymorphism in the angiotensin-converting enzyme gene (ACE) is responsible for elevated ACE concentrations in plasma.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “Angiotensin-converting enzyme (ACE) with insertion (I) and deletion (D) polymorphisms of an Alu-287 bp sequence has been implicated in multiple metabolic disorders, including obesity.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “PURPOSE: This is the first cross-sectional study studying the changes in haematological indicators of the response to recombinant human erythropoietin (rHuEPO) therapy in chronic renal failure (CRF) patients on haemodialysis (HD) stratified according to ACE G2350A (rs4343) gene polymorphism.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “Treating the cells with an ACE inhibitor, perindopril, at 100 µM reduced apoptosis, ROS, and MHC-II expression induced by S protein.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “Thus, the present study aimed to compare autonomous heart control, through symbolic analysis parameters, in the older adults carrying different ACE I/D gene polymorphisms (rs4646994).” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “Assessment of insertion/deletion polymorphism of ACE gene as a genetic risk marker for preeclampsia in pregnant women.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “Angiotensin-converting enzyme insertion/deletion (ACE I/D) gene polymorphism in Egyptian children with congenital heart disease.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “In this study, the effect of commonly used medications on the expression of SARS-CoV-2 receptor, angiotensin-converting enzyme (ACE)2, and TMPRSS2 protein in kidney tissues was evaluated.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “OBJECTIVE: To assess the polymorphism of angiotensin converting enzyme (ACE) in ischemic stroke in an Egyptian sample.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “For this reason, we investigated the involvement of genetic factors associated with SARS-CoV-2 infection with a focus on angiotensin-converting enzyme (ACE)-related genes, because ACE2 is a receptor for SARS-CoV-2.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “Studies from Egypt, Iraq, Jordan, Oman, Qatar, Saudi Arabia, Tunisia, and United Arab Emirates had been explored studying the associations of GIPR, ADIPOQ, FTO, (GRCh38.p12), MLXIP, AKNAD1, KCNJ11 CDKAL1, CDKN2A/2B, TCF7L2, ACE, SNAP25, ELMO1, VDR, KCTD8, GABRA4 and PRKD1 genes with T2D development.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “Angiotensin-Converting Enzyme (ACE) D Allele as a Risk Factor for Increase Serum Interleukin-6 and Interleukin-8 in Psoriasis Patients.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “Angiotensin-converting enzyme (ACE) gene is indispensable for endothelial control and vascular tone regulatory systems, usually affected in Systemic Lupus Erythematosus (SLE).” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “The communal relation of MTHFR, MTR, ACE gene polymorphisms and hyperhomocysteinemia as conceivable risk of coronary artery disease.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “An insertion/deletion (I/D) polymorphism of the gene encoding angiotensin-converting enzyme (ACE) was reported as a candidate gene predisposing to DN and ESRD.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “Results from published studies on the relationship between angiotensin-converting enzyme (ACE) insertion/ deletion (I/D) gene polymorphism and patients with DN are still conflicting.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “Polymorphisms of some genes of the renin-angiotensin system (RAS), such as angiotensinogen (AGT; M235T), angiotensin II type 2 receptor (AT2; C3123A), and angiotensin-converting enzyme (ACE; insertion/deletion (I/D)) are involved in the development and progression of coronary artery disease (CAD) in diabetic individuals.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “The link between the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and the prevalence of type 2 diabetes mellitus (T2DM) developing in the Saudi Arabian population remains controversial.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “Homozygous or compound heterozygous mutations in genes encoding components of the renin-angiotensin system (ACE, AGT, AGTR1 and REN) have been reported to cause RTD.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “BACKGROUND: An insertion/deletion (I/D) polymorphism in the angiotensin converting enzyme (ACE) gene has been associated with recurrent miscarriage (RM) in several populations.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “Angiotensin-converting enzyme gene insertion deletion (ACE I/D) polymorphism in Saudi children with congenital heart disease.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “INTRODUCTION: Angiotensin I converting enzyme (ACE) insertion and deletion (I/D) polymorphism has been implicated in the pathogenesis of osteoarthritis (OA).” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “The association of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism to MGH has been previously reported.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “OBJECTIVES: To investigate the association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and rheumatic heart disease (RHD) in Saudi patients.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “Our objectives in the present investigation were to determine whether three RAS polymorphisms, angiotensin-converting enzyme insertion/deletion (ACE I/D), angiotensin receptor II (Ang II AT2 - C3123A) and angiotensinogen (AGT-M235T), are associated with CAD in the Saudi population.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “The relationship between angiotensin converting enzyme (ACE) Insertion/Deletion (I/D) polymorphism and Familial Hypercholesterolemia (FH) has been not fully investigated in all the ethnicities.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “Insertion/deletion polymorphism of the ACE gene increased risk of Behcet disease: evidence from a meta-analysis.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “ACE I/D and MTHFR C677T polymorphisms are significantly associated with type 2 diabetes in Arab ethnicity: a meta-analysis.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “ACE I/D and eNOS E298D gene polymorphisms in Saudi subjects with hypertension.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “To study renal angiotensin-converting enzyme (ACE) messenger ribonucleic acid (mRNA) gene expression in patients with GN to determine its role in the disease process and other factors that may influence the course of the disease and the prognosis, e.g. treatment with ACE inhibitor (ACEI) drugs, we studied 20 patients with GN allocated to two groups: ten patients received an ACEI drug and ten patients did not receive ACEI in addition to a control group of ten healthy subjects.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “Real-time polymerase chain reaction (PCR) genotyping was carried out to determine the polymorphic variants of factor V Leiden 1695G/A, prothrombin 20210G/A, plasmin activator inhibitor 1 4G/5G, methylene tetrahydrofolate reductase (MTHFR) 677C/T, MTHFR 1298A/C, and angiotensin-converting enzyme (ACE) insertion/deletion (I/D) among a representative sample of healthy Saudi subjects.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “Whereas, FCGA studies have identified some candidate genes which are associated with vitiligo, such as HLA, AIRE, VIT1, CAT, FOXD3, ESR1, COMT, PTPN22, NALP1, PDGFRA, MYG1, MITF, CD117, XBP1, FAS, COX2, EDN1 and ACE, but few of them reports now appear to be false-positive.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “Methylene tetrahydrofolate reductase (MTHFR) and angiotensinogen converting enzyme (ACE) gene polymorphisms related to overweight and obesity among Saudi patients in Al Qassim.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “Among the genetic factors found to be associated with development of T2DM is the angiotensin-I converting enzyme (ACE) gene, which is located on chromosome 17q23.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “BACKGROUND: This work was planned to check for the association of polymorphisms related to methylenetetrahydrofolate reductase (MTHFR) and angiotensin converting enzyme (ACE) genes with overweight/obesity among Saudi subjects from Qassim region.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “Their DNAs were analyzed for genetic polymorphisms of the methylenetetrahydrofolate reductase (MTHFR; 677C/T and 1298 A/C) as well as angiotensin-converting enzyme genes (ACE; insertion/deletion [I/D]) using real-time polymerase chain reaction.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “Following the DNA extraction from the blood leukocytes, the genotypes of the angiotensin converting enzyme (ACE I/D), angiotensinogen (ANG M235T), and angiotensin II type 1 receptor (ATR1 A1166C) were determined by polymerase chain reaction.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “BACKGROUND: Several studies have been carried out to investigate the insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE) in obese and normal weight individuals, often with contradictory results in different populatios.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “OBJECTIVE: To determine the relevance of angiotensin I-converting enzyme (ACE) gene polymorphism for coronary artery disease (CAD) in the Saudi population.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “The angiotensin-converting enzyme (ACE) gene insertion/deletion dimorphism tracks with higher serum ace activities in both younger and older subjects.” | 0.98 | hgnc_dict_v1 |