SIRT1
HGNC:14929 · 87 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | SIRT1 | “In contrast, overactivity of PARP1 resulting from Aβ-induced oxidative stress and DNA damage induces neurodegeneration via multiple pathways, including NAD+/ATP exhaustion leading to metabolism collapse, creation of the AIF-MIF complex promoting parthanatos, NF-κB-induced neuroinflammation, dysregulation of mitophagy, and disruption of the neuroprotective SIRT1 signaling pathway.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Resveratrol alleviates neurological disorders and motor dysfunction in 3-NP induced- Huntington's Disease in rats: Role of activating AMPK/SIRT1/ULK1 autophagy pathway.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Beyond aldehyde metabolism, emerging evidence suggests that ALDH-associated pathways are linked to redox regulation, epithelial stress adaptation, inflammatory signaling, and tissue repair through NAD(P)+-dependent processes and stress-responsive networks such as Nrf2 and SIRT1.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Molecular docking analysis confirms that Silybin predominantly modulates AMPK and that Silydianin preferentially engages SIRT1, whereas Silychristin exhibits a dual-target modulatory activity.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Cell viability (MTT), membrane integrity (LDH), ion-dependent ATPase activities (Na+/K+, Ca2+, Mg2+), antioxidant enzyme activities (catalase, SOD), mitochondrial membrane potential (Muse™ MitoPotential flow cytometry), and SIRT1/AMPK mRNA expression were quantified.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “DSS induced marked colonic damage, inflammatory cytokine elevation, oxidative stress, alterations in selected gut microbial taxa, NF-κB activation, SIRT1/AMPK suppression, and miR-146a downregulation.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “The effects of oral administration of MESB at doses of 250, 500, and 750 mg/kg on body weight; fasting and postprandial hyperglycemia; oral glucose tolerance test (OGTT); serum concentrations of HbA1c, adiponectin, amylase, tumor necrosis factor-α (TNF-α), catalase, and superoxide dismutase (SOD); histopathological changes in the pancreas, liver, and kidney; and mRNA expression of TNF-α, SIRT1, and SIRT2 were studied over 28 days.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Exploring the Association of Genetic Determinants of SIRT1, MTHFR, and MIR146A Gene Polymorphism with the Ischemic Stroke Predisposition: A Case Control Study.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Tissue levels of SIRT1, mTOR, HO-1, Nrf2, STAT3, AMPK, and Dickkopf-related protein 1 (DKK1) were measured, along with colonic gene expression of NLRP3, Wnt, IL-6, TNF-α, and DKK1.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “The model disrupted several molecular pathways, including the AMP-activated protein kinase (AMPK) pathway, and enhanced oncogenic and inflammatory markers such as Yes-associated protein/ Transcriptional coactivator with PDZ-binding motif/ Hypoxia-inducible factor 1-alpha (YAP/TAZ/ HIF-1α), nuclear factor erythroid 2-related factor 2/ Sirtuin 1(Nrf2/SIRT1), and signal transducer and activator of transcription 3 (STAT3).” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “This was accompanied by a significant elevation of hepatic MDA and apoptotic genes expressions, alteration in miRNA-34a and P53/Nrf2/SIRT1 pathway as well as cytokines.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Mechanistic insights into the hepatoprotective role of rabeprazole against cyclophosphamide-induced hepatotoxicity via AMPK/SIRT1 activation and suppression of TLR4/NF-κB and MAPK pathways.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Mechanistically, topiramate mitigated cadmium-induced nephrotoxicity by suppressing renal pro-oxidants and augmenting several antioxidant signals, including sirtuin 1 (SIRT1), nuclear factor (erythroid-derived 2)-like 2 (Nrf2), and heme oxygenase 1 (HO-1) by 71.3%, 120.8%, and 78.7%, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Second, SIRT7 opposes SIRT1 in regulating adipogenic commitment, implicating sirtuin and NAD+ dysregulation in the age-related adipogenic deficit.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “By restoring autophagic flux, rebalancing metabolic axes (AMPK/SIRT1), and suppressing chronic inflammation, these compounds can rescue synaptic function and reactivate neurogenesis.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “PPAR-γ agonist Inactivate Cellular Senescence by Inhibiting SIRT1 Signaling to Confer Increased Sensitivity to Olaparib in Ovarian Cancer Cells.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Histopathological and immunohistochemical evaluations demonstrated that nano-treatments, particularly SNP, significantly decreased collagen deposition, α-SMA expression, and inflammatory infiltrates, while reinstating SIRT1 levels.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Inhibitory miRNAs (e.g., miR-31, miR-140-5p) suppress SATB2 via the Wnt/β-catenin or SIRT1/Smad3 pathways and reduce osteoblast differentiation.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “The protective effects of neferine against paracetamol-induced liver injury are associated with the activation of SIRT1/Nrf2/HO-1 signaling pathway and inhibition of NF-kappa B/TNF-alpha/iNOS/COX-II cascade.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “SIRT1 in Aging and Diseases.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Molecular Variants in SIRT1 Gene Among Saudi Women Diagnosed with Gestational Diabetes Mellitus: A Case-Control Study.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Ten hub genes were obtained based on maximum clique centrality (MCC), maximum neighborhood component (MNC), degree, closeness and betweenness using cytoHubba which included ACTB, ATM, ESR1, GAPDH, HNRNPK, KRAS, MDM2, SIRT1, TP53, and H3F3C (H3-5).” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “SYR improves cardiac function via ER/SIRT1/NLRP3/GSDMD and has a protective effect against hypoxia/reoxygenation injury.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Fold-change in glutathione peroxidase 7 [(GPX7) 1.26 ± 1.37], glutathione-disulfide reductase [(GSR) 1.22 ± 1.41], glutathione S-transferase Mu 3 [(GSTM3) 1.34 ± 1.49], peroxiredoxin 6 [(PRDX6) 1.36 ± 1.57], extracellular signal-regulated kinase 3 [(ERK3) 1.92 ± 2.42], NRF2 (1.62 ± 2.16), p38 alpha [(p38a) 1.33 ± 1.58] and sirtuin 1 [(SIRT1) 1.73 ± 2.25] gene expression were higher after T. chuii compared to placebo supplementation (p < 0.05).” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Melissa officinalis Attenuates Diclofenac-Induced Hepatorenal Toxicity via AMPK/SIRT1 and STAT3/Nrf2 Pathways.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “The expression levels of the oxidative stress (PGC-1α, SIRT1, GCLC, GCLM, and EPAS1) and metabolic (FBXL12, KPNA7, and LRRK1) genes were significantly higher in postpartum disorders sheep than in resistant ones.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Aging and metabolic disorders share intricate molecular pathways, with the Forkhead box O (FOXO)- Sirtuin 1 (SIRT1) axis emerging as a pivotal regulator of cellular stress adaptation, metabolic homeostasis, and longevity.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Thymoquinone-Loaded Chitosan Nanoparticles Combat Testicular Aging and Oxidative Stress Through SIRT1/FOXO3a Activation: An In Vivo and In Vitro Study.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Molecular mechanisms underlying the effects of beta-sitosterol on TGF-β1/Nrf2/SIRT1/p53-mediated signaling in the kidney of a high-fat diet and sucrose-induced type-2 diabetic rat.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Theaflavin alleviates cisplatin-induced nephrotoxicity: Targeting SIRT1/p53/FOXO3a/Nrf2 signaling and the NF-kB inflammatory cascade.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “This study examines how SIRT1 protein levels correlate with clinicopathological characteristics and survival outcomes in patients with breast cancer.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Ag NPs group displayed a reduction in kidney weight ( absolute and relative), excess in urinary levels of kidney injury molecule, neutrophil gelatinase-associated lipocalin, cystatin, and blood kidney biomarkers (creatinine, urea, and potassium), increases in oxidative stress markers with the reduction in antioxidant markers, and decreases in serum sirtuin 1(SIRT1) level.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Gut microbiota-derived TMAO and SIRT1/HMGB1 Axis: unveiling mechanisms of renal impairment in beta-thalassemia major.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “The Sirtuin (SIRT) family of NAD+-dependent enzymes has recently been shown to play a critical role in cardiovascular health and disease, and several SIRT isoforms, especially SIRT1 and SIRT3, have been amply investigated.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Dysregulation of Niacin-Derived NAD+ Salvage Pathway Markers (CD38, NAMPT, SIRT1) Across Albuminuria Stages in Type 2 Diabetes.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “In the present study, the effects of age and sex on the expression of meat quality marker genes such as the FASN (Fatty Acid Synthase), C/EBPα (CCAAT Enhancer Binding Protein Alpha), PLIN1 (Perilipin-1), PPARγ (Peroxisome Proliferator Activated Receptor Gamma), and SIRT1 (Sirtuin1) were explored.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “These are involved in energy balance and metabolism (SUGCT, HECW1, MMADHC), cells apoptosis (APP, SRBD1, NTN1, PUF60, SLC26A8, DAP, SUGCT), angiogenesis (RYR2, LDB2, SOX5), skin protection to solar radiation (FZD10, BCO2, WNT5B, COL6A2, SIRT1) as well as growth (NELL1).” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “High glucose stimulation of Neuro2a cells increased PARP1 expression, and with siRNA-ChNP (1:3000) treatment, significant inhibition of PARP1 expression is observed that consequently reversed the expression of regulatory genes like SIRT1, FOXO1, FOXO3, and p53.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Sirtuin 1 (SIRT1), an NAD+-dependent deacetylase, has emerged as a key regulator of cellular processes linked to ageing and neurodegeneration.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “LncRNA LYPLAL1, miR-204-5p, and SIRT1: novel signatures for risk assessment of diabetic macrovascular complications.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “On the 9th day, brain had been excised after scarification and had been assessed for reactive oxygen species measurement, histopathological analysis, immunohistochemical, gene and protein expressions for the nuclear factor erythroid 2-related factor 2 (Nrf2), p53 and Silent information regulator 2 homolog 1 (SIRT1).” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Relative expression levels of genes associated with energy (ACADM, PEPCK, GOT2, GLUT1, and CS), ROS modulation (SIRT1), mitochondrial free-radical scavengers (SOD1, PRX4, NOS2, GPX1, and GPX4), anti-apoptotic genes (NF-κβ), apoptotic (CASP7), and tissue damage using histology, during migration were assessed.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Ingenuity pathway analysis predicted miR-199b-5p to inhibit the target genes SIRT1, ETS1, and JAG1.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Hesperetin protects against rotenone-induced motor disability and neurotoxicity via the regulation of SIRT1/NLRP3 signaling.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “The nanostructures lead to an increase in the expression of genes encoding proteins related to oxidative stress (SIRT1, FOXO3, NFE2L2, and MAP3K5) and cyclin-dependent kinase inhibitors (CDKN1A and CDKN1B) in response to ROS.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Gene expressions of SIRT1, BDNF, and RAGE were assessed.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Pinocembrin's protective effect against acute pancreatitis in a rat model: The correlation between TLR4/NF-κB/NLRP3 and miR-34a-5p/SIRT1/Nrf2/HO-1 pathways.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “In conclusion, LGT elicits anti-proliferative, apoptotic, and anti-migratory effects on BC cells in obese conditions by suppressing the activity of survival pathways; however, this effect is independent of the AMPK/SIRT1 pathway in ADSCs or AMPK in BC cells.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Modulating SIRT1, Nrf2, and NF-κB signaling pathways by bergenin ameliorates the cadmium-induced nephrotoxicity in rats.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “On the controversy, the SIRT1 level in the CT group (4.53 ± 3.880) significantly decreased in the WOIT and WIT groups.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “SIRT1 is a protein associated with vital cell functions such as gene regulation, metabolism, ageing, and cellular energy restoration.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Resveratrol attenuates against high-fat-diet-promoted non-alcoholic fatty liver disease in rats mainly by targeting the miR-34a/SIRT1 axis.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Common Genetic Variants in SIRT1 Gene Promoter and Type 2 Diabetes Mellitus in Saudi Arabia.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Targeting SIRT1, NLRP3 inflammasome, and Nrf2 signaling with chrysin alleviates the iron-triggered hepatotoxicity in rats.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “METHODS: The current study was designed to explore the effect of observing four-week, dawn to dusk IF by participants with obesity on gene expression of the anti-inflammatory CD163, oxidative stress, and bioenergetics enzymes (SOD2, Nrf2, and TFAM), as well as metabolic and cellular regulatory genes (SIRT1 and SIRT3).” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Fenofibrate as an Adjunct Therapy for Ulcerative Colitis: Targeting Inflammation via SIRT1, NLRP3, and AMPK Pathways: A Randomized Controlled Pilot Study.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Activation of AMPK/SIRT1/FOXO3a signaling by BMS-477118 (saxagliptin) mitigates chronic colitis in rats: uncovering new anti-inflammatory and antifibrotic roles.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Oxidative stress and senescence in aging kidneys: the protective role of SIRT1.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “The difference included the expression of critical genes (SKT4, SIRT1, and TNF superfamily), metabolic and signaling pathways (Hippo, Sirtuin, ARE-mediated messenger RNA degradation, MSP-RON, and Huntington), and predicted biological functions (β-cell growth and proliferation, insulin and glucose metabolism, energy balance, inflammation, and neurodegeneration).” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “This study investigates the total serum IgE, FoxO1, and Sirtuin 1 (SIRT1) gene expressions in HDM-allergic asthma patients.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “SIRT1 inhibits mitochondrial hyperfusion associated mito-bulb formation to sensitize oral cancer cells for apoptosis in a mtROS-dependent signalling pathway.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “The stemness (proliferation and migration), senescence-related markers (p53, p21, SIRT1, and AMPK), oxidative stress/antioxidant markers, inflammatory cytokines, and cell cycle of BM-MSCs were measured by MTT assay, qPCR, ELISA, and flow cytometry.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “SIRT1/Nrf2/NF-κB Signaling Mediates Anti-Inflammatory and Anti-Apoptotic Activities of Oleanolic Acid in a Mouse Model of Acute Hepatorenal Damage.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Targeting SIRT1/FoxO3a/Nrf2 and PI3K/AKT Pathways with Rebamipide Attenuates Acetic Acid-Induced Colitis in Rats.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “The transcription factors E2F1, HSF1, SIRT1, RELA, NFKB, JUN, and MYC were found to be responsible.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Deletion of sirtuin protein, SIRT1 in the organs like brain, heart, liver and pancreas can cause inflammation and increases the level of free radical ions causing oxidative stress.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Targeting Autophagy, Apoptosis, and SIRT1/Nrf2 Axis with Topiramate Underlies Its Neuroprotective Effect against Cadmium-Evoked Cognitive Deficits in Rats.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Resveratrol, the most studied stilbene, lowers the Michaelis constant of SIRT1, and occupies the substrate binding pocket.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Canagliflozin ameliorates ulcerative colitis via regulation of TLR4/MAPK/NF-κB and Nrf2/PPAR-γ/SIRT1 signaling pathways.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Correction to: Umbelliferone ameliorates ulcerative colitis induced by acetic acid via modulation of TLR4/NF‑κB‑p65/iNOS and SIRT1/PPARγ signaling pathways in rats.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Moreover, the expression of sirtuin 1, 3, and 7 (SIRT1, SIRT3, and SIRT7) genes was increased (p < 0.05) in the liver of the HS groups that received Resv-Lipo NPs in a dose-dependent manner.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “On the molecular level, both compounds interfered with SIRT1 expression and consequently suppressed Akt phosphorylation, and PN5 blocked apoptosis escape.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Furthermore, mRNA and immunohistochemistry (IHC) analysis revealed that STR ameliorates UA (uric acid)-associated renal inflammation, fibrosis, and EMT (epithelial-mesenchymal transition) via MMPS (matrix metalloproteinases), inhibiting NF-κB/NLRP3 activation by the AMPK/SIRT1 pathway and modulating the JAK2-STAT3 and Nrf2 signaling pathways.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “The Value of SIRT1/FOXO1 Signaling Pathway in Early Detection of Cardiovascular Risk in Children with β-Thalassemia Major.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Urolithin A prevents streptozotocin-induced diabetic cardiomyopathy in rats by activating SIRT1.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Targeting oxidative stress, apoptosis, and autophagy by galangin mitigates cadmium-induced renal damage: Role of SIRT1/Nrf2 and AMPK/mTOR pathways.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Resveratrol can interact with several molecular targets (Nf-kB, SIRT1, mTOR, HIF-1α, miRNAs, and TNF-α) and effectively prevent/ alleviate IBD symptoms with promising results.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Umbelliferone ameliorates ulcerative colitis induced by acetic acid via modulation of TLR4/NF-κB-p65/iNOS and SIRT1/PPARγ signaling pathways in rats.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Recently miRNAs were also identified to act either as oncogenes or tumor suppressors in DLBCL pathology by altering the expression levels of some of the known DLBCL related oncogenes. i.e., miR-155, miR-17-92 and miR-21 act as oncogenes by altering the expression levels of MYC, SHIP and FOXO1, respectively, conversely; miR-34a, mir-144 and miR-181a act as tumor suppressors by altering the expression levels of SIRT1, BCL6 and CARD11, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “This LC-MS-MS validated senescence assay showed reduced lamin A, lamin A△10, lamin A△50, SIRT1, SIRT3, SIRT5, p53, and p16INK4a, as well as p53-β induction, are implicated in replicative senescence.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Kaempferol protects against streptozotocin-induced diabetic cardiomyopathy in rats by a hypoglycemic effect and upregulating SIRT1.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Exendin-4 Protects Against Myocardial Ischemia-Reperfusion Injury by Upregulation of SIRT1 and SIRT3 and Activation of AMPK.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Nephroprotective effect of umbelliferone against cisplatin-induced kidney damage is mediated by regulation of NRF2, cytoglobin, SIRT1/FOXO-3, and NF- kB-p65 signaling pathways.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “This study investigated the protective effect of ellagic acid (EA) against diabetic cardiomyopathy (DC) in streptozotocin (STZ)-treated rats and examined if the mechanism of protection involves modulating silent information regulator 1 (SIRT1).” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Of note, a significant upregulation of HDAC1, 3, 4, 11, SIRT3 and downregulation of HDAC2,8, SIRT1, SIRT2, SIRT3, SIRT7 among DFU patients were observed.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “Catalpol Ameliorates Insulin Sensitivity and Mitochondrial Respiration in Skeletal Muscle of Type-2 Diabetic Mice Through Insulin Signaling Pathway and AMPK/SIRT1/PGC-1α/PPAR-γ Activation.” | 0.98 | hgnc_dict_v1 |
| gene | SIRT1 | “BACKGROUND: Sirtuin 1 (SIRT1) and sirtuin 3 (SIRT3) proteins have an important role in counteracting oxidative stress.” | 0.98 | hgnc_dict_v1 |