Population record
Saudi Arabia · 20 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| population | Saudi Arabia | “Comparative molecular analysis of colorectal cancer in Saudi Arabia: distinct genetic alterations and clinical features. However, the scenario diverges in Saudi Arabia, where CRC ascends to the forefront as the most common cancer among males and the second most prevalent among females. Delving into the molecular and phenotypic profiles of CRC within the Saudi populace emerges as a crucial stride towards addressing the escalating disease burden afflicting the country. METHODS: To unravel the CRC driver molecular landscapes among the Saudi population, we performed Whole Exome Sequencing (WES) of 50 Saudi CRC patients collected by the Colorectal Cancer Research Center at King Saud University Medical Center (KSUMC) with MSS adenocarcinoma tumors. RESULTS: Tumors from Saudi patients have a significantly lower frequency of KRAS mutations (6.5% vs. The proportion of Saudi CRC patients who have sigmoid disease is higher (41.7% vs. CONCLUSION: The results indicate a distinct mutational landscape of CRC in Saudi Arabia, highlighting the importance of gathering population-specific data in order to inform diagnostic of molecular cancer screening and treatment strategies for patients in Saudi Arabia.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Potential association of certain microRNA gene polymorphisms with recurrent pregnancy loss susceptibility in Saudi women. This case control study investigated six miRNA polymorphisms (miR-10-A > T, miR-125-G > A, miR-146a-C > G, miR-149-T > C, miR-323b-C > T, miR-499-A > G) in 50 Saudi women with idiopathic (≥ 2 losses) and 50 matched controls (≥ 1 live birth, no loss history) using PCR Sanger sequencing. These results suggest miR-146a and miR-149 can contribute to RPL susceptibility in Saudi women, highlighting their potential as population-specific genetic biomarkers and underscoring the need for further research into miRNA-mediated pregnancy maintenance mechanisms.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “RESULTS: The LRRK2 mutation was not detected in any of the 50 Emirati PD patients (mean age 64.2 ± 14.1 years, of whom 56% are male) examined. CONCLUSION: The absence of the LRRK2 and specifically the G2019S mutation in Emirati PD patients corroborates findings from Saudi Arabia and indicates a distinct genetic pattern compared to other Arab regions like Egypt and Maghreb (North African) countries, where the G2019S mutation prevalence ranges from 10 to 40%.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Her4 in gastric adenocarcinoma and its association with molecular prognostic markers Ki-67 proliferation index and p53 mutational status in Saudis: A study at a tertiary care hospital in Eastern Saudi Arabia. The role of Her4 in gastric carcinogenesis and its prognostic implications have not been much investigated, as evidenced by the paucity of overall and Saudi regional-based studies. This study aimed to highlight the expression of Her4 in gastric adenocarcinoma (GA) as well as its association with clinicopathological parameters and molecular prognostic markers Ki-67 and p53 in a Saudi cohort. MATERIALS AND METHODS: In this descriptive cross-sectional study, data were retrospectively obtained by selecting all cases of GA from 2012 to 2022, for which Her4 immunohistochemical (IHC) analysis was done by total population sampling technique from the Pathology Department archives of King Fahd Hospital of the University, Al-Khobar, Saudi Arabia. RESULTS: Out of the 50 cases of GA selected, Her4-positive cases were 22% (n = 11), and in these Her4-positive cases, 63.6% had intestinal-type morphology, 54.5% were high-grade tumors, male preponderance was 63.6%, the median age was 73 years, and the mean age was 74 years (standard deviation [SD]: 9.3).” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Comparative analysis of safety and efficacy between brand and generic lamotrigine products in the Saudi market. In 2023, the World Health Organization (WHO) estimates that approximately 50 million individuals globally would be affected by epilepsy. Due to the increasing demand for transformation between brand and generic products, this study aims to evaluate the product safety and efficacy on liver enzymes, as well as the behavioral effects and pharmacokinetics of lamotrigine, specifically the brand Lamictal00AE and its generics available in the Saudi market.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Association of the Genetic Diversity of Killer Cell Immunoglobulin-like Receptor Genes and HLA-C Ligand in Saudi Women With Thyroid Cancer. Therefore, we investigated the association between KIR and HLA-C genotypes and TC risk in Saudi women. METHODS: In this retrospective study, sixteen KIR genotypes and 2 HLA-C allotypes were determined using the polymerase chain reaction-sequence-specific primer (PCR-SSP) method, and the genotypes of 50 Saudi female patients with TC were compared with those of 50 Saudi female healthy controls (HC). Our results showed significant differences in the KIR gene combinations and KIR-HLA combinations between Saudi female TC patients and HC. CONCLUSION: These results suggest that the expression of KIR genes and their HLA-C ligands may influence the risk of TC development in Saudi women.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Strategy for immunological analysis of pro-inflammatory cytokine marker studies with chronic hepatitis B virus in Southwestern region of Saudi Arabia. METHODS: In this study, we have selected 50 HBV patients and 40 control subjects from Saudi Population. Positive associations between blood levels of TNF-α and IL-6 were confirmed, while negative associations were found between PCR investigations involving the TNF-α (G-308A) and IL-6 (G-174 C) genes with the HBV prevalence in the Saudi population. CONCLUSION: This study confirmed serum levels are strongly associated with HBV patients in the Saudi population.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Surgical outcomes and stoma-related complications in inflammatory bowel disease in Saudi Arabia: a retrospective study. BACKGROUND: The prevalence of inflammatory bowel diseases (IBD), Crohn's (C) and ulcerative colitis (UC) has increased in Saudi Arabia during the past decade. Stoma creation complications in IBD are underreported in the literature of the Middle East and especially in Saudi Arabia. RESULTS: Of 50 IBD patients underwent stoma creation, 32 patients (64%) were diagnosed with CD and 18 patients (36%) with UC.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Identification of RPL5 gene variants and the risk of hepatic vein thrombosis in Saudi patients. OBJECTIVES: To identify ribosome protein L5 gene variants and the risk of hepatic vein thrombosis in Saudi patients. Sixty-five patient cases of hepatic vein thrombosis (HVT) were chosen, and 50 healthy individuals of the same ages and both gender were set as a control group. CONCLUSION: Our findings indicate that the 5 genetic novel variants examined in the RPL5 gene were associated with a risk of HVT in all our Saudi cases.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Targeted sequencing of crucial cancer causing genes of breast cancer in Saudi patients. In Saudi Arabia, breast cancer constitutes nearly 22% of the newly diagnosed cancer cases in women. Breast cancer incidence in the women population of Saudi Arabia is 25.9%, with 18.2% mortality. In this study, targeted sequencing of 164 selected genes was performed on germline and somatic DNA derived from the blood and tissue samples of 50 breast cancer patients using customized panel on Ion torrent platform. Among the mutations detected in our study, TP53 (p.R81X), VHL (p.E52X), and BRCA2 (p.K3326X) mutations, which lead to an aberrant transcript with a premature stop codon, were reported for the first time in breast cancer patients from Saudi Arabia. Our study will help in identifying the damaging mutations and predisposing genes in Saudi breast cancer patients.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Polymorphisms in proinflammatory cytokine genes, effect on gene expression and association with preterm delivery in Saudi females. The current study was designed with the aim to explore the association of genetic polymorphisms and mRNA expression of IL-1α, IL-1β, and TNF-α gene with preterm birth in the Saudi population. Genotyping of genomic DNA of 50 PTB patients and an equal number of controls were carried out using TaqMan Genotyping assay kits. In conclusion, this study revealed that rs361525 polymorphism plays a role as a protective marker for PTB and the levels of IL-1α, IL-6, TNF- α can be used as predicative biomarkers for PTB I Saudi women.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “The medical records of children with FJSLE seen at three pediatric rheumatology clinics in Saudi Arabia and Oman were retrospectively reviewed. There were 50 children with FJSLE belonging to 18 families; the frequency of FJSLE in our cohort was 20.8%.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Association between XRCC1 G399A Polymorphism and Late Complications to Radiotherapy in Saudi Head and Neck Cancer Patients. PATIENTS AND METHODS: In this case control study, 50 Head and Neck cancer patients were retrospectively recruited.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “A recent review indicates that approximately 50 patients have been reported in the world. PATIENTS AND METHODS: We retrospectively reviewed the clinical, radiological, biochemical and histopathological findings of four Saudi patients diagnosed with Wolman's disease at King Faisal Specialist Hospital and Research Centre.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “We have studied the relative levels of gamma-mRNA [%gamma/(gamma + beta)], Ggamma- and Agamma-mRNAs [%Ggamma/(Ggamma + Agamma)], hemoglobin (Hb) F, and the Ggamma and Agamma chains in some 50 patients with sickle cell anemia (SS) and with different haplotypes. As expected, the Hb F levels varied greatly and were high in patients with the Saudi Arabian-Indian haplotype.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “We investigated 50 Saudi children (< 15 years) with beta-thalassaemia major and 50 beta-thalassaemia minor, and age- and sex-matched controls for the prevalence of diabetes mellitus, and its relation to hitherto claimed predisposing factors. The prevalence of diabetes mellitus was significantly lower in the Saudi thalassaemic patients compared to the results obtained from patients of other ethnic groups reported in literature.(ABSTRACT TRUNCATED AT 250 WORDS)” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Analysis of available radiographs of the skeletal system in 50 patients suffering from sickle cell anaemia in the Assir Region (South Western height and valley) of the Kingdom of Saudi Arabia taken over a three year period showed a wide spectrum of bone changes.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “The clinical, haematological and biochemical features of 50 Sudanese patients with sickle cell disease (SCD) were determined. Thus, the observed pattern of SCD in Sudan is comparable to the severe type described for Africans and not comparable to the benign form found in Shiite Moslem Arabs of Saudi Arabia.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Juvenile myoclonic epilepsy: a study in Saudi Arabia. We studied 50 patients in Saudi Arabia with juvenile myoclonic epilepsy (JME).” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Evaluation of haematological findings in 50 Bahraini patients with sickle cell disease and in some of their parents. The mean Hb F level in the Bahraini patients was 13.8%, a value lower than that encountered in sickle cell homozygotes from Kuwait and Saudi Arabia.” | 0.95 | saudi_context_rules_v1 |