CCND1
HGNC:1582 · 27 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CCND1 | “Expression of cell cycle regulators (CCND1, CCND3, p21, and p27), apoptotic markers (BCL2, Bcl-2-associated X protein, cytochrome c, caspase-8, caspase-9, and caspase-3), and metabolic mediators (protein kinase B [Akt], mammalian target of rapamycin [mTOR], adenosine monophosphate-activated protein kinase [AMPK], and phosphatase and tensin homolog [PTEN]) was analyzed by quantitative reverse transcription-polymerase chain reaction.” | 0.98 | hgnc_dict_v1 |
| gene | CCND1 | “Validated targets concentrated on key leukemia-related genes like PTEN, BCL2L11, CDKN1A, CCND1, RB1, E2F1, and TGFBR2.” | 0.98 | hgnc_dict_v1 |
| gene | CCND1 | “Then, protein-protein interaction (PPI) network analysis pinpointed seven top-ranked DEGs (GAPDH, PTEN, CCND1, APOE, ESR1, MAPK3/ERK1, and SNCA) as KGs or central modulators of PD pathogenesis.” | 0.98 | hgnc_dict_v1 |
| gene | CCND1 | “In contrast, downregulation was discovered for 39 genes associated with immunity, regulation of cell cycle, and DNA damage response (HRAS, CCND1, ATM, CXCR1, and MIF).” | 0.98 | hgnc_dict_v1 |
| gene | CCND1 | “While IL-10 treatment showed minimal effects, IL-10Rα blockade or STAT3 inhibition led to cell cycle arrest and apoptosis in HT29 and SW620 cells, associated with increased p21, p27, and Caspase-3, and decreased CCND1, CCND3, PCNA, and survivin gene and protein expression.” | 0.98 | hgnc_dict_v1 |
| gene | CCND1 | “Gene and protein expression of molecules involved in apoptosis (BLC2, survivin, BAX, Cytochrome-C, and Caspase-3), cell cycle (CCND1, CCND3, p21, and p27), the PI3K/AKT/mTOR/HIF1α oncogenic pathway, and glycolysis (LDHA, PDH, and PDHK1) were also analysed by quantitative RT-PCR and Western blot.” | 0.98 | hgnc_dict_v1 |
| gene | CCND1 | “Ten genes (TNNI2, SPIN2, COL5A3, RNF169, CCND1, FGFR1, SLC17A2, FAMM71F2, RREB1, AOX1) were found to have significant correlations between methylation and expression, forming the basis for our predictive model.” | 0.98 | hgnc_dict_v1 |
| gene | CCND1 | “DS and DSN lowered CCND1 and survival in MCF-7/ADR cells while raising p21 and Casp3 gene and protein expression.” | 0.98 | hgnc_dict_v1 |
| gene | CCND1 | “It downregulated the expression of CCND1 and Ki-67 while exhibiting anti-BCL-2 effects and enhancing the levels of Bax and cleaved caspase-3.” | 0.98 | hgnc_dict_v1 |
| gene | CCND1 | “METHODS: Bone marrow aspirates were obtained from 72 patients with MM and evaluated by conventional cytogenetics (CCs) and interphase fluorescence in situ hybridization (iFISH) techniques for a panel of probes, including immunoglobulin heavy chain (IgH)/CCND1, IgH/fibroblast growth factor receptor 3 (FGFR3), IgH/MAFB, 13q deletion, and deletion 17p.” | 0.98 | hgnc_dict_v1 |
| gene | CCND1 | “Out of these genes, MCL1, IGF1R, CCND1, and PTEN were identified as hub genes and were found to have significant (p < 0.05) variations in their mRNA and protein expressions and effects on the overall survival (OS) of the KIRC patients.” | 0.98 | hgnc_dict_v1 |
| gene | CCND1 | “Out of a total of 25 PI3K pathway-related genes, we developed and validated a diagnostic and prognostic model based on the up-regulation of TP53 (tumor protein 53) and CCND1 (Cyclin D1) and the down-regulation of PTEN (Phosphatase and TENsin homolog deleted on chromosome 10), and GSK3B (Glycogen synthase kinase-3 beta) hub genes.” | 0.98 | hgnc_dict_v1 |
| gene | CCND1 | “Three of these (Amyloid Beta Precursor Protein (APP), Cyclin D1 (CCND1), and Cyclin E2 (CCNE2) are upregulated, and one protein phosphatase 2 phosphatase activator (PTPA) is simultaneously downregulated in both disorders.” | 0.98 | hgnc_dict_v1 |
| gene | CCND1 | “The best model of 7/52 genetic CNAs, which included the SPOP alteration, SPP1 alteration, CCND1 amplification, PTEN deletion, CDKN1B deletion, PARP8 deletion, and NKX3.1 deletion, stratified the PCa cases into a localised and advanced disease with an accuracy of 70.0%, sensitivity of 85.4%, specificity of 44.9%, positive predictive value of 71.67%, and negative predictive value of 65.35%.” | 0.98 | hgnc_dict_v1 |
| gene | CCND1 | “The gene and protein expression of apoptosis (PCNA/survivin/BAX/Cytochrome-C/Caspase-3) and cell cycle (CCND1/CCND3/p21/p27) molecules, the PI3K/mTOR/HIF1α oncogenic pathway, and glycolysis regulatory enzymes were measured by quantitative-PCR and Western blot.” | 0.98 | hgnc_dict_v1 |
| gene | CCND1 | “Association of CCND1 (c.723G > A, rs9344) variant with elevated risk of breast carcinoma: a retrospective case-control study.” | 0.98 | hgnc_dict_v1 |
| gene | CCND1 | “Integration of gene networking data, with additional parameters like estimation of mutation burden of tumors and cancer driver gene identification, has led to the finding of 4 hubs (JUN, VCAN, TOP2A, and COL1A1) and 8 bottleneck genes (PIK3R1, MYH11, KDR, ESR1, WT1, CCND1, EZH2, and CDKN2A), which showed a clear distinction in their distribution pattern among leiomyomas and leiomyosarcomas.” | 0.98 | hgnc_dict_v1 |
| gene | CCND1 | “BACKGROUND: Cyclin D1 (CCND1) polymorphisms, a regulator of the cell cycle progress from G1 to the S phase, may lead to uncontrolled cell proliferation and lack of apoptosis.” | 0.98 | hgnc_dict_v1 |
| gene | CCND1 | “Other frequent amplifications included ERBB2, GRB7, and cell-cycle pathway members CCND1 and CDK4/6, which showed mutually exclusivity with deletions of CDKN2A, CDKN2B, and CDKN1B.” | 0.98 | hgnc_dict_v1 |
| gene | CCND1 | “The commonly mutated genes were cyclin D1 (CCND1), Rb, p53, FLJ10540, and TC21.” | 0.98 | hgnc_dict_v1 |
| gene | CCND1 | “Purine analog therapy and the presence of trisomy 12, and CCND1 gene rearrangement have been linked to increased risk of Richter's transformation.” | 0.98 | hgnc_dict_v1 |
| gene | CCND1 | “Prediction of deleterious single nucleotide polymorphisms and their effect on the sequence and structure of the human CCND1 gene.” | 0.98 | hgnc_dict_v1 |
| gene | CCND1 | “In addition to confirming known genes of OSCC (TP53, CDKNA2, CASP8, PIK3CA, HRAS, FAT1, TP63, CCND1 and FADD) the analysis identified several candidate novel driver events including mutations of NOTCH3, CSMD3, CRB1, CLTCL1, OSMR and TRPM2, amplification of the proto-oncogenes FOSL1, RELA, TRAF6, MDM2, FRS2 and BAG1, and deletion of the recently described tumor suppressor SMARCC1.” | 0.98 | hgnc_dict_v1 |
| gene | CCND1 | “Tissue microarrays (TMA) based immunohistochemical stains were used to validate the protein expression of cyclinD1 (CCND1) and were scored semi-quantitatively from 0 to 3+ on the basis of absence or presence of staining intensity in the tumor cell.” | 0.98 | hgnc_dict_v1 |
| gene | CCND1 | “HER2, TOP2A, CCND1, EGFR and C-MYC oncogene amplification in colorectal cancer.” | 0.98 | hgnc_dict_v1 |
| gene | CCND1 | “Tissue microarrays were analyzed by fluorescence in situ hybridization for HER2, CCND1, MYC, and EGFR amplification.” | 0.98 | hgnc_dict_v1 |
| gene | CCND1 | “Multiple different oncogenes have been described previously to be amplified in breast cancer including HER2, EGFR, MYC, CCND1, and MDM2.” | 0.98 | hgnc_dict_v1 |