GFAP
HGNC:4235 · 33 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | GFAP | “Tumor cells were GLUT-1 positive and negative for S100, GFAP, pan-cytokeratin, SMA, WT-1, CD31, CD34, STAT6, β-catenin, and HMB-45, with Ki-67 nuclear staining of 10-15% of cells.” | 0.98 | hgnc_dict_v1 |
| gene | GFAP | “Histological analysis also revealed hippocampal gliosis, apoptosis, CA1 pyramidal cell degeneration, layer disorganization, and upregulation of glial fibrillary acidic protein (GFAP), NF-κB, and cleaved caspase-3.” | 0.98 | hgnc_dict_v1 |
| gene | GFAP | “SI rats showed marked reductions in locomotion, sucrose preference, social interaction, antioxidant capacity (Nrf2, SOD, CAT, GSH), neurotransmitters (serotonin, dopamine, GABA, glycine), and BDNF, alongside significant increases in oxidative stress markers (8-OHdG, MDA, NO), inflammatory cytokines (TNF-α, IL-1β, NF-κB), apoptotic mediators (Bax and Caspase-3), GFAP, and histological degeneration (P < 0.05).” | 0.98 | hgnc_dict_v1 |
| gene | GFAP | “RESULTS: Folic acid ameliorated LPS-induced neuronal damage in the hippocampus, suppressed microglial activation (GFAP and Iba-1), downregulated Notch1 and NF-κB p65, and improved neuroinflammatory responses (TNF-α, IL-6, and COX-2), regardless of the region.” | 0.98 | hgnc_dict_v1 |
| gene | GFAP | “Brain tissues were examined histologically and immunohistochemically for the expression of α-synuclein, β-amyloid, and GFAP.” | 0.98 | hgnc_dict_v1 |
| gene | GFAP | “PPA also significantly (p < .05) modulated the cerebellar protein levels of the gliosis biomarker GFAP and the neuronal loss biomarker calbindin D28K, as well as the cerebellar tissue levels of zinc, glutathione, and the oxidative stress biomarker malondialdehyde (MDA).” | 0.98 | hgnc_dict_v1 |
| gene | GFAP | “The mice were tested for anxiety, cognition and depression in an array of behavioral experiments, followed by analyzing the oxidative markers, morphological changes and mRNA expression of GFAP, BDNF and TrkB in isolated hippocampi.” | 0.98 | hgnc_dict_v1 |
| gene | GFAP | “There was a classical appearance of round cells with perinuclear halo, immunopositive for olig-2, glial fibrillary acidic protein (GFAP), and cluster of differentiation-34.” | 0.98 | hgnc_dict_v1 |
| gene | GFAP | “Additionally, there is a decrease in the immunoexpression of nuclear factor erythroid 2-related factor 2 (Nrf2) and gene expression of heme oxygenase-1 (HO-1), tropomyosin receptor kinase B (TrkB), and anti-apoptotic B-cell lymphoma-2 (Bcl-2), alongside an increase in the sera and protein levels of proinflammatory cytokines tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-1 beta (IL-1β), immunoexpression of glial fibrillary acidic protein (GFAP), nuclear factor kabba beta (NF-κB), caspase-3, and gene expression of proapoptotic Bax.” | 0.98 | hgnc_dict_v1 |
| gene | GFAP | “Parasitemia, survival, and body weight were assessed, and brains were collected on day 9 p.i. for histopathological analysis (H&E staining) and GFAP immunohistochemistry.” | 0.98 | hgnc_dict_v1 |
| gene | GFAP | “Histopathological examination demonstrated reduced neuronal degeneration and decreased immunoreactivity of glial fibrillary acidic protein (GFAP).” | 0.98 | hgnc_dict_v1 |
| gene | GFAP | “In addition, compound 7b attenuated excitotoxic glutamate accumulation by 61.5% and downregulated glial activation markers GFAP and Iba-1 by 73.9% and 49.8%, respectively, consistently outperforming valproic acid.” | 0.98 | hgnc_dict_v1 |
| gene | GFAP | “Mechanistic studies revealed that these compounds significantly reduced hippocampal oxidative stress (MDA, NO), excitotoxicity (glutamate), pro-inflammatory cytokine levels (TNF-α, IL-6), and glial activation (GFAP, Iba-1), indicating a multimodal neuroprotective profile.” | 0.98 | hgnc_dict_v1 |
| gene | GFAP | “Notably, 11a matched or surpassed valproic acid's effects, especially in lowering astrocytic activation (GFAP), while 7a performed better across all assessed parameters.” | 0.98 | hgnc_dict_v1 |
| gene | GFAP | “Hippocampal histopathological studies, along with GFAP and Ki67 immunoreactivity, were performed.” | 0.98 | hgnc_dict_v1 |
| gene | GFAP | “Ger mitigated MDA, NO, IL-1β, IL-6, TNF-α and IFN-γ, GFAP, caspase-3, and -9 levels and Bax gene expression and escalated GSH, SOD, catalase, BDNF and Bcl2 gene expression.” | 0.98 | hgnc_dict_v1 |
| gene | GFAP | “In addition, Van reduced AChE activity, and elevated glial fibrillary acidic proteins (GFAP) increased neurotransmitter and brain-derived neurotrophic factors (BDNF).” | 0.98 | hgnc_dict_v1 |
| gene | GFAP | “Furthermore, treated MD subjects showed decreased expression of α-synuclein, GFAP and Iba-1 proteins and modulation of the NF-kB pathway, which were impaired in MD patients.” | 0.98 | hgnc_dict_v1 |
| gene | GFAP | “Kidney functions, cognition, hippocampal OS markers, Gal-3, NF-қB, p65 and HMGB-1 gene expression, TNF-α level, t-JNK/p-JNK and t-ERK/p-ERK proteins, caspase-3, glial fibrillary acidic protein (GFAP) and ionized calcium binding protein-1 (Iba-1) were assessed.” | 0.98 | hgnc_dict_v1 |
| gene | GFAP | “Available hematoxylin-eosin, special, and immunostains were evaluated, and at least one section from each case was stained with anti-glial fibrillary acidic protein (GFAP), anti-amyloid precursor protein (APP), and anti-HLA-DR antibody.” | 0.98 | hgnc_dict_v1 |
| gene | GFAP | “RESULTS: We screened the most important shared genes (CDKN1A, COL22A1, EIF4A, GFAP, SLC1A1, and VIM) and essential human molecular pathways that motivate these diseases.” | 0.98 | hgnc_dict_v1 |
| gene | GFAP | “Histopathological examination, immunohistochemical glial fibrillary acidic protein (GFAP), and Bax expression analysis were detected.” | 0.98 | hgnc_dict_v1 |
| gene | GFAP | “Also, in the hippocampus, the expression of IL6 and Bcl-2 at the mRNA level and expression of Sirt-1, P53, caspase-3, GFAP, and NF-kB in CA3 hippocampal region by immunohistochemistry was investigated.” | 0.98 | hgnc_dict_v1 |
| gene | GFAP | “Also, the markers of oxidative stress (malondialdehyde (MDA), catalase, and reduced glutathione (GSH)), histopathological examination, the expression of glial fibrillary acidic protein (GFAP) (a marker of astrocytes) IGF-1, Nrf2, and HO-1 were assessed in the brain tissues by the end of the experiment.” | 0.98 | hgnc_dict_v1 |
| gene | GFAP | “Diffuse GFAP Immunopositivity in the Oligodendrocyte-like Component of Pilocytic Astrocytoma Distinguishes It from Mimickers.” | 0.98 | hgnc_dict_v1 |
| gene | GFAP | “Neuroglial heterotopic tissue presented in 7 days old girl with facial asymmetry and bulging in the oral cavity, maximal de-bulking was done, histopathology was positive for GFAP and S100p.” | 0.98 | hgnc_dict_v1 |
| gene | GFAP | “In particular, the gene expression profiles of astrocytes in HD showed multiple signatures, varying in phenotype from cells that had markedly upregulated metallothionein and heat shock genes, but had not completely lost the expression of genes associated with normal protoplasmic astrocytes, to astrocytes that had substantially upregulated glial fibrillary acidic protein (GFAP) and had lost expression of many normal protoplasmic astrocyte genes as well as metallothionein genes.” | 0.98 | hgnc_dict_v1 |
| gene | GFAP | “Duloxetine protects against experimental diabetic retinopathy in mice through retinal GFAP downregulation and modulation of neurotrophic factors.” | 0.98 | hgnc_dict_v1 |
| gene | GFAP | “The histopathological changes in the hippocampus were studied using hematoxylin and eosin stain and immunohistochemical stain for brain-derived neurotrophic factor (BDNF), glial fibrillary acidic protein (GFAP), beclin-1, nuclear factor kappa-B (NF-κB) and Bcl-2-like protein 4 (BAX).” | 0.98 | hgnc_dict_v1 |
| gene | GFAP | “Immunohistochemically, they express keratin, EMA, and variably S100 and GFAP.” | 0.98 | hgnc_dict_v1 |
| gene | GFAP | “The effect of duloxetine was assessed in terms of pain responses, histopathology of sciatic nerve and spinal cord, sciatic nerve growth factor (NGF) gene expression and on the spinal expression of astrocytes (glial fibrillary acidic protein, GFAP) and microglia (CD11b).” | 0.98 | hgnc_dict_v1 |
| gene | GFAP | “Neuronal damage was also assessed by performing tissue staining by hematoxylin and eosin, estimating hippocampus level of glutamate, gamma-aminobutyric acid (GABA), glial fibrillary acidic protein (GFAP) and brain-derived neurotrophic factor (BDNF).” | 0.98 | hgnc_dict_v1 |
| gene | GFAP | “Previous investigations have indicated that ischemia upregulates GFAP and PDGF-B expression.” | 0.98 | hgnc_dict_v1 |