MGMT
HGNC:7059 · 26 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MGMT | “BACKGROUND: The clinical management of glioma is increasingly dependent on the tumor's molecular profile, particularly the mutation status of Isocitrate Dehydrogenase (IDH), the promoter methylation of O-6-Methylguanine-DNA Methyltransferase (MGMT), and the co-deletion of chromosomal arms 1p and 19q.” | 0.98 | hgnc_dict_v1 |
| gene | MGMT | “In multivariable Cox regression adjusting for IDH status and tumor purity, Factor 1 remained independently prognostic (HR = 1.67, 95% CI 1.27-2.20, p = 0.0002); in a fully-adjusted model additionally including age, WHO grade, MGMT methylation, and 1p/19q codeletion (plus radiotherapy and chemotherapy status in the CGGA cohorts), Factor 1 remained prognostic in both CGGA cohorts (CGGA1: HR = 1.50, p = 3.8 × 10-5; CGGA2: HR = 1.18, p = 0.003) but lost significance in TCGA (HR = 1.04, p = 0.83), consistent with the cohort-dependent magnitude reported in the IDH-stratified and meta-regression analyses below.” | 0.98 | hgnc_dict_v1 |
| gene | MGMT | “AIM: To assess the methylation status of p16, DAPK, and MGMT in oral leukoplakia and OSMF.” | 0.98 | hgnc_dict_v1 |
| gene | MGMT | “This study integrates a literature review of microRNAs (miRNAs) implicated in TMZ resistance with in-silico transcriptomic miR analyses to elucidate novel biomarkers. miRNAs, small non-coding RNAs, regulate gene expression, including O6-methylguanine-DNA methyltransferase (MGMT), a key mediator of TMZ resistance.” | 0.98 | hgnc_dict_v1 |
| gene | MGMT | “Inhibitory effects of Gracilaria edulis and Gracilaria salicornia against the MGMT and VEGFA biomarkers involved in the onset and advancement of glioblastoma using in silico and in vitro approaches.” | 0.98 | hgnc_dict_v1 |
| gene | MGMT | “AIM: To evaluate the reliability of methylation of genes of saliva like P16, MGMT, and DAP-K as biomarkers for diagnosis of oral squamous cell carcinoma.” | 0.98 | hgnc_dict_v1 |
| gene | MGMT | “Saliva samples were obtained for analysis of the expression of genetic markers, such as p16, DAP-K, and MGMT.” | 0.98 | hgnc_dict_v1 |
| gene | MGMT | “The interplay mechanism between IDH, O-6-methylguanine-DNA methyltransferase (MGMT)-promoter methylation, and protein methyltransferase proteins-5 (PRMT5) activity, with tumor progression has never been described.” | 0.98 | hgnc_dict_v1 |
| gene | MGMT | “Constitutional BRCA1 and MGMT Methylation Are Significant Risk Factors for Triple-Negative Breast Cancer and High-Grade Serous Ovarian Cancer in Saudi Women.” | 0.98 | hgnc_dict_v1 |
| gene | MGMT | “Sample data from 45 OTSCC and normal groups were analyzed to exhibit the methylation levels of salivary biomarkers (TRH, FHIT, MGMT, p16, and RASSF1A).” | 0.98 | hgnc_dict_v1 |
| gene | MGMT | “The presence of O6 -methylguanine-DNA methyltransferase (MGMT) promoter methylation, a particular genetic sequence seen in tumors, has been proven to be a positive prognostic indicator and a significant predictor of recurrence.This strong revival of interest in AI is modeled in particular to major technological advances which have significantly increased the performance of the predicted model for medical decision support.” | 0.98 | hgnc_dict_v1 |
| gene | MGMT | “Furthermore, we demonstrated that ViT-WSI has high predictive power of inferring the status of three diagnostic glioma molecular markers, IDH1 mutation, p53 mutation, and MGMT methylation, directly from H&E-stained histopathological images, with patient level AUC scores of 0.960, 0.874, and 0.845, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | MGMT | “A patient with the H3 G34R mutation and 1 of 3 patients with the H3 K27 M mutation had MGMT promoter methylation.” | 0.98 | hgnc_dict_v1 |
| gene | MGMT | “Radiogenomic classification for MGMT promoter methylation status using multi-omics fused feature space for least invasive diagnosis through mpMRI scans.” | 0.98 | hgnc_dict_v1 |
| gene | MGMT | “A downward trend in the overall gene expression of select DNA repair and one carbon cycle genes (MGMT, MLH1, UNG, MTHFR, MTR) is noted with increased folate status and FA intake.” | 0.98 | hgnc_dict_v1 |
| gene | MGMT | “Several genes, such as isocitrate dehydrogenase (IDH) enzyme and O6-methylguanine-DNA methyltransferase (MGMT), have been implicated in pathogenesis of the disease.” | 0.98 | hgnc_dict_v1 |
| gene | MGMT | “Our aim in this study was to assess the relationship between CD204-expressed TAMs and O6-methylguanine-DNA methyltransferase (MGMT)-promoter methylation in World Health Organization (WHO) grade 4 astrocytomas, and its impact on patient's clinical outcome.” | 0.98 | hgnc_dict_v1 |
| gene | MGMT | “Within this cohort, histopathologic diagnoses included glioblastoma (N = 22, 40%) and anaplastic astrocytoma (N = 21, 38%), while genetic alterations included ATRX mutation (N = 22, 16%), PTPN11 mutation (N = 9, 7%), and MGMT promoter methylation (N = 9, 7%).” | 0.98 | hgnc_dict_v1 |
| gene | MGMT | “Deregulation of histone acetylation and methylation has been observed, together with gene methylation in genes such as p16, MGMT, APC, hMLH1, and also miR-143 repression.” | 0.98 | hgnc_dict_v1 |
| gene | MGMT | “The Impact of IDH1 Mutation and MGMT Promoter Methylation on Recurrence-Free Interval in Glioblastoma Patients Treated With Radiotherapy and Chemotherapeutic Agents.” | 0.98 | hgnc_dict_v1 |
| gene | MGMT | “Prognostic value of TP53 expression and MGMT methylation in glioblastoma patients treated with temozolomide combined with other chemotherapies.” | 0.98 | hgnc_dict_v1 |
| gene | MGMT | “In contrast to the majority of IDH-mutant gliomas, more than 60% of the samples in our cohort presented with an unmethylated MGMT promoter.” | 0.98 | hgnc_dict_v1 |
| gene | MGMT | “Two molecular biomarkers of treatment response are MGMT (O6-methylguanine-DNA methyltransferase) promoter methylation and IDH (isocitrate dehydrogenase) mutations, which prevent repair of tumor cell DNA damage caused by alkylating chemotherapy.” | 0.98 | hgnc_dict_v1 |
| gene | MGMT | “Genetic polymorphisms of methylenetetrahydrofolate reductase and promoter methylation of MGMT and FHIT genes in diffuse large B cell lymphoma risk in Middle East.” | 0.98 | hgnc_dict_v1 |
| gene | MGMT | “To investigate prevalence and interrelationship of recently suggested molecular prognostic markers in Middle East DLBCL, we analyzed coexpression of CD10/Bcl6 (by immunohistochemistry), t(14;18) translocations (by fluorescence in situ hybridization), and methylation of the gene encoding the DNA repair enzyme O(6)-methylguanine DNA methyltransferase (MGMT) in a series of 190 DLBCL patients from Saudi Arabia with clinical follow-up data.” | 0.98 | hgnc_dict_v1 |
| gene | MGMT | “We report here on the extent of concurrent methylation of E-cadherin, Dap-kinase, O(6)MGMT, p73, p16, p15 and p14 in 129 pediatric ALL cases.” | 0.98 | hgnc_dict_v1 |