prostate cancer
SaudiVarKB evidence summary derived from retained literature mentions.
147Phenotype mentions
100Publications
50Associated gene records
50Associated variant records
Associated gene records
Co-mentioned in the same publications| Gene | Identifier / context | Articles | Mentions |
|---|---|---|---|
| AR | HGNC:644 | 11 | 11 |
| PTEN | HGNC:9588 | 11 | 11 |
| BRCA2 | HGNC:1101 | 10 | 10 |
| BRCA1 | HGNC:1100 | 9 | 9 |
| TP53 | HGNC:11998 | 4 | 4 |
| GSK3B | HGNC:4617 | 3 | 3 |
| VEGFA | HGNC:12680 | 3 | 3 |
| EGFR | HGNC:3236 | 3 | 3 |
| MYC | HGNC:7553 | 3 | 3 |
| KLK3 | HGNC:6364 | 3 | 3 |
| HOXB13 | HGNC:5112 | 3 | 3 |
| BCL2 | HGNC:990 | 2 | 2 |
| CCND1 | HGNC:1582 | 2 | 2 |
| CREBBP | HGNC:2348 | 2 | 2 |
| RB1 | HGNC:9884 | 2 | 2 |
| CDK2 | HGNC:1771 | 2 | 2 |
| TERT | HGNC:11730 | 2 | 2 |
| NR3C1 | HGNC:7978 | 2 | 2 |
| KDM2B | HGNC:13610 | 2 | 2 |
| PSIP1 | HGNC:9527 | 2 | 2 |
| SPOP | HGNC:11254 | 2 | 2 |
| IRF4 | HGNC:6119 | 1 | 1 |
| ABCA2 | HGNC:32 | 1 | 1 |
| PAH | HGNC:8582 | 1 | 1 |
| COL1A1 | HGNC:2197 | 1 | 1 |
| CDK4 | HGNC:1773 | 1 | 1 |
| ACTB | HGNC:132 | 1 | 1 |
| FGFR3 | HGNC:3690 | 1 | 1 |
| TBX4 | HGNC:11603 | 1 | 1 |
| PPARG | HGNC:9236 | 1 | 1 |
| MSR1 | HGNC:7376 | 1 | 1 |
| CYP2D6 | HGNC:2625 | 1 | 1 |
| STAT3 | HGNC:11364 | 1 | 1 |
| CFTR | HGNC:1884 | 1 | 1 |
| CRP | HGNC:2367 | 1 | 1 |
| IL7R | HGNC:6024 | 1 | 1 |
| SQSTM1 | HGNC:11280 | 1 | 1 |
| PIK3CD | HGNC:8977 | 1 | 1 |
| LDLR | HGNC:6547 | 1 | 1 |
| PIK3R1 | HGNC:8979 | 1 | 1 |
| KRAS | HGNC:6407 | 1 | 1 |
| MAP2K1 | HGNC:6840 | 1 | 1 |
| BRAF | HGNC:1097 | 1 | 1 |
| ATM | HGNC:795 | 1 | 1 |
| CHD1 | HGNC:1915 | 1 | 1 |
| VHL | HGNC:12687 | 1 | 1 |
| HCN1 | HGNC:4845 | 1 | 1 |
| BAP1 | HGNC:950 | 1 | 1 |
| COL3A1 | HGNC:2201 | 1 | 1 |
| RAD51C | HGNC:9820 | 1 | 1 |
Associated variant records
Co-mentioned in the same publications| Variant | Identifier / context | Articles | Mentions |
|---|---|---|---|
| H874Y | H874Y | 2 | 2 |
| F876L | F876L | 1 | 1 |
| T877A | T877A | 1 | 1 |
| rs187084 | rs187084 | 1 | 1 |
| rs1800795 | rs1800795 | 1 | 1 |
| rs13091518 | rs13091518 | 1 | 1 |
| c.181T>G | c.181T>G | 1 | 1 |
| p.Cys61Gly | p.Cys61Gly | 1 | 1 |
| c.2457delC | c.2457delC | 1 | 1 |
| c.5357T>G | c.5357T>G | 1 | 1 |
| p.Leu1786Arg | p.Leu1786Arg | 1 | 1 |
| c.1111T>C | c.1111T>C | 1 | 1 |
| p.Leu371Pro | p.Leu371Pro | 1 | 1 |
| c.1201C>G | c.1201C>G | 1 | 1 |
| p.Thr401Arg | p.Thr401Arg | 1 | 1 |
| c.6275_6276del | c.6275_6276del | 1 | 1 |
| c.5347A>T | c.5347A>T | 1 | 1 |
| p.Met1783Leu | p.Met1783Leu | 1 | 1 |
| c.5198A>G | c.5198A>G | 1 | 1 |
| p.Asp1733Gly | p.Asp1733Gly | 1 | 1 |
| c.5158A>G | c.5158A>G | 1 | 1 |
| p.Thr1720Ala | p.Thr1720Ala | 1 | 1 |
| c.5117G>C | c.5117G>C | 1 | 1 |
| p.Gly1706Ala | p.Gly1706Ala | 1 | 1 |
| c.1014_1015insT | c.1014_1015insT | 1 | 1 |
| p.Glu339Ter | p.Glu339Ter | 1 | 1 |
| c.916C>T | c.916C>T | 1 | 1 |
| p.Arg306Ter | p.Arg306Ter | 1 | 1 |
| c.311T>C | c.311T>C | 1 | 1 |
| p.Ser104Pro | p.Ser104Pro | 1 | 1 |
| c.1129C>T | c.1129C>T | 1 | 1 |
| p.Arg377Cys | p.Arg377Cys | 1 | 1 |
| rs3829241 | rs3829241 | 1 | 1 |
| rs16901979 | rs16901979 | 1 | 1 |
| rs1197750201 | rs1197750201 | 1 | 1 |
| rs1199520604 | rs1199520604 | 1 | 1 |
| rs352140 | rs352140 | 1 | 1 |
| T877A | T877A | 1 | 1 |
| T877S | T877S | 1 | 1 |
| g.13430C>T | g.13430C>T | 1 | 1 |
| g.13737G>A | g.13737G>A | 1 | 1 |
| R273H | R273H | 1 | 1 |
| F281L | F281L | 1 | 1 |
| P188P | P188P | 1 | 1 |
| rs1800716 | rs1800716 | 1 | 1 |
| F147C | F147C | 1 | 1 |
| rs3750965 | rs3750965 | 1 | 1 |
| rs35264875 | rs35264875 | 1 | 1 |
| rs72932540 | rs72932540 | 1 | 1 |
| rs25644 | rs25644 | 1 | 1 |
Associated population records
Co-mentioned in the same publicationsSupporting publications
100 records- 2026Targeting the PI3K/AKT/mTOR signaling pathway in prostate cancer: Molecular dysregulation, therapeutic advances, and future directions.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society1 mentions
- 2026Bioinformatics and machine learning integration reveals a novel 4-gene (GFUS, ARHGAP8, NBL1, and ACTB) biomarker model for prostate cancer.Discover oncology1 mentions
- 2026Green biosynthesis of selenium nanoparticles by Ralstonia insidiosa which demonstrate effectiveness against human cancer cells, Candida species and multidrug-resistant Acinetobacter baumannii.RSC advances1 mentions
- 2026Microbial Genomic Consortia in Prostate Cancer: Mechanistic Signaling, the Gut-Prostate Axis, and Translational Perspectives.Cancers1 mentions
- 2026Structure-based virtual screening, molecular dynamics and MM-PBSA/GBSA analysis for the identification of novel CDK6 inhibitors against prostate cancer.In silico pharmacology1 mentions
- 2026Association Between Metabolic Syndrome and Prostate Cancer: A Systematic Review.Cancers1 mentions
- 2026Integrative in vitro - in silico evaluation of β-carotene-loaded nanoliposomes for targeted therapy against prostate carcinoma (PC-3) cells.Therapeutic delivery1 mentions
- 2025Investigating the antioxidant and anticancer potential of Daucus spp. extracts against human prostate cancer cell line C4-2, and lung cancer cell line A549.Journal of ethnopharmacology1 mentions
- 2025Management of Patients with Advanced Prostate Cancer. Report from the 2024 Advanced Prostate Cancer Consensus Conference (APCCC).European urology1 mentions
- 2025Prevalence of SPOP and IDH Gene Mutations in Prostate Cancer in a Jordanian Population.Biochemical genetics1 mentions
- 2025Non-coding RNAs in Cancer: Mechanistic insights and therapeutic implications.Pathology, research and practice1 mentions
- 2025Triplet therapy for metastatic castration-sensitive prostate cancer: Rationale and clinical evidence.International journal of urology : official journal of the Japanese Urological Association1 mentions
- 2025Comprehensive computational analysis of differentially expressed miRNAs and their influence on transcriptomic signatures in prostate cancer.Scientific reports1 mentions
- 2025The heat of the battle: inflammation's role in prostate cancer development and inflammation-targeted therapies.Discover oncology1 mentions
- 2025Analysing DNA methylation and transcriptomic signatures to predict prostate cancer recurrence risk.Discover oncology1 mentions
- 2025The incidence of venous thromboembolism by type of solid cancer worldwide: A systematic review.Cancer epidemiology1 mentions
- 2025Treatment switching between Enzalutamide and Abiraterone Acetate and time to oral opioid initiation in castration-resistant prostate cancer patients.Cancer epidemiology1 mentions
- 20253-Acetyl-11-keto-β-boswellic acid (AKBA) induced antiproliferative effect by suppressing Notch signaling pathway and synergistic interaction with cisplatin against prostate cancer cells.Naunyn-Schmiedeberg's archives of pharmacology1 mentions
- 2025Novel triazoloquinazoline derivatives as VEGFR inhibitors: synthesis, cytotoxic evaluation and in silico studies.Future medicinal chemistry1 mentions
- 2025Deciphering the anticancer potential of thymoquinone: in-depth exploration of the potent flavonoid from Nigella sativa.Molecular biology reports1 mentions
- 2025Integrative approach to decipher pharmacological mechanism of Cinnamomum zeylanicum essential oil in prostate cancer.Medical oncology (Northwood, London, England)1 mentions
- 2025Reduction of Prostate Cancer Risk: Role of Frequent Ejaculation-Associated Mechanisms.Cancers1 mentions
- 2025Epigenetic insights into prostate cancer: exploring histone modifications and their therapeutic implications.Frontiers in oncology1 mentions
- 2025Genomic profiling of urological malignancies using tissue-based next generation sequencing.Urologic oncology1 mentions
- 2025Creatine kinase in prostate cancer: A biosensor-driven diagnostic paradigm.Clinica chimica acta; international journal of clinical chemistry1 mentions
- 2025Dismantling the epigenetic alliance: Emerging strategies to disrupt the PRMT5:MEP50 complex for cancer therapy.European journal of medicinal chemistry1 mentions
- 2025In silico identification of PPARγ agonists from diffractaic acid analogs in prostate cancer: a comprehensive computational approach.3 Biotech1 mentions
- 2025Association of ATP-binding cassette transporter genomic alterations and expressions with patient survival in breast and prostate cancer.Physiological reports1 mentions
- 2025AZGP1: A proteomic biomarker in cancer.Clinica chimica acta; international journal of clinical chemistry1 mentions
- 2025A Comprehensive Review on the Molecular Mechanism of Lycopene in Cancer Therapy.Food science & nutrition1 mentions
- 2025[Neuroendocrine differentiation in prostate neoplasms. German version].Pathologie (Heidelberg, Germany)1 mentions
- 2025Epigenetic alterations in prostate cancer: the role of chromatin remodeling.Epigenomics1 mentions
- 2025Isolation and characterization of Boudabousia marimammalium from a mangrove habitat: identification of dual-function antimicrobial and anticancer peptides.Frontiers in microbiology1 mentions
- 2025Unveiling Ligand-Induced Conformational Changes in Mutant AR-LBD: Molecular Dynamics Insights into the Androgen Receptor-Coactivator Mechanism.Journal of chemical information and modeling1 mentions
- 2025Integrative bioinformatics and drug repurposing for metastatic prostate cancer: identifying novel therapeutic targets by transcriptional profiling and molecular Modeling.Integrative biology : quantitative biosciences from nano to macro1 mentions
- 2025Neuroendocrine differentiation in prostate neoplasms.Pathologie (Heidelberg, Germany)1 mentions
- 2025Evaluation of potential prognostic significance of JUNB in human prostate cancer: a bioinformatic and histopathological study.Journal of pathology and translational medicine1 mentions
- 2025Identifying drug targets and evaluating KLK3-targeted inhibitors for prostate cancer using in-silico and in-vitro approaches.Medical oncology (Northwood, London, England)1 mentions
- 2025Deciphering the role of zingiber officinale phytochemicals for the treatment of prostate cancer: Interactions of phytochemicals with androgen receptor prostate cancer mutant H874Y ligand binding domain.Urologic oncology1 mentions
- 2025A Pharmacoinformatics and Molecular Dynamics Approach to the Phytochemical Screening of Ficus hispida Fruits for Prostate Cancer Therapy.Current computer-aided drug design1 mentions
- 2024Structural insights into the mechanism of resistance to bicalutamide by the clinical mutations in androgen receptor in chemo-treatment resistant prostate cancer.Journal of biomolecular structure & dynamics1 mentions
- 2024Oral anticoagulant prescribing among patients with cancer and atrial fibrillation in England, 2009-2019.Cancer1 mentions
- 2024Possible prognostic impact of PKCι genetic variants in prostate cancer.Cancer cell international1 mentions
- 2024PTEN, ERG, SPINK1, and TFF3 Status and Relationship in a Prostate Cancer Cohort from Jordanian Arab Population.Medicina (Kaunas, Lithuania)1 mentions
- 2024The emerging role of non-coding RNAs in the Wnt/β-catenin signaling pathway in Prostate Cancer.Pathology, research and practice1 mentions
- 2024Single nucleotide polymorphism within chromosome 8q24 is associated with prostate cancer development in Saudi Arabia.Asian journal of urology1 mentions
- 2024Overcoming chemoresistance and radio resistance in prostate cancer: The emergent role of non-coding RNAs.Pathology, research and practice1 mentions
- 2024CRISPR/Cas9 model of prostate cancer identifies Kmt2c deficiency as a metastatic driver by Odam/Cabs1 gene cluster expression.Nature communications1 mentions
- 2024Cell Membrane-Camouflaged Chitosan-Polypyrrole Nanogels Co-Deliver Drug and Gene for Targeted Chemotherapy and Bone Metastasis Inhibition of Prostate Cancer.Advanced healthcare materials1 mentions
- 2024Activation of p53 signaling and regression of breast and prostate carcinoma cells by spirooxindole-benzimidazole small molecules.Frontiers in pharmacology1 mentions
- 2024Assessment of Silver Nanoparticles Derived from Brown Algae Sargassum vulgare: Insight into Antioxidants, Anticancer, Antibacterial and Hepatoprotective Effect.Marine drugs1 mentions
- 2024Unveiling the unexplored novel signatures for osteoporosis via a detailed bioinformatics and molecular experiments based approach.American journal of translational research1 mentions
- 2024CYP7B1 as a Biomarker for Prostate Cancer Risk and Progression: Metabolic and Oncogenic Signatures (Diagnostic Immunohistochemistry Analysis by Tissue Microarray in Prostate Cancer Patients-Diamond Study).International journal of molecular sciences1 mentions
- 2024Radiogenomics Map-Based Molecular and Imaging Phenotypical Characterization in Localised Prostate Cancer Using Pre-Biopsy Biparametric MR Imaging.International journal of molecular sciences1 mentions
- 2024Role of KDM2B epigenetic factor in regulating calcium signaling in prostate cancer cells.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society1 mentions
- 2024Effects of metformin on cancers in experimental and clinical studies: Focusing on autophagy and AMPK/mTOR signaling pathways.Cell biochemistry and function1 mentions
- 2024STIM1, ORAI1, and KDM2B in circulating tumor cells (CTCs) isolated from prostate cancer patients.Frontiers in cell and developmental biology1 mentions
- 2024Using multi-label ensemble CNN classifiers to mitigate labelling inconsistencies in patch-level Gleason grading.PloS one1 mentions
- 2024Epitranscriptomic mechanisms of androgen signalling and prostate cancer.Neoplasia (New York, N.Y.)1 mentions
- 2024Analyzing the mutational landscape of prostate cancer susceptibility genes through next-generation sequencing (NGS).American journal of translational research1 mentions
- 2024Phytochemical screening, HPLC fingerprinting and in vitro assessment of therapeutic potentials of different apricot cultivars against diabetes, Alzheimer's disease and cancer.Heliyon1 mentions
- 2024Cell Migration-Proliferation Dichotomy in Cancer: Biological Fact or Experimental Artefact?Biology1 mentions
- 2024Evidence of prostate cancer-linked virus zoonoses from biophysical genomic variations.PeerJ1 mentions
- 2024Efficacy of Next-Generation Sequencing in Identifying Genetic Markers for Prostate Cancer Risk.Journal of pharmacy & bioallied sciences1 mentions
- 2024Association between the expression of specific microRNAs and prostate cancer progression- a systematic review and meta-analysis.Frontiers in oncology1 mentions
- 2023Prostate cancer risk, screening and management in patients with germline BRCA1/2 mutations.Nature reviews. Urology1 mentions
- 2023Prostatic adenocarcinoma with transitional cell features among the Saudi Arabian population: a registry review.Annals of medicine and surgery (2012)1 mentions
- 2023Mutation pattern of cancer suppressor p53 gene in factory workers exposed to polypropylene and impact on their reproductive hormones.The journal of gene medicine1 mentions
- 2023The emerging role of MCPH1/BRIT1 in carcinogenesis.Frontiers in oncology1 mentions
- 2023Antiproliferative activity of antimicrobial peptides and bioactive compounds from the mangrove Glutamicibacter mysorens.Frontiers in microbiology1 mentions
- 2023Biosynthesis and characterization of polysaccharide-capped silver nanoparticles from Acalypha indica L. and evaluation of their biological activities.Environmental research1 mentions
- 2023The Prevalence of CHEK1 and CHEK2 Mutations in Prostate Cancer: a Retrospective Cohort Study.Medical archives (Sarajevo, Bosnia and Herzegovina)1 mentions
- 2023The association of genitourinary cancer among Saudi patients with gastrointestinal stromal tumors and a systematic literature review.Scientific reports1 mentions
- 2023BRCA1 and BRCA2 carriers with breast, ovarian and prostate cancer demonstrate a different pattern of metastatic disease compared with non-carriers: results from a rapid autopsy programme.Histopathology1 mentions
- 2023Radiogenomics Reveals Correlation between Quantitative Texture Radiomic Features of Biparametric MRI and Hypoxia-Related Gene Expression in Men with Localised Prostate Cancer.Journal of clinical medicine1 mentions
- 2023Prostate cancer and microRNAs: New insights into apoptosis.Pathology, research and practice1 mentions
- 2023Malignant function of nuclear factor-kappaB axis in prostate cancer: Molecular interactions and regulation by non-coding RNAs.Pharmacological research1 mentions
- 2023Chromosome-specific segment size alterations are determinants of prognosis in prostate cancer.Saudi journal of biological sciences1 mentions
- 2023PROTACs in the Management of Prostate Cancer.Molecules (Basel, Switzerland)1 mentions
- 2023An Update on Genetic Predisposition for Prostate Cancer: Perspectives and Prospects.Cellular and molecular biology (Noisy-le-Grand, France)1 mentions
- 2023Prognostic Values of Gene Copy Number Alterations in Prostate Cancer.Genes1 mentions
- 2023Angiogenesis and prostate cancer: MicroRNAs comes into view.Pathology, research and practice1 mentions
- 2023GNL3 and PA2G4 as Prognostic Biomarkers in Prostate Cancer.Cancers1 mentions
- 2023Promising bioactive metabolites of mangrove inhabitant Streptomyces tauricus and prostate cancer PC3 cell inhibition by antimicrobial peptides.Frontiers in microbiology1 mentions
- 2023A thorough understanding of the role of lncRNA in prostate cancer pathogenesis; Current knowledge and future research directions.Pathology, research and practice1 mentions
- 2023Glucocorticoid Receptor Regulates and Interacts with LEDGF/p75 to Promote Docetaxel Resistance in Prostate Cancer Cells.Cells1 mentions
- 2023The active phthalate metabolite, DHEP, induces proliferation and metastasis of prostate cancer cells via upregulation of β-catenin and downregulation of KLF7.Bioorganic chemistry1 mentions
- 2023Common Cancer Types and Risk of Stroke and Bleeding in Patients With Nonvalvular Atrial Fibrillation: A Population-Based Study in England.Journal of the American Heart Association1 mentions
- 2023Exploring GAS5's impact on prostate cancer: Recent discoveries and emerging paradigms.Pathology, research and practice1 mentions
- 2023Phytosterols activating nuclear receptors are involving in steroid hormone-dependent cancers: Myth or fact?Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie1 mentions
- 2023Exploring the role of lncrna neat1 knockdown in regulating apoptosis across multiple cancer types: A review.Pathology, research and practice1 mentions
- 2023Calcium Activation of the Androgen Receptor in Prostate Cells.International journal of endocrinology1 mentions
- 2023Aloe-emodin exhibits growth-suppressive effects on androgen-independent human prostate cancer DU145 cells via inhibiting the Wnt/β-catenin signaling pathway: an in vitro and in silico study.Frontiers in pharmacology1 mentions
- 2022Splice-disrupt genomic variants in prostate cancer.Molecular biology reports1 mentions
- 2022Quantifying Tumor Heterogeneity from Multiparametric Magnetic Resonance Imaging of Prostate Using Texture Analysis.Cancers1 mentions
- 2022Management of Patients with Advanced Prostate Cancer: Report from the Advanced Prostate Cancer Consensus Conference 2021.European urology1 mentions
- 2022Identification of Potential Key Genes in Prostate Cancer with Gene Expression, Pivotal Pathways and Regulatory Networks Analysis Using Integrated Bioinformatics Methods.Genes1 mentions
- 2022Prostate cancer in the Arab world: Bibliometric review and research priority recommendations.Arab journal of urology1 mentions
- 2022Chemopreventive Potential of Dietary Nanonutraceuticals for Prostate Cancer: An Extensive Review.Frontiers in oncology1 mentions
- 2022A patient-driven clinicogenomic partnership for metastatic prostate cancer.Cell genomics1 mentions