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Every result shows the extracted entities next to the sentences that support them; rows for the searched entities come first.
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Phenotype
HIV infection
146articles
146mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Effect of First-Line Antituberculosis Therapy on Nevirapine Pharmacokinetics in Children Younger than Three Years Old.
PMID 31332062 | PMCID PMC6761507 | DOI 10.1128/AAC.00839-19 · Antimicrobial agents and chemotherapy · 2019 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| phenotype | HIV infection | “While the mean difference in nevirapine PK parameters between the two groups was not significant (P > 0.05), 14/23 (61%) of the children with TB-HIV coinfection and 9/30 (30%) with HIV infection had a nevirapine minimum concentration (Cmin) below the proposed target of 3.0 mg/liter (P = 0.03).” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | 516G>T | “In multivariate analysis, anti-TB therapy and the CYP2B6 516G>T genotype were joint predictors of nevirapine PK parameters.” | 0.82 | literature_variant_regex_v2 |
| gene | CYP2B6 | “In multivariate analysis, anti-TB therapy and the CYP2B6 516G>T genotype were joint predictors of nevirapine PK parameters.” | 0.98 | hgnc_dict_v1 |
| phenotype | tuberculosis | “Nevirapine-based antiretroviral therapy (ART) is one of the limited options in HIV-infected children younger than 3 years old (young children) with tuberculosis (TB) coinfection.” | 0.98 | phenotype_alias_lexicon_v2 |