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Phenotype
Breast cancer
1,211articles
1,211mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60TLR-4 genetic variants as predictive biomarkers for susceptibility and clinical outcomes in triple-negative breast cancer: A case control study.
PMID 40550344 | DOI 10.1016/j.gene.2025.149643 · Gene · 2025 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| phenotype | breast cancer | “TLR-4 genetic variants as predictive biomarkers for susceptibility and clinical outcomes in triple-negative breast cancer: A case control study.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | rs2770150 | “Genotyping of rs2770150, rs2149356, rs1554973, and rs7856729 TLR-4 variants was done by real-time PCR.” | 0.90 | hgvs_regex_v1 |
| gene | MAF | “RESULTS: The significantly reduced minor allele (MAF) and genotype frequencies of rs1554973 were revealed in women with BC, and a dose-dependent decrease in the BC risk was identified among women with rs1554973 genotypes.” | 0.98 | hgnc_dict_v1 |
| variant | rs2149356 | “Genotyping of rs2770150, rs2149356, rs1554973, and rs7856729 TLR-4 variants was done by real-time PCR.” | 0.90 | hgvs_regex_v1 |
Toll-like receptor 4 as a predictor of clinical outcomes of estrogen receptor-negative breast cancer in Saudi women.
PMID 28280355 | PMCID PMC5338938 | DOI 10.2147/OTT.S112165 · OncoTargets and therapy · 2017 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| phenotype | breast cancer | “Toll-like receptor 4 as a predictor of clinical outcomes of estrogen receptor-negative breast cancer in Saudi women.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | rs2770150 | “Four TLR-4 polymorphisms (rs2770150, rs10759931, rs10759932, and rs4986790) were studied using 127 breast cancer patients and 117 controls.” | 0.90 | hgvs_regex_v1 |
| population | Saudi Arabia | “Toll-like receptor 4 as a predictor of clinical outcomes of estrogen receptor-negative breast cancer in Saudi women. The aim of this study was to investigate the association of the common polymorphisms of Toll-like receptor 4 (TLR-4) with breast cancer development in the Saudi Arabian population. Four TLR-4 polymorphisms (rs2770150, rs10759931, rs10759932, and rs4986790) were studied using 127 breast cancer patients and 117 controls.” | 0.95 | saudi_context_rules_v1 |
| variant | rs10759931 | “Four TLR-4 polymorphisms (rs2770150, rs10759931, rs10759932, and rs4986790) were studied using 127 breast cancer patients and 117 controls.” | 0.90 | hgvs_regex_v1 |