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Phenotype
Hypertension
828articles
828mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
3 records shown · first 60Association of MTHFR C677T and A1298C gene polymorphisms with hypertension.
PMID 23267299 | PMCID PMC3523778 | DOI 10.12816/0005968 · International journal of health sciences · 2012 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| phenotype | hypertension | “Association of MTHFR C677T and A1298C gene polymorphisms with hypertension.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | C677T | “Association of MTHFR C677T and A1298C gene polymorphisms with hypertension.” | 0.82 | literature_variant_regex_v2 |
| gene | MTHFR | “Association of MTHFR C677T and A1298C gene polymorphisms with hypertension.” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “The same was observed among cases-subgroups of hypertension associated with obesity with a notably higher odds ratio (OR=2.6, 95% CI=1.3-5.01, p=0.004).” | 0.98 | phenotype_alias_lexicon_v2 |
Case-control Study of methylenetetrahydrofolate reductase mutations and hyperhomocysteinemia and risk of stroke.
PMID 19717029 | DOI 10.1016/j.jstrokecerebrovasdis.2008.12.003 · Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2009 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| phenotype | hypertension | “In addition to hypertension, the significant predictors for stroke were MTHFR 677CT and TT and A1298CC genotypes, together with hyperhomocysteinemia, indicating a synergistic effect of MTHFR mutations with elevated homocysteine and other risk factors in pathogenesis of stroke.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | C677T | “The association of factor V-Leiden and methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C mutations with stroke was investigated in 118 patients with stroke and 120 control subjects.” | 0.82 | literature_variant_regex_v2 |
| gene | MTHFR | “The association of factor V-Leiden and methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C mutations with stroke was investigated in 118 patients with stroke and 120 control subjects.” | 0.98 | hgnc_dict_v1 |
| phenotype | stroke | “Case-control Study of methylenetetrahydrofolate reductase mutations and hyperhomocysteinemia and risk of stroke.” | 0.98 | phenotype_alias_lexicon_v2 |
Thrombophilia in young patients with acute myocardial infarction.
PMID 18176672 · Saudi medical journal · 2008 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| phenotype | hypertension | “RESULTS: There were statistically significant differences in terms of obesity, smoking, triglyceride, total cholesterol, high-density lipoprotein, high-density lipoprotein, and very-low-density lipoprotein cholesterol, family history, hypertension, diabetes, and left ventricular hypertrophy between patients and controls.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | C677T | “Traditional risk factors of CAD and protein C, S, antithrombin III deficiencies, factor V Leiden (FV Leiden), prothrombin G20210A and methylenetetrahydrofolate reductase (MTHFR) C677T mutations were investigated.” | 0.82 | literature_variant_regex_v2 |
| gene | MTHFR | “Traditional risk factors of CAD and protein C, S, antithrombin III deficiencies, factor V Leiden (FV Leiden), prothrombin G20210A and methylenetetrahydrofolate reductase (MTHFR) C677T mutations were investigated.” | 0.98 | hgnc_dict_v1 |
| phenotype | myocardial infarction | “Thrombophilia in young patients with acute myocardial infarction.” | 0.98 | phenotype_alias_lexicon_v2 |