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Phenotype
Hypertension
828articles
828mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Clinical Utility of Amplification Refractory Mutation System-Based PCR and Mutation-Specific PCR for Precise and Rapid Genotyping of Angiotensin-Converting Enzyme 1 (ACE1-rs4646996 D>I) and Angiotensin-Converting Enzyme 2 (ACE2-rs4240157T>C) Gene Variations in Coronary Artery Disease and Their Strong Association with Its Disease Susceptibility and Progression.
PMID 35741131 | PMCID PMC9222124 | DOI 10.3390/diagnostics12061321 · Diagnostics (Basel, Switzerland) · 2022 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| phenotype | hypertension | “Our results revealed that there was a significant correlation between ACE2-I/D genotypes and hypertension, T2D, and obesity (p < 0.05).” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | rs4646994 | “We utilized T-ARMS for the precise and rapid genotyping of ACE2-rs4240157; rs4646994.” | 0.90 | hgvs_regex_v1 |
| gene | ACE2 | “The results show that ACE2 (angiotensin I-converting enzyme 2) might act as a protective protein for cardiovascular diseases; however, only a few studies in human populations have been carried out.” | 0.98 | hgnc_dict_v1 |
| phenotype | coronary artery disease | “Clinical Utility of Amplification Refractory Mutation System-Based PCR and Mutation-Specific PCR for Precise and Rapid Genotyping of Angiotensin-Converting Enzyme 1 (ACE1-rs4646996 D>I) and Angiotensin-Converting Enzyme 2 (ACE2-rs4240157T>C) Gene Variations in Coronary Artery Disease and Their Strong Association with Its Disease Susceptibility and Progression.” | 0.98 | phenotype_alias_lexicon_v2 |
Strong Association of Angiotensin Converting Enzyme-2 Gene Insertion/Deletion Polymorphism with Susceptibility to SARS-CoV-2, Hypertension, Coronary Artery Disease and COVID-19 Disease Mortality.
PMID 34834450 | PMCID PMC8621157 | DOI 10.3390/jpm11111098 · Journal of personalized medicine · 2021 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| phenotype | hypertension | “Strong Association of Angiotensin Converting Enzyme-2 Gene Insertion/Deletion Polymorphism with Susceptibility to SARS-CoV-2, Hypertension, Coronary Artery Disease and COVID-19 Disease Mortality.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | rs4646994 | “In the present study, we hypothesize that a functional insertion/deletion polymorphism-rs4646994 I/D and rs4240157 T > C in the ACE gene could be associated with SARS-CoV-2 infection and mortality.” | 0.90 | hgvs_regex_v1 |
| gene | ACE2 | “Several reports have highlighted the importance of ACE2 on the pathogenesis of COVID-19.” | 0.98 | hgnc_dict_v1 |
| gene | ACE | “In the present study, we hypothesize that a functional insertion/deletion polymorphism-rs4646994 I/D and rs4240157 T > C in the ACE gene could be associated with SARS-CoV-2 infection and mortality.” | 0.98 | hgnc_dict_v1 |