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Phenotype
Hypertension
828articles
828mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Angiotensinogen Gene Missense Polymorphisms (rs699 and rs4762): The Association of End-Stage Renal Failure Risk with Type 2 Diabetes and Hypertension in Egyptians.
PMID 33668947 | PMCID PMC7996594 | DOI 10.3390/genes12030339 · Genes · 2021 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| phenotype | hypertension | “Angiotensinogen Gene Missense Polymorphisms (rs699 and rs4762): The Association of End-Stage Renal Failure Risk with Type 2 Diabetes and Hypertension in Egyptians.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | rs699 | “Angiotensinogen Gene Missense Polymorphisms (rs699 and rs4762): The Association of End-Stage Renal Failure Risk with Type 2 Diabetes and Hypertension in Egyptians.” | 0.90 | hgvs_regex_v1 |
| gene | AGT | “Gene polymorphisms linked to the renin-angiotensin (AGT)-aldosterone system (RAAS) were broadly inspected in patients with diabetic nephropathy (DN) and hypertension.” | 0.98 | hgnc_dict_v1 |
| phenotype | renal failure | “Angiotensinogen Gene Missense Polymorphisms (rs699 and rs4762): The Association of End-Stage Renal Failure Risk with Type 2 Diabetes and Hypertension in Egyptians.” | 0.98 | phenotype_alias_lexicon_v2 |
Association of the angiotensinogen gene polymorphism with atherosclerosis and its risk traits in the Saudi population.
PMID 23497386 | PMCID PMC3605175 | DOI 10.1186/1471-2261-13-17 · BMC cardiovascular disorders · 2013 · 12 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| phenotype | hypertension | “In this study, we employed TaqMan genotyping assays to evaluate the role of 8 AGT variants in primary hypertension (HTN), type 2 diabetes mellitus (T2DM), and obesity as a possible trigger of coronary artery disease (CAD) in a population of 4615 angiographed native Saudi individuals.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | rs699 | “RESULTS: Six variants, rs2067853 GG [Odds ratio(95% Confidence Interval) = 1.44(1.17-1.78); p = 0.001], rs7079 [1.49(1.20-1.85); p < 0.0001], rs699 G [1.19(1.08-1.13); p < 0.0001], rs3789679 A [1.51(1.14-1.99); p = 0.004], rs2148582 GG [1.31(1.11-1.55); p = 0.002] and rs5051 TC + CC [1.32(1.13-1.60); p = 0.001] conferred risk for HTN (3521 cases versus 1094 controls).” | 0.90 | hgvs_regex_v1 |
| phenotype | coronary artery disease | “In this study, we employed TaqMan genotyping assays to evaluate the role of 8 AGT variants in primary hypertension (HTN), type 2 diabetes mellitus (T2DM), and obesity as a possible trigger of coronary artery disease (CAD) in a population of 4615 angiographed native Saudi individuals.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | diabetes mellitus | “In this study, we employed TaqMan genotyping assays to evaluate the role of 8 AGT variants in primary hypertension (HTN), type 2 diabetes mellitus (T2DM), and obesity as a possible trigger of coronary artery disease (CAD) in a population of 4615 angiographed native Saudi individuals.” | 0.98 | phenotype_alias_lexicon_v2 |