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Phenotype
Infertility
199articles
199mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Impact of CYP2A6 genetic polymorphism on letrozole efficacy in Iraqi women with polycystic ovary syndrome.
PMID 40687181 | PMCID PMC12272899 | DOI 10.1016/j.jtumed.2025.06.009 · Journal of Taibah University Medical Sciences · 2025 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| phenotype | infertility | “OBJECTIVES: This study investigated the effects of a genetic polymorphism in CYP2A6 (CYP2A6∗2, 1799T>A) on the therapeutic response to letrozole in Iraqi women with polycystic ovarian syndrome (PCOS)-induced infertility.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | 1799T>A | “OBJECTIVES: This study investigated the effects of a genetic polymorphism in CYP2A6 (CYP2A6∗2, 1799T>A) on the therapeutic response to letrozole in Iraqi women with polycystic ovarian syndrome (PCOS)-induced infertility.” | 0.82 | literature_variant_regex_v2 |
| gene | CYP2A6 | “Impact of CYP2A6 genetic polymorphism on letrozole efficacy in Iraqi women with polycystic ovary syndrome.” | 0.98 | hgnc_dict_v1 |
| variant | rs1801272 | “Genotyping of CYP2A6∗2 (1799T>A, rs1801272) was performed using allele-specific PCR on blood-derived DNA, and the distribution of wild-type (AA), heterozygous (AT), and mutant (TT) alleles was recorded.” | 0.90 | hgvs_regex_v1 |