Advanced search

Combine gene, variant, phenotype, region and year filters

Every result shows the extracted entities next to the sentences that support them; rows for the searched entities come first.

Transparent by designEvery result links extracted entities to its source sentence and publication identifier.

Knowledge-base search

About your search

Phenotype

Leukemia

652articles

652mentions

12co-reported genes shown

Most co-reported genes (articles)

Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.

1 records shown · first 60

PMID 41821663 | PMCID PMC12976224 | DOI 10.1007/s13205-026-04753-8 · 3 Biotech · 2026 · 5 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
phenotype	leukemia	“IDH enzyme inhibition in cancer therapy: mechanisms, mutational insights, and effects of IDH inhibitors in glioma, acute myeloid leukemia and chondrosarcoma.”	0.98	phenotype_alias_lexicon_v2
variant	D279N	“In contrast, targeting specific IDH mutant with IDH inhibitors is associated with challenging and heterogenous outcome, as it causes resistance mechanisms such as isoform switching (From IDH 1-2 and vice versa), secondary mutations (D279N, S280F) and metabolic bypass, although these inhibitors are often well-tolerated with manageable side effects.”	0.82	literature_variant_regex_v2
gene	IDH1	“The functions of IDH1 and 2 under normal and cancer conditions are distinct from those of IDH3, although IDH1 and 2 are known to play a crucial role in cancer.”	0.98	hgnc_dict_v1
phenotype	breast cancer	“On the other hand, wild type IDH itself acts as an oncogene when overexpressed, via, enhancing HIF1α signalling driven through Warburg effect, increasing tumor cell proliferation through prevention of oxidative stress response and inhibiting ferroptosis pathway, as reported in various cancers, including lung and breast cancer.”	0.98	phenotype_alias_lexicon_v2