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Phenotype
Leukemia
652articles
652mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60A case-control study in NAT2 gene polymorphism studies in patients diagnosed with acute myeloid leukemia.
PMID 37715989 | DOI 10.18388/abp.2020_6235 · Acta biochimica Polonica · 2023 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| phenotype | leukemia | “A case-control study in NAT2 gene polymorphism studies in patients diagnosed with acute myeloid leukemia.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | G857A | “AIM: In this case-control study, C481T (rs1799929) and G857A (rs1799931) polymorphism studies were investigated in diagnosed AML patients in the Saudi population.” | 0.82 | literature_variant_regex_v2 |
| gene | NAT2 | “A case-control study in NAT2 gene polymorphism studies in patients diagnosed with acute myeloid leukemia.” | 0.98 | hgnc_dict_v1 |
| population | Saudi Arabia | “AIM: In this case-control study, C481T (rs1799929) and G857A (rs1799931) polymorphism studies were investigated in diagnosed AML patients in the Saudi population. METHODS: This case-control study included 100 AML patients and 100 control subjects recruited in Saudi Arabia.” | 0.95 | saudi_context_rules_v1 |
Evaluation of Genetic Polymorphisms of N-acetyltransferase 2 and Relation with Chronic Myeloid Leukemia.
PMID 33369472 | PMCID PMC8046315 | DOI 10.31557/APJCP.2020.21.12.3711 · Asian Pacific journal of cancer prevention : APJCP · 2020 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| phenotype | leukemia | “Evaluation of Genetic Polymorphisms of N-acetyltransferase 2 and Relation with Chronic Myeloid Leukemia.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | G857A | “The study indicated that the heterozygous (GA) and mutant (AA) variants of the G857A genotype also offer protection, (OR = 0.002, 95% CI: 0.002-0.019, p = 0.” | 0.82 | literature_variant_regex_v2 |
| gene | NAT2 | “OBJECTIVES: The N-Acetyltransferase 2 (NAT2) gene encodes a key enzyme involved in xenobiotic metabolism, which contributes to the detoxification of numerous cancer therapy-induced products.” | 0.98 | hgnc_dict_v1 |
| variant | C481T | “The aim of this study was to determine whether its polymorphisms (C481T, G590A, 803A>G and 857G>A) have a role in chronic myeloid leukemia susceptibility (CML) in Sudanese population.” | 0.82 | literature_variant_regex_v2 |