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Every result shows the extracted entities next to the sentences that support them; rows for the searched entities come first.
Transparent by designEvery result links extracted entities to its source sentence and publication identifier.
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Phenotype
Lung cancer
398articles
398mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Transcriptomic and multi-layer variant analysis identifies STAT3 and HIF1A as central regulators of regulated cell death pathways in lung squamous cell carcinoma.
PMID 41714375 | DOI 10.1007/s00210-026-05103-4 · Naunyn-Schmiedeberg's archives of pharmacology · 2026 · 14 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| phenotype | lung cancer | “Lung squamous cell carcinoma (LUSC) remains one of the most aggressive subtypes of non-small cell lung cancer (NSCLC), characterized by high mortality, therapeutic resistance, and molecular heterogeneity.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | C712R | “Variant analysis further revealed high-impact deleterious nsSNPs in both STAT3 (C712R; rs193922722 and Q633L; rs2144684101) and HIF1A (C255G; rs1242097924 and D55G; rs2044414353), each predicted to disrupt protein structural stability, metal-binding geometry, and interaction interfaces.” | 0.82 | literature_variant_regex_v2 |
| gene | STAT3 | “Transcriptomic and multi-layer variant analysis identifies STAT3 and HIF1A as central regulators of regulated cell death pathways in lung squamous cell carcinoma.” | 0.98 | hgnc_dict_v1 |
| gene | HIF1A | “Transcriptomic and multi-layer variant analysis identifies STAT3 and HIF1A as central regulators of regulated cell death pathways in lung squamous cell carcinoma.” | 0.98 | hgnc_dict_v1 |