Advanced search
Combine gene, variant, phenotype, region and year filters
Every result shows the extracted entities next to the sentences that support them; rows for the searched entities come first.
Transparent by designEvery result links extracted entities to its source sentence and publication identifier.
Knowledge-base search
About your search
Phenotype
Prostate cancer
218articles
218mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Mutation pattern of cancer suppressor p53 gene in factory workers exposed to polypropylene and impact on their reproductive hormones.
PMID 36786034 | DOI 10.1002/jgm.3483 · The journal of gene medicine · 2023 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| phenotype | prostate cancer | “Epidemiological information indicated the relation of endocrine-disturbing chemicals with prostate cancer, testis tumor and diminished fertility. p53 is a key tumor silencer gene.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | R273H | “MD simulation of missense mutation R273H showed no structural impact on the protein structure in MD simulation, but it resulted in weaker binding of p53 with the DNA that might lower the gene expression of cell cycle regulatory proteins.” | 0.82 | literature_variant_regex_v2 |
| variant | g.13430C>T | “Sequencing results found three variants i.e. g.13450 T>G, g.13430C>T and g.13737G>A.” | 0.95 | hgvs_regex_v1 |
| variant | g.13737G>A | “Sequencing results found three variants i.e. g.13450 T>G, g.13430C>T and g.13737G>A.” | 0.95 | hgvs_regex_v1 |