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8 records shown · first 60Impact of ABCB1 gene polymorphism on clopidogrel plasma concentration and cardiovascular events in post-PCI patients.
PMID 40689604 | PMCID PMC13374772 | DOI 10.1080/14622416.2025.2534325 · Pharmacogenomics · 2026 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1045642 | “Plasma concentrations of CAM were measured by high-performance liquid chromatography (HPLC), while the ABCB1 gene (rs1045642) was genotyped by Sanger sequencing to determine associations between genetic variants, CAM levels, and clinical outcomes.” | 0.90 | hgvs_regex_v1 |
| gene | ABCB1 | “Impact of ABCB1 gene polymorphism on clopidogrel plasma concentration and cardiovascular events in post-PCI patients.” | 0.98 | hgnc_dict_v1 |
Pharmacogenetics as a Future Tool to Risk-Stratify Breast Cancer Patients According to Chemotoxicity Potential from the Doxorubicin Hydrochloride and Cyclophosphamide (AC) Regimen.
PMID 40283974 | PMCID PMC12029990 | DOI 10.3390/ph18040539 · Pharmaceuticals (Basel, Switzerland) · 2025 · 9 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1045642 | “Before receiving AC therapy, venous blood was collected from female patients with BC for DNA extraction and the genotyping of four SNPs: rs2228100 in ALDH3A1 gene, rs12248560 in CYP2C19 gene, rs1045642 in ABCB1 gene, and rs6907567 in SLC22A16 gene.” | 0.90 | hgvs_regex_v1 |
| gene | ALDH3A1 | “Before receiving AC therapy, venous blood was collected from female patients with BC for DNA extraction and the genotyping of four SNPs: rs2228100 in ALDH3A1 gene, rs12248560 in CYP2C19 gene, rs1045642 in ABCB1 gene, and rs6907567 in SLC22A16 gene.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “Before receiving AC therapy, venous blood was collected from female patients with BC for DNA extraction and the genotyping of four SNPs: rs2228100 in ALDH3A1 gene, rs12248560 in CYP2C19 gene, rs1045642 in ABCB1 gene, and rs6907567 in SLC22A16 gene.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “Before receiving AC therapy, venous blood was collected from female patients with BC for DNA extraction and the genotyping of four SNPs: rs2228100 in ALDH3A1 gene, rs12248560 in CYP2C19 gene, rs1045642 in ABCB1 gene, and rs6907567 in SLC22A16 gene.” | 0.98 | hgnc_dict_v1 |
Investigating the role of genetic variations of ABCB1 (rs1045642) and CYP7A1 (rs3808607) genes on serum lipid level among Malaysian male patients treated with atorvastatin.
PMID 40840956 | PMCID PMC12376158 | DOI 10.15537/smj.2025.46.8.20250310 · Saudi medical journal · 2025 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1045642 | “Investigating the role of genetic variations of ABCB1 (rs1045642) and CYP7A1 (rs3808607) genes on serum lipid level among Malaysian male patients treated with atorvastatin.” | 0.90 | hgvs_regex_v1 |
| gene | ABCB1 | “Investigating the role of genetic variations of ABCB1 (rs1045642) and CYP7A1 (rs3808607) genes on serum lipid level among Malaysian male patients treated with atorvastatin.” | 0.98 | hgnc_dict_v1 |
| gene | CYP7A1 | “Investigating the role of genetic variations of ABCB1 (rs1045642) and CYP7A1 (rs3808607) genes on serum lipid level among Malaysian male patients treated with atorvastatin.” | 0.98 | hgnc_dict_v1 |
| variant | rs3808607 | “Investigating the role of genetic variations of ABCB1 (rs1045642) and CYP7A1 (rs3808607) genes on serum lipid level among Malaysian male patients treated with atorvastatin.” | 0.90 | hgvs_regex_v1 |
Bleeding Events Associated with Rivaroxaban Therapy in Naive Patients with Nonvalvular Atrial Fibrillation: A Longitudinal Study from a Genetic Perspective with INR Follow-Up.
PMID 39459499 | PMCID PMC11509751 | DOI 10.3390/medicina60101712 · Medicina (Kaunas, Lithuania) · 2024 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1045642 | “Results: The heterozygous and homozygous mutant genotypes of ABCB1 (rs2032582, rs1045642, rs1128503, and rs4148738) and CYP3A5 (rs776746) showed lower plasma concentrations as compared to the wild-type genotype.” | 0.90 | hgvs_regex_v1 |
| gene | ABCB1 | “Rivaroxaban is a substrate for P-glycoprotein, which is encoded by the ABCB1 gene.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A5 | “Rivaroxaban is also metabolized by the CYP3A5 gene.” | 0.98 | hgnc_dict_v1 |
| phenotype | stroke | “Background and Objectives: Rivaroxaban is a direct-acting anticoagulant used to prevent stroke in patients with atrial fibrillation.” | 0.98 | phenotype_alias_lexicon_v2 |
Polymorphisms in the Drug Transporter Gene ABCB1 Are Associated with Drug Response in Saudi Epileptic Pediatric Patients.
PMID 37760947 | PMCID PMC10526247 | DOI 10.3390/biomedicines11092505 · Biomedicines · 2023 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1045642 | “The polymorphism variants of ABCB1 rs1128503 at exon 12, rs2032582 at exon 21, and rs1045642 at exon 26 were genotyped using the Sanger sequencing technique.” | 0.90 | hgvs_regex_v1 |
| gene | ABCB1 | “Polymorphisms in the Drug Transporter Gene ABCB1 Are Associated with Drug Response in Saudi Epileptic Pediatric Patients.” | 0.98 | hgnc_dict_v1 |
| phenotype | epilepsy | “Epilepsy is one of the most common chronic neurodisorders in the pediatric age group.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia, Jeddah | “Polymorphisms in the Drug Transporter Gene ABCB1 Are Associated with Drug Response in Saudi Epileptic Pediatric Patients. This multicentric, cross-sectional study was conducted among Saudi children with epilepsy in Jeddah, Saudi Arabia. The study included 85 children with epilepsy: 43 patients demonstrated a good response to ASMs, while 42 patients exhibited a poor response. In conclusion, this study represents the first pharmacogenetic investigation of the ABCB1 gene in Saudi epileptic pediatric patients and demonstrates a significant association between rs1045642 and rs2032582 variants and patient responsiveness.” | 0.95 | saudi_context_rules_v1 |
Association between ABCB1, ABCG2 carrier protein and COX-2 enzyme gene polymorphisms and breast cancer risk in a Turkish population.
PMID 32042261 | PMCID PMC7000306 | DOI 10.1016/j.jsps.2019.11.024 · Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2020 · 9 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1045642 | “METHOD: ABCG2 C421A (rs2231142), ABCB1 C3435T (rs1045642), COX-2 T8473C (rs5275) and COX-2 G306C (rs5277) were genotyped 104 breast cancer patients and 90 healthy controls using a real-time PCR for breast cancer susceptibility.” | 0.90 | hgvs_regex_v1 |
| gene | ABCB1 | “Association between ABCB1, ABCG2 carrier protein and COX-2 enzyme gene polymorphisms and breast cancer risk in a Turkish population.” | 0.98 | hgnc_dict_v1 |
| gene | ABCG2 | “Association between ABCB1, ABCG2 carrier protein and COX-2 enzyme gene polymorphisms and breast cancer risk in a Turkish population.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Association between ABCB1, ABCG2 carrier protein and COX-2 enzyme gene polymorphisms and breast cancer risk in a Turkish population.” | 0.98 | phenotype_alias_lexicon_v2 |
Role of Four ABC Transporter Genes in Pharmacogenetic Susceptibility to Breast Cancer in Jordanian Patients.
PMID 31391850 | PMCID PMC6662487 | DOI 10.1155/2019/6425708 · Journal of oncology · 2019 · 11 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1045642 | “With regard to the clinical characteristics of BC, the ABCC2 SNPs rs2273697 and rs717620 were found to be significantly associated with age at breast cancer diagnosis and breastfeeding status, while the ABCB1 SNP rs1045642 was significantly associated with age at breast cancer diagnosis.” | 0.90 | hgvs_regex_v1 |
| gene | ABCC1 | “In the present study, single nucleotide polymorphisms (SNPs) from the ABCC1, ABCC2, ABCB1, and ABCG2 genes were screened in breast cancer patients and healthy volunteers from the Jordanian-Arab population.” | 0.98 | hgnc_dict_v1 |
| gene | ABCC2 | “In the present study, single nucleotide polymorphisms (SNPs) from the ABCC1, ABCC2, ABCB1, and ABCG2 genes were screened in breast cancer patients and healthy volunteers from the Jordanian-Arab population.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “In the present study, single nucleotide polymorphisms (SNPs) from the ABCC1, ABCC2, ABCB1, and ABCG2 genes were screened in breast cancer patients and healthy volunteers from the Jordanian-Arab population.” | 0.98 | hgnc_dict_v1 |
The influence of polymorphisms in the drug transporter, ABCB1 on the toxicity of glucocorticoids in Saudi children with acute lymphoblastic leukaemia.
PMID 30508724 | DOI 10.1016/j.pharep.2018.09.010 · Pharmacological reports : PR · 2019 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1045642 | “METHODS: Three single nucleotide polymorphisms (SNPs) of the ABCB1 gene (rs 3213619 T129C, rs 2032582 G2677T and rs1045642 C3435T) were analysed in 70 Saudi children with ALL and 60 control subjects.” | 0.90 | hgvs_regex_v1 |
| gene | ABCB1 | “The influence of polymorphisms in the drug transporter, ABCB1 on the toxicity of glucocorticoids in Saudi children with acute lymphoblastic leukaemia.” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “The influence of polymorphisms in the drug transporter, ABCB1 on the toxicity of glucocorticoids in Saudi children with acute lymphoblastic leukaemia.” | 0.93 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “The influence of polymorphisms in the drug transporter, ABCB1 on the toxicity of glucocorticoids in Saudi children with acute lymphoblastic leukaemia. This study, the first of its kind in a Saudi population, investigates associations of ABCB1 gene polymorphisms (pharmacodynamics and pharmacokinetic) with the development of toxicity and side effects (glucose abnormality, liver toxicity and infection) in a small population of Saudi children with ALL. METHODS: Three single nucleotide polymorphisms (SNPs) of the ABCB1 gene (rs 3213619 T129C, rs 2032582 G2677T and rs1045642 C3435T) were analysed in 70 Saudi children with ALL and 60 control subjects.” | 0.95 | saudi_context_rules_v1 |