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3 records shown · first 60Genetic determinants of age-related macular degeneration in Middle Eastern populations: a systematic review.
PMID 42180516 | PMCID PMC13193682 | DOI 10.3389/fgene.2026.1776779 · Frontiers in genetics · 2026 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1061170 | “The CFH Y402H variant (rs1061170) showed overall positive but heterogeneous associations with AMD risk across studied Middle Eastern populations, with reported odds ratios ranging from 0.36 to 17.34 and statistically significant p values ranging from <0.001 to 0.02 (total AMD cases and controls = 2,079).” | 0.90 | hgvs_regex_v1 |
| gene | CFH | “The most frequently studied genes were CFH, ARMS2, and HTRA1.” | 0.98 | hgnc_dict_v1 |
| gene | ARMS2 | “The most frequently studied genes were CFH, ARMS2, and HTRA1.” | 0.98 | hgnc_dict_v1 |
| gene | HTRA1 | “The most frequently studied genes were CFH, ARMS2, and HTRA1.” | 0.98 | hgnc_dict_v1 |
Host genetics impact on SARS-CoV-2 vaccine-induced immunoglobulin levels and dynamics: The role of TP53, ABO, APOE, ACE2, HLA-A, and CRP genes.
PMID 36531241 | PMCID PMC9748098 | DOI 10.3389/fgene.2022.1028081 · Frontiers in genetics · 2022 · 26 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1061170 | “In addition to age (p < 0.01), sex (p = 0.03), and type of vaccine (p < 0.0001), which partially accounted for the remarkable individual differences observed in the antibody levels and dynamics, interesting genetic determinants appeared as significant modifiers of both IgG and NAb responses among the selected genes investigated (TP53, rs1042522; APOE, rs7412/rs429358; ABO, rs657152; ACE2, rs2285666; HLA-A rs2571381/rs2499; CRP, rs2808635/rs876538; LZTFL1, rs35044562; OAS3, rs10735079; SLC6A20, rs11385942; CFH, rs1061170; and ACE1, ins/del, rs4646994).” | 0.90 | hgvs_regex_v1 |
| gene | TP53 | “Host genetics impact on SARS-CoV-2 vaccine-induced immunoglobulin levels and dynamics: The role of TP53, ABO, APOE, ACE2, HLA-A, and CRP genes.” | 0.98 | hgnc_dict_v1 |
| gene | ABO | “Host genetics impact on SARS-CoV-2 vaccine-induced immunoglobulin levels and dynamics: The role of TP53, ABO, APOE, ACE2, HLA-A, and CRP genes.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “Host genetics impact on SARS-CoV-2 vaccine-induced immunoglobulin levels and dynamics: The role of TP53, ABO, APOE, ACE2, HLA-A, and CRP genes.” | 0.98 | hgnc_dict_v1 |
Complement factor H gene polymorphisms and vivax malaria associated thrombotic microangiopathy.
PMID 31031394 | DOI 10.4103/1319-2442.256865 · Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia · 2019 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1061170 | “The complement workup confirmed dysregulated ACP and revealed two single-nucleotide polymorphisms in CFH gene, i.e. exon-7 rs1061147 (p.Ala243Ala) and exon-9 rs1061170 (p.His402Tyr) which predisposed this patient to develop TMA precipitated by vivax malaria.” | 0.90 | hgvs_regex_v1 |
| gene | CFH | “Herein, we describe the presence of two complement factor H (CFH) variants in an 8-year-old female with vivax malaria associated TMA.” | 0.98 | hgnc_dict_v1 |
| phenotype | malaria | “Complement factor H gene polymorphisms and vivax malaria associated thrombotic microangiopathy.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | p.Ala243Ala | “The complement workup confirmed dysregulated ACP and revealed two single-nucleotide polymorphisms in CFH gene, i.e. exon-7 rs1061147 (p.Ala243Ala) and exon-9 rs1061170 (p.His402Tyr) which predisposed this patient to develop TMA precipitated by vivax malaria.” | 0.95 | hgvs_regex_v1 |