Advanced search
Combine gene, variant, phenotype, region and year filters
Every result shows the extracted entities next to the sentences that support them; rows for the searched entities come first.
Transparent by designEvery result links extracted entities to its source sentence and publication identifier.
Knowledge-base search
Publications
5 records shown · first 60Association of NLRP3 Inflammasome rs10754558 Polymorphism with Type 2 Diabetes Mellitus and Its Complications: Clinical and Bioinformatics Study.
PMID 41836362 | PMCID PMC12988750 | DOI 10.2147/DMSO.S586787 · Diabetes, metabolic syndrome and obesity : targets and therapy · 2026 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs10754558 | “Association of NLRP3 Inflammasome rs10754558 Polymorphism with Type 2 Diabetes Mellitus and Its Complications: Clinical and Bioinformatics Study.” | 0.90 | hgvs_regex_v1 |
| gene | NLRP3 | “Association of NLRP3 Inflammasome rs10754558 Polymorphism with Type 2 Diabetes Mellitus and Its Complications: Clinical and Bioinformatics Study.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Association of NLRP3 Inflammasome rs10754558 Polymorphism with Type 2 Diabetes Mellitus and Its Complications: Clinical and Bioinformatics Study.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “METHODS: In this case control study, 250 T2DM cases and 150 matched-age and gender healthy subjects were genotyped for rs10754558. CONCLUSION: The NLRP3 rs10754558 C allele was associated with higher risk of T2DM and vascular complications in Saudi patients and correlated with elevated NLRP3 and IL-1β levels.” | 0.95 | saudi_context_rules_v1 |
Association of NLRP3 rs10754558 polymorphism with inflammasome-related cytokine responses in chronic spontaneous urticaria.
PMID 42183250 | PMCID PMC13194015 | DOI 10.3389/fimmu.2026.1804228 · Frontiers in immunology · 2026 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs10754558 | “Association of NLRP3 rs10754558 polymorphism with inflammasome-related cytokine responses in chronic spontaneous urticaria.” | 0.90 | hgvs_regex_v1 |
| gene | NLRP3 | “Association of NLRP3 rs10754558 polymorphism with inflammasome-related cytokine responses in chronic spontaneous urticaria.” | 0.98 | hgnc_dict_v1 |
Association of polymorphism of NLRP3, ICAM-1, PTPN22, INS genes in childhood onset type 1 diabetes in a Pakistani population.
PMID 39425874 | DOI 10.1007/s11033-024-09983-8 · Molecular biology reports · 2024 · 13 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs10754558 | “The polymorphisms in PTPN22 (rs601, rs33996649, rs2488457), INS (rs80356664), NLRP3 (rs10754558, rs35829419), and ICAM-1 (rs1799969, rs5498) genes were genotyped by Sanger sequencing.” | 0.90 | hgvs_regex_v1 |
| gene | NLRP3 | “Association of polymorphism of NLRP3, ICAM-1, PTPN22, INS genes in childhood onset type 1 diabetes in a Pakistani population.” | 0.98 | hgnc_dict_v1 |
| gene | PTPN22 | “Association of polymorphism of NLRP3, ICAM-1, PTPN22, INS genes in childhood onset type 1 diabetes in a Pakistani population.” | 0.98 | hgnc_dict_v1 |
| gene | INS | “Association of polymorphism of NLRP3, ICAM-1, PTPN22, INS genes in childhood onset type 1 diabetes in a Pakistani population.” | 0.98 | hgnc_dict_v1 |
NLRP3 (rs10754558) gene polymorphism and tumor necrosis factor alpha as predictors for disease activity and response to methotrexate and adalimumab in psoriasis.
PMID 38965465 | PMCID PMC11223426 | DOI 10.1186/s12865-024-00630-2 · BMC immunology · 2024 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs10754558 | “NLRP3 (rs10754558) gene polymorphism and tumor necrosis factor alpha as predictors for disease activity and response to methotrexate and adalimumab in psoriasis.” | 0.90 | hgvs_regex_v1 |
| gene | NLRP3 | “NLRP3 (rs10754558) gene polymorphism and tumor necrosis factor alpha as predictors for disease activity and response to methotrexate and adalimumab in psoriasis.” | 0.98 | hgnc_dict_v1 |
| gene | CRP | “Evaluation of the NLRP3 gene polymorphism, the serum level of CRP and TNFα in psoriasis patients and assessment of the NLRP3 (rs10754558) gene polymorphism, CRP and TNFα with disease severity and their role as biomarkers for response to Methotrexate and Adalimumab in psoriasis.” | 0.98 | hgnc_dict_v1 |
Evaluation of NLRP3 (rs10754558) and PTPN22 (1858C/T) (rs2476601) Functional Polymorphisms in Psoriasis Susceptibility in Egypt.
PMID 34345180 | PMCID PMC8324977 | DOI 10.2147/TACG.S319065 · The application of clinical genetics · 2021 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs10754558 | “Evaluation of NLRP3 (rs10754558) and PTPN22 (1858C/T) (rs2476601) Functional Polymorphisms in Psoriasis Susceptibility in Egypt.” | 0.90 | hgvs_regex_v1 |
| gene | NLRP3 | “Evaluation of NLRP3 (rs10754558) and PTPN22 (1858C/T) (rs2476601) Functional Polymorphisms in Psoriasis Susceptibility in Egypt.” | 0.98 | hgnc_dict_v1 |
| gene | PTPN22 | “Evaluation of NLRP3 (rs10754558) and PTPN22 (1858C/T) (rs2476601) Functional Polymorphisms in Psoriasis Susceptibility in Egypt.” | 0.98 | hgnc_dict_v1 |
| variant | rs2476601 | “Evaluation of NLRP3 (rs10754558) and PTPN22 (1858C/T) (rs2476601) Functional Polymorphisms in Psoriasis Susceptibility in Egypt.” | 0.90 | hgvs_regex_v1 |