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4 records shown · first 60Common variants in toll-like receptor family genes and risk of gastric cancer: a systematic review and meta-analysis.
PMID 38090147 | PMCID PMC10715274 | DOI 10.3389/fgene.2023.1280051 · Frontiers in genetics · 2023 · 15 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs10759932 | “No significant association was detected for TLR-2-196 to -174de (Delta22), TLR-2 rs3804100, TLR-4 rs11536889, TLR-4 rs11536878, TLR-4 rs2770150, TLR-4 rs10116253, TLR-4 rs1927911, TLR-4 rs10983755, TLR-4 rs10759932, TLR-4 rs1927914, and TLR-10 rs10004195.” | 0.90 | hgvs_regex_v1 |
| phenotype | gastric cancer | “Common variants in toll-like receptor family genes and risk of gastric cancer: a systematic review and meta-analysis.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | rs4986790 | “Variations in TLR-4 rs4986790, TLR-4 rs4986791, TLR-5 rs5744174, and TLR-9 rs187084 were significantly associated with increased risk of GC in different genetic models.” | 0.90 | hgvs_regex_v1 |
| variant | rs4986791 | “Variations in TLR-4 rs4986790, TLR-4 rs4986791, TLR-5 rs5744174, and TLR-9 rs187084 were significantly associated with increased risk of GC in different genetic models.” | 0.90 | hgvs_regex_v1 |
Association of toll-like receptor 4, 5 and 10 polymorphisms with Helicobacter pylori-positive peptic ulcer disease in a center in Jordan.
PMID 34420402 | PMCID PMC8380278 | DOI 10.5144/0256-4947.2021.206 · Annals of Saudi medicine · 2021 · 12 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs10759932 | “OBJECTIVE: Investigate the susceptibility and severity of H pylori infection with host TLR4 (rs11536889, rs4986790, rs200109652, rs10759932), TLR5 (rs5744174, rs2072493, rs746250566), TLR10 (rs559182335, rs10004195) polymorphisms.” | 0.90 | hgvs_regex_v1 |
| gene | TLR4 | “Polymorphisms in host genes such as the toll-like receptor 4 (TLR4) might affect the susceptibility and severity of infection and treatment success.” | 0.98 | hgnc_dict_v1 |
| gene | TLR5 | “OBJECTIVE: Investigate the susceptibility and severity of H pylori infection with host TLR4 (rs11536889, rs4986790, rs200109652, rs10759932), TLR5 (rs5744174, rs2072493, rs746250566), TLR10 (rs559182335, rs10004195) polymorphisms.” | 0.98 | hgnc_dict_v1 |
| gene | TLR10 | “OBJECTIVE: Investigate the susceptibility and severity of H pylori infection with host TLR4 (rs11536889, rs4986790, rs200109652, rs10759932), TLR5 (rs5744174, rs2072493, rs746250566), TLR10 (rs559182335, rs10004195) polymorphisms.” | 0.98 | hgnc_dict_v1 |
Toll-like receptor 4 as a predictor of clinical outcomes of estrogen receptor-negative breast cancer in Saudi women.
PMID 28280355 | PMCID PMC5338938 | DOI 10.2147/OTT.S112165 · OncoTargets and therapy · 2017 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs10759932 | “Four TLR-4 polymorphisms (rs2770150, rs10759931, rs10759932, and rs4986790) were studied using 127 breast cancer patients and 117 controls.” | 0.90 | hgvs_regex_v1 |
| phenotype | breast cancer | “Toll-like receptor 4 as a predictor of clinical outcomes of estrogen receptor-negative breast cancer in Saudi women.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “Toll-like receptor 4 as a predictor of clinical outcomes of estrogen receptor-negative breast cancer in Saudi women. The aim of this study was to investigate the association of the common polymorphisms of Toll-like receptor 4 (TLR-4) with breast cancer development in the Saudi Arabian population. Four TLR-4 polymorphisms (rs2770150, rs10759931, rs10759932, and rs4986790) were studied using 127 breast cancer patients and 117 controls.” | 0.95 | saudi_context_rules_v1 |
| variant | rs2770150 | “Four TLR-4 polymorphisms (rs2770150, rs10759931, rs10759932, and rs4986790) were studied using 127 breast cancer patients and 117 controls.” | 0.90 | hgvs_regex_v1 |
Expression and Polymorphism of Toll-Like Receptor 4 and Effect on NF-κB Mediated Inflammation in Colon Cancer Patients.
PMID 26771524 | PMCID PMC4714746 | DOI 10.1371/journal.pone.0146333 · PloS one · 2016 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs10759932 | “TLR4 (rs4986790, rs10759932, rs10759931 and rs2770150) were genotyped in blood samples from Colorectal patients and healthy controls.” | 0.90 | hgvs_regex_v1 |
| gene | TLR4 | “Our aim was to evaluate the association between the expression and the polymorphism of TLR4/NF-κB pathways and colon cancer.” | 0.98 | hgnc_dict_v1 |
| phenotype | colorectal cancer | “Expression and Polymorphism of Toll-Like Receptor 4 and Effect on NF-κB Mediated Inflammation in Colon Cancer Patients.” | 0.93 | phenotype_alias_lexicon_v2 |
| variant | rs4986790 | “TLR4 (rs4986790, rs10759932, rs10759931 and rs2770150) were genotyped in blood samples from Colorectal patients and healthy controls.” | 0.90 | hgvs_regex_v1 |