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3 records shown · first 60Association of MBL2 gene polymorphisms with pulmonary tuberculosis susceptibility: trial sequence meta-analysis as evidence.
PMID 30666135 | PMCID PMC6333159 | DOI 10.2147/IDR.S188980 · Infection and drug resistance · 2019 · 9 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs11003125 | “Conflictingly, a number of MBL2 variants, rs1800450 (A>B), rs1800451 (A>C), rs5030737 (A>D), rs7096206 (Y>X), rs11003125 (H>L), and rs7095891 (P>Q) allele, have been found to be associated with compromised serum levels and pulmonary tuberculosis (PTB) susceptibility.” | 0.90 | hgvs_regex_v1 |
| gene | MBL2 | “Association of MBL2 gene polymorphisms with pulmonary tuberculosis susceptibility: trial sequence meta-analysis as evidence.” | 0.98 | hgnc_dict_v1 |
| gene | MBP | “BACKGROUND: Mannose-binding lectin (MBL) or mannose-binding protein (MBP), encoded by MBL2 gene and secreted by the liver, activates complement system through lectin pathway in innate immunity against the host's infection.” | 0.98 | hgnc_dict_v1 |
| phenotype | tuberculosis | “Association of MBL2 gene polymorphisms with pulmonary tuberculosis susceptibility: trial sequence meta-analysis as evidence.” | 0.98 | phenotype_alias_lexicon_v2 |
Association of MBL2 Gene Polymorphism with Dental Caries in Saudi Children.
PMID 27894112 | DOI 10.1159/000450963 · Caries research · 2017 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs11003125 | “Out of the 6 SNPs tested in the 4 selected genes, only rs11003125 in the MBL2 gene was shown to be associated with a high prevalence of caries in our cohort.” | 0.90 | hgvs_regex_v1 |
| gene | MBL2 | “Association of MBL2 Gene Polymorphism with Dental Caries in Saudi Children.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “Using the TaqMan assay and direct DNA sequencing, the prevalence of 6 single-nucleotide polymorphisms (SNPs) in MMP9, MBL2, MMP2, and TIMP2 genes was determined in 102 children with caries and in 100 age-matched caries-free controls.” | 0.98 | hgnc_dict_v1 |
| gene | MMP2 | “Using the TaqMan assay and direct DNA sequencing, the prevalence of 6 single-nucleotide polymorphisms (SNPs) in MMP9, MBL2, MMP2, and TIMP2 genes was determined in 102 children with caries and in 100 age-matched caries-free controls.” | 0.98 | hgnc_dict_v1 |
A Meta-analysis of MBL2 Polymorphisms and Tuberculosis Risk.
PMID 27876780 | PMCID PMC5120291 | DOI 10.1038/srep35728 · Scientific reports · 2016 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs11003125 | “Earlier studies revealed that MBL2 gene variants, rs1800451, rs1800450, rs5030737, rs7096206, rs11003125 and rs7095891 are associated with impaired serum level and susceptibility to TB, but their results are inconsistent.” | 0.90 | hgvs_regex_v1 |
| gene | MBL2 | “A Meta-analysis of MBL2 Polymorphisms and Tuberculosis Risk.” | 0.98 | hgnc_dict_v1 |
| phenotype | tuberculosis | “A Meta-analysis of MBL2 Polymorphisms and Tuberculosis Risk.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | rs1800451 | “Earlier studies revealed that MBL2 gene variants, rs1800451, rs1800450, rs5030737, rs7096206, rs11003125 and rs7095891 are associated with impaired serum level and susceptibility to TB, but their results are inconsistent.” | 0.90 | hgvs_regex_v1 |