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3 records shown · first 60Differential associations of statin treatment and polymorphism in genes coding for HMGCR and PCSK9 to risk for insomnia.
PMID 34994160 | DOI 10.52586/5039 · Frontiers in bioscience (Landmark edition) · 2021 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs11591147 | “A similar effect was observed for PCSK9 rs11591147-T allele (1.07 [1.01-1.14]; 0.014), while the two gene variants of HMGCR were associated with a reduced risk for insomnia (rs17238484-G: 0.97 [0.95 to 0.99]; 0.014 and rs12916-T: 0.97 [0.96 to 0.99]; 0.002).” | 0.90 | hgvs_regex_v1 |
| gene | HMGCR | “Differential associations of statin treatment and polymorphism in genes coding for HMGCR and PCSK9 to risk for insomnia.” | 0.98 | hgnc_dict_v1 |
| gene | PCSK9 | “Differential associations of statin treatment and polymorphism in genes coding for HMGCR and PCSK9 to risk for insomnia.” | 0.98 | hgnc_dict_v1 |
| phenotype | stroke | “European participants without any history of psychiatric/neurological disorders or of stroke and with available genetic data as well as information on statin use were included in the present study.” | 0.98 | phenotype_alias_lexicon_v2 |
Identification of Genetic Variants Associated With Myocardial Infarction in Saudi Arabia.
PMID 32726218 | DOI 10.1532/hsf.2955 · The heart surgery forum · 2020 · 14 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs11591147 | “Reference single nucleotide polymorphisms (SNPs) of these variants are rs5174, rs11591147, rs2259816, rs111245230, rs3782886 and rs2259820, referring to genes LRP8, PCSK9, HNF1A, SVEP1, BRAP and HNF1A, respectively.” | 0.90 | hgvs_regex_v1 |
| gene | LRP8 | “Reference single nucleotide polymorphisms (SNPs) of these variants are rs5174, rs11591147, rs2259816, rs111245230, rs3782886 and rs2259820, referring to genes LRP8, PCSK9, HNF1A, SVEP1, BRAP and HNF1A, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | PCSK9 | “Reference single nucleotide polymorphisms (SNPs) of these variants are rs5174, rs11591147, rs2259816, rs111245230, rs3782886 and rs2259820, referring to genes LRP8, PCSK9, HNF1A, SVEP1, BRAP and HNF1A, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | HNF1A | “Reference single nucleotide polymorphisms (SNPs) of these variants are rs5174, rs11591147, rs2259816, rs111245230, rs3782886 and rs2259820, referring to genes LRP8, PCSK9, HNF1A, SVEP1, BRAP and HNF1A, respectively.” | 0.98 | hgnc_dict_v1 |
Rosuvastatin, proprotein convertase subtilisin/kexin type 9 concentrations, and LDL cholesterol response: the JUPITER trial.
PMID 22065156 | DOI 10.1373/clinchem.2011.172932 · Clinical chemistry · 2012 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs11591147 | “We also evaluated rs11591147, a single nucleotide polymorphism known to have an impact on plasma PCSK9 concentrations.” | 0.90 | hgvs_regex_v1 |
| gene | PCSK9 | “BACKGROUND: Although statin therapy is known to increase concentrations of PCSK9, whether this effect is related to the magnitude of LDL reduction is uncertain.” | 0.98 | hgnc_dict_v1 |