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7 records shown · first 60Comprehensive Molecular Evaluation of Transcription Factor 7-like 2, Long Noncoding RNA (ANRIL), and CYP2C19*17 Gene Variants and Their Association with Predisposition and Progression in Stroke Patients.
PMID 41247572 | PMCID PMC12623554 | DOI 10.1007/s10571-025-01625-2 · Cellular and molecular neurobiology · 2025 · 11 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs12255372 | “In this study, we examined the associations of ANRIL rs1333045 C>T, CYP2C19*17 (C806T, rs12248560C>T, and TCF7L2 rs12255372 G>T with stroke in 100 stroke cases and 100 matched healthy controls from Tabuk population using the amplification refractory mutation system PCR (ARMS-PCR).” | 0.90 | hgvs_regex_v1 |
| gene | CYP2C19 | “Comprehensive Molecular Evaluation of Transcription Factor 7-like 2, Long Noncoding RNA (ANRIL), and CYP2C19*17 Gene Variants and Their Association with Predisposition and Progression in Stroke Patients.” | 0.98 | hgnc_dict_v1 |
| gene | TCF7L2 | “The Transcription factor 7-like 2 (TCF7L2) has crucial roles in biological and pathological processes such as inflammation, metabolism, and atherosclerosis.” | 0.98 | hgnc_dict_v1 |
| phenotype | stroke | “Comprehensive Molecular Evaluation of Transcription Factor 7-like 2, Long Noncoding RNA (ANRIL), and CYP2C19*17 Gene Variants and Their Association with Predisposition and Progression in Stroke Patients.” | 0.98 | phenotype_alias_lexicon_v2 |
Dysregulated Vitamin D, CYP2R1, TCF7L2, and CCR5 Δ32 Gene Variations are Associated with Coronary Artery Disease.
PMID 39600283 | DOI 10.24976/Discov.Med.202436190.210 · Discovery medicine · 2024 · 10 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs12255372 | “Genotyping of the CYP2R1 rs1562902 C > T, TCF7L2 rs12255372 G > T, and CCR5 Δ32 bp deletion mutation were performed using amplification-refractory mutation system polymerase chain reaction (PCR) and allele-specific PCR to evaluate their association with CAD risk.” | 0.90 | hgvs_regex_v1 |
| gene | CYP2R1 | “Dysregulated Vitamin D, CYP2R1, TCF7L2, and CCR5 Δ32 Gene Variations are Associated with Coronary Artery Disease.” | 0.98 | hgnc_dict_v1 |
| gene | TCF7L2 | “Dysregulated Vitamin D, CYP2R1, TCF7L2, and CCR5 Δ32 Gene Variations are Associated with Coronary Artery Disease.” | 0.98 | hgnc_dict_v1 |
| gene | CCR5 | “Dysregulated Vitamin D, CYP2R1, TCF7L2, and CCR5 Δ32 Gene Variations are Associated with Coronary Artery Disease.” | 0.98 | hgnc_dict_v1 |
Genetic variants related to insulin metabolism are associated with gestational diabetes mellitus.
PMID 38885821 | DOI 10.1016/j.gene.2024.148704 · Gene · 2024 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs12255372 | “The amplification-refractory mutation system (ARMS) was used for genotyping four single nucleotide polymorphisms (SNPs), namely FTO (rs9939609), PPARG2 (rs1801282), SLC30A8 (rs13266634), and TCF7L2 (rs12255372).” | 0.90 | hgvs_regex_v1 |
| gene | FTO | “The amplification-refractory mutation system (ARMS) was used for genotyping four single nucleotide polymorphisms (SNPs), namely FTO (rs9939609), PPARG2 (rs1801282), SLC30A8 (rs13266634), and TCF7L2 (rs12255372).” | 0.98 | hgnc_dict_v1 |
| gene | SLC30A8 | “The amplification-refractory mutation system (ARMS) was used for genotyping four single nucleotide polymorphisms (SNPs), namely FTO (rs9939609), PPARG2 (rs1801282), SLC30A8 (rs13266634), and TCF7L2 (rs12255372).” | 0.98 | hgnc_dict_v1 |
| gene | TCF7L2 | “The amplification-refractory mutation system (ARMS) was used for genotyping four single nucleotide polymorphisms (SNPs), namely FTO (rs9939609), PPARG2 (rs1801282), SLC30A8 (rs13266634), and TCF7L2 (rs12255372).” | 0.98 | hgnc_dict_v1 |
Associations of transcription factor 7-Like 2 (TCF7L2) gene polymorphism in patients of type 2 diabetes mellitus from Khyber Pakhtunkhwa population of Pakistan.
PMID 34394276 | PMCID PMC8356593 | DOI 10.4314/ahs.v21i1.4 · African health sciences · 2021 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs12255372 | “Genomic DNA was extracted and genotype of common variants (rs7903146 C/T and rs12255372 G/T) was carried out by amplification-refractory mutation system (ARMS)-PCR of sequence specific oligonucleotides.” | 0.90 | hgvs_regex_v1 |
| gene | TCF7L2 | “Associations of transcription factor 7-Like 2 (TCF7L2) gene polymorphism in patients of type 2 diabetes mellitus from Khyber Pakhtunkhwa population of Pakistan.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Associations of transcription factor 7-Like 2 (TCF7L2) gene polymorphism in patients of type 2 diabetes mellitus from Khyber Pakhtunkhwa population of Pakistan.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | metabolic syndrome | “BACKGROUND: Type 2 diabetes mellitus (T2DM) is the most prevalent component of metabolic syndrome.” | 0.98 | phenotype_alias_lexicon_v2 |
Genetic variants in the WNT signaling pathway are protectively associated with colorectal cancer in a Saudi population.
PMID 31485167 | PMCID PMC6717108 | DOI 10.1016/j.sjbs.2018.05.018 · Saudi journal of biological sciences · 2019 · 22 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs12255372 | “We studied thirteen single nucleotide polymorphisms (SNPs) located in SFRP3 (rs7775), CTNNB1 (β-catenin) [rs4135385, rs13072632], APC (rs454886, rs459552), LRP6 (rs2075241, rs2284396), DKK4 (rs3763511), DKK3 (rs6485350), TCF4 (rs12255372) and AXIN2 (rs3923086, rs3923087, rs4791171) in patients with colorectal cancer (n = 122) and controls (n = 110).” | 0.90 | hgvs_regex_v1 |
| gene | CTNNB1 | “We studied thirteen single nucleotide polymorphisms (SNPs) located in SFRP3 (rs7775), CTNNB1 (β-catenin) [rs4135385, rs13072632], APC (rs454886, rs459552), LRP6 (rs2075241, rs2284396), DKK4 (rs3763511), DKK3 (rs6485350), TCF4 (rs12255372) and AXIN2 (rs3923086, rs3923087, rs4791171) in patients with colorectal cancer (n = 122) and controls (n = 110).” | 0.98 | hgnc_dict_v1 |
| gene | APC | “We studied thirteen single nucleotide polymorphisms (SNPs) located in SFRP3 (rs7775), CTNNB1 (β-catenin) [rs4135385, rs13072632], APC (rs454886, rs459552), LRP6 (rs2075241, rs2284396), DKK4 (rs3763511), DKK3 (rs6485350), TCF4 (rs12255372) and AXIN2 (rs3923086, rs3923087, rs4791171) in patients with colorectal cancer (n = 122) and controls (n = 110).” | 0.98 | hgnc_dict_v1 |
| gene | LRP6 | “We studied thirteen single nucleotide polymorphisms (SNPs) located in SFRP3 (rs7775), CTNNB1 (β-catenin) [rs4135385, rs13072632], APC (rs454886, rs459552), LRP6 (rs2075241, rs2284396), DKK4 (rs3763511), DKK3 (rs6485350), TCF4 (rs12255372) and AXIN2 (rs3923086, rs3923087, rs4791171) in patients with colorectal cancer (n = 122) and controls (n = 110).” | 0.98 | hgnc_dict_v1 |
Type 2 diabetes mellitus susceptibility gene TCF7L2 is strongly associated with hyperglycemia in the Saudi Arabia Population of the eastern province of Saudi Arabia.
PMID 26367734 · European review for medical and pharmacological sciences · 2015 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs12255372 | “OBJECTIVE: We studied the association of single nucleotide polymorphisms (SNPs) rs7903146, rs12255372 and rs4506565 in type 2 diabetes mellitus (T2DM) susceptibility gene, transcription factor 7 like 2 (TCF7L2) with T2DM among the population of the Eastern Province of Saudi Arabia.” | 0.90 | hgvs_regex_v1 |
| gene | TCF7L2 | “Type 2 diabetes mellitus susceptibility gene TCF7L2 is strongly associated with hyperglycemia in the Saudi Arabia Population of the eastern province of Saudi Arabia.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Type 2 diabetes mellitus susceptibility gene TCF7L2 is strongly associated with hyperglycemia in the Saudi Arabia Population of the eastern province of Saudi Arabia.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia, Eastern Province | “Type 2 diabetes mellitus susceptibility gene TCF7L2 is strongly associated with hyperglycemia in the Saudi Arabia Population of the eastern province of Saudi Arabia. OBJECTIVE: We studied the association of single nucleotide polymorphisms (SNPs) rs7903146, rs12255372 and rs4506565 in type 2 diabetes mellitus (T2DM) susceptibility gene, transcription factor 7 like 2 (TCF7L2) with T2DM among the population of the Eastern Province of Saudi Arabia. PATIENTS AND METHODS: In a case-control study, blood samples were collected from 359 T2DM patients and 351 age and sex-matched normoglycemic controls. RESULTS: Our results revealed a strong association between risk T alleles in variants rs12255372 (OR: G/T=1.4233; T/T=2.0395) and rs4506565 (OR: A/T=1.6066; T/T=3.1301) and T2DM among the Saudi population of the Eastern Province of Saudi Arabia. This is the first time that this association has been identified in a Saudi population. These data further strengthens the hypothesis that Saudi populations might carry a distinct risk allele in T2DM susceptibility gene TCF7L2. CONCLUSIONS: The present results confirm that rs12255372 and rs4506565 variants of TCF7L2 show an association, but not rs7903146, with T2DM for the Saudi population of the Eastern Province of Saudi Arabia.” | 0.95 | saudi_context_rules_v1 |
Weak or no association of TCF7L2 variants with Type 2 diabetes risk in an Arab population.
PMID 18655717 | PMCID PMC2515290 | DOI 10.1186/1471-2350-9-72 · BMC medical genetics · 2008 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs12255372 | “BACKGROUND: The rs7903146 and rs12255372 variants of TCF7L2 have been strongly associated with type 2 diabetes (T2D) risk in most populations studied to date.” | 0.90 | hgvs_regex_v1 |
| gene | TCF7L2 | “Weak or no association of TCF7L2 variants with Type 2 diabetes risk in an Arab population.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Weak or no association of TCF7L2 variants with Type 2 diabetes risk in an Arab population.” | 0.93 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “METHODS: We performed a case-control association study using 522 Saudi T2D patients (WHO criteria), and 346 controls (age > 60; fasting plasma glucose < 7 mmol/L).” | 0.95 | saudi_context_rules_v1 |