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1 records shown · first 60Chloroquine and Hydroxychloroquine Interact Differently with ACE2 Domains Reported to Bind with the Coronavirus Spike Protein: Mediation by ACE2 Polymorphism.
PMID 33525415 | PMCID PMC7865913 | DOI 10.3390/molecules26030673 · Molecules (Basel, Switzerland) · 2021 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1238146879 | “The frequencies of these allele variants range from 3.88 × 10-3 to 5.47 × 10-6 for rs4646116 (K26R) and rs1238146879 (P426A), respectively.” | 0.90 | hgvs_regex_v1 |
| gene | ACE2 | “Chloroquine and Hydroxychloroquine Interact Differently with ACE2 Domains Reported to Bind with the Coronavirus Spike Protein: Mediation by ACE2 Polymorphism.” | 0.98 | hgnc_dict_v1 |
| phenotype | COVID-19 | “The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection inducing coronavirus disease 2019 (COVID-19) is still an ongoing challenge.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | malaria | “Chloroquine (CQ) and its metabolite hydroxychloroquine (HCQ) are mainly used to prevent and treat malaria and rheumatic diseases.” | 0.98 | phenotype_alias_lexicon_v2 |