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2 records shown · first 60In Silico Characterization of Pathogenic ESR2 Coding and UTR Variants as Oncogenic Potential Biomarkers in Hormone-Dependent Cancers.
PMID 41153361 | PMCID PMC12562404 | DOI 10.3390/genes16101144 · Genes · 2025 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs139004885 | “At the post-transcriptional level, rs139004885 was predicted to disrupt miRNA binding, while 3'UTR rs4986938 showed strong regulatory potential and comparatively high population frequency; by contrast, most other identified SNPs were rare.” | 0.90 | hgvs_regex_v1 |
| gene | ESR2 | “In Silico Characterization of Pathogenic ESR2 Coding and UTR Variants as Oncogenic Potential Biomarkers in Hormone-Dependent Cancers.” | 0.98 | hgnc_dict_v1 |
| gene | NCOA1 | “Several substitutions were predicted to impair coactivator binding and disrupt interactions with key transcriptional partners, including JUN, NCOA1, and SP1.” | 0.98 | hgnc_dict_v1 |
| variant | rs4986938 | “At the post-transcriptional level, rs139004885 was predicted to disrupt miRNA binding, while 3'UTR rs4986938 showed strong regulatory potential and comparatively high population frequency; by contrast, most other identified SNPs were rare.” | 0.90 | hgvs_regex_v1 |
Association of genetic polymorphisms of chemokines and their receptors with clearance or persistence of hepatitis C virus infection.
PMID 30175654 | DOI 10.1080/09674845.2018.1518299 · British journal of biomedical science · 2019 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs13900 | “All were genotyped for single nucleotide polymorphisms: rs13900 C/T of CCL2, rs3817655 T/A of CCL5 and rs743660 G/A and rs1799864 G/A of CCR2 using allelic discrimination real-time PCR technique.” | 0.90 | hgvs_regex_v1 |
| gene | CCL2 | “We hypothesized that one or more variants of chemokines (CCL2 and CCL5) and chemokine receptors (CC chemokine receptor type 2 [CCR2]) genes are associated with the susceptibility to HCV infection.” | 0.98 | hgnc_dict_v1 |
| gene | CCL5 | “We hypothesized that one or more variants of chemokines (CCL2 and CCL5) and chemokine receptors (CC chemokine receptor type 2 [CCR2]) genes are associated with the susceptibility to HCV infection.” | 0.98 | hgnc_dict_v1 |
| gene | CCR2 | “We hypothesized that one or more variants of chemokines (CCL2 and CCL5) and chemokine receptors (CC chemokine receptor type 2 [CCR2]) genes are associated with the susceptibility to HCV infection.” | 0.98 | hgnc_dict_v1 |