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1 records shown · first 60The severity of COVID-19 in hypertensive patients is associated with mirSNPs in the 3' UTR of ACE2 that associate with miR-3658: In silico and in vitro studies.
PMID 36926053 | PMCID PMC9981452 | DOI 10.1016/j.jtumed.2023.02.009 · Journal of Taibah University Medical Sciences · 2023 · 10 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1423809569 | “RESULTS: Interestingly, the binding site of miR-3658 corresponding to the 3' UTR of ACE2 featured three SNPs (rs1457913029, C>T; rs960535757, A>C, G; rs1423809569, C>T), and its genomic sequence featured a single SNP (rs1024225815, C>T) with the same nucleotide variation (rs1457913029, C>T) which potentially increases the severity of COVID-19.” | 0.90 | hgvs_regex_v1 |
| gene | ACE2 | “The severity of COVID-19 in hypertensive patients is associated with mirSNPs in the 3' UTR of ACE2 that associate with miR-3658: In silico and in vitro studies.” | 0.98 | hgnc_dict_v1 |
| phenotype | COVID-19 | “The severity of COVID-19 in hypertensive patients is associated with mirSNPs in the 3' UTR of ACE2 that associate with miR-3658: In silico and in vitro studies.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | hypertension | “UNLABELLED: The SARS-CoV-2 virus targets the antigen converting enzyme 2 (ACE2) receptor, thus resulting in elevated morbidity and an increased risk of severe and fatal COVID-19 infection in individuals with hypertension and diabetes mellitus.” | 0.98 | phenotype_alias_lexicon_v2 |