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8 records shown · first 60Molecular dynamics investigation of single nucleotide polymorphism-driven variations in GSTP1 phosphorylation and substrate interaction.
PMID 41569518 | DOI 10.1080/07391102.2026.2619869 · Journal of biomolecular structure & dynamics · 2026 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1695 | “This study evaluated the impact of the rs1695 (Ile105Val) substitution on GSTP1 structural stability, phosphorylation accessibility, and interaction with ethacrynic acid (EA), as a substrate.” | 0.90 | hgvs_regex_v1 |
| gene | GSTP1 | “Molecular dynamics investigation of single nucleotide polymorphism-driven variations in GSTP1 phosphorylation and substrate interaction.” | 0.98 | hgnc_dict_v1 |
Molecular Characterization and Impact of the Genetic Variants GSTP1, LncRNA H19, TCF7L2 and HNF1A on the Risk of Coronary Artery Disease With and Without T2DM Comorbidity: A Genomic Biomarker Study.
PMID 40485517 | DOI 10.24976/Discov.Med.202537197.89 · Discovery medicine · 2025 · 11 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1695 | “Given the strong genetic basis underlying the pathogenesis of T2DM and CAD, this study aimed to investigate the potential significance of the following genetic variants in the pathogenesis of CAD with and without T2DM comorbidity: hepatocyte nuclear factor-1 alpha (HNF1A) [p.I27L] rs1169288, glutathione S-transferase Pi 1 (GSTP1) rs1695 (A>G; Ile→Val), transcription factor 7-like 2 (TCF7L2) rs7903146 (C>T), and long non-coding RNA H19 (LncRNA H19) rs217727 (C>T).” | 0.90 | hgvs_regex_v1 |
| gene | GSTP1 | “Molecular Characterization and Impact of the Genetic Variants GSTP1, LncRNA H19, TCF7L2 and HNF1A on the Risk of Coronary Artery Disease With and Without T2DM Comorbidity: A Genomic Biomarker Study.” | 0.98 | hgnc_dict_v1 |
| gene | H19 | “Molecular Characterization and Impact of the Genetic Variants GSTP1, LncRNA H19, TCF7L2 and HNF1A on the Risk of Coronary Artery Disease With and Without T2DM Comorbidity: A Genomic Biomarker Study.” | 0.98 | hgnc_dict_v1 |
| gene | TCF7L2 | “Molecular Characterization and Impact of the Genetic Variants GSTP1, LncRNA H19, TCF7L2 and HNF1A on the Risk of Coronary Artery Disease With and Without T2DM Comorbidity: A Genomic Biomarker Study.” | 0.98 | hgnc_dict_v1 |
Investigation of GSTP1 and PTEN gene polymorphisms and their association with susceptibility to colorectal cancer.
PMID 39754630 | PMCID PMC11867568 | DOI 10.2478/raon-2025-0001 · Radiology and oncology · 2025 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1695 | “BACKGROUND: This study investigates the association of single nucleotide polymorphism in glutathione S transferase P1 (rs1695 and rs1138272) and phosphatase and TENsin homolog (rs701848 and rs2735343) with the risk of colorectal cancer (CRC).” | 0.90 | hgvs_regex_v1 |
| gene | GSTP1 | “Investigation of GSTP1 and PTEN gene polymorphisms and their association with susceptibility to colorectal cancer.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Investigation of GSTP1 and PTEN gene polymorphisms and their association with susceptibility to colorectal cancer.” | 0.98 | hgnc_dict_v1 |
| phenotype | colorectal cancer | “Investigation of GSTP1 and PTEN gene polymorphisms and their association with susceptibility to colorectal cancer.” | 0.98 | phenotype_alias_lexicon_v2 |
Exposure to heavy metals, antioxidant status, and the interaction of single nucleotide polymorphisms in the genes CAT rs7943316, GSTP1 rs1695, as well as GSTM1 and GSTT1 genes, among workers in occupational settings.
PMID 38663648 | DOI 10.1016/j.etap.2024.104452 · Environmental toxicology and pharmacology · 2024 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1695 | “Exposure to heavy metals, antioxidant status, and the interaction of single nucleotide polymorphisms in the genes CAT rs7943316, GSTP1 rs1695, as well as GSTM1 and GSTT1 genes, among workers in occupational settings.” | 0.90 | hgvs_regex_v1 |
| gene | GSTP1 | “Exposure to heavy metals, antioxidant status, and the interaction of single nucleotide polymorphisms in the genes CAT rs7943316, GSTP1 rs1695, as well as GSTM1 and GSTT1 genes, among workers in occupational settings.” | 0.98 | hgnc_dict_v1 |
| gene | GSTM1 | “Exposure to heavy metals, antioxidant status, and the interaction of single nucleotide polymorphisms in the genes CAT rs7943316, GSTP1 rs1695, as well as GSTM1 and GSTT1 genes, among workers in occupational settings.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “Exposure to heavy metals, antioxidant status, and the interaction of single nucleotide polymorphisms in the genes CAT rs7943316, GSTP1 rs1695, as well as GSTM1 and GSTT1 genes, among workers in occupational settings.” | 0.98 | hgnc_dict_v1 |
Platinum-induced ototoxicity in pediatric cancer survivors: GSTP1 c.313A>G variant association.
PMID 36397425 | PMCID PMC9666226 | DOI 10.1097/MD.0000000000031627 · Medicine · 2022 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1695 | “We aimed to detect the frequency of ototoxicity and associated risk factors in survivors of childhood cancer receiving platinum-based chemotherapy and to detect the relation between GSTP1 c.313A>G (rs1695) polymorphisms and ototoxicity.” | 0.90 | hgvs_regex_v1 |
| gene | GSTP1 | “Platinum-induced ototoxicity in pediatric cancer survivors: GSTP1 c.313A>G variant association.” | 0.98 | hgnc_dict_v1 |
| phenotype | hearing loss | “Hearing loss (HL) was identified in 16/64 patients (25%), including 62.5% treated with cisplatin and 37.5% treated with carboplatin.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | c.313A>G | “Platinum-induced ototoxicity in pediatric cancer survivors: GSTP1 c.313A>G variant association.” | 0.95 | hgvs_regex_v1 |
Single-nucleotide polymorphisms (SNPs) of antioxidant enzymes SOD2 and GSTP1 genes and SLE risk and severity in an Egyptian pediatric population.
PMID 33264651 | DOI 10.1016/j.clinbiochem.2020.11.010 · Clinical biochemistry · 2021 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1695 | “This study was designed to investigate the effects of genetic polymorphisms of the antioxidant enzymes genes that code for SOD2 (rs2758332) and GSTP1 (rs1695) on SLE risk and severity in Egyptian children and adolescents cohort from Delta region.” | 0.90 | hgvs_regex_v1 |
| gene | SOD2 | “Single-nucleotide polymorphisms (SNPs) of antioxidant enzymes SOD2 and GSTP1 genes and SLE risk and severity in an Egyptian pediatric population.” | 0.98 | hgnc_dict_v1 |
| gene | GSTP1 | “Single-nucleotide polymorphisms (SNPs) of antioxidant enzymes SOD2 and GSTP1 genes and SLE risk and severity in an Egyptian pediatric population.” | 0.98 | hgnc_dict_v1 |
| phenotype | systemic lupus erythematosus | “Single-nucleotide polymorphisms (SNPs) of antioxidant enzymes SOD2 and GSTP1 genes and SLE risk and severity in an Egyptian pediatric population.” | 0.93 | phenotype_alias_lexicon_v2 |
Association of GSTP1 p.Ile105Val (rs1695, c.313A > G) Variant with the Risk of Breast Carcinoma among Egyptian Women.
PMID 33939082 | DOI 10.1007/s10528-021-10070-x · Biochemical genetics · 2021 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1695 | “Association of GSTP1 p.Ile105Val (rs1695, c.313A > G) Variant with the Risk of Breast Carcinoma among Egyptian Women.” | 0.90 | hgvs_regex_v1 |
| gene | GSTP1 | “Association of GSTP1 p.Ile105Val (rs1695, c.313A > G) Variant with the Risk of Breast Carcinoma among Egyptian Women.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Association of GSTP1 p.Ile105Val (rs1695, c.313A > G) Variant with the Risk of Breast Carcinoma among Egyptian Women.” | 0.93 | phenotype_alias_lexicon_v2 |
| variant | p.Ile105Val | “Association of GSTP1 p.Ile105Val (rs1695, c.313A > G) Variant with the Risk of Breast Carcinoma among Egyptian Women.” | 0.95 | hgvs_regex_v1 |
Association Of GSTM1, GSTT1 And GSTP1 Polymorphisms With Breast Cancer Among Jordanian Women.
PMID 31571925 | PMCID PMC6760517 | DOI 10.2147/OTT.S207255 · OncoTargets and therapy · 2019 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1695 | “Gel electrophoresis of PCR products was used to visualize and genotype both the GSTM1 and GSTT1 genes, while PCR-RFLP was employed to genotype the rs1695 of the GSTP1 gene.” | 0.90 | hgvs_regex_v1 |
| gene | GSTM1 | “Association Of GSTM1, GSTT1 And GSTP1 Polymorphisms With Breast Cancer Among Jordanian Women.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “Association Of GSTM1, GSTT1 And GSTP1 Polymorphisms With Breast Cancer Among Jordanian Women.” | 0.98 | hgnc_dict_v1 |
| gene | GSTP1 | “Association Of GSTM1, GSTT1 And GSTP1 Polymorphisms With Breast Cancer Among Jordanian Women.” | 0.98 | hgnc_dict_v1 |