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4 records shown · first 60Genetic Variants and Dental Caries Susceptibility: An Umbrella Review and Multilevel Meta-Analysis.
PMID 42353883 | PMCID PMC13299435 | DOI 10.3390/genes17060724 · Genes · 2026 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1800450 | “The multilevel meta-analysis showed statistically significant associations for polymorphisms in TAS2R38 rs713598 (OR = 0.26, 95% CI: 0.09-0.73) and VDR Cdx-2 rs11568820 (OR = 0.66, 95% CI: 0.46-0.95), both indicating lower odds of dental caries, while MBL2 rs1800450 was associated with increased odds (OR = 1.48, 95% CI: 1.03-2.14).” | 0.90 | hgvs_regex_v1 |
| gene | TAS2R38 | “The multilevel meta-analysis showed statistically significant associations for polymorphisms in TAS2R38 rs713598 (OR = 0.26, 95% CI: 0.09-0.73) and VDR Cdx-2 rs11568820 (OR = 0.66, 95% CI: 0.46-0.95), both indicating lower odds of dental caries, while MBL2 rs1800450 was associated with increased odds (OR = 1.48, 95% CI: 1.03-2.14).” | 0.98 | hgnc_dict_v1 |
| gene | VDR | “The multilevel meta-analysis showed statistically significant associations for polymorphisms in TAS2R38 rs713598 (OR = 0.26, 95% CI: 0.09-0.73) and VDR Cdx-2 rs11568820 (OR = 0.66, 95% CI: 0.46-0.95), both indicating lower odds of dental caries, while MBL2 rs1800450 was associated with increased odds (OR = 1.48, 95% CI: 1.03-2.14).” | 0.98 | hgnc_dict_v1 |
| gene | MBL2 | “The multilevel meta-analysis showed statistically significant associations for polymorphisms in TAS2R38 rs713598 (OR = 0.26, 95% CI: 0.09-0.73) and VDR Cdx-2 rs11568820 (OR = 0.66, 95% CI: 0.46-0.95), both indicating lower odds of dental caries, while MBL2 rs1800450 was associated with increased odds (OR = 1.48, 95% CI: 1.03-2.14).” | 0.98 | hgnc_dict_v1 |
Mannose-binding lectin gene polymorphism in psoriasis and vitiligo: an observational study and computational analysis.
PMID 38404462 | PMCID PMC10885344 | DOI 10.3389/fmed.2023.1340703 · Frontiers in medicine · 2023 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1800450 | “Therefore, in this study, we investigated the role of the MBL variant, rs1800450, in psoriasis and vitiligo disease susceptibility.” | 0.90 | hgvs_regex_v1 |
| gene | MBL2 | “DISCUSSION: Our findings highlighted that the rs1800450 SNP on the MBL2 gene has no role in the disease susceptibility to autoimmune skin diseases, such as psoriasis and vitiligo, among Egyptian patients.” | 0.98 | hgnc_dict_v1 |
Association of MBL2 gene polymorphisms with pulmonary tuberculosis susceptibility: trial sequence meta-analysis as evidence.
PMID 30666135 | PMCID PMC6333159 | DOI 10.2147/IDR.S188980 · Infection and drug resistance · 2019 · 9 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1800450 | “Conflictingly, a number of MBL2 variants, rs1800450 (A>B), rs1800451 (A>C), rs5030737 (A>D), rs7096206 (Y>X), rs11003125 (H>L), and rs7095891 (P>Q) allele, have been found to be associated with compromised serum levels and pulmonary tuberculosis (PTB) susceptibility.” | 0.90 | hgvs_regex_v1 |
| gene | MBL2 | “Association of MBL2 gene polymorphisms with pulmonary tuberculosis susceptibility: trial sequence meta-analysis as evidence.” | 0.98 | hgnc_dict_v1 |
| gene | MBP | “BACKGROUND: Mannose-binding lectin (MBL) or mannose-binding protein (MBP), encoded by MBL2 gene and secreted by the liver, activates complement system through lectin pathway in innate immunity against the host's infection.” | 0.98 | hgnc_dict_v1 |
| phenotype | tuberculosis | “Association of MBL2 gene polymorphisms with pulmonary tuberculosis susceptibility: trial sequence meta-analysis as evidence.” | 0.98 | phenotype_alias_lexicon_v2 |
A Meta-analysis of MBL2 Polymorphisms and Tuberculosis Risk.
PMID 27876780 | PMCID PMC5120291 | DOI 10.1038/srep35728 · Scientific reports · 2016 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1800450 | “Earlier studies revealed that MBL2 gene variants, rs1800451, rs1800450, rs5030737, rs7096206, rs11003125 and rs7095891 are associated with impaired serum level and susceptibility to TB, but their results are inconsistent.” | 0.90 | hgvs_regex_v1 |
| gene | MBL2 | “A Meta-analysis of MBL2 Polymorphisms and Tuberculosis Risk.” | 0.98 | hgnc_dict_v1 |
| phenotype | tuberculosis | “A Meta-analysis of MBL2 Polymorphisms and Tuberculosis Risk.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | rs1800451 | “Earlier studies revealed that MBL2 gene variants, rs1800451, rs1800450, rs5030737, rs7096206, rs11003125 and rs7095891 are associated with impaired serum level and susceptibility to TB, but their results are inconsistent.” | 0.90 | hgvs_regex_v1 |