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5 records shown · first 60Interleukin-1β and Tumor Necrosis Factor-α Gene Polymorphisms in Systemic Sclerosis.
PMID 40070856 | PMCID PMC11892941 | DOI 10.2478/bjmg-2024-0017 · Balkan journal of medical genetics : BJMG · 2024 · 14 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1800871 | “Variations in allele, genotype, or haplotype distribution between patients and healthy volunteers were observed for the following SNPs: IL-1β -511 C/T (rs16944) and +3962 T/C (rs1143634); IL-4Rα +1902 G/A (rs1801275); IL-12 -1188 C/A (rs3212227); TGF-β1 codon 25 G/C (rs1800471); TNF-α-308 G/A (rs1800629) and -238 G/A (rs361525); IL-4 -1098 T/G (rs2243248) and -590 T/C (rs2243250); IL-6 -174 G/C (rs1800795) and nt565 G/A (rs1800797); and IL-10 -1082 G/A (rs1800896), -819 C/T (rs1800871) and -592 C/A (rs1800872).” | 0.90 | hgvs_regex_v1 |
| variant | rs16944 | “Variations in allele, genotype, or haplotype distribution between patients and healthy volunteers were observed for the following SNPs: IL-1β -511 C/T (rs16944) and +3962 T/C (rs1143634); IL-4Rα +1902 G/A (rs1801275); IL-12 -1188 C/A (rs3212227); TGF-β1 codon 25 G/C (rs1800471); TNF-α-308 G/A (rs1800629) and -238 G/A (rs361525); IL-4 -1098 T/G (rs2243248) and -590 T/C (rs2243250); IL-6 -174 G/C (rs1800795) and nt565 G/A (rs1800797); and IL-10 -1082 G/A (rs1800896), -819 C/T (rs1800871) and -592 C/A (rs1800872).” | 0.90 | hgvs_regex_v1 |
| variant | rs1143634 | “Variations in allele, genotype, or haplotype distribution between patients and healthy volunteers were observed for the following SNPs: IL-1β -511 C/T (rs16944) and +3962 T/C (rs1143634); IL-4Rα +1902 G/A (rs1801275); IL-12 -1188 C/A (rs3212227); TGF-β1 codon 25 G/C (rs1800471); TNF-α-308 G/A (rs1800629) and -238 G/A (rs361525); IL-4 -1098 T/G (rs2243248) and -590 T/C (rs2243250); IL-6 -174 G/C (rs1800795) and nt565 G/A (rs1800797); and IL-10 -1082 G/A (rs1800896), -819 C/T (rs1800871) and -592 C/A (rs1800872).” | 0.90 | hgvs_regex_v1 |
| variant | rs1801275 | “Variations in allele, genotype, or haplotype distribution between patients and healthy volunteers were observed for the following SNPs: IL-1β -511 C/T (rs16944) and +3962 T/C (rs1143634); IL-4Rα +1902 G/A (rs1801275); IL-12 -1188 C/A (rs3212227); TGF-β1 codon 25 G/C (rs1800471); TNF-α-308 G/A (rs1800629) and -238 G/A (rs361525); IL-4 -1098 T/G (rs2243248) and -590 T/C (rs2243250); IL-6 -174 G/C (rs1800795) and nt565 G/A (rs1800797); and IL-10 -1082 G/A (rs1800896), -819 C/T (rs1800871) and -592 C/A (rs1800872).” | 0.90 | hgvs_regex_v1 |
Impacts of circulating cytokine levels and gene polymorphism predisposition on type 1 diabetes mellitus.
PMID 39231486 | PMCID PMC11374510 | DOI 10.6065/apem.2346178.089 · Annals of pediatric endocrinology & metabolism · 2024 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1800871 | “RESULTS: The levels of 3 circulating cytokines (transforming growth factor [TGF]-β1, interleukin [IL]-10, and IL-6) and 6 SNPs in 3 cytokine genes (TGF-β1 [rs1800470 and rs1800471], IL-10 [rs1800896, rs1800871, and rs1800872], and IL-6 [rs1800795]) that contribute to genetic susceptibility were measured by enzyme-linked immunosorbent assay and polymerase chain reaction with sequence-specific primers.” | 0.90 | hgvs_regex_v1 |
| phenotype | diabetes mellitus | “Impacts of circulating cytokine levels and gene polymorphism predisposition on type 1 diabetes mellitus.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “The aim of this study was to investigate the roles of cytokine levels and the association of single-nucleotide polymorphisms (SNPs) within cytokine genes with T1DM in Saudi children. Moreover, our data demonstrated no appreciable diferences in circulating serum level or genotype and phenotype of IL- 10 between the patients and controls. CONCLUSION: This kind of measurement, which considers the prediction of T1DM, may be useful in assessing the severity of T1DM and susceptibility to T1DM among Saudi children.” | 0.95 | saudi_context_rules_v1 |
| variant | rs1800470 | “RESULTS: The levels of 3 circulating cytokines (transforming growth factor [TGF]-β1, interleukin [IL]-10, and IL-6) and 6 SNPs in 3 cytokine genes (TGF-β1 [rs1800470 and rs1800471], IL-10 [rs1800896, rs1800871, and rs1800872], and IL-6 [rs1800795]) that contribute to genetic susceptibility were measured by enzyme-linked immunosorbent assay and polymerase chain reaction with sequence-specific primers.” | 0.90 | hgvs_regex_v1 |
Interleukin 10 (IL-10) gene variants and haplotypes in Tunisian women with polycystic ovary syndrome (PCOS): a case-control study.
PMID 37541999 | DOI 10.1007/s11033-023-08706-9 · Molecular biology reports · 2023 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1800871 | “Genotyping for IL-10, rs1800896, rs1800871 and rs1800872 variants, was performed by real time PCR.” | 0.90 | hgvs_regex_v1 |
| phenotype | diabetes mellitus | “BACKGROUND: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder that affects women in their child-bearing age, and is associated with insulin resistance and type 2 diabetes.” | 0.93 | phenotype_alias_lexicon_v2 |
| variant | rs1800896 | “Genotyping for IL-10, rs1800896, rs1800871 and rs1800872 variants, was performed by real time PCR.” | 0.90 | hgvs_regex_v1 |
| variant | rs1800872 | “Genotyping for IL-10, rs1800896, rs1800871 and rs1800872 variants, was performed by real time PCR.” | 0.90 | hgvs_regex_v1 |
Investigation of polymorphisms in anti-inflammatory cytokine genes in hematogenous osteomyelitis.
PMID 26681045 | DOI 10.4238/2015.December.15.4 · Genetics and molecular research : GMR · 2015 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1800871 | “The genotypes CC (P = 0.009) and CT (P = 0.041) of SNP rs2070874, and alleles A (P = 0.044) and G of SNP rs1800871 were significantly different between the patients and healthy controls.” | 0.90 | hgvs_regex_v1 |
| variant | rs2070874 | “The genotypes CC (P = 0.009) and CT (P = 0.041) of SNP rs2070874, and alleles A (P = 0.044) and G of SNP rs1800871 were significantly different between the patients and healthy controls.” | 0.90 | hgvs_regex_v1 |
Meta-analysis of diabetic nephropathy associated genetic variants in inflammation and angiogenesis involved in different biochemical pathways.
PMID 25280384 | PMCID PMC4411872 | DOI 10.1186/s12881-014-0103-8 · BMC medical genetics · 2014 · 11 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1800871 | “These included genetic variants within or near VEGFA, CCR5, CCL2, IL-1, MMP9, EPO, IL-8, ADIPOQ and IL-10. rs1800871 (T) genetic variant in IL-10 showed protective effect for DN.” | 0.90 | hgvs_regex_v1 |
| gene | VEGFA | “These included genetic variants within or near VEGFA, CCR5, CCL2, IL-1, MMP9, EPO, IL-8, ADIPOQ and IL-10. rs1800871 (T) genetic variant in IL-10 showed protective effect for DN.” | 0.98 | hgnc_dict_v1 |
| gene | CCR5 | “These included genetic variants within or near VEGFA, CCR5, CCL2, IL-1, MMP9, EPO, IL-8, ADIPOQ and IL-10. rs1800871 (T) genetic variant in IL-10 showed protective effect for DN.” | 0.98 | hgnc_dict_v1 |
| gene | CCL2 | “These included genetic variants within or near VEGFA, CCR5, CCL2, IL-1, MMP9, EPO, IL-8, ADIPOQ and IL-10. rs1800871 (T) genetic variant in IL-10 showed protective effect for DN.” | 0.98 | hgnc_dict_v1 |