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10 records shown · first 60Interleukin-1β and Tumor Necrosis Factor-α Gene Polymorphisms in Systemic Sclerosis.
PMID 40070856 | PMCID PMC11892941 | DOI 10.2478/bjmg-2024-0017 · Balkan journal of medical genetics : BJMG · 2024 · 14 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1800896 | “Variations in allele, genotype, or haplotype distribution between patients and healthy volunteers were observed for the following SNPs: IL-1β -511 C/T (rs16944) and +3962 T/C (rs1143634); IL-4Rα +1902 G/A (rs1801275); IL-12 -1188 C/A (rs3212227); TGF-β1 codon 25 G/C (rs1800471); TNF-α-308 G/A (rs1800629) and -238 G/A (rs361525); IL-4 -1098 T/G (rs2243248) and -590 T/C (rs2243250); IL-6 -174 G/C (rs1800795) and nt565 G/A (rs1800797); and IL-10 -1082 G/A (rs1800896), -819 C/T (rs1800871) and -592 C/A (rs1800872).” | 0.90 | hgvs_regex_v1 |
| variant | rs16944 | “Variations in allele, genotype, or haplotype distribution between patients and healthy volunteers were observed for the following SNPs: IL-1β -511 C/T (rs16944) and +3962 T/C (rs1143634); IL-4Rα +1902 G/A (rs1801275); IL-12 -1188 C/A (rs3212227); TGF-β1 codon 25 G/C (rs1800471); TNF-α-308 G/A (rs1800629) and -238 G/A (rs361525); IL-4 -1098 T/G (rs2243248) and -590 T/C (rs2243250); IL-6 -174 G/C (rs1800795) and nt565 G/A (rs1800797); and IL-10 -1082 G/A (rs1800896), -819 C/T (rs1800871) and -592 C/A (rs1800872).” | 0.90 | hgvs_regex_v1 |
| variant | rs1143634 | “Variations in allele, genotype, or haplotype distribution between patients and healthy volunteers were observed for the following SNPs: IL-1β -511 C/T (rs16944) and +3962 T/C (rs1143634); IL-4Rα +1902 G/A (rs1801275); IL-12 -1188 C/A (rs3212227); TGF-β1 codon 25 G/C (rs1800471); TNF-α-308 G/A (rs1800629) and -238 G/A (rs361525); IL-4 -1098 T/G (rs2243248) and -590 T/C (rs2243250); IL-6 -174 G/C (rs1800795) and nt565 G/A (rs1800797); and IL-10 -1082 G/A (rs1800896), -819 C/T (rs1800871) and -592 C/A (rs1800872).” | 0.90 | hgvs_regex_v1 |
| variant | rs1801275 | “Variations in allele, genotype, or haplotype distribution between patients and healthy volunteers were observed for the following SNPs: IL-1β -511 C/T (rs16944) and +3962 T/C (rs1143634); IL-4Rα +1902 G/A (rs1801275); IL-12 -1188 C/A (rs3212227); TGF-β1 codon 25 G/C (rs1800471); TNF-α-308 G/A (rs1800629) and -238 G/A (rs361525); IL-4 -1098 T/G (rs2243248) and -590 T/C (rs2243250); IL-6 -174 G/C (rs1800795) and nt565 G/A (rs1800797); and IL-10 -1082 G/A (rs1800896), -819 C/T (rs1800871) and -592 C/A (rs1800872).” | 0.90 | hgvs_regex_v1 |
Molecular Determination of Tumor Necrosis Factor-alpha, Interleukin-8, Interleukin-10, and C-X-C Chemokine Receptor-2 Genetic Variations and their Association with Disease Susceptibility and Mortality in COVID-19 Patients.
PMID 38544825 | PMCID PMC10964085 | DOI 10.2174/0113892029272497240103052359 · Current genomics · 2024 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1800896 | “The polymorphisms in TNFα -308 G>A (rs1800629), IL-8 -251T>A (rs4073), CXCR2 +785 C>T (rs2230054) genes were detected by ARMS -PCR assay whereas for IL-10 (-1082 G>A), rs1800896 G>A allele-specific PCR assay was used and their association with COVID-19 susceptibility and mortality was estimated by multivariate analysis.” | 0.90 | hgvs_regex_v1 |
| gene | CXCR2 | “The polymorphisms in TNFα -308 G>A (rs1800629), IL-8 -251T>A (rs4073), CXCR2 +785 C>T (rs2230054) genes were detected by ARMS -PCR assay whereas for IL-10 (-1082 G>A), rs1800896 G>A allele-specific PCR assay was used and their association with COVID-19 susceptibility and mortality was estimated by multivariate analysis.” | 0.98 | hgnc_dict_v1 |
| phenotype | COVID-19 | “Molecular Determination of Tumor Necrosis Factor-alpha, Interleukin-8, Interleukin-10, and C-X-C Chemokine Receptor-2 Genetic Variations and their Association with Disease Susceptibility and Mortality in COVID-19 Patients.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | rs1800629 | “The polymorphisms in TNFα -308 G>A (rs1800629), IL-8 -251T>A (rs4073), CXCR2 +785 C>T (rs2230054) genes were detected by ARMS -PCR assay whereas for IL-10 (-1082 G>A), rs1800896 G>A allele-specific PCR assay was used and their association with COVID-19 susceptibility and mortality was estimated by multivariate analysis.” | 0.90 | hgvs_regex_v1 |
Impacts of circulating cytokine levels and gene polymorphism predisposition on type 1 diabetes mellitus.
PMID 39231486 | PMCID PMC11374510 | DOI 10.6065/apem.2346178.089 · Annals of pediatric endocrinology & metabolism · 2024 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1800896 | “RESULTS: The levels of 3 circulating cytokines (transforming growth factor [TGF]-β1, interleukin [IL]-10, and IL-6) and 6 SNPs in 3 cytokine genes (TGF-β1 [rs1800470 and rs1800471], IL-10 [rs1800896, rs1800871, and rs1800872], and IL-6 [rs1800795]) that contribute to genetic susceptibility were measured by enzyme-linked immunosorbent assay and polymerase chain reaction with sequence-specific primers.” | 0.90 | hgvs_regex_v1 |
| phenotype | diabetes mellitus | “Impacts of circulating cytokine levels and gene polymorphism predisposition on type 1 diabetes mellitus.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “The aim of this study was to investigate the roles of cytokine levels and the association of single-nucleotide polymorphisms (SNPs) within cytokine genes with T1DM in Saudi children. Moreover, our data demonstrated no appreciable diferences in circulating serum level or genotype and phenotype of IL- 10 between the patients and controls. CONCLUSION: This kind of measurement, which considers the prediction of T1DM, may be useful in assessing the severity of T1DM and susceptibility to T1DM among Saudi children.” | 0.95 | saudi_context_rules_v1 |
| variant | rs1800470 | “RESULTS: The levels of 3 circulating cytokines (transforming growth factor [TGF]-β1, interleukin [IL]-10, and IL-6) and 6 SNPs in 3 cytokine genes (TGF-β1 [rs1800470 and rs1800471], IL-10 [rs1800896, rs1800871, and rs1800872], and IL-6 [rs1800795]) that contribute to genetic susceptibility were measured by enzyme-linked immunosorbent assay and polymerase chain reaction with sequence-specific primers.” | 0.90 | hgvs_regex_v1 |
Interleukin 10 (IL-10) gene variants and haplotypes in Tunisian women with polycystic ovary syndrome (PCOS): a case-control study.
PMID 37541999 | DOI 10.1007/s11033-023-08706-9 · Molecular biology reports · 2023 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1800896 | “Genotyping for IL-10, rs1800896, rs1800871 and rs1800872 variants, was performed by real time PCR.” | 0.90 | hgvs_regex_v1 |
| phenotype | diabetes mellitus | “BACKGROUND: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder that affects women in their child-bearing age, and is associated with insulin resistance and type 2 diabetes.” | 0.93 | phenotype_alias_lexicon_v2 |
| variant | rs1800871 | “Genotyping for IL-10, rs1800896, rs1800871 and rs1800872 variants, was performed by real time PCR.” | 0.90 | hgvs_regex_v1 |
| variant | rs1800872 | “Genotyping for IL-10, rs1800896, rs1800871 and rs1800872 variants, was performed by real time PCR.” | 0.90 | hgvs_regex_v1 |
IL-10 rs1800896 Polymorphism: A Risk Factor for Adult Acute Lymphoblastic Leukemia.
PMID 36119849 | PMCID PMC9480578 | DOI 10.2147/PGPM.S377356 · Pharmacogenomics and personalized medicine · 2022 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1800896 | “IL-10 rs1800896 Polymorphism: A Risk Factor for Adult Acute Lymphoblastic Leukemia.” | 0.90 | hgvs_regex_v1 |
| phenotype | leukemia | “IL-10 rs1800896 Polymorphism: A Risk Factor for Adult Acute Lymphoblastic Leukemia.” | 0.98 | phenotype_alias_lexicon_v2 |
A preliminary study of cytokine gene polymorphism effects on Saudi patients with colorectal cancer.
PMID 33294886 | PMCID PMC7841582 | DOI 10.15537/smj.2020.12.25543 · Saudi medical journal · 2020 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1800896 | “OBJECTIVE: To determine the possible associations of polymorphisms in interleukin (IL)-8 (rs4073 T/A), IL-10 (rs1800896 A/G), IL-22 (rs1179251 C/G and rs2227485 C/T), IL-27 (rs17855750 T/G), and transforming growth factor beta 1 (TGFß1) (rs1800469 C/T) with colorectal cancer (CRC) susceptibility in Saudi patients.” | 0.90 | hgvs_regex_v1 |
| phenotype | colorectal cancer | “A preliminary study of cytokine gene polymorphism effects on Saudi patients with colorectal cancer.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia, Riyadh | “A preliminary study of cytokine gene polymorphism effects on Saudi patients with colorectal cancer. OBJECTIVE: To determine the possible associations of polymorphisms in interleukin (IL)-8 (rs4073 T/A), IL-10 (rs1800896 A/G), IL-22 (rs1179251 C/G and rs2227485 C/T), IL-27 (rs17855750 T/G), and transforming growth factor beta 1 (TGFß1) (rs1800469 C/T) with colorectal cancer (CRC) susceptibility in Saudi patients. METHODS: The case-control study was carried out between July 2019 and January 2020 in King Khaled University Hospital, Riyadh, Saudi Arabia. A total of 70 patients with CRC and 70 healthy controls were included in the study.” | 0.95 | saudi_context_rules_v1 |
| variant | rs4073 | “OBJECTIVE: To determine the possible associations of polymorphisms in interleukin (IL)-8 (rs4073 T/A), IL-10 (rs1800896 A/G), IL-22 (rs1179251 C/G and rs2227485 C/T), IL-27 (rs17855750 T/G), and transforming growth factor beta 1 (TGFß1) (rs1800469 C/T) with colorectal cancer (CRC) susceptibility in Saudi patients.” | 0.90 | hgvs_regex_v1 |
Two novel SNPs in genes involved in immune response and their association with mandibular residual ridge resorption.
PMID 32127761 | PMCID PMC7042620 | DOI 10.1016/j.sjbs.2020.01.016 · Saudi journal of biological sciences · 2020 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1800896 | “We found that rs1800896 in the IL10 gene and rs5743289 in NOD2 gene showed significant association with RRR.” | 0.90 | hgvs_regex_v1 |
| gene | IL10 | “We found that rs1800896 in the IL10 gene and rs5743289 in NOD2 gene showed significant association with RRR.” | 0.98 | hgnc_dict_v1 |
| gene | NOD2 | “We found that rs1800896 in the IL10 gene and rs5743289 in NOD2 gene showed significant association with RRR.” | 0.98 | hgnc_dict_v1 |
| population | Saudi Arabia | “The study group included 96 RRR patients and 96 controls. Finally, we suggest that the results of this study may be utilized for developing novel genetic diagnostic tests and for identifying Saudi individuals who may be more susceptible to RRR development following dental extraction.” | 0.95 | saudi_context_rules_v1 |
Interleukin-10 (1082G/A) Polymorphism is Associated with Susceptibility of Acute Myeloid Leukemia Patients in Sudanese Population.
PMID 31350948 | PMCID PMC6745212 | DOI 10.31557/APJCP.2019.20.7.1939 · Asian Pacific journal of cancer prevention : APJCP · 2019 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1800896 | “We examined the association between a single nucleotide polymorphism (SNP) in IL-10 -1082G/A (rs1800896) in Sudanese acute myeloid leukemia (AML) patients and to assess the association between polymorphisms in IL-10 -1082G/A (rs1800896) and the hematological profile in Sudanese patients with AML.” | 0.90 | hgvs_regex_v1 |
| phenotype | leukemia | “Interleukin-10 (1082G/A) Polymorphism is Associated with Susceptibility of Acute Myeloid Leukemia Patients in Sudanese Population.” | 0.98 | phenotype_alias_lexicon_v2 |
IL-10 -1082 A>G (rs1800896) polymorphism confers susceptibility to pulmonary tuberculosis in Caucasians but not in Asians and Africans: a meta-analysis.
PMID 28951522 | PMCID PMC5658633 | DOI 10.1042/BSR20170240 · Bioscience reports · 2017 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1800896 | “IL-10 -1082 A>G (rs1800896) polymorphism confers susceptibility to pulmonary tuberculosis in Caucasians but not in Asians and Africans: a meta-analysis.” | 0.90 | hgvs_regex_v1 |
| phenotype | tuberculosis | “IL-10 -1082 A>G (rs1800896) polymorphism confers susceptibility to pulmonary tuberculosis in Caucasians but not in Asians and Africans: a meta-analysis.” | 0.98 | phenotype_alias_lexicon_v2 |
Interleukin-10.rs1800896 and Interleukin-18.rs1946518 gene polymorphisms could not predict the outcome of hepatitis C virus infection in Egyptian patients treated with pegylated interferon plus ribavirin.
PMID 27352267 | DOI 10.1007/s00705-016-2948-y · Archives of virology · 2016 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1800896 | “Interleukin-10.rs1800896 and Interleukin-18.rs1946518 gene polymorphisms could not predict the outcome of hepatitis C virus infection in Egyptian patients treated with pegylated interferon plus ribavirin.” | 0.90 | hgvs_regex_v1 |
| phenotype | hepatitis C | “Interleukin-10.rs1800896 and Interleukin-18.rs1946518 gene polymorphisms could not predict the outcome of hepatitis C virus infection in Egyptian patients treated with pegylated interferon plus ribavirin.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | rs1946518 | “Interleukin-10.rs1800896 and Interleukin-18.rs1946518 gene polymorphisms could not predict the outcome of hepatitis C virus infection in Egyptian patients treated with pegylated interferon plus ribavirin.” | 0.90 | hgvs_regex_v1 |