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2 records shown · first 60A CD40 variant is associated with systemic bone loss among patients with rheumatoid arthritis.
PMID 35107652 | DOI 10.1007/s10067-021-05998-9 · Clinical rheumatology · 2022 · 12 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs2230926 | “METHODS: IRAK-1 rs3027898, IRAK-2 rs3844283, IRAK-2 rs708035, IFIH1 rs1990760, CD40 rs48104850, TNFAIP3 rs2230926, and miR146-a rs2910164 were genotyped in 176 adult RA patients.” | 0.90 | hgvs_regex_v1 |
| gene | CD40 | “A CD40 variant is associated with systemic bone loss among patients with rheumatoid arthritis.” | 0.98 | hgnc_dict_v1 |
| gene | IFIH1 | “METHODS: IRAK-1 rs3027898, IRAK-2 rs3844283, IRAK-2 rs708035, IFIH1 rs1990760, CD40 rs48104850, TNFAIP3 rs2230926, and miR146-a rs2910164 were genotyped in 176 adult RA patients.” | 0.98 | hgnc_dict_v1 |
| gene | TNFAIP3 | “METHODS: IRAK-1 rs3027898, IRAK-2 rs3844283, IRAK-2 rs708035, IFIH1 rs1990760, CD40 rs48104850, TNFAIP3 rs2230926, and miR146-a rs2910164 were genotyped in 176 adult RA patients.” | 0.98 | hgnc_dict_v1 |
Characterization of Rheumatoid Arthritis Risk-Associated SNPs and Identification of Novel Therapeutic Sites Using an In-Silico Approach.
PMID 34199962 | PMCID PMC8227790 | DOI 10.3390/biology10060501 · Biology · 2021 · 10 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs2230926 | “The damaging effect of 23 non-synonymous SNPs on proteins using different tools suggested four SNPs, including rs2476601 in PTPN22, rs5029941 and rs2230926 in TNFAIP3, and rs34536443 in TYK2, to be the most damaging.” | 0.90 | hgvs_regex_v1 |
| gene | PTPN22 | “The damaging effect of 23 non-synonymous SNPs on proteins using different tools suggested four SNPs, including rs2476601 in PTPN22, rs5029941 and rs2230926 in TNFAIP3, and rs34536443 in TYK2, to be the most damaging.” | 0.98 | hgnc_dict_v1 |
| gene | TNFAIP3 | “The damaging effect of 23 non-synonymous SNPs on proteins using different tools suggested four SNPs, including rs2476601 in PTPN22, rs5029941 and rs2230926 in TNFAIP3, and rs34536443 in TYK2, to be the most damaging.” | 0.98 | hgnc_dict_v1 |
| gene | TYK2 | “The damaging effect of 23 non-synonymous SNPs on proteins using different tools suggested four SNPs, including rs2476601 in PTPN22, rs5029941 and rs2230926 in TNFAIP3, and rs34536443 in TYK2, to be the most damaging.” | 0.98 | hgnc_dict_v1 |