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5 records shown · first 60ABCG2 polymorphisms and susceptibility to ARV-associated hepatotoxicity.
PMID 38451012 | PMCID PMC10955225 | DOI 10.1002/mgg3.2362 · Molecular genetics & genomic medicine · 2024 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs2231142 | “METHODS: To investigate this, we examined ABCG2 34G/A (rs2231137) and 421C/A (rs2231142) genetic variations in 149 HIV-infected patients (116 without hepatotoxicity, 33 with ARV-induced hepatotoxicity) and 151 healthy controls through the PCR-restriction fragment length polymorphism (PCR-RFLP) technique.” | 0.90 | hgvs_regex_v1 |
| gene | ABCG2 | “ABCG2 polymorphisms and susceptibility to ARV-associated hepatotoxicity.” | 0.98 | hgnc_dict_v1 |
| phenotype | HIV infection | “Moreover, when comparing HIV patients with hepatotoxicity to healthy controls, the haplotype GA had an association with an elevated risk for the development of hepatotoxicity (p = 0.041, OR = 1.73, 95% CI: 1.02-2.93).” | 0.93 | phenotype_alias_lexicon_v2 |
| variant | rs2231137 | “METHODS: To investigate this, we examined ABCG2 34G/A (rs2231137) and 421C/A (rs2231142) genetic variations in 149 HIV-infected patients (116 without hepatotoxicity, 33 with ARV-induced hepatotoxicity) and 151 healthy controls through the PCR-restriction fragment length polymorphism (PCR-RFLP) technique.” | 0.90 | hgvs_regex_v1 |
The frequency of rs2231142 in ABCG2 among Asian subgroups: implications for personalized rosuvastatin dosing.
PMID 36651271 | PMCID PMC9979151 | DOI 10.2217/pgs-2022-0155 · Pharmacogenomics · 2023 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs2231142 | “The frequency of rs2231142 in ABCG2 among Asian subgroups: implications for personalized rosuvastatin dosing.” | 0.90 | hgvs_regex_v1 |
| gene | ABCG2 | “The frequency of rs2231142 in ABCG2 among Asian subgroups: implications for personalized rosuvastatin dosing.” | 0.98 | hgnc_dict_v1 |
| variant | Q141K | “The missense variant Q141K within ABCG2, highly prevalent in some Asian subgroups, results in decreased transporter efflux function and increased exposure to rosuvastatin.” | 0.82 | literature_variant_regex_v2 |
Association between ABCB1, ABCG2 carrier protein and COX-2 enzyme gene polymorphisms and breast cancer risk in a Turkish population.
PMID 32042261 | PMCID PMC7000306 | DOI 10.1016/j.jsps.2019.11.024 · Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2020 · 9 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs2231142 | “METHOD: ABCG2 C421A (rs2231142), ABCB1 C3435T (rs1045642), COX-2 T8473C (rs5275) and COX-2 G306C (rs5277) were genotyped 104 breast cancer patients and 90 healthy controls using a real-time PCR for breast cancer susceptibility.” | 0.90 | hgvs_regex_v1 |
| gene | ABCB1 | “Association between ABCB1, ABCG2 carrier protein and COX-2 enzyme gene polymorphisms and breast cancer risk in a Turkish population.” | 0.98 | hgnc_dict_v1 |
| gene | ABCG2 | “Association between ABCB1, ABCG2 carrier protein and COX-2 enzyme gene polymorphisms and breast cancer risk in a Turkish population.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Association between ABCB1, ABCG2 carrier protein and COX-2 enzyme gene polymorphisms and breast cancer risk in a Turkish population.” | 0.98 | phenotype_alias_lexicon_v2 |
Role of Four ABC Transporter Genes in Pharmacogenetic Susceptibility to Breast Cancer in Jordanian Patients.
PMID 31391850 | PMCID PMC6662487 | DOI 10.1155/2019/6425708 · Journal of oncology · 2019 · 11 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs2231142 | “In terms of pathological characteristics, the ABCC1 SNP rs35628 and the ABCB1 SNP rs2032582 were significantly associated with tumor size, the ABCC2 SNP rs2273697 was significantly associated with estrogen receptor status, and the ABCG2 SNP rs2231142 was significantly associated with axillary lymph node status.” | 0.90 | hgvs_regex_v1 |
| gene | ABCC1 | “In the present study, single nucleotide polymorphisms (SNPs) from the ABCC1, ABCC2, ABCB1, and ABCG2 genes were screened in breast cancer patients and healthy volunteers from the Jordanian-Arab population.” | 0.98 | hgnc_dict_v1 |
| gene | ABCC2 | “In the present study, single nucleotide polymorphisms (SNPs) from the ABCC1, ABCC2, ABCB1, and ABCG2 genes were screened in breast cancer patients and healthy volunteers from the Jordanian-Arab population.” | 0.98 | hgnc_dict_v1 |
| gene | ABCB1 | “In the present study, single nucleotide polymorphisms (SNPs) from the ABCC1, ABCC2, ABCB1, and ABCG2 genes were screened in breast cancer patients and healthy volunteers from the Jordanian-Arab population.” | 0.98 | hgnc_dict_v1 |
Genetic polymorphism of the methotrexate transporter ABCG2, blood pressure and markers of arterial function in patients with rheumatoid arthritis: repeated cross-sectional study.
PMID 30519074 | PMCID PMC6237132 | DOI 10.2147/PGPM.S170557 · Pharmacogenomics and personalized medicine · 2018 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs2231142 | “We investigated associations between single-nucleotide polymorphism (SNP) of the ATP-binding cassette efflux transporter gene ABCG2 (rs2231142), BP, and arterial stiffness in RA patients treated with MTX.” | 0.90 | hgvs_regex_v1 |
| gene | ABCG2 | “Genetic polymorphism of the methotrexate transporter ABCG2, blood pressure and markers of arterial function in patients with rheumatoid arthritis: repeated cross-sectional study.” | 0.98 | hgnc_dict_v1 |
| phenotype | rheumatoid arthritis | “Genetic polymorphism of the methotrexate transporter ABCG2, blood pressure and markers of arterial function in patients with rheumatoid arthritis: repeated cross-sectional study.” | 0.98 | phenotype_alias_lexicon_v2 |